Protein Alignment PlexB and PLXNB1

DIOPT Version :10

• Sequence 1: NP_524616.2
• Gene: PlexB / 43766
• FlyBaseID: FBgn0025740
• Length: 2051
• Species: Drosophila melanogaster
• Sequence 2: XP_011532135.1
• Gene: PLXNB1 / 5364
• HGNCID: 9103
• Length: 2136
• Species: Homo sapiens
• Alignment Length: 2293
• Identity: 667/2293 - (29%)
• Similarity: 1035/2293 - (45%)
• Gaps: 522/2293 - (22%)

  Fly    86 YFTHMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQCHAGGCPEDI-ETSLVNNFN 149
            |..|::.|.....|:.||||.:.:|:..|::.|...|||:.||..|.....|::. :....||.|
Human    34 YLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQAQPTNNPN 98

  Fly   150 KILVVSYAHDGILIACGSIRQGACEIYSL---------PRFPATPQFFAVPLAANDENASTYAFV 205
            ::|:||   .|.|:.|||:.||.||...|         |..|...|:    :||||...||   |
Human    99 QLLLVS---PGALVVCGSVHQGVCEQRRLGQLEQLLLRPERPGDTQY----VAANDPAVST---V 153

  Fly   206 GPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRL---DDLNYAEFSIQQS---IINIDVKYR 264
            |........|.:|:||..:|:.| ....:|.|::|.|   |.  .|.||.:::   .:....:|.
Human   154 GLVAQGLAGEPLLFVGRGYTSRG-VGGGIPPITTRALWPPDP--QAAFSYEETAKLAVGRLSEYS 215

  Fly   265 DHFLVDYIYGFNSSEYAYFIIVQKKSHLADEAGYVTRLARICITDPNYDSYTEITVQCTATENNV 329
            .||:..:..|.:    |||:.:::... |....:...::|:|:.|.:|.||.|:.:.|....
Human   216 HHFVSAFARGAS----AYFLFLRRDLQ-AQSRAFRAYVSRVCLRDQHYYSYVELPLACEGGR--- 272

  Fly   330 DYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVFSPSR--EISNQPES------KSAMCIYSIKD 386
             |.:::.|.|. .|.::|.       ..||...||.:.  .:...|.:      .||:|.:.:.:
Human   273 -YGLIQAAAVA-TSREVAH-------GEVLFAAFSSAAPPTVGRPPSAAAGASGASALCAFPLDE 328

  Fly   387 IEDMFIENIHLCF--NGTTKD-RNLGYISGTIND--GRCPI----VGSLGNIYNFCSVGLKISGV 442
            ::.:.......|:  .|..:| ..:.||...:|.  .:.|:    ....|:.:....:..::
Human   329 VDRLANRTRDACYTREGRAEDGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTPSPMASRV--- 390

  Fly   443 SPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLSGQSPGE-YEEIVVDAGNR 506
             |:.|..:..:..:.:|:|..  |.:..|::||||.:.|.:.:|.|...|.|. |....:..|:.
Human   391 -PLEATPILEWPGIQLTAVAV--TMEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQSIQQGSA 452

  Fly   507 ILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTNCSACLESRDPFCGWCSLEKRCTVRSTCQRD 571
            :..:.......:.|||::|..:.|:.:..|:.:.:|::||..|||:||||.|..||:.||.|.|.
Human   453 VSRDLTFDGTFEHLYVMTQSTLLKVPVASCAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSRG 517

  Fly   572 TSASRWL-----SLGSGQQCIEFESIIPEKIPISELSHLHLIIRTLPEPF-NAKYRCVFG-NSTP 629
            ....:||     .||    |::..::.|..|...|...:.|.:..||..: ...|.|.|| :.:|
Human   518 QGPEQWLWSFQPELG----CLQVAAMSPANISREETREVFLSVPDLPPLWPGESYSCHFGEHQSP 578

  Fly   630 IDAEILENGLGCATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSRNFAFFDC------SHHG 688
              |.:..:|:.|.:|...|.|::|...|::.|.:.:|....  .....:.:|:||      ....
Human   579 --ALLTGSGVMCPSPDPSEAPVLPRGADYVSVSVELRFGAV--VIAKTSLSFYDCVAVTELRPSA 639

  Fly   689 NCQECLQSSWGCNWCIFDNKCVHK----------------------------------------- 712
            .||.|:.|.||||||::.:.|.||
Human   640 QCQACVSSRWGCNWCVWQHLCTHKASCDAGPMVASHQSPLVSPDPPARGGPSPSPPTAPKALATP 704

  Fly   713 ----------------------------------------------------------------- 712
                                                                             
Human   705 APDTLPVEPGAPSTATASDISPGASPSLLSPWGPWAGSGSISSPGSTGSPLHEEPSPPSPQNGPG 769

  Fly   713 ----------------------------------------------------------------- 712
                                                                             
Human   770 TAVPAPTDFRPSATPEDLLASPLSPSEVAAVPPADPGPEALHPTVPLDLPPATVPATTFPGAMGS 834

  Fly   713 -------------------------------------------------------SLQCR----- 717
                                                                   ||..:
Human   835 VKPALDWLTREGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEGPPAPLILPSSLDYQYDTPG 899

  Fly   718 --NIENAVSTVGHCPHLKKNRPEILLPVRVPIEIRLEIENLPKPKSAHAGFLCTIHIEAAQMLLP 780
              .:|.|......||.::..:...|:||.|..||||...||...:.......|.:.:|..::::.
Human   900 LWELEEATLGASSCPCVESVQGSTLMPVHVEREIRLLGRNLHLFQDGPGDNECVMELEGLEVVVE 964

  Fly   781 AHVE------SNKIVVCEKTPYFYEINTHEYQAKVVVTWNFQHYVDTA---IVTLYKCDVLGSHR 836
            |.||      :...|.|::....||....|.:..:.:....:..||:|   .|.||.|.|
Human   965 ARVECEPPPDTQCHVTCQQHQLSYEALQPELRVGLFLRRAGRLRVDSAEGLHVVLYDCSV----- 1024

  Fly   837 EHPDCSLCVTRDPKYKCAWCSNS---CVYNETCIADKNSISSGSKSAIENECPLPRIDIIKPLSG 898
            .|.|||.|.|..|:|.|.||...   ||..|.|         |...|:..:||.|.|..::||:|
Human  1025 GHGDCSRCQTAMPQYGCVWCEGERPRCVTREAC---------GEAEAVATQCPAPLIHSVEPLTG 1080

  Fly   899 PVEGGTLITIEGSNLGIREEDVRGKIFIGSVPC--ELENYQISVKIECRTGASLYEMSAPIKV-- 959
            ||:|||.:||.|||||...:||.|.:.:..|||  :.:.|::|..:.|.||||..|::....|
Human  1081 PVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGASGEEVAGATAVEV 1145

  Fly   960 -ANDAGFTESSVQFHFKNVLLTGLYPTIGPRSGGTQLSLIGKFLNIG--STMRAFLDEYECHIDV 1021
             ....|.:|.  .|.:::..:..::|..|||:|||:|:|.|..|..|  ..:|..:.:..||: :
Human  1146 PGRGRGVSEH--DFAYQDPKVHSIFPARGPRAGGTRLTLNGSKLLTGRLEDIRVVVGDQPCHL-L 1207

  Fly  1022 TQASSSQVSCTTSEATQPEPIRSLHLVIDGANRTLECQISTPSITNTNPTRSNFGSYQLRSLPRQ 1086
            .:..|.|:.|.||    |.|                    ||:   |.|....||:.:.|....|
Human  1208 PEQQSEQLRCETS----PRP--------------------TPA---TLPVAVWFGATERRLQRGQ 1245

  Fly  1087 PCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSIQKPELEVFYDNERVNKTSCVVINSNQ 1151
                |.||.||.|....|.:||.||||.:.|.|..|:.:|.|.:.|            .|:  ::
Human  1246 ----FKYTLDPNITSAGPTKSFLSGGREICVRGQNLDVVQTPRIRV------------TVV--SR 1292

  Fly  1152 MECPSPPVNYKFETFKKT---------NRKMDTELHLQNSSFQTETRYKNEYDRKKRRADFGDTF 1207
            |..||..:..:.....:|         :::.:...|:.:|..                    .|.
Human  1293 MLQPSQGLGRRRRVVPETACSLGPSCSSQQFEEPCHVNSSQL--------------------ITC 1337

  Fly  1208 RLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFVMDNVQL-VRNLNKYFHDIRSTIVYLAD 1271
            |.....|...:.:|                   ::.|::||:.. ...||.      :...|.||
Human  1338 RTPALPGLPEDPWV-------------------RVEFILDNLVFDFATLNP------TPFSYEAD 1377

  Fly  1272 PKYLPF-PNDGVKLYK---GDSLVIEGELLNLAADEYDVNVTIGTSQCNITSLALNQLLCIPPEQ 1332
            |...|. |.|....::   |....:|||.|:||..:.:|...||...|.:.:|..:.|.|.||.:
Human  1378 PTLQPLNPEDPTMPFRHKPGSVFSVEGENLDLAMSKEEVVAMIGDGPCVVKTLTRHHLYCEPPVE 1442

  Fly  1333 QPLPTDENGVDQSTDLPLVVVKVGRNLRFVIGYLKYDLNKPYVFSHALLVGI-LTVALLVVVFVI 1396
            ||||......:....||...|::| ||||.:|:::||...|..|..|..||: :..:||.:..:|
Human  1443 QPLPRHHALREAPDSLPEFTVQMG-NLRFSLGHVQYDGESPGAFPVAAQVGLGVGTSLLALGVII 1506

  Fly  1397 VLIIFRRKSTQAEREYKRIQIQMITLESNVRSECKQAFAELQTDMTDLTADLESTGIPTLDHVNY 1461
            :::::||||.||.|:||::|||:..|||:||..||:.|.:|.|:|||||:||..:|||.||:..|
Human  1507 IVLMYRRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDLMTEMTDLTSDLLGSGIPFLDYKVY 1571

  Fly  1462 IMKVFFPGVSDHPI---LNSPKFREGSPQTNYDAAMVQFEQLIGNKYFLLMFIETLEAQRSSFSI 1523
            ..::||||..:.|:   |..|:.|    :...:..:.|...|:.:|.||..||.|||:|| :||.
Human  1572 AERIFFPGHRESPLHRDLGVPESR----RPTVEQGLGQLSNLLNSKLFLTKFIHTLESQR-TFSA 1631

  Fly  1524 RDRVNVASLIMVVLMNKMEYATEILKSLLLRLIDKSLASKHPQLMLRRTESVVEKMLTNYLAICM 1588
            |||..||||:.|.|..|:||.|:||::||..|:.:.:| |:|:|||||||:||||:|||:::||:
Human  1632 RDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVA-KNPKLMLRRTETVVEKLLTNWMSICL 1695

  Fly  1589 YDYLKEYAGSNLFLLFKAIKHQIEKGLVDAITNDARYSLSEERLLHEQVTHSVVILHIL-----Q 1648
            |.::::..|..|::||:.||||::||.||::|..|:|:|::.|||.|.|.:..:.|:.|     .
Human  1696 YTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGPG 1760

  Fly  1649 DDLDEKVQCRVNDWDTISQVKLKILDAIFKNTPFSMRPSVNEVDLEWRHGRGGHLTLQDEDLTTK 1713
            ....:.|..:|.|.|||||.|.|:||.::|..|.:.||....:|:|||.|..|||.|.|||:|::
Human  1761 AGEAQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDPRTLDVEWRSGVAGHLILSDEDVTSE 1825

  Fly  1714 TVNGWKRLNTLAHY-GVKESAVMSL-------IARQNDNYHIPYSKNQNSAPYHNFYFINNSQSH 1770
            ....|:|||||.|| .|.:.|.::|       :.|:|.:| :|..:..
Human  1826 VQGLWRRLNTLQHYKQVPDGATVALVPCLTKHVLRENQDY-VPGERTP----------------- 1872

  Fly  1771 IIINNDIESGLQQPRVYHLVKPNIPDHYMNIKNSVLSGGSPAFQSHVVNNCNDRVNKTIPEVYLT 1835
              :..|::.|..:|  :|||||:........:...|.||.           .:|. |.|||:|||
Human  1873 --MLEDVDEGGIRP--WHLVKPSDEPEPPRPRRGSLRGGE-----------RERA-KAIPEIYLT 1921

  Fly  1836 RLLATKGTIQKFVDDFFSIILTVNEELPPAVKWLFDLLDEAARRHDIADTDIVHAWKSNCLPLRF 1900
            |||:.|||:||||||.|.:||:.:..:|.|||:.||||||.|::|.|:|.|.:|.||:|.|||||
Human  1922 RLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTNSLPLRF 1986

  Fly  1901 WVNFIKNPDFIFDVNKTYSVDSCLSVIAQTFMDACSTSEHRLGKDSPSNKLLFAKDIPNYRIMVK 1965
            |:|.||||.|:|||..:.::|:.|.||||||||||:.::|:||:|||.||||:|:|||.|:.||:
Human  1987 WINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLYARDIPRYKRMVE 2051

  Fly  1966 EFYRDVSRLPQISDQEMSTAMQQLSVRQNEEFDTISALKELYIYITKYKDQIMESLETDINCRKM 2030
            .:|.|:.:....|||||::.:.:||...:.:.....||.|||.||.||.|||:.:||.|...:||
Human  2052 RYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKM 2116

  Fly  2031 HLSRKLGNVAATLDGDCT 2048
            .|..:|..:||.::...|
Human  2117 QLGYRLQQIAAAVENKVT 2134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PlexB	NP_524616.2	Sema_plexin_like	86..534	CDD:200497	118/481 (25%)
		PSI	535..586	CDD:396154	22/55 (40%)
		TIG_plexin	594..682	CDD:465588	21/89 (24%)
		PSI	683..730	CDD:214655	19/285 (7%)
		TIG_2	738..827	CDD:465619	24/97 (25%)
		PSI	836..877	CDD:214655	15/43 (35%)
		IPT_plexin_repeat1	888..976	CDD:238585	35/92 (38%)
		IPT_plexin_repeat2	977..1095	CDD:238584	32/119 (27%)
		IPT_plexin_repeat3	1097..1211	CDD:238586	24/122 (20%)
		TIG	1277..>1334	CDD:460355	18/60 (30%)
		Plexin_cytopl	1452..2012	CDD:462434	246/575 (43%)
PLXNB1	XP_011532135.1	Sema_plexin_B1	28..480	CDD:200536	118/481 (25%)
		PSI	481..527	CDD:396154	20/45 (44%)
		TIG_plexin	541..627	CDD:465588	21/89 (24%)
		PSI	641..677	CDD:214655	13/35 (37%)
		PHA03247	<681..839	CDD:223021	0/157 (0%)
		TIG_2	921..1020	CDD:465619	24/98 (24%)
		PSI	1021..>1061	CDD:396154	18/53 (34%)
		IPT_plexin_repeat1	1070..1161	CDD:238585	35/92 (38%)
		IPT_plexin_repeat2	1162..1249	CDD:238584	31/118 (26%)
		IPT_plexin_repeat3	1252..1376	CDD:238586	32/182 (18%)
		Plexin_cytopl	1562..2098	CDD:462434	246/575 (43%)