DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexB and PLXNA1

DIOPT Version :9

Sequence 1:	NP_001245400.1	Gene:	PlexB / 43766	FlyBaseID:	FBgn0025740	Length:	2051	Species:	Drosophila melanogaster
Sequence 2:	NP_115618.3	Gene:	PLXNA1 / 5361	HGNCID:	9099	Length:	1896	Species:	Homo sapiens

Alignment Length:	2107	Identity:	718/2107 - (34%)
Similarity:	1080/2107 - (51%)	Gaps:	300/2107 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LHVLCIIIILGSQHYCVNCIEELPAQALSPLNDIVAQFNLPSIPVQSTASSYGNRSIGNNIESVR 79
            |.||.::::|                 |..|..:.|:..||             |:.|.:....|
Human     8 LQVLLLLLLL-----------------LLLLPGMWAEAGLP-------------RAGGGSQPPFR 42

  Fly    80 DSQSKNY-FTHMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQCH----AGGCPED 139
            ...:.:: .||:........::.||.|:|.||:.||.:|...||||:.|:.:|:    ...||..
Human    43 TFSASDWGLTHLVVHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVEDNEKCYPPPSVQSCPHG 107

  Fly   140 IETSLVNNFNKILVVSYAHDGILIACGSIRQGACEIYSLPRF--PATPQFFAVPLAANDENASTY 202
            :.::  :|.||:|::.||.:. |:||||..||.|:...|...  ...|........::.:.|.:.
Human   108 LGST--DNVNKLLLLDYAANR-LLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVQEAGSM 169

  Fly   203 AFVGPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRL----DDLNYAEFSIQQSIINIDVKY 263
            |.|..|....:.:..|:|||......:|   .|.:|||||    :|.:...|..|...::..:|.
Human   170 AGVLIAGPPGQGQAKLFVGTPIDGKSEY---FPTLSSRRLMANEEDADMFGFVYQDEFVSSQLKI 231

  Fly   264 RDH-------FLVDYIYGFNSSEYAYFIIVQKKSHLA--DEAG---YVTRLARICITDPNYDSYT 316
            ...       |.:.|:|.|.|.::.|::.:|..:.|.  |.||   :.:::.|:|:.||.:.||.
Human   232 PSDTLSKFPAFDIYYVYSFRSEQFVYYLTLQLDTQLTSPDAAGEHFFTSKIVRLCVDDPKFYSYV 296

  Fly   317 EITVQCTATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVFSPSREISNQPESKSAMCI 381
            |..:.|  .:..|:|.:|:||.::.....||.::|:.:|:.||.|||:..::...:|..:||:|:
Human   297 EFPIGC--EQAGVEYRLVQDAYLSRPGRALAHQLGLAEDEDVLFTVFAQGQKNRVKPPKESALCL 359

  Fly   382 YSIKDIEDMFIENIHLCFNGTTK-------DRNLGYISG--TINDGRCPIVGSLGNIYNFCSVGL 437
            ::::.|::...|.|..|:.|..|       ::.||.|:.  .|:|..|      |..:|     .
Human   360 FTLRAIKEKIKERIQSCYRGEGKLSLPWLLNKELGCINSPLQIDDDFC------GQDFN-----Q 413

  Fly   438 KISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLSGQSPG-----EYE 497
            .:.|...|....||...:..:|:|.|...  :..::.|.||..|.|:|:|:...:||     .||
Human   414 PLGGTVTIEGTPLFVDKDDGLTAVAAYDY--RGRTVVFAGTRSGRIRKILVDLSNPGGRPALAYE 476

  Fly   498 EIVVDAGNRILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTNCSACLESRDPFCGWCSLEKRC 562
            .:|...|:.||.:.::||...:||.::::::|::.:|.|..||:|..||.||||.||||.|...|
Human   477 SVVAQEGSPILRDLVLSPNHQYLYAMTEKQVTRVPVESCVQYTSCELCLGSRDPHCGWCVLHSIC 541

  Fly   563 TVRSTCQRDTSASRWLSLGSGQQCIEFESIIPEKIPISELSHLHLIIRTLPEP-FNAKYRCVFGN 626
            :.|..|:|.....|:.:  ...||::. ::.|..:.:: :|.:.|:::....| .:|...|.|.:
Human   542 SRRDACERADEPQRFAA--DLLQCVQL-TVQPRNVSVT-MSQVPLVLQAWNVPDLSAGVNCSFED 602

  Fly   627 STPIDAEILENG-LGCATPPLDE-RPLIPTNTDHILVPLSVRSSETNKDFVSRNFAFFDCSHHGN 689
            .|..:: :||:| :.|.:|...| .|:.....|..:|.|.::|.||.|.|.|.:|.|::||.|.:
Human   603 FTESES-VLEDGRIHCRSPSAREVAPITRGQGDQRVVKLYLKSKETGKKFASVDFVFYNCSVHQS 666

  Fly   690 CQECLQSSWGCNWCIFDNKCVHKSLQCRNIENAVSTVGHCPHLKKNRPEILLPVRVPIEIRLEIE 754
            |..|:..|:.|:||.:.:.|.|....|..:|..|:....||.:..: .:|.:||.|...|.|...
Human   667 CLSCVNGSFPCHWCKYRHVCTHNVADCAFLEGRVNVSEDCPQILPS-TQIYVPVGVVKPITLAAR 730

  Fly   755 NLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKTPYFYEIN-THEYQAKVVVTWNFQHY 818
            |||:|:|...|:.|..||..:...:.|...::..:.|:.:.|.||.| ..:....:.|.||....
Human   731 NLPQPQSGQRGYECLFHIPGSPARVTALRFNSSSLQCQNSSYSYEGNDVSDLPVNLSVVWNGNFV 795

  Fly   819 VD---TAIVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWC--SNSCVYNETCIADKNSISSGSK 878
            :|   .....||||..|   ||  .|.||:..||:::|.||  ...|.....|.||..:....::
Human   796 IDNPQNIQAHLYKCPAL---RE--SCGLCLKADPRFECGWCVAERRCSLRHHCAADTPASWMHAR 855

  Fly   879 SAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIFIGSVPCE-LENYQISV-K 941
            .. .:.|..|:|..:.|.:||.:|||.:||.|.|||:|.||||..:.:|.|.|. :|:..||. :
Human   856 HG-SSRCTDPKILKLSPETGPRQGGTRLTITGENLGLRFEDVRLGVRVGKVLCSPVESEYISAEQ 919

  Fly   942 IECRTG--ASLYEMSAPIKV-ANDAG---FTESSVQFHFKNVLLTGLYPTIGPRSGGTQLSLIGK 1000
            |.|..|  :|:....|.::| ..|..   ...|..:|.|.......:.|:.||.||||.:.:.|.
Human   920 IVCEIGDASSVRAHDALVEVCVRDCSPHYRALSPKRFTFVTPTFYRVSPSRGPLSGGTWIGIEGS 984

  Fly  1001 FLNIGSTMRAFLDEYECHIDVTQASSSQVSCTTSEATQPEPIRSLHLVIDGANRTLECQISTPSI 1065
            .||.||.:...:....|  ..:..:|.::.|.|.....|.                    |.|.|
Human   985 HLNAGSDVAVSVGGRPC--SFSWRNSREIRCLTPPGQSPG--------------------SAPII 1027

  Fly  1066 TNTNPTRSNFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSIQKPEL 1130
            .|.|           |:....|...:|||:||.|::|.|..|..|||.:|||.|..|.::::|.:
Human  1028 ININ-----------RAQLTNPEVKYNYTEDPTILRIDPEWSINSGGTLLTVTGTNLATVREPRI 1081

  Fly  1131 EVFYDN-ERVNKTSCVVINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQNSSFQTETRYKNEY 1194
            ...|.. ||.|  .|:|.|...|.|.:|.|.....:..:...:.|
Human  1082 RAKYGGIEREN--GCLVYNDTTMVCRAPSVANPVRSPPELGERPD-------------------- 1124

  Fly  1195 DRKKRRADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFVMDNVQLVRNLNKYF 1259
                                                          :|.||||||:.:..||.
Human  1125 ----------------------------------------------ELGFVMDNVRSLLVLNS-- 1141

  Fly  1260 HDIRSTIVYLADPKYLPF-PNDGVKLYKGDSLVIEG-ELLNLAADEYDVNVT--IGTSQCNITSL 1320
                ::.:|..||...|. |...::|.....|:::| .||..|.....:|.|  ||::.|.:| :
Human  1142 ----TSFLYYPDPVLEPLSPTGLLELKPSSPLILKGRNLLPPAPGNSRLNYTVLIGSTPCTLT-V 1201

  Fly  1321 ALNQLLCIPPEQQPLPTDENGVDQSTDLPLVVVKVGRNLRFVIGYLKYDLNKPYVFSHALLV--G 1383
            :..||||..|             ..|....|.|:.| ...|..|.|:       |:|.:||.  .
Human  1202 SETQLLCEAP-------------NLTGQHKVTVRAG-GFEFSPGTLQ-------VYSDSLLTLPA 1245

  Fly  1384 ILTV----ALLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESNVRSECKQAFAELQTDMTDL 1444
            |:.:    .||::|.|.|||.::|||..|:|..||:|:||..|||.|..|||:||||||||:.:|
Human  1246 IVGIGGGGGLLLLVIVAVLIAYKRKSRDADRTLKRLQLQMDNLESRVALECKEAFAELQTDIHEL 1310

  Fly  1445 TADLESTGIPTLDHVNYIMKVFFPGVSDHPILNSPKFREGSPQTNYDAAMVQFEQLIGNKYFLLM 1509
            |.||:..|||.||:..|.|:|.|||:.|||:|     :|...|.|.:.::..|.||:..|:|||.
Human  1311 TNDLDGAGIPFLDYRTYAMRVLFPGIEDHPVL-----KEMEVQANVEKSLTLFGQLLTKKHFLLT 1370

  Fly  1510 FIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSLLLRLIDKSLASK-HPQLMLRRTE 1573
            ||.|||||| |||:|||.|||||||..|..:|||||.:||.||..||:|:|.|| ||:|:|||||
Human  1371 FIRTLEAQR-SFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIEKNLESKNHPKLLLRRTE 1434

  Fly  1574 SVVEKMLTNYLAICMYDYLKEYAGSNLFLLFKAIKHQIEKGLVDAITNDARYSLSEERLLHEQVT 1638
            ||.||||||:....:|.:|||.||..||:|:.|||.|:|||.:||||.:|||||||::|:.:|:.
Human  1435 SVAEKMLTNWFTFLLYKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQID 1499

  Fly  1639 HSVVILHILQDDLDEKVQCRVN--DWDTISQVKLKILDAIFKNTPFSMRPSVNEVDLEWRHGRGG 1701
            :..:.|:.:..:.:...:..|.  |.||::|.|.|:|||.:|..|:|.||...::|||||.||..
Human  1500 YKTLTLNCVNPENENAPEVPVKGLDCDTVTQAKEKLLDAAYKGVPYSQRPKAADMDLEWRQGRMA 1564

  Fly  1702 HLTLQDEDLTTKTVNGWKRLNTLAHYGVKESAVMSLIARQNDNYHIPYSK--NQNSAPYHNFYFI 1764
            .:.|||||:|||..|.||||||||||.|.:.:.::|:.:|...|:|..|.  .::.:.|.:....
Human  1565 RIILQDEDVTTKIDNDWKRLNTLAHYQVTDGSSVALVPKQTSAYNISNSSTFTKSLSRYESMLRT 1629

  Fly  1765 NNSQSHI-----IINNDIESGLQQPRVYHLVKPNIPDHYMNIKNSVLSGGSPAFQSHVVNNCNDR 1824
            .:|...:     :|..|:|||   .:::||||    :|                 .|:.....||
Human  1630 ASSPDSLRSRTPMITPDLESG---TKLWHLVK----NH-----------------DHLDQREGDR 1670

  Fly  1825 VNKTIPEVYLTRLLATKGTIQKFVDDFFSIILTV---NEELPPAVKWLFDLLDEAARRHDIADTD 1886
            .:|.:.|:|||||||||||:||||||.|..|.:.   ...||.|:|::||.|||.|.:|.|.|.|
Human  1671 GSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQIHDAD 1735

  Fly  1887 IVHAWKSNCLPLRFWVNFIKNPDFIFDVNKTYSVDSCLSVIAQTFMDACSTSEHRLGKDSPSNKL 1951
            :.|.|||||||||||||.||||.|:||::|....|:||||:||||||:||||||:||||||||||
Human  1736 VRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHKLGKDSPSNKL 1800

  Fly  1952 LFAKDIPNYRIMVKEFYRDVSRLPQISDQEMSTAMQQLSVRQNEEFDTISALKELYIYITKYKDQ 2016
            |:|||||||:..|:.:|.|::::|.||||:||..:.:.|.....:|:::|||.|:|.|||||||:
Human  1801 LYAKDIPNYKSWVERYYADIAKMPAISDQDMSAYLAEQSRLHLSQFNSMSALHEIYSYITKYKDE 1865

  Fly  2017 IMESLETDINCRKMHLSRKLGNVAATL 2043
            |:.:||.|...|:..|..||..|..|:
Human  1866 ILAALEKDEQARRQRLRSKLEQVVDTM 1892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexB	NP_001245400.1	Sema_plexin_like	86..534	CDD:200497	132/484 (27%)
		PSI	535..586	CDD:279745	20/50 (40%)
		PSI	683..730	CDD:214655	14/46 (30%)
		PSI	836..877	CDD:214655	14/42 (33%)
		IPT_plexin_repeat1	888..976	CDD:238585	35/95 (37%)
		IPT_plexin_repeat2	977..1095	CDD:238584	26/117 (22%)
		IPT_plexin_repeat3	1097..1211	CDD:238586	26/114 (23%)
		Plexin_cytopl	1452..2017	CDD:285529	286/577 (50%)
PLXNA1	NP_115618.3	Sema_plexin_A1	38..513	CDD:200532	133/495 (27%)
		PSI	514..>556	CDD:279745	19/41 (46%)
		PSI	660..707	CDD:279745	14/46 (30%)
		PSI	809..862	CDD:279745	16/58 (28%)
		IPT_plexin_repeat1	864..960	CDD:238585	35/95 (37%)
		IPT_plexin_repeat2	961..1046	CDD:238584	26/117 (22%)
		IPT_plexin_repeat3	1048..1148	CDD:238586	36/173 (21%)
		TIG	1150..1234	CDD:280079	26/98 (27%)
		Plexin_cytopl	1318..1866	CDD:285529	286/577 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I11130
eggNOG	1	0.900	-	-		E1_KOG3610
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D56043at33208
OrthoFinder	1	1.000	-	-		FOG0000391
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100269
Panther	1	1.100	-	-	O	PTHR22625
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.820