Protein Alignment PlexB and MET

DIOPT Version :9

• Sequence 1: NP_001245400.1
• Gene: PlexB / 43766
• FlyBaseID: FBgn0025740
• Length: 2051
• Species: Drosophila melanogaster
• Sequence 2: XP_011514525.1
• Gene: MET / 4233
• HGNCID: 7029
• Length: 1409
• Species: Homo sapiens
• Alignment Length: 1836
• Identity: 360/1836 - (19%)
• Similarity: 606/1836 - (33%)
• Gaps: 722/1836 - (39%)

  Fly    17 VLCIIIILGSQHYCVNCIEELPAQALSPLNDIVAQFNLPSI----PVQSTASSYGNRSIGNNIES 77
            ||...::..|...|..      |.|.|.:| :..::.||:.    |:|
Human    32 VLLFTLVQRSNGECKE------ALAKSEMN-VNMKYQLPNFTAETPIQ----------------- 72

  Fly    78 VRDSQSKNYFTHMSFDFMHNVLFAGATNKILKLN-ENLRVLAEAVTGPLHDSPQCH--------- 132
                   |...|     .|:: |.||||.|..|| |:|:.:||..|||:.:.|.|.
Human    73 -------NVILH-----EHHI-FLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKA 124

  Fly   133 --AGGCPEDIETSLVNNFNKILVVSYAHDGILIACGSIRQGACEIYSLPRFPAT----------- 184
              :||..:|       |.|..|||...:|..||:|||:.:|.|:.:..|.....
Human   125 NLSGGVWKD-------NINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFS 182

  Fly   185 ---------PQFFAVPLAANDENASTYAFVGPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSR 240
                     |......|.|...::....|:.           .:||.|..:.....|.:.:||.|
Human   183 PQIEEPSQCPDCVVSALGAKVLSSVKDRFIN-----------FFVGNTINSSYFPDHPLHSISVR 236

  Fly   241 RLDDLNYA-EFSIQQSIINIDVKYRDHFLVDYIYGFNSSEYAYFIIVQKKSHLADEAGYVTRLAR 304
            ||.:.... .|...||.|::..::||.:.:.|::.|.|:.:.||:.||:::  .|...:.||:.|
Human   237 RLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRET--LDAQTFHTRIIR 299

  Fly   305 ICITDPNYDSYTEITVQCTATENNVD-------YNIVRDAKVTPASHKLAQKMGIKKDDHVLVTV 362
            .|..:....||.|:.::|..||....       :||::.|.|:....:||:::|...:|.:|..|
Human   300 FCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGV 364

  Fly   363 FSPSREISNQPESKSAMCIYSIKDIEDMFIENIHLCFNGTTKDRNLGYISGTINDGRCPIVGSLG 427
            |:.|:..|.:|..:||||.:.||.:.|.|.:.::.                  |:.||
Human   365 FAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNK------------------NNVRC------- 404

  Fly   428 NIYNFCSVGLKISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLSGQS 492
                                                     .||   |.|.|.
Human   405 -----------------------------------------LQH---FYGPNH------------ 413

  Fly   493 PGEYEEIVVDAGNRILPNTMMSPKKDFLYVLSQRKITKLRIEHC---SVYTNCSACLESRDPFCG 554
                                                     |||   ::..|.|.|...||
Human   414 -----------------------------------------EHCFNRTLLRNSSGCEARRD---- 433

  Fly   555 WCSLEKRCTVRSTCQRDTSASRWLSLGSGQQCIEFESIIPEKIPISELSHLHLIIRTLPEPFNAK 619
                |.|....:..||       :.|..||    |..::...|
Human   434 ----EYRTEFTTALQR-------VDLFMGQ----FSEVLLTSI---------------------- 461

  Fly   620 YRCVFGNSTPIDAEILENGLGCATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSRNFAFFDC 684
                   ||.|..::....||.:
Human   462 -------STFIKGDLTIANLGTS------------------------------------------ 477

  Fly   685 SHHGNCQECLQSSWGCNWCIFDNKCVHKSLQCRNIENAVSTVGHCPHLKKNRPEILLPVRVPIEI 749
                                          :.|.::..||..|
Human   478 ------------------------------EGRFMQVVVSRSG---------------------- 490

  Fly   750 RLEIENLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKTPYFYEINTHEYQAKVVVTWN 814
                     |.:.|..|           ||.:|..|.:::| |.|     :|.:.|  .:|:|..
Human   491 ---------PSTPHVNF-----------LLDSHPVSPEVIV-EHT-----LNQNGY--TLVITGK 527

  Fly   815 FQHYVDTAIVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWCSNSCVYNETCIADKNSISSGSKS 879
                    .:|....:.||. |....||.|::..|..:|.||.:.||.:|.|:       ||:.:
Human   528 --------KITKIPLNGLGC-RHFQSCSQCLSAPPFVQCGWCHDKCVRSEECL-------SGTWT 576

  Fly   880 AIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREED----VRGKIFIGSVPCELENYQISV 940
              :..| ||.|..:.|.|.|:||||.:||.|.:.|.|..:    .:.::.:|:..|.|...:.::
Human   577 --QQIC-LPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTM 638

  Fly   941 K-IECRTGASL---YEMSAPIKVANDAGFTESSVQFHFKNVLLTGLYPTIGPRSGGTQLSLIGKF 1001
            . ::|..|.::   :.||  |.::|..|.|:.|. |.:.:.::|.:.|..||.:|||.|:|.|.:
Human   639 NTLKCTVGPAMNKHFNMS--IIISNGHGTTQYST-FSYVDPVITSISPKYGPMAGGTLLTLTGNY 700

  Fly  1002 LNIGSTMRAFLDEYECHIDVTQASSSQVSCTTSEATQPEPIRSLHLVIDGANRTLECQISTPSIT 1066
            ||.|::.         ||.:     ...:||         ::|:      :|..|||.  ||:.|
Human   701 LNSGNSR---------HISI-----GGKTCT---------LKSV------SNSILECY--TPAQT 734

  Fly  1067 NTNPTRSNFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSIQKPELE 1131
                ..:.|.......|..:..|||:|.:||.:.:|.|.:||.|||..:|..|..|||:..|.:
Human   735 ----ISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRM- 794

  Fly  1132 VFYDNERVNKTSCVVINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQNSSFQTETRYKNEYDR 1196
                          |||                            :|....:|....:::
Human   795 --------------VIN----------------------------VHEAGRNFTVACQHR----- 812

  Fly  1197 KKRRADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLS------FVMDNVQLVRNL 1255
                                      :|.::.........||||||.      |::|.:     |
Human   813 --------------------------SNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGI-----L 846

  Fly  1256 NKYFHDIRSTIVYLADPKYLPFP--------NDGVKLYKGDSL---VIEGELLNLAADEYDVNVT 1309
            :|||     .::|:.:|.:.||.        |:.|...||:.:   .::||:|.
Human   847 SKYF-----DLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLK----------- 895

  Fly  1310 IGTSQCNITSLALNQLLCIPPEQQPLPTDENGVD-----QSTDLPLVVVKVGRNLRFVIGYLKYD 1369
            :|...|....|....:||..|........|..::     .||.|..|:|:..:|...:|
Human   896 VGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLI------ 954

  Fly  1370 LNKPYVFSHALLVGILTVALLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESNVRSECKQAF 1434
                     |.:|.|.|..||::.|.:.|        :..::.|.:..:::..::.|.:......
Human   955 ---------AGVVSISTALLLLLGFFLWL--------KKRKQIKDLGSELVRYDARVHTPHLDRL 1002

  Fly  1435 AELQ-----TDM-----TDLTADLESTGIPTLDHVNYIMKVFFPGVSDHPILNSPKFREGSP--- 1486
            ...:     |:|     .|..|.......|.........:|.:|.....|||.|......||
Human  1003 VSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQ 1067

  Fly  1487 -QTNYD--------------------AAMVQFEQLIGNKYFLLMFIETL---EAQRSSFSIRDRV 1527
             ..:.|                    :.:|.|.::||..:|..::..||   :.::...:::.
Human  1068 NTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKS-- 1130

  Fly  1528 NVASLIMVVLMNKMEYATEILKSLLLRLIDKSLASKHPQLMLRRTESVVEKMLTNYLAICMYDYL 1592
                      :|::....|:.:.|...:|.|..:  ||.::             :.|.||:
Human  1131 ----------LNRITDIGEVSQFLTEGIIMKDFS--HPNVL-------------SLLGICL---- 1166

  Fly  1593 KEYAGSNLFLLFKAIKH------------------------QIEKGLVDAITNDARYSLSEERLL 1633
             ...||.|.:| ..:||                        |:.||:        :| |:.::.:
Human  1167 -RSEGSPLVVL-PYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGM--------KY-LASKKFV 1220

  Fly  1634 HEQVTHSVVILHILQDDLDEKVQCRVNDWDTISQVKLKILDAIFKNTPFSMRPSVNEVDLEWRHG 1698
            |..:.....:       ||||...:|.|:.....:..|...::...|  ..:..|..:.||
Human  1221 HRDLAARNCM-------LDEKFTVKVADFGLARDMYDKEYYSVHNKT--GAKLPVKWMALE---- 1272

  Fly  1699 RGGHLTLQDEDLTTKT 1714
                 :||.:..|||:
Human  1273 -----SLQTQKFTTKS 1283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PlexB	NP_001245400.1	Sema_plexin_like	86..534	CDD:200497	103/487 (21%)
		PSI	535..586	CDD:279745	14/53 (26%)
		PSI	683..730	CDD:214655	4/46 (9%)
		PSI	836..877	CDD:214655	13/40 (33%)
		IPT_plexin_repeat1	888..976	CDD:238585	27/95 (28%)
		IPT_plexin_repeat2	977..1095	CDD:238584	31/117 (26%)
		IPT_plexin_repeat3	1097..1211	CDD:238586	19/113 (17%)
		Plexin_cytopl	1452..2017	CDD:285529	55/314 (18%)
MET	XP_011514525.1	Sema_MET	44..535	CDD:200539	154/847 (18%)
		PSI	538..580	CDD:214655	15/51 (29%)
		IPT_plexin_repeat1	582..675	CDD:238585	27/95 (28%)
		IPT_plexin_repeat2	676..759	CDD:238584	31/117 (26%)
		IPT_plexin_repeat3	761..856	CDD:238586	33/178 (19%)
		IPT	857..953	CDD:214657	23/106 (22%)
		Pkinase_Tyr	1097..1356	CDD:285015	45/247 (18%)
		PTKc_Met_Ron	1101..1362	CDD:270649	43/243 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3610
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810