DRSC/TRiP Functional Genomics Resources

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Protein Alignment PlexB and Plxnc1

DIOPT Version :9

Sequence 1:NP_001245400.1 Gene:PlexB / 43766 FlyBaseID:FBgn0025740 Length:2051 Species:Drosophila melanogaster
Sequence 2:XP_038936027.1 Gene:Plxnc1 / 362873 RGDID:1307420 Length:1759 Species:Rattus norvegicus


Alignment Length:2005 Identity:484/2005 - (24%)
Similarity:761/2005 - (37%) Gaps:653/2005 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 AGGCPEDIETSLV--------NNFNKILVVSYAH-----DGILIACGSIRQGACEIYSLPRFPAT 184
            ||.|.|.:  ||.        ::|:|:| :.|..     :|:|:...:..:||||:..|.....:
  Rat   269 AGNCTEPV--SLAPPARPRPGSSFSKLL-LPYREGATGLEGLLLTGWTFDRGACEVRPLGNLNRS 330

  Fly   185 PQFFAVPLAANDENASTYAFVGPARYAWKEEDILYVGTTFTNVGDYRHDVP-------------- 235
            .......:.:.....||...|    |.....|:.|:....|.|      :|              
  Rat   331 SLRNGTEVVSCHPQGSTAGVV----YRASGTDLWYLAVAATYV------LPEPETANRCNPAASD 385

  Fly   236 ---AISSRRLDDLNYAEFSIQQSIINIDVKYRD-----HFLVDYIYGFNSSEYAYFIIVQKKSHL 292
               ||:.:..:..:.|...:.:      :|.|.     ||:..:::  |.|.|..:......|..
  Rat   386 RDTAIALKNTEGRSLATQELGR------LKLRGSAGSLHFVDAFLW--NGSVYFPYYPYNYTSGA 442

  Fly   293 ADEAGYVTRLARICITDPNYDSYTEITVQCTATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDH 357
            |  .|:.: :|||.       ..||:..|..|.        :......|...:|.....:.:...
  Rat   443 A--TGWPS-MARIA-------QSTEVLFQGQAA--------LDCGHGHPEGRRLLLSSSLVEAVD 489

  Fly   358 VLVTVFSPSREISNQPES--KSAMCIYSIKDIEDMFIENIHLC---FNGTTKDRNLGYISGTIND 417
            :...|||.:.....:..|  .:|:|::.:.:|:    .....|   |..|..:            
  Rat   490 IWAGVFSAATGEGQEKRSPATTALCLFRMSEIQ----ARARSCSWDFQATEHN------------ 538

  Fly   418 GRCPIVGSLGNIYNFCSVGLKISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGV 482
                           |..|.:...|.||.:..|.|.|   :|||..|...::  .:.||||..|.
  Rat   539 ---------------CKEGDQPEQVQPIASSTLIHSD---LTSVYGTVVMNR--IVLFLGTGDGQ 583

  Fly   483 IKKVLLSGQSPGEYEEIVVDAGN------RILPNTMMSPKKD-FLYVLSQRKITKLRIEHCSVYT 540
            :.||:|.........|::.:...      :::|:    |.|| ::|:.:.:::.::::.:||...
  Rat   584 LLKVVLGENLTSNCPEVIYEIKEETPVFYKLVPH----PVKDTYIYLTAGKEVRRIQVANCSKRK 644

  Fly   541 NCSACLESRDPFCGWCSLEKRCTVRSTCQRDTSASRWLSLGSGQQCIEFESIIPEKIPISELSHL 605
            :|..||.:.||.||||...:|||.:..|....|...||.:.||          |:|.|..:    
  Rat   645 SCFQCLAAADPHCGWCLPLQRCTFQGDCTHAGSFENWLDISSG----------PKKCPKIQ---- 695

  Fly   606 HLIIRTLPE--------PFNAKY-RCVFGNSTPIDAEILENGLG-----CATPPLDERPLIPTNT 656
              |||:|.|        ..:|:: .||..|:.  ..::|..|..     ||.    ..|..|:|.
  Rat   696 --IIRSLRERTTVTIVGSVSARHSECVVKNAD--TGKLLCQGRSQMNRTCAC----NIPSRPSNN 752

  Fly   657 DHILVPLSVRSSETNKDF------VSRNFAFFDCSHHGNCQECLQSSWGCNWCIFDNKCVHKSLQ 715
            ..::          |..|      ||..|.|.:|:....|..|:::  ||.||..|.:|:|....
  Rat   753 VFVV----------NATFTFPSWSVSERFNFTNCASVRECPACIET--GCAWCKRDKRCIHPFTP 805

  Fly   716 C------RNIENAVSTV---------GHCPHLKKNRPEILLPVRVPIEIRLEIENLPKPKSAHAG 765
            |      ||.|.....|         |.....|:||.:..|.|                      
  Rat   806 CEPSDYERNQELCHVAVEKPPKDSGGGRVKESKRNRTDPALQV---------------------- 848

  Fly   766 FLCTIHIEAAQMLLPAHVESNKIVVCEKTPYFYEINTHEYQAKVVVTW-NFQHYVDTAIV----- 824
                .:|:|        :|..||....|             :.|:||. ||....:..::     
  Rat   849 ----FYIKA--------IEPQKISTLGK-------------SNVIVTGANFTQASNITMILRGTS 888

  Fly   825 TLYKCDVLGSHREHPDCSLCVTRDPKYKCAWCSNSCVYNETCIA--DKNSISSGSKSAIENECPL 887
            |..|..:..||         |..|...|.:..|:.....:.||.  ..|..|:|:.|.|    .|
  Rat   889 TCEKDVIRVSH---------VLNDTHMKFSLPSSRKEMKDVCIQFDGGNCSSAGALSYI----AL 940

  Fly   888 PRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIFIGSVPCELE-NYQISVKIECRTGASLY 951
            |...:|.|.:..:.||..|||.|.|.     ||...:.|..   ||: |..:|:.:      |.|
  Rat   941 PHCSLIVPATTWISGGQNITIMGRNF-----DVIDNLIISH---ELKGNINVSINV------SEY 991

  Fly   952 EMSAPIKVANDAGFTESSVQFHFKNVLLTGLYPTIGPRSGGTQLSLIGKFLNIGSTMRAFLDEYE 1016
            .|:             :|.:|         |.|.:....|.|  :::.| |.:..|   :||   
  Rat   992 CMA-------------TSCRF---------LAPNLKSSKGRT--NVVVK-LRVQDT---YLD--- 1025

  Fly  1017 CHIDVTQASSSQVSCTTSEATQPEPIRSLHLVIDGANRTLECQISTPSITNTNPTRSNFGSYQLR 1081
                                                                             
  Rat  1026 ----------------------------------------------------------------- 1025

  Fly  1082 SLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSIQKPELEVFYDNERVNKTSCVV 1146
                  |....|.:|||.          :|.||        .|....||||....|..|      
  Rat  1026 ------CGTLQYLEDPRF----------TGYRV--------ESEIDTELEVKIQKENDN------ 1060

  Fly  1147 INSNQMECPSPPVNYKFETFKKTNRKMD-TELHLQNSSFQTETRYKNEYDRKKRRADFGDTFRLY 1210
                               |..:...:| |..|.:|..|...  ::|                  
  Rat  1061 -------------------FNISRDDIDITLFHGENKQFNCS--FEN------------------ 1086

  Fly  1211 TNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFVMDNVQLVRNLNKYFHDIRSTIVYLADPKYL 1275
                      :..|.|:||               ::..::.::|.|                   
  Rat  1087 ----------ITRNQDLTT---------------ILCKIKSIKNAN------------------- 1107

  Fly  1276 PFPNDGVKLYKGDSLVIEGELLNLAADEYDVNVTIGTSQCNITSLALNQLLCIPPEQQPLPTDEN 1340
                                  .:|.....|.|.:|..:..:             ||:.:|:   
  Rat  1108 ----------------------TIATSSKKVRVKLGNLELYV-------------EQESVPS--- 1134

  Fly  1341 GVDQSTDLPLVVVKVGRNLRFVIGYLKYDLNKPYVFSHALLVGILTVALLVVVFVIVLIIFRRKS 1405
                                            .:.|..||.:      ||.:|.|:.:::.|.||
  Rat  1135 --------------------------------TWYFLIALPI------LLAIVIVVAVVVTRHKS 1161

  Fly  1406 TQAEREYKRIQIQMITLESNVRSECKQAFAELQTDMTDLTADLESTG-IPTLDHVNYIMKVFFP- 1468
            .:..|:..:   |:..|||.:|.|.:..|||||.|..|:   ::|.| :|.||:.::.::.||| 
  Rat  1162 KELSRKQSQ---QLELLESELRKEIRDGFAELQMDKLDV---VDSFGTVPFLDYKHFALRTFFPE 1220

  Fly  1469 -GVSDHPILNSPKFREGSPQTNYDAAMVQFEQLIGNKYFLLMFIETLEAQRSSFSIRDRVNVASL 1532
             |...|........|:.:.:   :.::...:.||.||.||:..|.|||.|: :||::||...||.
  Rat  1221 SGGFTHIFTEDMHNRDANDK---NESLTALDALICNKSFLVTVIHTLEKQK-NFSVKDRCLFASF 1281

  Fly  1533 IMVVLMNKMEYATEILKSLLLRLIDKSLASKHPQLMLRRTESVVEKMLTNYLAICMYDYLKEYAG 1597
            :.:.|..|:.|.|.||: :|.|.:.:..::..|:||||||||||||:|||::::|:..:|:|..|
  Rat  1282 LTIALQTKLVYLTSILE-VLTRDLMEQCSNMQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVG 1345

  Fly  1598 SNLFLLFKAIKHQIEKGLVDAITNDARYSLSEERLLHEQVTHSVVILHILQDDLDEKVQ---CR- 1658
            ...:||...:..:|.||.||.||..|.|:|:|:.||.:....:.|.|:::.:.:.|...   || 
  Rat  1346 EPFYLLVTTLNQKINKGPVDVITCKALYTLNEDWLLWQVPEFNTVALNVVFEKIPENESADVCRN 1410

  Fly  1659 ----VNDWDTISQVKLKILDA-IFKN-TPFSMRPSVNEVDLEWRHGRGGHLTLQDE--DLTTKTV 1715
                |.|.|||.|.|.||..| :.|| :|:.::  :||:.||.:.|     |.|.|  |:.:.:|
  Rat  1411 ISVNVLDCDTIGQAKEKIFQAFLSKNGSPYGLQ--LNEIGLELQVG-----TRQKELLDIDSSSV 1468

  Fly  1716 ---NGWKRLNTLAHYGVKESAVMSLIARQNDNYHIPYSKNQNSAPYHNFYFINNSQSHIIINNDI 1777
               :|..:|||:.||.:...:.:.:                       |..|.|..|.:..::| 
  Rat  1469 ILEDGITKLNTIGHYEISNGSTIKV-----------------------FKKIANFTSDVEYSDD- 1509

  Fly  1778 ESGLQQPRVYHLVKPNIPDHYMNIKNSVLSGGSPAFQSHVVNNCNDRVNK--TIPEVYLTRLLAT 1840
                    ..||:.|:                |.|||  ||.....|...  .:.|:|||:||:|
  Rat  1510 --------HCHLILPD----------------SEAFQ--VVQGKRHRGKHKFKVKEMYLTKLLST 1548

  Fly  1841 KGTIQKFVDDFFSIILTV-NEELPPAVKWLFDLLDEAARRHDIADTDIVHAWKSNCLPLRFWVNF 1904
            |..|...::..|..|.:: |...|.|:|:.||.||..|....|.|.|:||.||:|.||||||||.
  Rat  1549 KVAIHSVLEKLFRSIWSLPNSRAPFAIKYFFDFLDAQAENKKITDPDVVHIWKTNSLPLRFWVNI 1613

  Fly  1905 IKNPDFIFDVNKTYSVDSCLSVIAQTFMDACSTSEHRLGKDSPSNKLLFAKDIPNYRIMVKEFYR 1969
            :|||.|:||:.||..:|||||||||.||||.|.:|.:|||::|:||||:|||||.|:..||.:|:
  Rat  1614 LKNPQFVFDIKKTPHIDSCLSVIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKSYYK 1678

  Fly  1970 DVSRLPQISDQEMSTAMQQLSVRQNEEFDTISALKELYIYITKYKDQIMESLETD 2024
            .:..||.:|..||...:.|.|.:...||:...||.|:|.||.||.|:|:..||.:
  Rat  1679 AIRDLPPLSSLEMEEFLTQESKKHENEFNEEVALTEIYKYIVKYFDEILNKLERE 1733

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexBNP_001245400.1 Sema_plexin_like 86..534 CDD:200497 84/447 (19%)
PSI 535..586 CDD:279745 20/50 (40%)
PSI 683..730 CDD:214655 16/61 (26%)
PSI 836..877 CDD:214655 8/42 (19%)
IPT_plexin_repeat1 888..976 CDD:238585 22/88 (25%)
IPT_plexin_repeat2 977..1095 CDD:238584 11/117 (9%)
IPT_plexin_repeat3 1097..1211 CDD:238586 19/114 (17%)
Plexin_cytopl 1452..2017 CDD:285529 213/585 (36%)
Plxnc1XP_038936027.1 Sema_plexin_C1 229..638 CDD:200507 84/447 (19%)
PSI 639..692 CDD:396154 22/62 (35%)
PSI 775..819 CDD:396154 14/45 (31%)
TIG 851..937 CDD:396414 24/115 (21%)
IPT 940..1032 CDD:214657 33/207 (16%)
Plexin_cytopl 1203..1726 CDD:400574 212/584 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166340904
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D90434at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR22625
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.950

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