Protein Alignment PlexB and Plxnb2

DIOPT Version :10

• Sequence 1: NP_524616.2
• Gene: PlexB / 43766
• FlyBaseID: FBgn0025740
• Length: 2051
• Species: Drosophila melanogaster
• Sequence 2: NP_001101576.1
• Gene: Plxnb2 / 315217
• RGDID: 1305495
• Length: 1841
• Species: Rattus norvegicus
• Alignment Length: 2083
• Identity: 641/2083 - (30%)
• Similarity: 999/2083 - (47%)
• Gaps: 356/2083 - (17%)

  Fly    67 GNRSIGNNIESVRDS--QSKNYFTHMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDS- 128
            |...:|.::.|.:..  :|:....|:..|....|::.||.|.:.:|:.:|:|....||||..|:
  Rat    12 GLMGLGLSLRSRKPESFRSETELNHLVVDEASGVVYVGAVNALYQLSADLQVQQHVVTGPFLDNK 76

  Fly   129 --------PQCHAGGCPEDIETSLVNNFNKILVVSYAHDGILIACGSIRQGACEIYSLPRFPATP 185
                    .|||        |..|.:|||::|::. .....|:.|||:.:|.|.:.::... :..
  Rat    77 KCTPPIEPSQCH--------EAMLTDNFNQLLLLD-PPGKRLVECGSLFKGICALRAMSNI-SVR 131

  Fly   186 QFFAVP------LAANDENASTYAFVGPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRLDD 244
            .|:...      :|:|||..:|...|...|.  ..|.:|:||.     |:..||...|.|.||.|
  Rat   132 LFYEDGSGEKSFVASNDERVATVGLVSSTRP--DGERVLFVGK-----GNGPHDNGIIVSTRLLD 189

  Fly   245 LNYAEFSIQQSIINIDVKYRDH--FLVDY--------IYGFNSSEYAYFIIVQKKSHLADEAGYV 299
            .:....:.:        .|.||  |...|        :..|....|.:||..|:..|.|...
  Rat   190 RSEGREAFE--------AYSDHTTFKAGYLSTNTQQFVAAFEDGRYVFFIFNQQDKHPAKNR--- 243

  Fly   300 TRLARICITDPNYDSYTEITVQC---TATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVT 361
            |.|||:|..||:|.||.|:.:.|   |..:|:|....:..:..||.:.:            .|..
  Rat   244 TLLARMCKDDPSYYSYVEMDLLCKDPTEPQNSVFGTCLAASVATPGAGR------------ALYA 296

  Fly   362 VFSPSREISNQPESKSAMCIYSIKDIEDMFIENIHLCFNGTTKDRNLGYISGTINDGRCPIVG-- 424
            |||.....:..|  .:.:|::.::.:.:|...|.:.|:.||.:.....:......|.:|   |
  Rat   297 VFSRDGRSTGGP--GAGLCMFPLEKVHEMMEANRNTCYAGTRESGRTNFYKPFHGDIQC---GGH 356

  Fly   425 SLGNIYNF-CS---VGLKISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKK 485
            :.|...:| |.   :...:.....:.|.||.|...:::|:||.|:  :..|::|||||:.|.|.|
  Rat   357 ARGASESFPCGSEHLPYPLGSRDGLEATALLHRGGLNLTAVTVTA--ENGHTIAFLGTSDGRILK 419

  Fly   486 VLLS--GQSPGEYEEIVVDAGNRILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTNCSACLES 548
            |.|:  |.| .||..|.||...:|..:..:|.....||.::|.|:.:|.::.|..|..|:.|.:|
  Rat   420 VYLAPDGTS-SEYGSIPVDINKKIKGDLALSGNLSNLYAMTQDKVFRLPVQECLSYATCAQCRDS 483

  Fly   549 RDPFCGWCSLEKRCTVRSTCQRDTSASRWLSLGSGQQCIEFESIIPEKIPISELSHLHLIIRTLP 613
            :||:||||.:|.|||.:|.|.|...|..|| ....:.|:......|:.:.......:.|.:..||
  Rat   484 QDPYCGWCVIEGRCTRKSECSRAEEAGHWL-WSREKSCVTITDAFPQNMSRRAQGEVRLSVSPLP 547

  Fly   614 E-PFNAKYRCVFGNSTPIDAEILENGLGCATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSR 677
            . ....:..|:||.|.|..|.:.::.:.|.:|  ...|..|...||:.|.:.:.....|....|.
  Rat   548 TLAKEDELLCLFGESPPHSARVEDDAVICNSP--SSIPSTPPGQDHVDVSIQLLFKHGNVFLTSH 610

  Fly   678 NFAFFDCSHHGN------CQECLQSSWGCNWCIFDNKCVHKSLQCR----NIENAVSTVGHCPHL 732
            .:.|:||....:      |..|..:.|.|.|.:       :..:||    |.|:.:...    |:
  Rat   611 QYPFYDCREAMSLVENLPCISCASNRWTCQWDL-------QYYECREASPNPEDGIIRA----HM 664

  Fly   733 KKNRPEILLPVRVPIEIRLEIENLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKTPYF 797
            :.|.|:.|.|..:.|.:..|.|...:.|:.....:.::::            .:.::..|:|...
  Rat   665 EDNCPQFLAPNPLVIPMNHETEVTFQGKNLETVKVSSLYV------------GSDLLKFEETVTM 717

  Fly   798 YEINTHEYQAKV------------VVTWNFQHYVDTAI-VTLYKCDVLGSHREHPDCSLCVTRDP 849
            :|.:|..::...            :...:|...:|:.: ||||.|....|     |||||:..||
  Rat   718 HESDTFSFRTPKLSHDANETLPLHLYVKSFGKNIDSKLQVTLYNCSFGRS-----DCSLCLAADP 777

  Fly   850 KYKCAWC--SNSCVYNETCIADKNSISSGSKSAIENECPLPRIDIIKPLSGPVEGGTLITIEGSN 912
            .|:|.||  .|.|||...|            |.:.:|||.|.|..|:|.:||:.||.|:||.|||
  Rat   778 AYRCVWCRGQNRCVYEALC------------SNVTSECPPPVITRIQPETGPLGGGILVTIHGSN 830

  Fly   913 LGIREEDVRGKIFIGSVPCELE--NYQISVKIECRTGASLYEMSAPIK--VANDAGFTESSVQFH 973
            ||::.:||: ||.:....|..|  .|.:|.:|.|...||....:..|:  |....|.:...|||.
  Rat   831 LGVKADDVK-KITVAGQDCAFEPRGYSVSTRIVCAIEASETPFTGGIEVDVNGKLGHSPPHVQFT 894

  Fly   974 FKNVLLTGLYPTIGPRSGGTQLSLIGKFLNIGS--TMRAFLDEYECHIDVTQASSSQVSCTTSEA 1036
            ::......:.|..||::|||.|::.|.:|:.||  .:|..|::..|  :||: ..:|:.|.|...
  Rat   895 YQQPQPLSVEPRQGPQAGGTTLTINGTYLDTGSKEDVRVTLNDVPC--EVTK-FGAQLQCVTGSQ 956

  Fly  1037 TQPEPIRSLHLVIDGANRTLECQISTPSITNTNPTRSNFGSYQLRSLPRQPCSIFNYTQDPRIMQ 1101
            ..|..: :|.:...|:      ::.:|.|:                        |.|.::|.:..
  Rat   957 LAPGQV-ALEISYGGS------RVPSPGIS------------------------FTYCENPVLRA 990

  Fly  1102 IKPLRSFKSGGRVLTVHGIYLNSIQKPELEVFYDNER---------------VNKTSCVVINSNQ 1151
            .:|||||.||||.:.|.|...:.|||..:.|..:..|               |..|..|..|..:
  Rat   991 FEPLRSFVSGGRSINVTGQGFSLIQKFAMIVIAEPLRSWRRRREAGSLEPVTVMGTEYVFYNDTK 1055

  Fly  1152 MECPSPPVNYKFETFKKTNR-KMDTELHLQNSSFQTETRYKNEYDRKKRRADFGDTFRLYTNAGS 1215
            :...||.|..:.|.:..|.. :||                             |....|.|.||:
  Rat  1056 VVFLSPAVPEEPEAYNLTALIQMD-----------------------------GHRALLRTEAGA 1091

  Fly  1216 SANYFVNNNMDVTTFVKVHETQLNLQLSFVMDNVQLVRNLNKYFHDIRSTIVYLADPKYLPFPND 1280
                                                              ..|:|||.:..| ..
  Rat  1092 --------------------------------------------------FEYVADPTFENF-TG 1105

  Fly  1281 GVKLYKGDSLVIEGELLNLAADEYDVNVTIGTSQCNITSLALNQLLCIPPEQQPLPTDENGVDQS 1345
            |||......:...|..||.|....:....:|..:|.:.:|....|.|.|||.||.|......|.:
  Rat  1106 GVKKQVNKLIHARGTNLNKAMTLEEAEAFVGAERCIMKTLTETDLYCEPPEVQPPPKRRQKRDTA 1170

  Fly  1346 TDLPLVVVKVGRNLRFVIGYLKYDLNKPYVFSHALLVGILTVALLVVVFVIVLII--FRRKSTQA 1408
            .:||..:||.| :..:|:|.::||...    |...|..||.:.::.:||:||:.|  :.|||.||
  Rat  1171 HNLPEFIVKFG-SREWVLGRVEYDTRA----SDVPLSLILPLVMVPMVFIIVVSIYCYWRKSQQA 1230

  Fly  1409 EREYKRIQIQMITLESNVRSECKQAFAELQTDMTDLTADLESTGIPTLDHVNYIMKVFF----PG 1469
            ||||::|:.|:..||.:||..||:.|.:|..:|.|.|.|:...||||||:..|..:|||    .|
  Rat  1231 EREYEKIKSQLEGLEESVRDRCKKEFTDLMIEMEDQTNDVHEAGIPTLDYKTYTDRVFFLPSKDG 1295

  Fly  1470 VSDHPI---LNSPKFREGSPQTNYDAAMVQFEQLIGNKYFLLMFIETLEAQRSSFSIRDRVNVAS 1531
            ..|..|   |:.|:.|    :...:.|:.||..|:.:|.||:.||.|||.|| .||.|.:|..||
  Rat  1296 DKDVMITGKLDIPESR----RPIVEQALYQFSNLLNSKSFLINFIHTLENQR-EFSARAKVYFAS 1355

  Fly  1532 LIMVVLMNKMEYATEILKSLLLRLIDKSLASKHPQLMLRRTESVVEKMLTNYLAICMYDYLKEYA 1596
            |:.|.|..|:||.|:|:::|.|.|:::.:.:|:|:|||||:|:|||:||:|:::||:|.|||:.|
  Rat  1356 LLTVALHGKLEYYTDIMRTLFLELMEQYVVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSA 1420

  Fly  1597 GSNLFLLFKAIKHQIEKGLVDAITNDARYSLSEERLLHEQVTHS-VVILHILQDDLDEKVQCRVN 1660
            |..|:.||||||||:|||.|||:...|:|:|::..||.:.|.:: :.:..|:||:..:.:..:|.
  Rat  1421 GEPLYKLFKAIKHQVEKGPVDAVQKKAKYTLNDTGLLGDDVEYAPLTVSVIVQDEGIDAIPVKVL 1485

  Fly  1661 DWDTISQVKLKILDAIFKNTPFSMRPSVNEVDLEWRHGRGGHLTLQDEDLTTKTVNGWKRLNTLA 1725
            :.|||||||.||:|.:::..|.|..|..:.|.||||.|....: |.|.|||::....|||:|||.
  Rat  1486 NCDTISQVKEKIIDQVYRTQPCSCWPKPDSVVLEWRPGSTAQI-LSDLDLTSQREGRWKRINTLM 1549

  Fly  1726 HYGVKESAVMSL----IARQNDNYHIPYSKNQNSAPYHNFYFINNSQSHIIINNDIESGLQQPRV 1786
            ||.|::.|.:.|    :::|.::       :|...|         .:.|.::.       ::.||
  Rat  1550 HYNVRDGATLILSKVGVSQQPED-------SQQDLP---------GERHALLE-------EENRV 1591

  Fly  1787 YHLVKPNIPDHYMNIKNSVLSGGSPAFQSHVVNNCNDRV-NKTIPEVYLTRLLATKGTIQKFVDD 1850
            :|||:|.         :.|..|.|..      .:..::. .|.|.|:||||||:.|||:|:|||:
  Rat  1592 WHLVRPT---------DEVDEGKSKR------GSMKEKERTKAITEIYLTRLLSVKGTLQQFVDN 1641

  Fly  1851 FFSIILTVNEELPPAVKWLFDLLDEAARRHDIADTDIVHAWKSNCLPLRFWVNFIKNPDFIFDVN 1915
            ||..:|.....:|||||:.||.|||.|.:|||.|.|.:|.||:|.||||||||.:|||.|||||:
  Rat  1642 FFQSVLAPGHAVPPAVKYFFDFLDEQAEKHDIRDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVH 1706

  Fly  1916 KTYSVDSCLSVIAQTFMDACSTSEHRLGKDSPSNKLLFAKDIPNYRIMVKEFYRDVSRLPQISDQ 1980
            ....||:.||||||||||||:.:||:|.:||||||||:||:|..|:.||:::|:.:.::.|:|||
  Rat  1707 VHEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQ 1771

  Fly  1981 EMSTAMQQLSVRQNEEFDTISALKELYIYITKYKDQIMESLETDINCRKMHLSRKLGNVAATLDG 2045
            :|:|.:.::|....:..:|:.||.:||.|..||.|:|:.:||.|...:||.|:.:|..:||.|:.
  Rat  1772 DMNTHLAEISRAHTDSLNTLVALHQLYQYTQKYYDEIINALEEDPAAQKMQLAFRLQQIAAALEN 1836

  Fly  2046 DCT 2048
            ..|
  Rat  1837 KVT 1839

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PlexB	NP_524616.2	Sema_plexin_like	86..534	CDD:200497	128/483 (27%)
		PSI	535..586	CDD:396154	21/50 (42%)
		TIG_plexin	594..682	CDD:465588	19/88 (22%)
		PSI	683..730	CDD:214655	11/56 (20%)
		TIG_2	738..827	CDD:465619	14/101 (14%)
		PSI	836..877	CDD:214655	16/42 (38%)
		IPT_plexin_repeat1	888..976	CDD:238585	34/91 (37%)
		IPT_plexin_repeat2	977..1095	CDD:238584	26/119 (22%)
		IPT_plexin_repeat3	1097..1211	CDD:238586	30/129 (23%)
		TIG	1277..>1334	CDD:460355	16/56 (29%)
		Plexin_cytopl	1452..2012	CDD:462434	242/572 (42%)
Plxnb2	NP_001101576.1	Sema	27..469	CDD:472829	129/489 (26%)
		PSI	471..519	CDD:396154	21/48 (44%)
		TIG_plexin	528..615	CDD:465588	19/88 (22%)
		PSI	761..>803	CDD:396154	19/58 (33%)
		IPT_plexin_repeat1	806..897	CDD:238585	34/91 (37%)
		IPT_plexin_repeat2	898..984	CDD:238584	26/119 (22%)
		IPT	986..>1068	CDD:472823	24/81 (30%)
		RasGAP_plexin_B2	1274..1840	CDD:213352	257/610 (42%)
		Plexin_RBD	1451..1561	CDD:466321	42/110 (38%)