Protein Alignment PlexB and Plxnd1

DIOPT Version :10

• Sequence 1: NP_524616.2
• Gene: PlexB / 43766
• FlyBaseID: FBgn0025740
• Length: 2051
• Species: Drosophila melanogaster
• Sequence 2: NP_001381981.2
• Gene: Plxnd1 / 312652
• RGDID: 1310796
• Length: 1925
• Species: Rattus norvegicus
• Alignment Length: 2137
• Identity: 636/2137 - (29%)
• Similarity: 989/2137 - (46%)
• Gaps: 424/2137 - (19%)

  Fly    75 IESVRDSQSKNYFTHMSFDFMHNVLFAGATNKILKLN-ENLRVLAEAVTGPLHDSPQCHAGGCPE 138
            :|..|...|.....:.:.|.....::..|.|::.:|: .||.:.|||..||:.|||.|||...|:
  Rat    49 LEIQRRFPSPTPTNNFALDGTAGTVYLAAVNRLYQLSGANLSLEAEATVGPVPDSPLCHAPQLPQ 113

  Fly   139 ---DIETSLVNNFNKILVVSYAHDGILIACGSIRQGACEI----------YSLPRFPATPQFFAV 190
               :....|.:|:||||.:. ...|:::|||||.||.|::          .|.|  ||.|.  |.
  Rat   114 ASCEHPRRLTDNYNKILQLD-PGQGLVVACGSIYQGLCQLRRRGNISALAVSFP--PAAPT--AE 173

  Fly   191 P---------LAANDENASTYAFVGPARYAWKEEDILYVGTTFTNVG-----------DYR-HDV 234
            |         :|||..||||...|.|.........:| ||.|:|..|           |:| .:.
  Rat   174 PVTVFPSMLNVAANHPNASTVGLVLPPASGTGGSRLL-VGATYTGYGSAFFPRNRSLEDHRFENT 237

  Fly   235 PAISSRRLD-----------DLNYAEFSIQQSIINIDVKYRDHFLVDYIYGF--------NSSEY 280
            |.||.|.||           |||.::    .:|:.|....::...:.::..|        ::..|
  Rat   238 PEISIRSLDARGDLAKLFTFDLNPSD----DNILKIKQGAKEQHKLGFVRAFLHPAVPPHSAHPY 298

  Fly   281 AYFIIVQKKSHLADEAGYV-TRLARICITDPN---------YDSYTEITVQCTATENNVDYNIVR 335
            || :.:..::...|:.... :.|||||:  |.         .:||.::.:||..
  Rat   299 AY-LALNSEARAGDKDSQARSLLARICL--PRGAGGDAKKLTESYIQLGLQCAG----------- 349

  Fly   336 DAKVTPASHKLAQKMGIKKDD--HVLVTVFSPSRE----ISNQPE-------SKSAMCIYSIKDI 387
                           |..:.|  ..||:|| |:||    :..:|:       :.:|:|.:...|:
  Rat   350 ---------------GAGRGDLYSRLVSVF-PAREQFFAVFERPQGTPGARNAPAALCAFRFADV 398

  Fly   388 EDMFIENIHLCFNGTTKDRNLGYISGTINDGRCPIVGSLGNIY--------NFCSVGLKISGVSP 444
            :.........||.....|  :..:..::..|..|...|..||.        ....:...::.:.|
  Rat   399 QAAIRAARTACFVEPAPD--VVAVLDSVVQGTGPACESKRNIQLQPEQLDCGAAHLQHPLTILQP 461

  Fly   445 ITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLSGQSPGEYEEIVVDAGNRILP 509
            :.|..:|....::..:|...:    .::..||||..|.:.|:.|:.........::..|....:.
  Rat   462 LRASPVFRAPGLTAVAVANAN----NYTAVFLGTATGRLLKISLNESMQVVSRRVLTVAYGEPVH 522

  Fly   510 NTMMSPKKD--FLYVLSQRKITKLRIEHCSVYTNCSACLESRDPFCGWCSLEKRCTVRSTCQRDT 572
            :.|.....|  :||:::..::.::::..|.|::.|..|:.:.|.:||||:||.|||.:..|...:
  Rat   523 HVMQFDPMDPGYLYLMTSHQMARVKVAACEVHSTCGDCVGAADAYCGWCTLETRCTFKQDCANSS 587

  Fly   573 SASRWLSLGSGQQCIEFESIIPEKIPISELSHLHLIIR---TLPEPFNAKYRCVFGNSTPIDAEI 634
            ....|.|...|.......:::|.:|.:.. .:..:|::   :||.....:..|.:||.....|.:
  Rat   588 LPHFWTSASEGPSRCPAMTVLPSEIDVHR-DYTGMILQISGSLPSLSGMEMACDYGNGVRTVARV 651

  Fly   635 LENGLG-----CATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSRNFAFFDCSH------HG 688
            .....|     |...|..:.|..|...||:.|.:|||....|  .||.||..:|||.      |.
  Rat   652 PGPAYGHQIAYCNLLPRAQFPPFPAGQDHVTVEMSVRVKGHN--IVSANFTIYDCSRIGQVYPHT 714

  Fly   689 NCQECLQSSWGCNWCIFDNKCVHKSLQCRNIENAVSTVGHCPHLKKNRPEILLPVRVPIEIRLEI 753
            .|..||.:.|.|:|||..:.||....:|::..|..|. ..||.:.   |..|.|  ||.....:|
  Rat   715 ACTSCLSTQWPCSWCIQLHSCVSNQSRCQDSPNPTSP-QDCPQIV---PSPLAP--VPTGGSQDI 773

  Fly   754 ENLPKPKSA--HAGFL-CTIHIEAAQMLLPAHVESNKIVVCEKTPYFYEINTHEYQAKVVVTWNF 815
             .:|..|:|  |...| |:..:|..   ..|...::.:|.|.      ::..|..|...|...:.
  Rat   774 -LVPLTKAAFFHGTSLQCSFGLEEN---FEAVWANDSLVRCN------QVVLHTTQKSQVFPLSL 828

  Fly   816 Q------HYVDT---AIVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWCSNSCVYNETCIADKN 871
            :      .::|:   ..|.:|.| .:||    ||||.|:.|:.      ..:.||:|:.|..
  Rat   829 KLKGPPDRFLDSPNPMTVVVYNC-AMGS----PDCSQCLGRED------LGHLCVWNDGCRL--- 879

  Fly   872 SISSGSKSAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIFIGSVPCE--LE 934
               .|....:...||.|.|..|:|||||:.||||:||.|.|||.|..||...::||:|.||  .:
  Rat   880 ---RGPLQPLSGTCPAPEIRAIEPLSGPLNGGTLLTIRGKNLGRRLSDVAHGVWIGNVACEPLAD 941

  Fly   935 NYQISVKIECRTGASLYEMSAPIKVANDAGFTESSVQFHFKNVLLTGLYPTIGPRSGGTQLSLIG 999
            .|.:|.:|.|.||.:....|..:.| |.:....|..||.:....:..|.|::||::|||::::.|
  Rat   942 RYTVSEEIVCATGPAPGAFSDVVTV-NVSKEGRSREQFSYVLPRVHSLEPSMGPKAGGTRITIHG 1005

  Fly  1000 KFLNIGSTMRAFLDEYECHIDVTQASSSQVSCTTSEATQPEPIRSLHLVIDGANRTLECQISTPS 1064
            ..||:||.::..:::.:...|:|:.::| ::||....|.|.|:
  Rat  1006 SDLNVGSMLQVLVNDTDPCTDLTRTATS-ITCTVPRGTLPSPV---------------------- 1047

  Fly  1065 ITNTNPTRSNFGSYQLRSLPRQPC----SIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSI 1125
                 |....|.|        :.|    ..|.|.|:|.|..|.|.||..||||.:||.|...:.:
  Rat  1048 -----PVCVRFES--------RGCVHGNLTFWYMQNPVITAISPGRSPVSGGRTITVAGERFHMV 1099

  Fly  1126 QKPELEVFYDNERVNKTSCVVINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQNSSFQTETRY 1190
            |...:.|.:...  ..|.|.|:||..:.||||..
  Rat  1100 QNVSMAVHHIGR--EPTFCKVLNSTLIICPSPGA------------------------------- 1131

  Fly  1191 KNEYDRKKRRADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFVMDNVQLVRNL 1255
                               .:||.:..::|:|.        :.:..:...:|   :|..:..|.
  Rat  1132 -------------------LSNASAPVDFFING--------RAYADEAAEEL---LDPAEAQRG- 1165

  Fly  1256 NKYFHDIRSTIVYLADPKYLPFPND-GVKLYKGD--SLVIEGELLNLAADEYDVNVTIGTSQCNI 1317
                  .|..:.||.:|::.....: .:|.:.|:  :|||..|..:|..:.::.::.||...|:|
  Rat  1166 ------SRFRLDYLPNPQFSTAKREKWIKHHPGEPLTLVIHKEQDSLGLESHEYHIKIGQVSCDI 1224

  Fly  1318 TSLALNQLLCIPPEQQPLPTDENGVDQSTDLPLVVVKVGRNLRFVIGYLKYDLNKPYVFSHALLV 1382
            ..::...:.|...|.  |.|.|.      .|| :.::|| |....|..|:...::.     |::|
  Rat  1225 QIISDRVIHCSVNES--LGTAEG------QLP-ITIQVG-NFNQTIATLQLGGSET-----AIVV 1274

  Fly  1383 GILTVALLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESNVRSECKQAFAELQTDMTDLTAD 1447
            .|:..::|:::.|:.|.:|..||.:|||.:::..:||..:||.:|.|.::.||||||||||||.:
  Rat  1275 SIVICSVLLLLSVVALFVFCTKSRRAERYWQKTLLQMEEMESQIREEIRKGFAELQTDMTDLTKE 1339

  Fly  1448 L-ESTGIPTLDHVNYIMKVFFPGVSD------------------------HPILNS--------P 1479
            | .|.|||.|::.:::.:.|||..|.                        ||:|..        |
  Rat  1340 LNRSQGIPFLEYKHFVTRTFFPKCSSLYEERYVLPSKTLNSQGGSPPQETHPLLGEWNIPEHCRP 1404

  Fly  1480 KFREGSPQTNYDAAMVQFEQLIGNKYFLLMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYA 1544
            ...||         :..|..|:.||:||::|:..|| |:..|::|||.::|||:.:.|..|:||.
  Rat  1405 SMEEG---------ISLFSSLLNNKHFLIVFVHALE-QQKDFAVRDRCSLASLLTIALHGKLEYY 1459

  Fly  1545 TEILKSLLLRLIDKSLASKHPQLMLRRTESVVEKMLTNYLAICMYDYLKEYAGSNLFLLFKAIKH 1609
            |.|:|.||:.|||.| |:|:|:||||||||||||||||:::||||..|:|..|...|||..|||.
  Rat  1460 TSIMKELLVDLIDAS-AAKNPKLMLRRTESVVEKMLTNWMSICMYGCLRETVGEPFFLLLCAIKQ 1523

  Fly  1610 QIEKGLVDAITNDARYSLSEERLLHEQVTHSVVILHI-LQDDLDEKVQCRVNDWDTISQVKLKIL 1673
            ||.||.:||||..|||:|:||.||.|.:......|:: .|....:.:..|..|.||::|||.|||
  Rat  1524 QINKGSIDAITGKARYTLNEEWLLRENIEAKPRNLNVSFQGCGMDSLSVRAMDTDTLTQVKEKIL 1588

  Fly  1674 DAIFKNTPFSMRPSVNEVDLEWRHGRGGHLTLQDEDLTTKTVNGWKRLNTLAHYGVKESA--VMS 1736
            :|..||.|:|..|...:|||||.........|:|.|.|:...:|.|:|||||||.:.|.|  .||
  Rat  1589 EAFCKNVPYSQWPRAEDVDLEWFASSTQSYVLRDLDDTSVVEDGRKKLNTLAHYKIPEGASLAMS 1653

  Fly  1737 LIARQNDNYHIPYSKNQNSAPYHNFYFINNSQSHIIINNDIESGLQQPRVYHLVKPNIPDHYMNI 1801
            |..::                       :|:...:       ..|...:.:|||.|.  |..:..
  Rat  1654 LTDKK-----------------------DNTLGRV-------KDLDTEKYFHLVLPT--DELVEP 1686

  Fly  1802 KNSVLSGGSPAFQSHVVNNCNDRVNKTIPEVYLTRLLATKGTIQKFVDDFFSIILTVNEELPP-A 1865
            |.|       ..|||        ..|.:||:||||||:||||:|||:||.|..||::.|:.|| |
  Rat  1687 KKS-------HRQSH--------RKKVLPEIYLTRLLSTKGTLQKFLDDLFKAILSIREDKPPLA 1736

  Fly  1866 VKWLFDLLDEAARRHDIADTDIVHAWKSNCLPLRFWVNFIKNPDFIFDVNKTYSVDSCLSVIAQT 1930
            ||:.||.|:|.|.:..|:|.|.:|.||:|.||||||||.:|||.|:||:.||..:|:|||||||.
  Rat  1737 VKYFFDFLEEQAEKRGISDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIEKTDHIDACLSVIAQA 1801

  Fly  1931 FMDACSTSEHRLGKDSPSNKLLFAKDIPNYRIMVKEFYRDVSRLPQISDQEMSTAMQQLSVRQNE 1995
            |:||||.|:.:||||||:||||:||:||.||.:|:.:|:.:..:..:|:|||:..:.:.|.:...
  Rat  1802 FIDACSISDLQLGKDSPTNKLLYAKEIPEYRKIVQRYYKQIQDMTPLSEQEMNAHLAEESRKYQN 1866

  Fly  1996 EFDTISALKELYIYITKYKDQIMESLETDINCRKMHLSRKLGNVAATLDG---DCTS 2049
            ||:|..|:.|:|.|..:|:.|||.:||.:...|:..|..|...|.|.::.   :|.|
  Rat  1867 EFNTNVAMAEIYKYAKRYRPQIMAALEANPTARRTQLQYKFEQVVALMENNIYECYS 1923

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PlexB	NP_524616.2	Sema_plexin_like	86..534	CDD:200497	120/534 (22%)
		PSI	535..586	CDD:396154	18/50 (36%)
		TIG_plexin	594..682	CDD:465588	25/95 (26%)
		PSI	683..730	CDD:214655	17/52 (33%)
		TIG_2	738..827	CDD:465619	20/100 (20%)
		PSI	836..877	CDD:214655	10/40 (25%)
		IPT_plexin_repeat1	888..976	CDD:238585	38/89 (43%)
		IPT_plexin_repeat2	977..1095	CDD:238584	26/121 (21%)
		IPT_plexin_repeat3	1097..1211	CDD:238586	24/113 (21%)
		TIG	1277..>1334	CDD:460355	13/59 (22%)
		Plexin_cytopl	1452..2012	CDD:462434	245/595 (41%)
Plxnd1	NP_001381981.2	Sema_plexin_D1	51..549	CDD:200508	122/543 (22%)
		PSI	551..603	CDD:396154	18/51 (35%)
		TIG_plexin	<629..702	CDD:465588	22/74 (30%)
		PSI	713..755	CDD:214655	14/42 (33%)
		IPT_plexin_repeat1	893..981	CDD:238585	38/88 (43%)
		IPT_plexin_repeat2	983..1069	CDD:238584	26/121 (21%)
		IPT_plexin_repeat3	1071..1174	CDD:238586	33/172 (19%)
		Plexin_cytopl	1345..1883	CDD:462434	245/595 (41%)