Protein Alignment PlexB and Mst1r

DIOPT Version :10

• Sequence 1: NP_524616.2
• Gene: PlexB / 43766
• FlyBaseID: FBgn0025740
• Length: 2051
• Species: Drosophila melanogaster
• Sequence 2: XP_063121316.1
• Gene: Mst1r / 300999
• RGDID: 1306465
• Length: 1446
• Species: Rattus norvegicus
• Alignment Length: 1821
• Identity: 334/1821 - (18%)
• Similarity: 543/1821 - (29%)
• Gaps: 717/1821 - (39%)

  Fly    18 LCIIIILGSQHYCVNCIEELPAQALSPLNDIVAQFNLPSIPVQSTASSYGNRSIGNNIESVRDSQ 82
            |.::::|.......|...:.|....:...|...::.:||.            |.|..:::
  Rat    12 LLLMLLLRLPEASTNLDWQCPRIPFAASRDFSVKYVVPSF------------SAGGRVQA----- 59

  Fly    83 SKNYFTHMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQCHA--------GGCPED 139
                 |.:..|..::.:|....|::..|..:|:.:....|||:.| |.|..        .|.|.|
  Rat    60 -----TAVYEDSKNSAVFVAIRNRLHVLGPDLQYIESLTTGPIGD-PGCQTCASCGPGPHGPPND 118

  Fly   140 IETSLVNNFNKILVVSYAHDGI--LIACGSIRQGACEIYSLPRFPATPQFFAVPLAA-------- 194
            .:|          :|.....|:  |::|||..||.|.::.|     .||..|:.|||
  Rat   119 TDT----------LVLVMEPGLPALVSCGSTLQGRCFLHEL-----EPQGEALHLAAPACLFSAS 168

  Fly   195 -NDENASTYAFVGPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRLDDLNYAEFS------- 251
             |...|.|.....            ::||..| |.:..|......:..||....|.||
  Rat   169 NNKPEACTDCVAS------------HLGTRVT-VVEQGHASYFYVASSLDPELAASFSPRSVSIR 220

  Fly   252 --------IQQSIINIDV--KYRDHFLVDYIYGFNSSEYAYFIIVQKKSHLADEAGYVTRLARIC 306
                    .|....::.|  ||...:|:.|::.|:|.::.||:.||.....:..:...|||.|:.
  Rat   221 RLKSDTSGFQPGFPSLSVLPKYLASYLIKYVHSFHSGDFVYFLTVQPMDVRSPPSALQTRLVRLN 285

  Fly   307 ITDPNYDSYTEITVQC----------TATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVT 361
            ..:|....|.|:.:.|          .|.::...|.:::.|...|...|||..:.|.:...||..
  Rat   286 AIEPEIGDYRELVLDCHFAPKRRRRSGAPKSLQAYQVLQAAHSAPVDAKLALDLSISEGQEVLFG 350

  Fly   362 VFSPSREISNQPESKSAMCIYSIKDIEDMFIENIHLCFNGT-----TKDRNLGYISGTINDGRCP 421
            ||...::.|:.|  .|.:|.:.|..::::..|.:..|.:.:     |:.|.|.:..   ....||
  Rat   351 VFVAVKDSSSGP--NSVVCAFPINHLDNLIEEGVERCCHPSNSSLLTRRRGLDFFQ---TPSFCP 410

  Fly   422 IVGSLGNIYNFCSVGLKISGVSPITAHALFH--------FDNVSVTSVTATSTTDQQHSLAFLGT 478
              ...|...:.|.       ..|:..|..|.        ..:|.||::..|...:.  ::|.:||
  Rat   411 --NPPGAPSSRCH-------YFPLMVHDSFTRVDLFNGLLGSVKVTALHVTRLGNV--TVAHMGT 464

  Fly   479 NMGVIKKVLLSGQSPGEYEEIVVDAGNRILPNTMMSPKKDF--LYVLSQRKITKLRIEHCSVYTN 541
            ..|   ::|..|.|.           :.::|.:...|...|  |..|||.:|.:
  Rat   465 EDG---RILQVGPSL-----------SHLVPQSCPLPLLFFSELTCLSQVEIAR----------- 504

  Fly   542 CSACLESRDPFCGWCSLEKRCTVRSTCQRDTSASRWLSLGSGQQCIEFESIIPEKIPISELSHLH 606
                           ||.....|.:           .||||..|            |:.:
  Rat   505 ---------------SLNYLLYVSN-----------FSLGSSGQ------------PVHQ----- 526

  Fly   607 LIIRTLPEPFNAKYRCVFGNSTPIDAEILENGLGCATPPLDERPLIPTNTDHILVPLSVRSSETN 671
                                    |...|.|.|           |..:......||:....
  Rat   527 ------------------------DVSRLGNDL-----------LFASGDQVFKVPIQGPG---- 552

  Fly   672 KDFVSRNFAFFDCSHHGNCQECL--QSSWGCNWCIFDNKCVHKSLQCRNIENAVSTVGHCPHLKK 734
                        |.|...|..||  |...||.||  .::|..:.              .||.
  Rat   553 ------------CGHFLTCWRCLRAQRFMGCGWC--GDRCGRQK--------------ECPG--- 586

  Fly   735 NRPEILLPVRVPIEIRLEIENLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKTPYFYE 799
                                                                             
  Rat   587 ----------------------------------------------------------------- 586

  Fly   800 INTHEYQAKVVVTWNFQHYVDTAIVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWCSNSCVYNE 864
                        :|. |.|
  Rat   587 ------------SWQ-QDY---------------------------------------------- 592

  Fly   865 TCIADKNSISSGSKSAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDV----RGKIF 925
                                || |.|....|.|||:.|.|.:|:.|||..:|.:.|    ..:|.
  Rat   593 --------------------CP-PEITEFHPHSGPLRGTTRLTLCGSNFYLRPDGVVPEGTHQIT 636

  Fly   926 IGSVPCEL-----------ENYQISVKIECR-----------TGASLYEMSAP---------IKV 959
            :|..||.|           ...:...::||.           |..||...:.|         :.|
  Rat   637 VGQSPCRLLPKDSSTRRSGSQKEFIEELECELEPLETQAVGTTNISLLITNMPAGKHFRVEGVSV 701

  Fly   960 ANDAGFTESSVQFHFKNVLLTGLYPTIGPRSGGTQLSLIGKFLNIGSTMRAFLDEYECHIDVTQA 1024
            ..|         |.|...:||.:.|..|||:|||.|:|.|:.|::|::....::..:|.::  |.
  Rat   702 RED---------FSFMEPMLTSIKPDFGPRAGGTYLTLEGQSLSVGTSRAVLVNGTQCRLE--QV 755

  Fly  1025 SSSQVSCTTSEATQPEPIRSLHLVIDGANRTLECQISTPSITNTNPTRSNFGSYQLRSLPRQPCS 1089
            |..::.|.|.               .||        .|.|:    |.|...|..::|.     ..
  Rat   756 SEEKILCVTP---------------PGA--------GTASV----PLRLQIGGAEVRG-----SR 788

  Fly  1090 IFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSIQKPELEV-FYDNERVNKTSCV-VINSNQM 1152
            .|:|.:||.::.|.|...: ||..|: |||.:|.|..  .|.| |.|.:.:.::.|. .....|.
  Rat   789 TFHYKEDPIVLDISPKCGY-SGSHVM-VHGQHLTSAW--HLTVSFNDGQSIVESRCAGQFLEQQH 849

  Fly  1153 ECPSPPVNYKFETFKKTNRKMDTELHLQNSSFQTETRYKNEYDRKKRRADFGDTFRLYTNAGSSA 1217
            :|..|
  Rat   850 QCRLP------------------------------------------------------------ 854

  Fly  1218 NYFVNNNMDVTTFVKVHETQLNLQL------SFVMDNVQLVRNLNKYFHDIRSTIVYLADPKYLP 1276
            .|.|.|.....|.        ||.|      .|.:...:                 :|..|.
  Rat   855 EYMVRNPQGWATG--------NLSLWGDGAAGFTLPGFR-----------------FLPPPS--- 891

  Fly  1277 FPNDGVKLYKGDSLVIEGELLNL--AADEYDVNVTIGTSQCNITSLALNQLLC-IPPEQQPLPTD 1338
            .|..|..|.|.:...::.|.:.|  .||...||||:|...|. ..|..:.::| :||.   |...
  Rat   892 LPRTGPVLLKPEEHSVKVEYIGLGAVADCVTVNVTVGGEVCQ-HELRGDVVICPLPPS---LQLG 952

  Fly  1339 ENGVDQSTDLPLVVVK------VGRNLRFVIGYLKYDLNKPYVFSHALLVGILTVALLVVVFVIV 1397
            ::||      ||.|..      :|:.:|...|...         ...||:.:|.:.|||....|.
  Rat   953 KDGV------PLQVCVDGGCHILGQVVRSGPGRAS---------QRTLLIALLALILLVAGLAIA 1002

  Fly  1398 LII-FRRKSTQ----------AEREYKRIQIQMITLESNVRSECKQAFAELQTDMTDLTADLEST 1451
            |:. .||:..|          ..|:.....:.:....|.  |:.:...|....:..:.:...:.|
  Rat  1003 LVCNSRRRKKQLVLTPNLDDLTSRDLSPRAMSLSIFRSG--SDYRNGLASRPPNHEESSEGQDGT 1065

  Fly  1452 GIPTL--DHVNY--IMKVFFPGVSDHPILNSPKFREGSPQTNYDAAMVQFEQLIGNKYFLLMF-- 1510
            .:|.|  |.:..  :.|:....|.|..|             .::..::..:|:||..:|.:::
  Rat  1066 SVPLLRTDSIRLQDLDKMLLAEVKDVLI-------------PHEQVVIHTDQVIGKGHFGVVYHG 1117

  Fly  1511 -------------IETL----EAQRSSFSIRDRV--------NVASLIMV---------VLMNKM 1541
                         |::|    |.|.....:|:.:        |:.:||.:         ||:..|
  Rat  1118 EYTDEAQNQIHCAIKSLSRITEVQEVEAFLREGLIMRGLHHPNILALIGIMLPPEGLPRVLLPYM 1182

  Fly  1542 EYATEILKSLLLRLIDKS------------LASKH-----PQLMLRRTESVVEKMLTNYLAICMY 1589
            .:..      |||.|...            .||.|     |.....:..:|.:.:.......|..
  Rat  1183 RHGD------LLRFIRSPQRVSAQCPGWGVSASTHLCRCSPVSSCPQNPTVKDLISFGLQVACGM 1241

  Fly  1590 DYL-------KEYAGSNLFLLFKAIKHQIEKGLVDAITNDARYSLSEERLLHEQVTHSVVILHIL 1647
            :||       ::.|..|..|.........:.||...|.:...||:.:.|  |.::....:.|..|
  Rat  1242 EYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARGILDKEYYSVRQHR--HARLPVKWMALESL 1304

  Fly  1648 Q 1648
            |
  Rat  1305 Q 1305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PlexB	NP_524616.2	Sema_plexin_like	86..534	CDD:200497	113/508 (22%)
		PSI	535..586	CDD:396154	7/50 (14%)
		TIG_plexin	594..682	CDD:465588	8/87 (9%)
		PSI	683..730	CDD:214655	11/48 (23%)
		TIG_2	738..827	CDD:465619	3/88 (3%)
		PSI	836..877	CDD:214655	0/40 (0%)
		IPT_plexin_repeat1	888..976	CDD:238585	29/122 (24%)
		IPT_plexin_repeat2	977..1095	CDD:238584	29/117 (25%)
		IPT_plexin_repeat3	1097..1211	CDD:238586	19/115 (17%)
		TIG	1277..>1334	CDD:460355	18/59 (31%)
		Plexin_cytopl	1452..2012	CDD:462434	47/261 (18%)
Mst1r	XP_063121316.1	None