DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexB and Mst1r

DIOPT Version :9

Sequence 1:	NP_001245400.1	Gene:	PlexB / 43766	FlyBaseID:	FBgn0025740	Length:	2051	Species:	Drosophila melanogaster
Sequence 2:	XP_038937153.1	Gene:	Mst1r / 300999	RGDID:	1306465	Length:	1418	Species:	Rattus norvegicus

Alignment Length:	1819	Identity:	326/1819 - (17%)
Similarity:	528/1819 - (29%)	Gaps:	741/1819 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LCIIIILGSQHYCVNCIEELPAQALSPLNDIVAQFNLPSIPVQSTASSYGNRSIGNNIESVRDSQ 82
            |.::::|.......|...:.|....:...|...::.:||.            |.|..:::
  Rat    12 LLLMLLLRLPEASTNLDWQCPRIPFAASRDFSVKYVVPSF------------SAGGRVQA----- 59

  Fly    83 SKNYFTHMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQCHA--------GGCPED 139
                 |.:..|..::.:|....|::..|..:|:.:....|||:.| |.|..        .|.|.|
  Rat    60 -----TAVYEDSKNSAVFVAIRNRLHVLGPDLQYIESLTTGPIGD-PGCQTCASCGPGPHGPPND 118

  Fly   140 IETSLVNNFNKILVVSYAHDGI--LIACGSIRQGACEIYSLPRFPATPQFFAVPLAA-------- 194
            .:|          :|.....|:  |::|||..||.|.::.|     .||..|:.|||
  Rat   119 TDT----------LVLVMEPGLPALVSCGSTLQGRCFLHEL-----EPQGEALHLAAPACLFSAS 168

  Fly   195 -NDENASTYAFVGPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRLDDLNYAEFS------- 251
             |...|.|.....            ::||..| |.:..|......:..||....|.||
  Rat   169 NNKPEACTDCVAS------------HLGTRVT-VVEQGHASYFYVASSLDPELAASFSPRSVSIR 220

  Fly   252 --------IQQSIINIDV--KYRDHFLVDYIYGFNSSEYAYFIIVQKKSHLADEAGYVTRLARIC 306
                    .|....::.|  ||...:|:.|::.|:|.::.||:.||.....:..:...|||.|:.
  Rat   221 RLKSDTSGFQPGFPSLSVLPKYLASYLIKYVHSFHSGDFVYFLTVQPMDVRSPPSALQTRLVRLN 285

  Fly   307 ITDPNYDSYTEITVQC----------TATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVT 361
            ..:|....|.|:.:.|          .|.::...|.:::.|...|...|||..:.|.:...||..
  Rat   286 AIEPEIGDYRELVLDCHFAPKRRRRSGAPKSLQAYQVLQAAHSAPVDAKLALDLSISEGQEVLFG 350

  Fly   362 VFSPSREISNQPESKSAMCIYSIKDIEDMFIENIHLCFNGT-----TKDRNLGYISGTINDGRCP 421
            ||...::.|:.|  .|.:|.:.|..::::..|.:..|.:.:     |:.|.|.:..   ....||
  Rat   351 VFVAVKDSSSGP--NSVVCAFPINHLDNLIEEGVERCCHPSNSSLLTRRRGLDFFQ---TPSFCP 410

  Fly   422 IVGSLGNIYNFCSVGLKISGVSPITAHALFH--------FDNVSVTSVTATSTTDQQHSLAFLGT 478
              ...|...:.|.       ..|:..|..|.        ..:|.||::..|...:.  ::|.:||
  Rat   411 --NPPGAPSSRCH-------YFPLMVHDSFTRVDLFNGLLGSVKVTALHVTRLGNV--TVAHMGT 464

  Fly   479 NMGVIKKVLLSGQSPGEYEEIVVDAGNRILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTNCS 543
            ..|                        |||...:.......|||.:
  Rat   465 EDG------------------------RILQVEIARSLNYLLYVSN------------------- 486

  Fly   544 ACLESRDPFCGWCSLEKRCTVRSTCQRDTSASRWLSLGSGQQCIEFESIIPEKIPISELSHLHLI 608
                                              .||||..|            |:.:
  Rat   487 ----------------------------------FSLGSSGQ------------PVHQ------- 498

  Fly   609 IRTLPEPFNAKYRCVFGNSTPIDAEILENGLGCATPPLDERPLIPTNTDHILVPLSVRSSETNKD 673
                                  |...|.|.|           |..:......||:....
  Rat   499 ----------------------DVSRLGNDL-----------LFASGDQVFKVPIQGPG------ 524

  Fly   674 FVSRNFAFFDCSHHGNCQECL--QSSWGCNWCIFDNKCVHKSLQCRNIENAVSTVGHCPHLKKNR 736
                      |.|...|..||  |...||.||  .::|..:.              .||.
  Rat   525 ----------CGHFLTCWRCLRAQRFMGCGWC--GDRCGRQK--------------ECPG----- 558

  Fly   737 PEILLPVRVPIEIRLEIENLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKTPYFYEIN 801

  Rat   559 ----------------------------------------------------------------- 558

  Fly   802 THEYQAKVVVTWNFQHYVDTAIVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWCSNSCVYNETC 866
                      :|. |.|
  Rat   559 ----------SWQ-QDY------------------------------------------------ 564

  Fly   867 IADKNSISSGSKSAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDV----RGKIFIG 927
                              || |.|....|.|||:.|.|.:|:.|||..:|.:.|    ..:|.:|
  Rat   565 ------------------CP-PEITEFHPHSGPLRGTTRLTLCGSNFYLRPDGVVPEGTHQITVG 610

  Fly   928 SVPCEL-----------ENYQISVKIECR-----------TGASLYEMSAP---------IKVAN 961
            ..||.|           ...:...::||.           |..||...:.|         :.|..
  Rat   611 QSPCRLLPKDSSTRRSGSQKEFIEELECELEPLETQAVGTTNISLLITNMPAGKHFRVEGVSVRE 675

  Fly   962 DAGFTESSVQFHFKNVLLTGLYPTIGPRSGGTQLSLIGKFLNIGSTMRAFLDEYECHIDVTQASS 1026
            |         |.|...:||.:.|..|||:|||.|:|.|:.|::|::....::..:|.::  |.|.
  Rat   676 D---------FSFMEPMLTSIKPDFGPRAGGTYLTLEGQSLSVGTSRAVLVNGTQCRLE--QVSE 729

  Fly  1027 SQVSCTTSEATQPEPIRSLHLVIDGANRTLECQISTPSITNTNPTRSNFGSYQLRSLPRQPCSIF 1091
            .::.|.|.               .||        .|.|:    |.|...|..::|.     ...|
  Rat   730 EKILCVTP---------------PGA--------GTASV----PLRLQIGGAEVRG-----SRTF 762

  Fly  1092 NYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSIQKPELEV-FYDNERVNKTSCV-VINSNQMEC 1154
            :|.:||.::.|.|...: ||..|: |||.:|.|..  .|.| |.|.:.:.::.|. .....|.:|
  Rat   763 HYKEDPIVLDISPKCGY-SGSHVM-VHGQHLTSAW--HLTVSFNDGQSIVESRCAGQFLEQQHQC 823

  Fly  1155 PSPPVNYKFETFKKTNRKMDTELHLQNSSFQTETRYKNEYDRKKRRADFGDTFRLYTNAGSSANY 1219
            ..|                                                            .|
  Rat   824 RLP------------------------------------------------------------EY 828

  Fly  1220 FVNNNMDVTTFVKVHETQLNLQL------SFVMDNVQLVRNLNKYFHDIRSTIVYLADPKYLPFP 1278
            .|.|.....|.        ||.|      .|.:...:                 :|..|.   .|
  Rat   829 MVRNPQGWATG--------NLSLWGDGAAGFTLPGFR-----------------FLPPPS---LP 865

  Fly  1279 NDGVKLYKGDSLVIEGELLNL--AADEYDVNVTIGTSQCNITSLALNQLLC-IPPEQQPLPTDEN 1340
            ..|..|.|.:...::.|.:.|  .||...||||:|...|. ..|..:.::| :||.   |...::
  Rat   866 RTGPVLLKPEEHSVKVEYIGLGAVADCVTVNVTVGGEVCQ-HELRGDVVICPLPPS---LQLGKD 926

  Fly  1341 GVDQSTDLPLVVVK------VGRNLRFVIGYLKYDLNKPYVFSHALLVGILTVALLVVVFVIVLI 1399
            ||      ||.|..      :|:.:|...|...         ...||:.:|.:.|||....|.|:
  Rat   927 GV------PLQVCVDGGCHILGQVVRSGPGRAS---------QRTLLIALLALILLVAGLAIALV 976

  Fly  1400 I-FRRKSTQ----------AEREYKRIQIQMITLESNVRSECKQAFAELQTDMTDLTADLESTGI 1453
            . .||:..|          ..|:.....:.:....|.  |:.:...|....:..:.:...:.|.:
  Rat   977 CNSRRRKKQLVLTPNLDDLTSRDLSPRAMSLSIFRSG--SDYRNGLASRPPNHEESSEGQDGTSV 1039

  Fly  1454 PTL--DHVNY--IMKVFFPGVSDHPILNSPKFREGSPQTNYDAAMVQFEQLIGNKYFLLMF---- 1510
            |.|  |.:..  :.|:....|.|..|             .::..::..:|:||..:|.:::
  Rat  1040 PLLRTDSIRLQDLDKMLLAEVKDVLI-------------PHEQVVIHTDQVIGKGHFGVVYHGEY 1091

  Fly  1511 -----------IETL----EAQRSSFSIRDRV--------NVASLIMV---------VLMNKMEY 1543
                       |::|    |.|.....:|:.:        |:.:||.:         ||:..|.:
  Rat  1092 TDEAQNQIHCAIKSLSRITEVQEVEAFLREGLIMRGLHHPNILALIGIMLPPEGLPRVLLPYMRH 1156

  Fly  1544 ATEILKSLLLRLIDKS------------LASKH-----PQLMLRRTESVVEKMLTNYLAICMYDY 1591
            ..      |||.|...            .||.|     |.....:..:|.:.:.......|..:|
  Rat  1157 GD------LLRFIRSPQRVSAQCPGWGVSASTHLCRCSPVSSCPQNPTVKDLISFGLQVACGMEY 1215

  Fly  1592 L-------KEYAGSNLFLLFKAIKHQIEKGLVDAITNDARYSLSEERLLHEQVTHSVVILHILQ 1648
            |       ::.|..|..|.........:.||...|.:...||:.:.|  |.::....:.|..||
  Rat  1216 LAEQKFVHRDLAARNCMLDESFTVKVADFGLARGILDKEYYSVRQHR--HARLPVKWMALESLQ 1277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexB	NP_001245400.1	Sema_plexin_like	86..534	CDD:200497	108/506 (21%)
		PSI	535..586	CDD:279745	4/50 (8%)
		PSI	683..730	CDD:214655	11/48 (23%)
		PSI	836..877	CDD:214655	0/40 (0%)
		IPT_plexin_repeat1	888..976	CDD:238585	29/122 (24%)
		IPT_plexin_repeat2	977..1095	CDD:238584	29/117 (25%)
		IPT_plexin_repeat3	1097..1211	CDD:238586	19/115 (17%)
		Plexin_cytopl	1452..2017	CDD:285529	47/261 (18%)
Mst1r	XP_038937153.1	Sema_RON	29..521	CDD:200540	127/687 (18%)
		PSI	524..566	CDD:396154	16/220 (7%)
		IPT	567..681	CDD:417750	29/122 (24%)
		IPT_plexin_repeat2	682..766	CDD:238584	29/117 (25%)
		IPT	767..>828	CDD:214657	20/124 (16%)
		PKc_like	1076..1364	CDD:419665	40/210 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I11963
eggNOG	1	0.900	-	-		E1_KOG3610
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810