DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PlexB and Plxna2

DIOPT Version :9

Sequence 1:NP_001245400.1 Gene:PlexB / 43766 FlyBaseID:FBgn0025740 Length:2051 Species:Drosophila melanogaster
Sequence 2:NP_001099458.2 Gene:Plxna2 / 289392 RGDID:1305325 Length:1894 Species:Rattus norvegicus


Alignment Length:2055 Identity:702/2055 - (34%)
Similarity:1061/2055 - (51%) Gaps:313/2055 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 SQSKNY-FTHMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQCH----AGGCPEDI 140
            |::::: |.|::.......::.||.|::.||..||.:.....|||..|:..|:    ...|.|.:
  Rat    43 SENRDWTFNHLTVHRRTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKACYPPLIVQPCSEVL 107

  Fly   141 ETSLVNNFNKILVVSYAHDGILIACGSIRQGACEIYSLPRFPATPQFFAVP--------LAANDE 197
              :|.||.||:|::.|: :..|:||||:.||.|::..|...     |..|.        |::.::
  Rat   108 --TLTNNVNKLLIIDYS-ENRLLACGSLYQGVCKLLRLDDL-----FILVEPSHKKEHYLSSVNK 164

  Fly   198 NASTYAFVGPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRL----DDLNYAEFSIQQSIIN 258
            ..:.|..:..:.   .|:..|::||......||   .|.:|||:|    :.....::.:....::
  Rat   165 TGTMYGVIVRSE---GEDGKLFIGTAVDGKQDY---FPTLSSRKLPRDPESSAMLDYELHSDFVS 223

  Fly   259 IDVKYR-------DHFLVDYIYGFNSSEYAYFIIVQKKS------HLADEAGYVTRLARICITDP 310
            ..:|..       .||.:.|||||.|..:.||:.||.::      :.|.:..|.:|:.|:|..||
  Rat   224 SLIKIPSDTLALVSHFDIFYIYGFASGGFVYFLTVQPETPEGMAINSAGDLFYTSRIVRLCKDDP 288

  Fly   311 NYDSYTEITVQCTATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVFSPSREISNQPES 375
            .:.||..:...||..  .|:|.:::.|.:......|||...|..::.||..:||..::..:.|..
  Rat   289 KFHSYVSLPFGCTRA--GVEYRLLQAAYLAKPGEALAQAFNISSEEDVLFAIFSKGQKQYHHPPD 351

  Fly   376 KSAMCIYSIKDIEDMFIENIHLCFNGTTKDRNLGYISGTINDGRC-----PIVGSLGNIYNFCSV 435
            .||:|.:.|:.|.....|.:..|::| ..:..|.::.|  .|.:|     ||..      |||.:
  Rat   352 DSALCAFPIRAINLQIKERLQSCYHG-EGNLELNWLLG--KDVQCTKAPVPIDD------NFCGL 407

  Fly   436 GLK--ISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLSGQSPG--EY 496
            .:.  :.|.:|:....|:......:|||  .|.....:|:.|:||..|.:||:...|...|  :|
  Rat   408 DINQPLGGSTPVEGLTLYTTSRDRLTSV--ASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQY 470

  Fly   497 EEI-VVDAGNRILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTNCSACLESRDPFCGWCSLEK 560
            |.: |...|:.||.:...|..:.:|||:|:|::|::.:|.|..||.|..||.|.||.||||:|..
  Rat   471 EMVSVFKDGSPILRDMAFSINQLYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALHN 535

  Fly   561 RCTVRSTCQRDTSASRWLSLGSGQQCIEFESIIPEKIPISELSH-LHLIIRTLPEPFNAKYRCVF 624
            .|:.|..|||...|:|:.:  |..||:..| :.|..|.:|:.|. |.|::...|. .:....|.|
  Rat   536 MCSRRDKCQRAWEANRFAA--SISQCMSLE-VHPNSISVSDHSRLLSLVVNDAPN-LSEGIACAF 596

  Fly   625 GNSTPIDAEILENGLGCATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSRNFAFFDCSHHGN 689
            ||.|.::.::..:.:.|.:|...:.|:||.:.|...:.|.:||.||.|.|||..|.|::||.|..
  Rat   597 GNLTEVEGQVSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVSTEFKFYNCSAHQL 661

  Fly   690 CQECLQSSWGCNWCIFDNKCVHKSLQCRNIENAVSTVGHCPHLKKNRPEILLPVRVPIEIRLEIE 754
            |..|:.|::.|:||.:.|.|.|....|...|..::....||.|.... |||:||.....|.|:..
  Rat   662 CLSCVNSAFRCHWCKYRNLCTHDPTTCSFQEGRINVSEDCPQLVPTE-EILIPVGEVKPITLKAR 725

  Fly   755 NLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKTPYFYE-INTHEYQAKVVVTWNFQHY 818
            |||:|:|...|:.|.::|:.|...:||...::..|.|:.:.|.|: ::.........|.||....
  Rat   726 NLPQPQSGQRGYECVLNIQGAVHRVPALRFNSSSVQCQNSSYQYDGMDISNLAVDFAVVWNGNFI 790

  Fly   819 VDT---AIVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWCSNS--CVYNETCIADKNSISSGSK 878
            :|.   ..|.||||   .:.||  .|.||:..|.|::|.|||..  |...:.|.:..:.....|.
  Rat   791 IDNPQDLKVHLYKC---AAQRE--SCGLCLKADHKFECGWCSGERRCTLRQHCPSTSSPWLDWSS 850

  Fly   879 SAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIFIGSVPCE--LENYQISVK 941
            ..:  :|..|:|..|..:|||.||||.:||.|.|||:...::...:.:..|||.  ...|.|:.:
  Rat   851 HNV--KCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAGVPCTPIPGEYIIAEQ 913

  Fly   942 IECRTGASLY-EMSAPIKV----ANDAGFTESSVQFHFKNVLLTGLYPTIGPRSGGTQLSLIGKF 1001
            |.|..|.:|. ..|.|:::    ......|:|..|:.|.|..:..|.|..||.||||.:::.|.:
  Rat   914 IVCEMGHALMGTTSGPVRLCIGECKPEFMTKSHQQYTFVNPSVLSLSPIRGPESGGTMVTITGHY 978

  Fly  1002 LNIGSTMRAFLDEYECHIDVTQASSSQVSCTTSEATQPEPIRSLHLVIDGANRTLECQISTPSIT 1066
            |..||::..:|....|  :....|.:::.|                            :|.||..
  Rat   979 LGAGSSVAVYLGNQTC--EFYGRSMNEIVC----------------------------VSPPSSN 1013

  Fly  1067 NTNPTRSNFGSYQLRSLPRQPCSI------------FNYTQDPRIMQIKPLRSFKSGGRVLTVHG 1119
            ...|.               |.|:            |.|..|||:.:|:|..|..||...||:.|
  Rat  1014 GLGPV---------------PVSVSVDRARVDSSLQFEYIDDPRVQRIEPEWSITSGHTPLTITG 1063

  Fly  1120 IYLNSIQKPELEV-FYDNERVNKTSCVVINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQNSS 1183
            ..|:.||:|.:.| |...|.||  .|.|:|:..:.|.:|.:.                       
  Rat  1064 FNLDVIQEPRIRVKFNGKESVN--VCTVVNTTTLTCLAPSLT----------------------- 1103

  Fly  1184 FQTETRYKNEYDRKKRRADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFVMDN 1248
                :.|:...|..:|..:||                                       |:.:|
  Rat  1104 ----SDYRPGLDTVERPDEFG---------------------------------------FLFNN 1125

  Fly  1249 VQLVRNLNKYFHDIRSTIVYLADPKYLPFPNDGVKLYK---------GDSLVIEGELLNLAAD-- 1302
            ||             |.::| .|.|::.:||...:|..         |..::::|:.|...|.  
  Rat  1126 VQ-------------SLLIY-NDTKFIYYPNPTFELLSPTGILDQKPGSPIILKGKNLCPPASGG 1176

  Fly  1303 -EYDVNVTIGTSQCNITSLALNQLLCIPPEQQPLPTDENGVDQSTDLPLVVVKVGRNLRFVIGYL 1366
             :.:..|.||.:.|.:| ::..||||.||             ..|....|:|.|| .:.|..|.:
  Rat  1177 AKLNYTVMIGETPCTVT-VSETQLLCEPP-------------NLTGQHKVMVHVG-GMVFSPGSV 1226

  Fly  1367 KYDLNKPYVFSHALLV--GILTVA----LLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESN 1425
            .       |.|.:||.  .|:::|    ||:::.:||||.::|||.:.:...||:|:||..|||.
  Rat  1227 S-------VISDSLLTLPAIISIAAGGSLLLIIVIIVLIAYKRKSRENDLTLKRLQMQMDNLESR 1284

  Fly  1426 VRSECKQAFAELQTDMTDLTADLESTGIPTLDHVNYIMKVFFPGVSDHPILNSPKFREGSPQTNY 1490
            |..|||:||||||||:.:||:||:.:|||.||:..|.|:|.|||:.|||:|...:. :|:.|.:.
  Rat  1285 VALECKEAFAELQTDINELTSDLDRSGIPYLDYRTYAMRVLFPGIEDHPVLRELEV-QGNGQQHV 1348

  Fly  1491 DAAMVQFEQLIGNKYFLLMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSLLLRL 1555
            :.|:..|.|||.||.|||.||.|||.|| |||:|||.|||||||..|..::||||::||.||..|
  Rat  1349 EKALKLFAQLINNKVFLLTFIRTLELQR-SFSMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDL 1412

  Fly  1556 IDKSLASK-HPQLMLRRTESVVEKMLTNYLAICMYDYLKEYAGSNLFLLFKAIKHQIEKGLVDAI 1619
            |||:|.:| ||:|:|||||||.||||||:.|..::.:|||.||..||:|:.|||.|:|||.:|||
  Rat  1413 IDKNLENKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAI 1477

  Fly  1620 TNDARYSLSEERLLHEQVTHSVVILHILQDDLDE--KVQCRVNDWDTISQVKLKILDAIFKNTPF 1682
            |.:|||||||::|:.:|:.:..:||:.:..|.:.  ::..:|.:.|||:|||.|||||::||.|:
  Rat  1478 TGEARYSLSEDKLIRQQIEYKTLILNCVNPDNENSPEIPVKVLNCDTITQVKEKILDAVYKNVPY 1542

  Fly  1683 SMRPSVNEVDLEWRHGRGGHLTLQDEDLTTKTVNGWKRLNTLAHYGVKESAVMSLIARQNDNYHI 1747
            |.||...::|||||.||...:.|||||:|||....|||||||.||.|.:.:|::|:.:|..:|:|
  Rat  1543 SQRPRAVDMDLEWRQGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNI 1607

  Fly  1748 PYS---KNQNSAPYHNFYFINNSQSHI-----IINNDIESGLQQPRVYHLVKPNIPDHYMNIKNS 1804
            |.|   ...:.:.|.:.:....|...:     :|..|:|||:   :|:||||    :|       
  Rat  1608 PASASISRTSISRYDSSFRYTGSPDSLRSRVPMITPDLESGV---KVWHLVK----NH------- 1658

  Fly  1805 VLSGGSPAFQSHVVNNCNDRVNKTIPEVYLTRLLATKGTIQKFVDDFFSIILTV---NEELPPAV 1866
                      .|......||.:|.:.|:|||||||||||:||||||.|..:.:.   ...||.|:
  Rat  1659 ----------DHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETLFSTVHRGSALPLAI 1713

  Fly  1867 KWLFDLLDEAARRHDIADTDIVHAWKSNCLPLRFWVNFIKNPDFIFDVNKTYSVDSCLSVIAQTF 1931
            |::||.|||.|.||.|.|||:.|.|||||||||||||.||||.|:||::|....|:||||:||||
  Rat  1714 KYMFDFLDEQADRHSIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKGSITDACLSVVAQTF 1778

  Fly  1932 MDACSTSEHRLGKDSPSNKLLFAKDIPNYRIMVKEFYRDVSRLPQISDQEMSTAMQQLSVRQNEE 1996
            ||:||||||||||||||||||:|||||:|:..|:.:|.|:::||.||||:|:..:.:.|.....|
  Rat  1779 MDSCSTSEHRLGKDSPSNKLLYAKDIPSYKNWVERYYADIAKLPAISDQDMNAYLAEQSRLHATE 1843

  Fly  1997 FDTISALKELYIYITKYKDQIMESLETDINCRKMHLSRKL 2036
            |:.:|||.|:|.|::||.::::.:||.|...|:..|:.|:
  Rat  1844 FNMLSALNEIYSYVSKYSEELIGALEQDEQARRQRLAYKV 1883

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexBNP_001245400.1 Sema_plexin_like 86..534 CDD:200497 129/487 (26%)
PSI 535..586 CDD:279745 22/50 (44%)
PSI 683..730 CDD:214655 14/46 (30%)
PSI 836..877 CDD:214655 13/42 (31%)
IPT_plexin_repeat1 888..976 CDD:238585 31/94 (33%)
IPT_plexin_repeat2 977..1095 CDD:238584 24/129 (19%)
IPT_plexin_repeat3 1097..1211 CDD:238586 29/114 (25%)
Plexin_cytopl 1452..2017 CDD:285529 290/578 (50%)
Plxna2NP_001099458.2 Sema_plexin_A2 38..552 CDD:200533 151/535 (28%)
PSI 655..702 CDD:279745 14/46 (30%)
PSI 806..855 CDD:279745 14/52 (27%)
IPT_plexin_repeat1 858..953 CDD:238585 31/94 (33%)
IPT_plexin_repeat2 954..1037 CDD:238584 23/127 (18%)
IPT_plexin_repeat3 1041..1141 CDD:238586 37/181 (20%)
TIG 1143..1227 CDD:280079 23/98 (23%)
Plexin_cytopl 1311..1864 CDD:285529 290/578 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 54 1.000 Domainoid score I10916
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D56043at33208
OrthoFinder 1 1.000 - - FOG0000391
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100269
Panther 1 1.100 - - O PTHR22625
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
98.820

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