Protein Alignment PlexB and plx-1

DIOPT Version :10

• Sequence 1: NP_524616.2
• Gene: PlexB / 43766
• FlyBaseID: FBgn0025740
• Length: 2051
• Species: Drosophila melanogaster
• Sequence 2: NP_001294554.1
• Gene: plx-1 / 246019
• WormBaseID: WBGene00004047
• Length: 1956
• Species: Caenorhabditis elegans
• Alignment Length: 2137
• Identity: 653/2137 - (30%)
• Similarity: 1021/2137 - (47%)
• Gaps: 376/2137 - (17%)

  Fly    63 ASSYGNRSIGNNIESVRDS--------QSKNYFTHMSFDFMHNVLFAGATNKILKL-NENLRVLA 118
            |::.|::    |:.|:.|:        .....|..|:.|.....:|.||.|.:..| :.:|.|..
 Worm    15 AAAAGSK----NVYSIDDNLVFKNPSHDGHEVFEKMAIDPSTTRVFVGAVNSLYDLTSADLTVRR 75

  Fly   119 EAVTGPLHDSPQCHAGGCPEDI--ETSLVNNFNKILVVSYAHDGILIACGSIRQGACEIYSLPRF 181
            ...|||..|||.|......|:.  :.|..|:..|.|.| |.....||.|.::.||.|.:.:|...
 Worm    76 HVQTGPQDDSPLCRDARNREECRHQLSRTNSHTKALSV-YDKSSKLIECSNLYQGRCRLRNLHNI 139

  Fly   182 PATPQFFAVPLAANDENASTYAFVGPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRLDDLN 246
            .........|..:||.::|...|||........|.:||||.|   :|...||..::||..|....
 Worm   140 SEVISEAIEPRVSNDTSSSVVIFVGSGPANLSSEPVLYVGAT---IGSGDHDRMSVSSLFLRPQK 201

  Fly   247 YAEFSIQ----QSIINIDVKYRDH--FLVDYIYGFNSSEYAYFIIVQKKSHLADEAGYVTRLARI 305
            ..|....    .:.:::|.:.|.:  :.:|||.||.|.:|||| :.:::.::||::...:||.|:
 Worm   202 AFEVVFPGLYGGTHVSLDYRSRGYYKYQIDYINGFESGDYAYF-VTRQRVNIADDSSIQSRLVRV 265

  Fly   306 CITDPNYDSYTEITVQCTATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVF---SPSR 367
            |..|.|:.||||:.::|  |:|.|::|:|:|..||.|.::||:.:.|...|.||..||   ..:.
 Worm   266 CTGDKNFHSYTEVPLEC--TQNGVEFNLVQDVYVTRAGYELAKSLDISVSDPVLYGVFWEGDKNS 328

  Fly   368 EISNQPESKSAMCIYSIKDIEDMFIENIHLCFNGTT-KDRNLGYISGTINDGRC-----PIVG-S 425
            ..|.:|..|||:|::::::||..|.:||..|:.||: ..:||.:.|.  ||. |     |..| .
 Worm   329 YRSQEPTGKSAICMFTMREIETSFKQNIMKCYKGTSGLKKNLPWFSS--NDD-CRFTTLPWEGIK 390

  Fly   426 LGNIYNFCSVGLKISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLL-S 489
            .|.     .|..||.|.:||:..|.:..::.|.........|.:..::||:||..|.:.|:|: |
 Worm   391 CGK-----DVNSKIGGDTPISTSATYVMEDSSNLLTAIAINTTRSSTVAFVGTQGGQLHKILIES 450

  Fly   490 GQSPGEYEEIVVDAGNRILPNTMMSPKKDFLYVLSQRKITKLRIEHC-SVYTNCSACLESRDPFC 553
            .:|..:|...::.....||.:.........:|:|:..|:.|:....| ::.|.|..||.||||:|
 Worm   451 KRSAEKYATEMLTDNEPILSDMEFGGDGKHVYILTPSKVIKMPTSRCEALSTQCDTCLSSRDPYC 515

  Fly   554 GWCSLEKRCTVRSTCQRDT--SASRWLSLGSGQQCIEFESIIPEKIPISELSHLHLIIRTLPEPF 616
            |||.....||...:|:|:.  ::..||.. ...:|....|:.|::|.|:...:|::.|..|..|.
 Worm   516 GWCVSNNHCTQEESCEREVPHTSRGWLDF-QNSKCPRIRSVKPDQIQINTADYLNVTIENLQAPK 579

  Fly   617 NAKYRCVF----GNSTPIDAEILENGLGCATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSR 677
            ..:.:|:|    |::...|....:..|.|||||::..|.||||..|:...|.|.|..:.....:.
 Worm   580 GRRMQCLFQFSTGDAVVSDPMPFDGSLKCATPPMNRLPRIPTNEYHLPAKLIVVSDGSKLPLATT 644

  Fly   678 NFAFFDCSHHGNCQECLQSSWGCNWCIFDNKCVHKSL---QCR--NIENAVSTVG--------HC 729
            ||:|:||:.:.:|..|..|.:.|:||:..|:||...|   :||  :|.|.::..|        .|
 Worm   645 NFSFYDCNRYTSCSTCSASQFPCDWCLESNECVAGKLTEDKCRKQHIVNGLNRDGSSIRKGPSKC 709

  Fly   730 PHLKKNRPEILLPV-RVPI------EIRLEIENLPKPKSAHAGFLC-----TIHIEAAQMLLPAH 782
            ||       |:.|| ::.:      .|.:::||:  ..:....|.|     |:..|...|.
 Worm   710 PH-------IVAPVSKMSVATGERRNISVKVENV--DATFMGDFKCEFKYGTVTHEKIAMR---- 761

  Fly   783 VESNKIVVCEK---------------TPYFYEINTHEYQAKVVVTWNFQHY-------------V 819
             .|:..:.|::               |||.:.           |.|:...:             |
 Worm   762 -TSDDTITCDEMLFEPYGTSLLGSGSTPYGFN-----------VIWSATGFAVGKKSINRVLDNV 814

  Fly   820 DTAIVTLYKCDVLGSHREHPDCSLCVTRD-PKYKCAWCS--NSCVYNETCIADKNSISSGSKSAI 881
            .:..:.:|.|:.|.:     :|..|:|.| .||.|.|||  :.|.....|         .::...
 Worm   815 ASLAIDVYSCENLAT-----NCGRCLTLDADKYDCGWCSLDSKCARPHQC---------SNRQIP 865

  Fly   882 EN------ECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIFIGSVPCELENYQISV 940
            ||      .||.|.|:..||..|.:.|||.:||.|.|||....||...:.|.:||||:..|..|.
 Worm   866 ENWLNASQLCPNPVIEDFKPKKGSIFGGTRVTINGINLGRHVSDVEKAVQIANVPCEVVEYVPSQ 930

  Fly   941 KIECRTGASLYEMSAPIKVANDAG-------------FTESSVQFHFKNVLLTGLYPTIGPRSGG 992
            ||.|.||.|      |||.:|:.|             |..|:..|.:...:::.:.|..||||||
 Worm   931 KIVCVTGKS------PIKGSNERGVVAVTLRHDSLKFFAHSTEHFSYVQPVVSSMKPVKGPRSGG 989

  Fly   993 TQLSLIGKFLNIGSTMRAFLDEYECHIDVTQASSSQVSC---TTSEATQ-PEPIRSLHLVIDGAN 1053
            |.::|.|..|:.|:.:.....:..|.|  .:.:|..:.|   .:.|..| |     ||:..||
 Worm   990 TDVTLTGVDLDTGAEVTVRFGQIGCKI--LERASGWLRCRMGASGEGGQFP-----LHIAFDG-- 1045

  Fly  1054 RTLECQISTPSITNTNPTRSNFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVH 1118
                                     ||::||..  ..|.:|.||.:..|.|.::..|||..:.|:
 Worm  1046 -------------------------QLQNLPIP--IYFEFTSDPSVQSISPNKTIPSGGITVDVY 1083

  Fly  1119 GIYLNSIQKPELEVF--YDNERVNKTSCVVINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQN 1181
            |.....:|:|.: ||  ..:|:....:|.:.:...|:|.:|....|
 Worm  1084 GQGFTLLQRPRM-VFTGLGDEKSYGPACSIEDDQMMKCATPTAPGK------------------- 1128

  Fly  1182 SSFQTETRYKNEYDRKKRRADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFVM 1246
                              .:|.|...|:                              .:.:|..
 Worm  1129 ------------------DSDRGSQERI------------------------------TEYAFDF 1145

  Fly  1247 DNVQLVRNLNKYFHDIRSTIVYLADPKYLPFPNDGVKLYKGDSLVIEGELLNLAADEYDVNVTIG 1311
            |..:|.|:..|....  .|...|::|:::. |.:       |.|.:.|..|||||.|.|::|.:|
 Worm  1146 DGAELYRSRIKVMPS--PTFETLSEPRFVR-PGE-------DFLTLNGNHLNLAASERDIDVKVG 1200

  Fly  1312 TSQCNITSLALNQLLCIPPEQQPLPTDENGVDQSTDLPLVVVKVGRNLRFVIGYLKYDLNKPYVF 1376
            ...|.:|:||...|.|.||.::|     .|..:..  |.:||.|| |..|.||.:.||  .|.:.
 Worm  1201 GEPCPLTALANKVLTCQPPVKKP-----RGAGKLN--PEIVVTVG-NASFSIGEVSYD--SPGLS 1255

  Fly  1377 SHALLVGILTVALLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESNVRSECKQAFAELQTDM 1441
            |....:.:..:..::.:.:.:::::||||...:|:.|.::.||.|:|..|.:|||:|||||||.:
 Worm  1256 SSLFFIIMFFIIFMIALIICLIVLYRRKSNTHQRQMKYLKTQMDTIEMKVATECKEAFAELQTSL 1320

  Fly  1442 TDLTADLESTGIPT---LDHVNYIMKVFFPGV-SDHPILNSPKFREGSPQTNYDAAMVQFEQLIG 1502
            ...|||| ..|.||   |::.:|..:|.||.. .:|.:|.:.:......:. .:|.:.:|.:|:.
 Worm  1321 NQYTADL-PLGTPTAPFLEYKDYCARVLFPNAGKNHAVLKNLEVDTHKAEA-IEAGLREFHKLLM 1383

  Fly  1503 NKYFLLMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSLLLRLIDKSLASK-HPQ 1566
            ||.|||..:.|:||.: .|..:|||.|.||:||||..||.|.||:||.||..||:|::..| .|:
 Worm  1384 NKTFLLTMVRTMEANK-YFVGKDRVYVGSLLMVVLQEKMGYCTEMLKQLLRELIEKTVEKKFQPK 1447

  Fly  1567 LMLRRTESVVEKMLTNYLAICMYDYLKEY-AGSNLFLLFKAIKHQIEKGLVDAITNDARYSLSEE 1630
            ::.||:||:.|:||..:....::|:||.| ||..|:.||..||.|:|||..||:|.:||||||||
 Worm  1448 ILFRRSESIAERMLAAWFTFLLHDHLKTYDAGKKLYELFWGIKQQMEKGPQDALTLEARYSLSEE 1512

  Fly  1631 RLLHEQVTHSVVILHILQDD----LDEKVQCRVNDWDTISQVKLKILDAIFKNTPFSMRPSVNEV 1691
            :||.....:..:::.:...|    ..:.:..||.|.|||:|||.|.|||.::...|:.||:..::
 Worm  1513 KLLRATFEYKELMVFVSASDSVYSSTQDIPVRVLDCDTITQVKEKCLDAKYRGYRFADRPAPGDM 1577

  Fly  1692 DLEWRHGRGGHLTLQDEDLTTKTVNG-WKRLNTLAHYGVKESAVMSLIARQNDNYHIPYSKNQNS 1755
            :|||:.|..|.:.|||.|.:::...| ||||||||||.|..:|:::|.::.|..|::   .|.:|
 Worm  1578 ELEWKTGMNGKMALQDIDSSSRVEGGNWKRLNTLAHYNVPNNAILTLTSKSNSLYNL---VNFSS 1639

  Fly  1756 APYHNFYFINNSQ--------------------------SHIIINNDIESGLQQPRVYHLVKPNI 1794
            ........:::..                          .|...:.|.::|.   ::||||||.
 Worm  1640 TSMKTASILSDRSEKSSVSMKTPGVGSPKPWGAPPSVIADHASSSADTDNGF---KLYHLVKPT- 1700

  Fly  1795 PDHYMNIKNSVLSGGSPAFQSHVVNNCNDRVNKTIPEVYLTRLLATKGTIQKFVDDFFSIILTVN 1859
             :|            .|          .|...|.:.|:||||||..|||:.||:......|.: :
 Worm  1701 -EH------------GP----------TDSQEKMVTEIYLTRLLMMKGTLAKFITSLLESIFS-S 1741

  Fly  1860 EELPPAVKWLFDLLDEAARRHDIADTDIVHAWKSNCLPLRFWVNFIKNPDFIFDVNKTYSVDSCL 1924
            ..:||.:|::||.:||.||.|.|.|.::|||||||.||||||||.||||.|:||:.|...::.||
 Worm  1742 STVPPCIKYMFDFMDEQAREHGINDPEVVHAWKSNALPLRFWVNLIKNPHFLFDIQKPTKIEGCL 1806

  Fly  1925 SVIAQTFMDACSTSEHRLGKDSPSNKLLFAKDIPNYRIMVKEFYRDVSRLPQISDQEMSTAMQQL 1989
            ||:|||.||||||.:|:|.|||||:|||||||:..||.:|..:|.::|..|:|.|..|...:...
 Worm  1807 SVVAQTLMDACSTQDHQLTKDSPSSKLLFAKDMYQYRDLVDSYYTEISMTPRIDDATMGANLSAE 1871

  Fly  1990 SVRQNEEFDTISALKELYIYITKYKDQIMESLETDINCRKMHLSRKLGNVAATLDGD 2046
            |.:.|.||...|||.|||.|:.:||:.|:::||::.:.:...|..:|.::.|.::.|
 Worm  1872 SRQHNGEFHVFSALNELYKYLDQYKESIIDALESNEHAQASRLPGRLQDLLALMESD 1928

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PlexB	NP_524616.2	Sema_plexin_like	86..534	CDD:200497	141/467 (30%)
		PSI	535..586	CDD:396154	19/53 (36%)
		TIG_plexin	594..682	CDD:465588	28/91 (31%)
		PSI	683..730	CDD:214655	17/59 (29%)
		TIG_2	738..827	CDD:465619	19/128 (15%)
		PSI	836..877	CDD:214655	12/43 (28%)
		IPT_plexin_repeat1	888..976	CDD:238585	37/100 (37%)
		IPT_plexin_repeat2	977..1095	CDD:238584	28/121 (23%)
		IPT_plexin_repeat3	1097..1211	CDD:238586	21/115 (18%)
		TIG	1277..>1334	CDD:460355	21/56 (38%)
		Plexin_cytopl	1452..2012	CDD:462434	233/596 (39%)
plx-1	NP_001294554.1	Sema_plexin_like	42..495	CDD:200497	141/467 (30%)
		PSI	496..550	CDD:396154	19/54 (35%)
		TIG_plexin	556..649	CDD:465588	28/92 (30%)
		PSI	650..>677	CDD:396154	9/26 (35%)
		TIG_2	717..822	CDD:465619	16/122 (13%)
		PSI	823..876	CDD:396154	16/66 (24%)
		IPT_plexin_repeat1	878..973	CDD:238585	37/100 (37%)
		IPT_PCSR	974..1059	CDD:238337	28/120 (23%)
		IPT	1062..1146	CDD:472823	22/151 (15%)
		IPT_PCSR	1179..1248	CDD:238337	30/76 (39%)
		Plexin_cytopl	1333..1894	CDD:462434	231/593 (39%)