DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PlexB and plx-1

DIOPT Version :9

Sequence 1:NP_001245400.1 Gene:PlexB / 43766 FlyBaseID:FBgn0025740 Length:2051 Species:Drosophila melanogaster
Sequence 2:NP_001294554.1 Gene:plx-1 / 246019 WormBaseID:WBGene00004047 Length:1956 Species:Caenorhabditis elegans


Alignment Length:2137 Identity:653/2137 - (30%)
Similarity:1021/2137 - (47%) Gaps:376/2137 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 ASSYGNRSIGNNIESVRDS--------QSKNYFTHMSFDFMHNVLFAGATNKILKL-NENLRVLA 118
            |::.|::    |:.|:.|:        .....|..|:.|.....:|.||.|.:..| :.:|.|..
 Worm    15 AAAAGSK----NVYSIDDNLVFKNPSHDGHEVFEKMAIDPSTTRVFVGAVNSLYDLTSADLTVRR 75

  Fly   119 EAVTGPLHDSPQCHAGGCPEDI--ETSLVNNFNKILVVSYAHDGILIACGSIRQGACEIYSLPRF 181
            ...|||..|||.|......|:.  :.|..|:..|.|.| |.....||.|.::.||.|.:.:|...
 Worm    76 HVQTGPQDDSPLCRDARNREECRHQLSRTNSHTKALSV-YDKSSKLIECSNLYQGRCRLRNLHNI 139

  Fly   182 PATPQFFAVPLAANDENASTYAFVGPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRLDDLN 246
            .........|..:||.::|...|||........|.:||||.|   :|...||..::||..|....
 Worm   140 SEVISEAIEPRVSNDTSSSVVIFVGSGPANLSSEPVLYVGAT---IGSGDHDRMSVSSLFLRPQK 201

  Fly   247 YAEFSIQ----QSIINIDVKYRDH--FLVDYIYGFNSSEYAYFIIVQKKSHLADEAGYVTRLARI 305
            ..|....    .:.:::|.:.|.:  :.:|||.||.|.:|||| :.:::.::||::...:||.|:
 Worm   202 AFEVVFPGLYGGTHVSLDYRSRGYYKYQIDYINGFESGDYAYF-VTRQRVNIADDSSIQSRLVRV 265

  Fly   306 CITDPNYDSYTEITVQCTATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVF---SPSR 367
            |..|.|:.||||:.::|  |:|.|::|:|:|..||.|.::||:.:.|...|.||..||   ..:.
 Worm   266 CTGDKNFHSYTEVPLEC--TQNGVEFNLVQDVYVTRAGYELAKSLDISVSDPVLYGVFWEGDKNS 328

  Fly   368 EISNQPESKSAMCIYSIKDIEDMFIENIHLCFNGTT-KDRNLGYISGTINDGRC-----PIVG-S 425
            ..|.:|..|||:|::::::||..|.:||..|:.||: ..:||.:.|.  ||. |     |..| .
 Worm   329 YRSQEPTGKSAICMFTMREIETSFKQNIMKCYKGTSGLKKNLPWFSS--NDD-CRFTTLPWEGIK 390

  Fly   426 LGNIYNFCSVGLKISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLL-S 489
            .|.     .|..||.|.:||:..|.:..::.|.........|.:..::||:||..|.:.|:|: |
 Worm   391 CGK-----DVNSKIGGDTPISTSATYVMEDSSNLLTAIAINTTRSSTVAFVGTQGGQLHKILIES 450

  Fly   490 GQSPGEYEEIVVDAGNRILPNTMMSPKKDFLYVLSQRKITKLRIEHC-SVYTNCSACLESRDPFC 553
            .:|..:|...::.....||.:.........:|:|:..|:.|:....| ::.|.|..||.||||:|
 Worm   451 KRSAEKYATEMLTDNEPILSDMEFGGDGKHVYILTPSKVIKMPTSRCEALSTQCDTCLSSRDPYC 515

  Fly   554 GWCSLEKRCTVRSTCQRDT--SASRWLSLGSGQQCIEFESIIPEKIPISELSHLHLIIRTLPEPF 616
            |||.....||...:|:|:.  ::..||.. ...:|....|:.|::|.|:...:|::.|..|..|.
 Worm   516 GWCVSNNHCTQEESCEREVPHTSRGWLDF-QNSKCPRIRSVKPDQIQINTADYLNVTIENLQAPK 579

  Fly   617 NAKYRCVF----GNSTPIDAEILENGLGCATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSR 677
            ..:.:|:|    |::...|....:..|.|||||::..|.||||..|:...|.|.|..:.....:.
 Worm   580 GRRMQCLFQFSTGDAVVSDPMPFDGSLKCATPPMNRLPRIPTNEYHLPAKLIVVSDGSKLPLATT 644

  Fly   678 NFAFFDCSHHGNCQECLQSSWGCNWCIFDNKCVHKSL---QCR--NIENAVSTVG--------HC 729
            ||:|:||:.:.:|..|..|.:.|:||:..|:||...|   :||  :|.|.::..|        .|
 Worm   645 NFSFYDCNRYTSCSTCSASQFPCDWCLESNECVAGKLTEDKCRKQHIVNGLNRDGSSIRKGPSKC 709

  Fly   730 PHLKKNRPEILLPV-RVPI------EIRLEIENLPKPKSAHAGFLC-----TIHIEAAQMLLPAH 782
            ||       |:.|| ::.:      .|.:::||:  ..:....|.|     |:..|...|.    
 Worm   710 PH-------IVAPVSKMSVATGERRNISVKVENV--DATFMGDFKCEFKYGTVTHEKIAMR---- 761

  Fly   783 VESNKIVVCEK---------------TPYFYEINTHEYQAKVVVTWNFQHY-------------V 819
             .|:..:.|::               |||.:.           |.|:...:             |
 Worm   762 -TSDDTITCDEMLFEPYGTSLLGSGSTPYGFN-----------VIWSATGFAVGKKSINRVLDNV 814

  Fly   820 DTAIVTLYKCDVLGSHREHPDCSLCVTRD-PKYKCAWCS--NSCVYNETCIADKNSISSGSKSAI 881
            .:..:.:|.|:.|.:     :|..|:|.| .||.|.|||  :.|.....|         .::...
 Worm   815 ASLAIDVYSCENLAT-----NCGRCLTLDADKYDCGWCSLDSKCARPHQC---------SNRQIP 865

  Fly   882 EN------ECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIFIGSVPCELENYQISV 940
            ||      .||.|.|:..||..|.:.|||.:||.|.|||....||...:.|.:||||:..|..|.
 Worm   866 ENWLNASQLCPNPVIEDFKPKKGSIFGGTRVTINGINLGRHVSDVEKAVQIANVPCEVVEYVPSQ 930

  Fly   941 KIECRTGASLYEMSAPIKVANDAG-------------FTESSVQFHFKNVLLTGLYPTIGPRSGG 992
            ||.|.||.|      |||.:|:.|             |..|:..|.:...:::.:.|..||||||
 Worm   931 KIVCVTGKS------PIKGSNERGVVAVTLRHDSLKFFAHSTEHFSYVQPVVSSMKPVKGPRSGG 989

  Fly   993 TQLSLIGKFLNIGSTMRAFLDEYECHIDVTQASSSQVSC---TTSEATQ-PEPIRSLHLVIDGAN 1053
            |.::|.|..|:.|:.:.....:..|.|  .:.:|..:.|   .:.|..| |     ||:..||  
 Worm   990 TDVTLTGVDLDTGAEVTVRFGQIGCKI--LERASGWLRCRMGASGEGGQFP-----LHIAFDG-- 1045

  Fly  1054 RTLECQISTPSITNTNPTRSNFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVH 1118
                                     ||::||..  ..|.:|.||.:..|.|.::..|||..:.|:
 Worm  1046 -------------------------QLQNLPIP--IYFEFTSDPSVQSISPNKTIPSGGITVDVY 1083

  Fly  1119 GIYLNSIQKPELEVF--YDNERVNKTSCVVINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQN 1181
            |.....:|:|.: ||  ..:|:....:|.:.:...|:|.:|....|                   
 Worm  1084 GQGFTLLQRPRM-VFTGLGDEKSYGPACSIEDDQMMKCATPTAPGK------------------- 1128

  Fly  1182 SSFQTETRYKNEYDRKKRRADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFVM 1246
                              .:|.|...|:                              .:.:|..
 Worm  1129 ------------------DSDRGSQERI------------------------------TEYAFDF 1145

  Fly  1247 DNVQLVRNLNKYFHDIRSTIVYLADPKYLPFPNDGVKLYKGDSLVIEGELLNLAADEYDVNVTIG 1311
            |..:|.|:..|....  .|...|::|:::. |.:       |.|.:.|..|||||.|.|::|.:|
 Worm  1146 DGAELYRSRIKVMPS--PTFETLSEPRFVR-PGE-------DFLTLNGNHLNLAASERDIDVKVG 1200

  Fly  1312 TSQCNITSLALNQLLCIPPEQQPLPTDENGVDQSTDLPLVVVKVGRNLRFVIGYLKYDLNKPYVF 1376
            ...|.:|:||...|.|.||.::|     .|..:..  |.:||.|| |..|.||.:.||  .|.:.
 Worm  1201 GEPCPLTALANKVLTCQPPVKKP-----RGAGKLN--PEIVVTVG-NASFSIGEVSYD--SPGLS 1255

  Fly  1377 SHALLVGILTVALLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESNVRSECKQAFAELQTDM 1441
            |....:.:..:..::.:.:.:::::||||...:|:.|.::.||.|:|..|.:|||:|||||||.:
 Worm  1256 SSLFFIIMFFIIFMIALIICLIVLYRRKSNTHQRQMKYLKTQMDTIEMKVATECKEAFAELQTSL 1320

  Fly  1442 TDLTADLESTGIPT---LDHVNYIMKVFFPGV-SDHPILNSPKFREGSPQTNYDAAMVQFEQLIG 1502
            ...|||| ..|.||   |::.:|..:|.||.. .:|.:|.:.:......:. .:|.:.:|.:|:.
 Worm  1321 NQYTADL-PLGTPTAPFLEYKDYCARVLFPNAGKNHAVLKNLEVDTHKAEA-IEAGLREFHKLLM 1383

  Fly  1503 NKYFLLMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSLLLRLIDKSLASK-HPQ 1566
            ||.|||..:.|:||.: .|..:|||.|.||:||||..||.|.||:||.||..||:|::..| .|:
 Worm  1384 NKTFLLTMVRTMEANK-YFVGKDRVYVGSLLMVVLQEKMGYCTEMLKQLLRELIEKTVEKKFQPK 1447

  Fly  1567 LMLRRTESVVEKMLTNYLAICMYDYLKEY-AGSNLFLLFKAIKHQIEKGLVDAITNDARYSLSEE 1630
            ::.||:||:.|:||..:....::|:||.| ||..|:.||..||.|:|||..||:|.:||||||||
 Worm  1448 ILFRRSESIAERMLAAWFTFLLHDHLKTYDAGKKLYELFWGIKQQMEKGPQDALTLEARYSLSEE 1512

  Fly  1631 RLLHEQVTHSVVILHILQDD----LDEKVQCRVNDWDTISQVKLKILDAIFKNTPFSMRPSVNEV 1691
            :||.....:..:::.:...|    ..:.:..||.|.|||:|||.|.|||.::...|:.||:..::
 Worm  1513 KLLRATFEYKELMVFVSASDSVYSSTQDIPVRVLDCDTITQVKEKCLDAKYRGYRFADRPAPGDM 1577

  Fly  1692 DLEWRHGRGGHLTLQDEDLTTKTVNG-WKRLNTLAHYGVKESAVMSLIARQNDNYHIPYSKNQNS 1755
            :|||:.|..|.:.|||.|.:::...| ||||||||||.|..:|:::|.::.|..|::   .|.:|
 Worm  1578 ELEWKTGMNGKMALQDIDSSSRVEGGNWKRLNTLAHYNVPNNAILTLTSKSNSLYNL---VNFSS 1639

  Fly  1756 APYHNFYFINNSQ--------------------------SHIIINNDIESGLQQPRVYHLVKPNI 1794
            ........:::..                          .|...:.|.::|.   ::||||||. 
 Worm  1640 TSMKTASILSDRSEKSSVSMKTPGVGSPKPWGAPPSVIADHASSSADTDNGF---KLYHLVKPT- 1700

  Fly  1795 PDHYMNIKNSVLSGGSPAFQSHVVNNCNDRVNKTIPEVYLTRLLATKGTIQKFVDDFFSIILTVN 1859
             :|            .|          .|...|.:.|:||||||..|||:.||:......|.: :
 Worm  1701 -EH------------GP----------TDSQEKMVTEIYLTRLLMMKGTLAKFITSLLESIFS-S 1741

  Fly  1860 EELPPAVKWLFDLLDEAARRHDIADTDIVHAWKSNCLPLRFWVNFIKNPDFIFDVNKTYSVDSCL 1924
            ..:||.:|::||.:||.||.|.|.|.::|||||||.||||||||.||||.|:||:.|...::.||
 Worm  1742 STVPPCIKYMFDFMDEQAREHGINDPEVVHAWKSNALPLRFWVNLIKNPHFLFDIQKPTKIEGCL 1806

  Fly  1925 SVIAQTFMDACSTSEHRLGKDSPSNKLLFAKDIPNYRIMVKEFYRDVSRLPQISDQEMSTAMQQL 1989
            ||:|||.||||||.:|:|.|||||:|||||||:..||.:|..:|.::|..|:|.|..|...:...
 Worm  1807 SVVAQTLMDACSTQDHQLTKDSPSSKLLFAKDMYQYRDLVDSYYTEISMTPRIDDATMGANLSAE 1871

  Fly  1990 SVRQNEEFDTISALKELYIYITKYKDQIMESLETDINCRKMHLSRKLGNVAATLDGD 2046
            |.:.|.||...|||.|||.|:.:||:.|:::||::.:.:...|..:|.::.|.::.|
 Worm  1872 SRQHNGEFHVFSALNELYKYLDQYKESIIDALESNEHAQASRLPGRLQDLLALMESD 1928

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexBNP_001245400.1 Sema_plexin_like 86..534 CDD:200497 141/467 (30%)
PSI 535..586 CDD:279745 19/53 (36%)
PSI 683..730 CDD:214655 17/59 (29%)
PSI 836..877 CDD:214655 12/43 (28%)
IPT_plexin_repeat1 888..976 CDD:238585 37/100 (37%)
IPT_plexin_repeat2 977..1095 CDD:238584 28/121 (23%)
IPT_plexin_repeat3 1097..1211 CDD:238586 21/115 (18%)
Plexin_cytopl 1452..2017 CDD:285529 235/601 (39%)
plx-1NP_001294554.1 Sema_plexin_like 42..495 CDD:200497 141/467 (30%)
PSI 496..550 CDD:366642 19/54 (35%)
TIG_plexin 557..649 CDD:375449 28/91 (31%)
PSI 650..710 CDD:366642 17/59 (29%)
TIG_2 717..822 CDD:375492 16/122 (13%)
PSI 823..876 CDD:366642 16/66 (24%)
IPT_plexin_repeat1 878..973 CDD:238585 37/100 (37%)
IPT_PCSR 974..1059 CDD:238337 28/120 (23%)
IPT 1062..1146 CDD:387656 22/151 (15%)
IPT_PCSR 1179..1248 CDD:238337 30/76 (39%)
Plexin_cytopl 1333..1897 CDD:369821 232/596 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 55 1.000 Domainoid score I7480
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S4424
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D56043at33208
OrthoFinder 1 1.000 - - FOG0000391
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100269
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.770

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