Protein Alignment PlexB and Met

DIOPT Version :10

• Sequence 1: NP_524616.2
• Gene: PlexB / 43766
• FlyBaseID: FBgn0025740
• Length: 2051
• Species: Drosophila melanogaster
• Sequence 2: NP_113705.2
• Gene: Met / 24553
• RGDID: 3082
• Length: 1382
• Species: Rattus norvegicus
• Alignment Length: 1782
• Identity: 339/1782 - (19%)
• Similarity: 584/1782 - (32%)
• Gaps: 730/1782 - (40%)

  Fly    95 MHNV------LFAGATNKILKLNE-NLRVLAEAVTGPLHDSPQCH-----------AGGCPEDIE 141
            :|||      ::.||||.|..|:: :|:.::|..|||:.:.|.|.           :||..:|
  Rat    52 IHNVVLHGHHIYLGATNYIYVLDDKDLQKVSEFKTGPVVEHPDCFPCQDCSSKANVSGGVWKD-- 114

  Fly   142 TSLVNNFNKILVVSYAHDGILIACGSIRQGACEIYSLPRFPATPQFFAVPLAANDENASTYAFVG 206
                 |.|..|:|...:|..||:|||:.:|.|:.:.||           |..|.|..:..:....
  Rat   115 -----NVNMALLVDTYYDDQLISCGSVNRGTCQRHVLP-----------PDNAADIQSEVHCMFS 163

  Fly   207 P------------------ARYAWKEED---ILYVGTTFTNVGDYRHDVPAISSRRLDDLNYA-E 249
            |                  |:....|:|   ..:||.|..:.....:.:.:||.|||.:.... :
  Rat   164 PLAEEESGQCPDCVVSALGAKVLLSEKDRFINFFVGNTINSSYPPDYSLHSISVRRLKETQDGFK 228

  Fly   250 FSIQQSIINIDVKYRDHFLVDYIYGFNSSEYAYFIIVQKKSHLADEAGYVTRLARICITDPNYDS 314
            |...||.|::..::||.:.:.||:.|.|:.:.||:.|||::  .|...:.||:.|.|..|....|
  Rat   229 FLTDQSYIDVLPEFRDSYPIKYIHAFESNHFIYFLTVQKET--LDAQTFHTRIIRFCSVDSGLHS 291

  Fly   315 YTEITVQCTATENNVD-------YNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVFSPSREISNQ 372
            |.|:.::|..||....       :||::.|.|:.....||:::|....|.:|..||:.|:..|.:
  Rat   292 YMEMPLECILTEKRRKRSTREEVFNILQAAYVSKPGANLAKQIGASPYDDILYGVFAQSKPDSAE 356

  Fly   373 PESKSAMCIYSIKDIEDMFIE----------------NIHLCFNGTTKDRNLGYISGTINDGRCP 421
            |.::||:|.:.||.:.|.|.:                |...|||.|.. ||........::.|..
  Rat   357 PMNRSAVCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLL-RNSSGCEVRSDEYRTE 420

  Fly   422 IVGSLGNIYNFCSVGLKISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKV 486
            ...:|..:..|                 :...::|.:||::.....|.  ::|.|||:.|...:|
  Rat   421 FTTALQRVDLF-----------------MGRLNHVLLTSISTFIKGDL--TIANLGTSEGRFMQV 466

  Fly   487 LLSGQSPGEYEEIVVDAGNRILPNTMMSPKKDFL---YVLSQRKITKLRIEHCSVYTNCSACLES 548
            :||                   .....:|..:||   |.:|...|    :||.|.....:..:..
  Rat   467 VLS-------------------RTAHFTPHVNFLLDSYPVSPEVI----VEHPSNQNGYTLVVTG 508

  Fly   549 RDPFCGWCSLEKRCTVRSTCQRDTSASRWLSLGSGQQCIEFESIIPEKIPISELSHLHLIIRTLP 613
                       |:.|                                |||:
  Rat   509 -----------KKIT--------------------------------KIPL-------------- 516

  Fly   614 EPFNAKYRCVFGNSTPIDAEILENGLGCATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSRN 678
                                   ||||
  Rat   517 -----------------------NGLG-------------------------------------- 520

  Fly   679 FAFFDCSHHGNCQECLQSSWGCNWCIFDNKCVHKSLQCRNIENAVSTVGHCPHLKKNRPEILLPV 743
                 |.|..:|.:||.:
  Rat   521 -----CGHFQSCSQCLSA----------------------------------------------- 533

  Fly   744 RVPIEIRLEIENLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKTPYFYEINTHEYQAK 808
                                                               |||.:
  Rat   534 ---------------------------------------------------PYFIQ--------- 538

  Fly   809 VVVTWNFQHYVDTAIVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWCSNSCVYNETCIADKNSI 873
                                                        |.||.|.||::
  Rat   539 --------------------------------------------CGWCHNRCVHS---------- 549

  Fly   874 SSGSKSAIENECP---------LPRIDIIKPLSGPVEGGTLITIEGSNLGIREE---DVR-GKIF 925
                     ||||         ||.:..:.|.|.|:||||::||.|.:.|.::.   |:| .|:.
  Rat   550 ---------NECPSGTWTQEICLPAVYKVFPTSAPLEGGTMLTICGWDFGFKKNNKFDLRKTKVL 605

  Fly   926 IGSVPCELENYQISVK-IECRTGASLYE-MSAPIKVANDAGFTESSVQFHFKNVLLTGLYPTIGP 988
            :|:..|.|...:.:.. ::|..|.::.| .:..:.|:|....|:.|. |.:.:.::|.:.|..||
  Rat   606 LGNESCTLTLSESTTNTLKCTVGPAMSEHFNVSVIVSNSRETTQYSA-FSYVDPVITSISPRYGP 669

  Fly   989 RSGGTQLSLIGKFLNIGSTMRAFLDEYECHIDVTQASSSQVSCTTSEATQPE--PIRSLHLVIDG 1051
            .:|||.|:|.||:||.|::....:....|  .:...|.|.:.|.|...|...  |::   |.||.
  Rat   670 HAGGTLLTLTGKYLNSGNSRHISIGGKTC--TLKSVSDSILECYTPGHTVSAEFPVK---LKIDL 729

  Fly  1052 ANRTLECQISTPSITNTNPTRSNFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLT 1116
            |:|.                                .|.|:|.:||.:.:|.|.:||.|||..:|
  Rat   730 ADRV--------------------------------TSSFSYREDPVVSEIHPTKSFISGGSTIT 762

  Fly  1117 VHGIYLNSIQKPELEVFYDNERVNKT-SCVVINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQ 1180
            ..|..|||:..|:|.:...:..||.| :|...:|:::.|.:.|          :.:::|.:|.|:
  Rat   763 GIGKNLNSVSTPKLVIEVHDVGVNYTVACQHRSSSEIICCTTP----------SLQQLDLQLPLK 817

  Fly  1181 NSSFQTETRYKNEYDRKKRRADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFV 1245
            ..:|                                                           |:
  Rat   818 TKAF-----------------------------------------------------------FL 823

  Fly  1246 MDNVQLVRNLNKYFHDIRSTIVYLADPKYLPFP--------NDGVKLYKGDSL---VIEGELLNL 1299
            :|.:     |:|:|     .:.|:.||.:.||.        |:.|...|||.:   .::||:|.
  Rat   824 LDGI-----LSKHF-----DLTYVHDPMFKPFEKPVMISMGNENVVEIKGDDIDPEAVKGEVLK- 877

  Fly  1300 AADEYDVNVTIGTSQCNITSLALNQLLC-IPPEQQPLPTDENGVD-----QSTDLPLVVVKVGRN 1358
                      :|...|.........||| :|.:...|...|..::     .||.|..|:|:..:|
  Rat   878 ----------VGNKSCENLHWHSEALLCTVPSDLLKLNGGELNIEWKQAVSSTVLGKVIVQPDQN 932

  Fly  1359 LRFVIGYLKYDLNKPYVFSHALLVGILTVALLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLE 1423
            ..                  .|::|.:::: :||:.|..|.::.||     |::|.:..:::..:
  Rat   933 FA------------------GLIIGAVSIS-VVVLLVSGLFLWLRK-----RKHKDLGSELVRYD 973

  Fly  1424 SNVRSECKQAFAELQ-----TDM-----TDLTADLESTGIPTLDHVNYIMKVFFPGVSDHPILNS 1478
            :.|.:.........:     |:|     .|..|.......|.........:|.:|.....|||.|
  Rat   974 ARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGACRQVQYPLTDLSPILTS 1038

  Fly  1479 PKFREGSP----QTNYD--------------------AAMVQFEQLIGNKYFLLMFIETL---EA 1516
            ......||    ..:.|                    :.:|.|.::||..:|..::..||   :.
  Rat  1039 GDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDSDG 1103

  Fly  1517 QRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSLLLRLIDKSLASKHPQLMLRRTESVVEKMLT 1581
            ::...:::.            :|::....|:.:.|...:|.|..:  ||.::
  Rat  1104 KKIHCAVKS------------LNRITDIEEVSQFLTEGIIMKDFS--HPNVL------------- 1141

  Fly  1582 NYLAICMYDYLKEYAGSNLFLLFKAIKH------------------------QIEKGLVDAITND 1622
            :.|.||:     ...||.|.:| ..:||                        |:.||:
  Rat  1142 SLLGICL-----RSEGSPLVVL-PYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGM------- 1193

  Fly  1623 ARYSLSEERLLHEQVTHSVVILHILQDDLDEKVQCRVNDWDTISQVKLKILDAIFKNTPFSMRPS 1687
             :| |:.::.:|..:.....:       ||||...:|.|:.....:..|...::...|  ..:..
  Rat  1194 -KY-LASKKFVHRDLAARNCM-------LDEKFTVKVADFGLARDMYDKEYYSVHNKT--GAKLP 1247

  Fly  1688 VNEVDLEWRHGRGGHLTLQDEDLTTKT 1714
            |..:.||         :||.:..|||:
  Rat  1248 VKWMALE---------SLQTQKFTTKS 1265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PlexB	NP_524616.2	Sema_plexin_like	86..534	CDD:200497	124/504 (25%)
		PSI	535..586	CDD:396154	4/50 (8%)
		TIG_plexin	594..682	CDD:465588	7/87 (8%)
		PSI	683..730	CDD:214655	5/46 (11%)
		TIG_2	738..827	CDD:465619	3/88 (3%)
		PSI	836..877	CDD:214655	6/40 (15%)
		IPT_plexin_repeat1	888..976	CDD:238585	26/93 (28%)
		IPT_plexin_repeat2	977..1095	CDD:238584	29/119 (24%)
		IPT_plexin_repeat3	1097..1211	CDD:238586	26/114 (23%)
		TIG	1277..>1334	CDD:460355	15/68 (22%)
		Plexin_cytopl	1452..2012	CDD:462434	55/314 (18%)
Met	NP_113705.2	Sema	25..517	CDD:472829	132/607 (22%)
		PSI	520..562	CDD:214655	19/254 (7%)
		IPT_plexin_repeat1	564..657	CDD:238585	26/93 (28%)
		IPT_plexin_repeat2	658..741	CDD:238584	29/119 (24%)
		IPT	743..838	CDD:472823	32/173 (18%)
		IPT	839..>903	CDD:214657	18/74 (24%)
		PTKc_Met_Ron	1083..1344	CDD:270649	43/243 (18%)
		Interaction with RANBP9. /evidence=ECO:0000250	1213..1382		16/64 (25%)
		Interaction with MUC20. /evidence=ECO:0000250	1321..1360