DRSC/TRiP Functional Genomics Resources

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Protein Alignment PlexB and Plxna4

DIOPT Version :9

Sequence 1:NP_001245400.1 Gene:PlexB / 43766 FlyBaseID:FBgn0025740 Length:2051 Species:Drosophila melanogaster
Sequence 2:NP_786926.2 Gene:Plxna4 / 243743 MGIID:2179061 Length:1893 Species:Mus musculus


Alignment Length:2056 Identity:717/2056 - (34%)
Similarity:1069/2056 - (51%) Gaps:309/2056 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 FTHMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQCHAGGCPEDIET-----SLVN 146
            |.|:..|.....::.||.|:|.||:.:|:||....|||..|:|:|:.   |..::|     :..|
Mouse    50 FNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHQTGPDEDNPKCYP---PRIVQTCNEPLASTN 111

  Fly   147 NFNKILVVSYAHDGILIACGSIRQGACEIYSL-PRFPATPQFFAVP--LAANDENASTYAFVGPA 208
            |.||:|::.| .:..||||||:.||.|::..| ..|.....|....  |:..:|:.|.:..:  .
Mouse   112 NVNKMLLIDY-KENRLIACGSLYQGICKLLRLEDLFKLGEPFHKKEHYLSGVNESGSVFGVI--V 173

  Fly   209 RYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRLDDLNYAE----FSIQQSIINIDVKY-RDHFL 268
            .|: ..:|.|::.|......:|   .|.||||:|...:.|:    :......:...:|. .|.|.
Mouse   174 SYS-NFDDKLFIATAVDGKPEY---FPTISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFT 234

  Fly   269 V------DYIYGFNSSEYAYFIIVQKK-----SHLADEAGYVTRLARICITDPNYDSYTEITVQC 322
            |      .|:|||:|..:.||:.:|.:     .....|..|.::|.|:|..|..::||.|:.:.|
Mouse   235 VIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTSKLVRLCKEDTAFNSYVEVPIGC 299

  Fly   323 TATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVFSPSREISNQPESKSAMCIYSIKDI 387
              ..|.|:|.:::.|.::.|...|.:.:|::.||.:|.||||..::...:...:||:||:.:|.|
Mouse   300 --ERNGVEYRLLQAAYLSKAGAVLGRTLGVRPDDDLLFTVFSKGQKRKMKSLDESALCIFILKQI 362

  Fly   388 EDMFIENIHLCFNG---------TTKDRNLGYISGTINDGRCPIVGSLGNIYNFCSVGLKIS-GV 442
            .|...:.:..|:.|         ..||........||:|             |||.:.:... ||
Mouse   363 NDRIKDRLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDD-------------NFCGLDMNAPLGV 414

  Fly   443 SP-ITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLSGQSPG--EYEEI-VVDA 503
            |. :....:|..|...:|||.|  ...:.|||||:||..|.:||:.:.|....  :||.: |||:
Mouse   415 SEMVRGIPVFTEDRDRMTSVIA--YVYKNHSLAFVGTKSGKLKKIRVDGPKGNALQYETVQVVDS 477

  Fly   504 GNRILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTNCSACLESRDPFCGWCSLEKRCTVRSTC 568
            | .:|.:...|...:.||::|:|::|::.:|.|..|.:|..||.|.||.||||.|...||.:..|
Mouse   478 G-PVLRDMAFSKDHEQLYIMSERQLTRVPVESCGQYRSCGECLGSGDPHCGWCVLHNTCTRKERC 541

  Fly   569 QRDTSASRWLSLGSGQQCIEFESIIPEKIPISELSHLHLIIRT--LPEPFNAKYRCVFGNSTPID 631
            :|.....|:.|  ..:||:.. ::.|..|.:|:.:.| |::.|  :|| .:|...|.|.:.:.:|
Mouse   542 ERSREPRRFAS--EMKQCVRL-TVHPNNISVSQYNVL-LVLETYNVPE-LSAGVNCTFEDLSEMD 601

  Fly   632 AEILENGLGCATPPLDERP-LIPTNTDHILVPLSVRSSETNKDFVSRNFAFFDCSHHGNCQECLQ 695
            ..::.|.:.|.:|...|.| :|..|.||.:|.|.::|.||...|.|.:|.|::||.|.:|..|::
Mouse   602 GLVIGNQIQCYSPAAKEVPRIITENGDHHVVQLQLKSKETGMTFASTSFVFYNCSVHNSCLSCVE 666

  Fly   696 SSWGCNWCIFDNKCVHKSLQCRNIENAVSTVGHCPHLKKNRPEILLPVRVPIEIRLEIENLPKPK 760
            |.:.|:||.:.:.|.|....|...|..|.....||.|.: ..:||:||.|...|.|:.:|||:|:
Mouse   667 SPYRCHWCKYRHVCTHDPNTCSFQEGRVKLPEDCPQLLR-VDKILVPVEVIKPITLKAKNLPQPQ 730

  Fly   761 SAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKTPYFYE-INTHEYQAKVVVTWNFQHYVDTAI- 823
            |...|:.|.::|:..:..:||...::..|.|:.|.|.|| :..:....::.|.||....:|... 
Mouse   731 SGQRGYECILNIQGIEQRVPALRFNSSSVQCQNTSYSYEGMEINNLPVELTVVWNGHFNIDNPAQ 795

  Fly   824 --VTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWCSN--SCVYNETCIADKNS--ISSGSKSAIE 882
              |.||||   |:.||  .|.||:..||.::|.||.:  .|...:.|.|.::.  ..||:.|   
Mouse   796 NKVYLYKC---GAMRE--SCGLCLKADPDFECGWCQSPGQCTLRQHCPAHESRWLELSGANS--- 852

  Fly   883 NECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIFIGSVPCE--LENYQISVKIECR 945
             :|..|||..|.|::||.||||.:||.|.|||:...|:...:.:..|.|.  ::.|..:.:|.|.
Mouse   853 -KCTNPRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVECSPLVDGYIPAEQIVCE 916

  Fly   946 TGASLYEMSAPIKVANDAGFTE-------------SSVQFHFKNVLLTGLYPTIGPRSGGTQLSL 997
            .|.:        |.:..|||.|             ||..::|..:.|..|.|..||.|||||:::
Mouse   917 MGEA--------KPSQHAGFVEICVAVCRPEFMARSSQLYYFMTLTLADLKPNRGPMSGGTQVTI 973

  Fly   998 IGKFLNIGSTMRAFLDEYEC--HIDVTQASSSQVSCTTSEATQPEPIRSLHLVIDGANRTLECQI 1060
            .|..||.||.:........|  |    :.|.|.:.|.|   |..|.:..:.:.:         |:
Mouse   974 TGTNLNAGSNVVVMFGSQPCLFH----RRSPSYIICNT---TSSEEVLDMKVTV---------QV 1022

  Fly  1061 STPSITNTNPTRSNFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSI 1125
            .                   |:..||.. :|.|.:||.|::|:|..|..||...:.|.|.:|:.|
Mouse  1023 D-------------------RARIRQDL-VFQYVEDPTIVRIEPEWSIVSGNTPIAVWGTHLDLI 1067

  Fly  1126 QKPELEVFY-DNERVNKTSCVVINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQNSSFQTETR 1189
            |.|::...: ..|.:|  .|.|:|:.:|.|.:|.:                .|...:.|..||  
Mouse  1068 QNPQIRAKHGGKEHIN--ICEVLNATEMTCQAPAL----------------ALGPDHQSDLTE-- 1112

  Fly  1190 YKNEYDRKKRRADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFVMDNVQLVRN 1254
                     |..:||                                       |::||||.:..
Mouse  1113 ---------RPEEFG---------------------------------------FILDNVQSLLI 1129

  Fly  1255 LNKYFHDIRSTIVYLADPKYLPFPNDGV-KLYKGDSLVIEGELL--NLAADEYDVNVT--IGTSQ 1314
            |||      :...|..:|.:..|...|: :|..|..::::|:.|  .:|.....:|.|  :|...
Mouse  1130 LNK------TNFTYYPNPVFEAFSPSGILELKPGTPIILKGKNLIPPVAGGNVKLNYTVLVGEKP 1188

  Fly  1315 CNITSLALNQLLCIPPEQQPLPTDENGVDQSTDLPLVVVKVGRN-LRFVIGYLKYDLNKPYVF-- 1376
            |.:| ::..||||..|.                      .:||: :...:|.::|.....|:.  
Mouse  1189 CTVT-VSDVQLLCESPN----------------------LIGRHKVMARVGGMEYSPGMVYIAPD 1230

  Fly  1377 SHALLVGILTVA----LLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESNVRSECKQAFAEL 1437
            |...|..|:::|    ||::..|.|||.::|||.:::...||:|:||..|||.|..|||:|||||
Mouse  1231 SPLSLPAIVSIAVAGGLLIIFIVAVLIAYKRKSRESDLTLKRLQMQMDNLESRVALECKEAFAEL 1295

  Fly  1438 QTDMTDLTADLESTGIPTLDHVNYIMKVFFPGVSDHPILNS---PKFREGSPQTNYDAAMVQFEQ 1499
            |||:.:||:||:..|||.||:..|.|:|.|||:.|||:|..   |.:|    |...:..:..|.|
Mouse  1296 QTDIHELTSDLDGAGIPFLDYRTYTMRVLFPGIEDHPVLRDLEVPGYR----QERVEKGLKLFAQ 1356

  Fly  1500 LIGNKYFLLMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSLLLRLIDKSLASK- 1563
            ||.||.|||.||.|||:|| |||:|||.|||||||.||.:|:||||::||.||..||||:|.|| 
Mouse  1357 LINNKVFLLSFIRTLESQR-SFSMRDRGNVASLIMTVLQSKLEYATDVLKQLLADLIDKNLESKN 1420

  Fly  1564 HPQLMLRRTESVVEKMLTNYLAICMYDYLKEYAGSNLFLLFKAIKHQIEKGLVDAITNDARYSLS 1628
            ||:|:|||||||.||||||:....:|.:|||.||..||.||.|||.|:|||.:||||.:||||||
Mouse  1421 HPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFSLFCAIKQQMEKGPIDAITGEARYSLS 1485

  Fly  1629 EERLLHEQVTHSVVILHILQDD--LDEKVQCRVNDWDTISQVKLKILDAIFKNTPFSMRPSVNEV 1691
            |::|:.:|:.:..::|..:..|  ...:|..::.:.|||:|||.|||||||||.|.|.||...::
Mouse  1486 EDKLIRQQIEYKTLVLSCVSPDNVNSPEVPVKILNCDTITQVKEKILDAIFKNVPCSHRPKAADM 1550

  Fly  1692 DLEWRHGRGGHLTLQDEDLTTKTVNGWKRLNTLAHYGVKESAVMSLIARQNDNYHIPYS---KNQ 1753
            |||||.|.|..:.|||||:|||..|.||||||:|||.|.:.:|::|:::|...|:...:   ...
Mouse  1551 DLEWRQGSGARMILQDEDITTKIENDWKRLNTVAHYQVPDGSVVALVSKQVTAYNAVNNSTVSRT 1615

  Fly  1754 NSAPYHNFYFINNSQSHI-----IINNDIESGLQQPRVYHLVKPNIPDHYMNIKNSVLSGGSPAF 1813
            :::.|.|......|...:     :|..|:|||:   :::||||    :|                
Mouse  1616 SASKYENMIRYTGSPDSLRSRTPMITPDLESGV---KLWHLVK----NH---------------- 1657

  Fly  1814 QSHVVNNCNDRVNKTIPEVYLTRLLATKGTIQKFVDDFFSIILTV---NEELPPAVKWLFDLLDE 1875
             .|......||.:|.:.|:|||||||||||:||||||.|..|.:.   ...||.|:|::||.|||
Mouse  1658 -EHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDE 1721

  Fly  1876 AARRHDIADTDIVHAWKSNCLPLRFWVNFIKNPDFIFDVNKTYSVDSCLSVIAQTFMDACSTSEH 1940
            .|.:|.|.|..:.|.|||||||||||||.||||.|:||::|....|:||||:||||||:||||||
Mouse  1722 QADKHGIHDPHVRHTWKSNCLPLRFWVNMIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEH 1786

  Fly  1941 RLGKDSPSNKLLFAKDIPNYRIMVKEFYRDVSRLPQISDQEMSTAMQQLSVRQNEEFDTISALKE 2005
            ||||||||||||:|||||:|:..|:.:|.|:.::|.||||:|:..:.:.|.....||:|:|||.|
Mouse  1787 RLGKDSPSNKLLYAKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMNEFNTMSALSE 1851

  Fly  2006 LYIYITKYKDQIMESLETDINCRKMHLSRKLGNVAATLDGD 2046
            ::.|:.||.::|:..|:.|..|.|..|:.||..|...:..|
Mouse  1852 IFSYVGKYSEEILGPLDHDDQCGKQKLAYKLEQVITLMSLD 1892

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexBNP_001245400.1 Sema_plexin_like 86..534 CDD:200497 139/484 (29%)
PSI 535..586 CDD:279745 19/50 (38%)
PSI 683..730 CDD:214655 14/46 (30%)
PSI 836..877 CDD:214655 14/44 (32%)
IPT_plexin_repeat1 888..976 CDD:238585 32/102 (31%)
IPT_plexin_repeat2 977..1095 CDD:238584 29/119 (24%)
IPT_plexin_repeat3 1097..1211 CDD:238586 28/114 (25%)
Plexin_cytopl 1452..2017 CDD:285529 290/581 (50%)
Plxna4NP_786926.2 Sema_plexin_A4 38..510 CDD:200535 140/487 (29%)
PSI 509..547 CDD:214655 17/37 (46%)
PSI 654..701 CDD:279745 14/46 (30%)
PSI 803..855 CDD:279745 18/60 (30%)
IPT_plexin_repeat1 857..952 CDD:238585 32/102 (31%)
IPT_plexin_repeat2 954..1037 CDD:238584 29/118 (25%)
IPT_plexin_repeat3 1039..1139 CDD:238586 37/173 (21%)
IPT_PCSR 1141..1221 CDD:238337 21/102 (21%)
Plexin_cytopl 1310..1863 CDD:285529 290/581 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 54 1.000 Domainoid score I11157
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D56043at33208
OrthoFinder 1 1.000 - - FOG0000391
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100269
Panther 1 1.100 - - O PTHR22625
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.820

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