DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PlexB and PLXNB2

DIOPT Version :9

Sequence 1:NP_001245400.1 Gene:PlexB / 43766 FlyBaseID:FBgn0025740 Length:2051 Species:Drosophila melanogaster
Sequence 2:NP_001363793.1 Gene:PLXNB2 / 23654 HGNCID:9104 Length:1917 Species:Homo sapiens


Alignment Length:2091 Identity:634/2091 - (30%)
Similarity:993/2091 - (47%) Gaps:328/2091 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 QSKNYFTHMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQC----HAGGCPEDIET 142
            :|:....|::.|....|::.||.|.:.:|:..|::..:..|||..|:.:|    .|..|.   |.
Human    29 RSEKELNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQCH---EA 90

  Fly   143 SLVNNFNKILVVSYAHDGILIACGSIRQGACEIYSLPRFP--------ATPQFFAVPLAANDENA 199
            .:.:|.|::|::...... |:.|||:.:|.|.:.:|....        :..:.|   :|:|||..
Human    91 EMTDNVNQLLLLDPPRKR-LVECGSLFKGICALRALSNISLRLFYEDGSGEKSF---VASNDEGV 151

  Fly   200 STYAFV---GPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRLDDLNYAEFSIQQSIINIDV 261
            :|...|   ||.     .:.:|:||.     |:..||...|.|.||.|...:..:.:        
Human   152 ATVGLVSSTGPG-----GDRVLFVGK-----GNGPHDNGIIVSTRLLDRTDSREAFE-------- 198

  Fly   262 KYRDHFLV----------DYIYGFNSSEYAYFIIVQKKSHLADEAGYVTRLARICITDPNYDSYT 316
            .|.||...          .::..|....|.:|:..|:..|.|...   |.|||:|..||||.||.
Human   199 AYTDHATYKAGYLSTNTQQFVAAFEDGPYVFFVFNQQDKHPARNR---TLLARMCREDPNYYSYL 260

  Fly   317 EITVQCTATENNVDYNIVRDAKVTPASHK--LAQKMGIKKDDHVLVTVFSPSREISNQPESKSAM 379
            |:.:||            ||..:..|:..  ||..:.......||..|||.....|..|  .:.:
Human   261 EMDLQC------------RDPDIHAAAFGTCLAASVAAPGSGRVLYAVFSRDSRSSGGP--GAGL 311

  Fly   380 CIYSIKDIEDMFIENIHLCFNGTTKDRNLGY--ISGTIN-DGRCPIVGSLGNIYNF-CS---VGL 437
            |::.:..:......|.:.|:.||.:.|::.|  ..|.|. .|..|     |:..:| |.   :..
Human   312 CLFPLDKVHAKMEANRNACYTGTREARDIFYKPFHGDIQCGGHAP-----GSSKSFPCGSEHLPY 371

  Fly   438 KISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLS--GQSPGEYEEIV 500
            .:.....:...|:.....:::|:||..:  :..|::|||||:.|.|.||.|:  |.| .||:.|:
Human   372 PLGSRDGLRGTAVLQRGGLNLTAVTVAA--ENNHTVAFLGTSDGRILKVYLTPDGTS-SEYDSIL 433

  Fly   501 VDAGNRILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTNCSACLESRDPFCGWCSLEKRCTVR 565
            |:...|:..:.::|.....||.::|.|:.:|.::.|..|..|:.|.:|:||:||||.:|.|||.:
Human   434 VEINKRVKRDLVLSGDLGSLYAMTQDKVFRLPVQECLSYPTCTQCRDSQDPYCGWCVVEGRCTRK 498

  Fly   566 STCQRDTSASRWLSLGSGQQCIEFESIIPEKIPISELSHLHLIIRTLPE-PFNAKYRCVFGNSTP 629
            :.|.|...||.|| ....:.|:...|..|:.:.......:.|.:..||. ....:..|:||.|.|
Human   499 AECPRAEEASHWL-WSRSKSCVAVTSAQPQNMSRRAQGEVQLTVSPLPALSEEDELLCLFGESPP 562

  Fly   630 IDAEILENGLGCATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSRNFAFFDC----SHHGN- 689
            ..|.:....:.|.:|  ...|:.|...||:.|.:.:.....|....|..:.|:||    |...| 
Human   563 HPARVEGEAVICNSP--SSIPVTPPGQDHVAVTIQLLLRRGNIFLTSYQYPFYDCRQAMSLEENL 625

  Fly   690 -CQECLQSSWGCNWCIFDNKCVHKSLQCRNIENAVSTVGHCPHLKKNRPEIL------LPVRVPI 747
             |..|:.:.|.|.|.:..::|...|   .|.|:.:...    |::.:.|:.|      :|:....
Human   626 PCISCVSNRWTCQWDLRYHECREAS---PNPEDGIVRA----HMEDSCPQFLGPSPLVIPMNHET 683

  Fly   748 EIRLEIENLP--KPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKTPYFYEINTHEYQAKVV 810
            ::..:.:||.  |..|.|.|......:|...|     .||.....  :||..    :|:....:.
Human   684 DVNFQGKNLDTVKGSSLHVGSDLLKFMEPVTM-----QESGTFAF--RTPKL----SHDANETLP 737

  Fly   811 VTWNFQHY---VDTAI-VTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWC--SNSCVYNETCIAD 869
            :....:.|   :|:.: ||||.|....|     |||||...:|.|:||||  .:.|||...|   
Human   738 LHLYVKSYGKNIDSKLHVTLYNCSFGRS-----DCSLCRAANPDYRCAWCGGQSRCVYEALC--- 794

  Fly   870 KNSISSGSKSAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIFIGSVPCEL- 933
             |:.|         |||.|.|..|:|.:||:.||..|||.|||||::..|:: :|.:....|.. 
Human   795 -NTTS---------ECPPPVITRIQPETGPLGGGIRITILGSNLGVQAGDIQ-RISVAGRNCSFQ 848

  Fly   934 -ENYQISVKIEC--RTGASLYEMSAPIKVANDAGFTESSVQFHFKNVLLTGLYPTIGPRSGGTQL 995
             |.|.:|.:|.|  ....:.:.....:.|....|.:..:|||.|:......:.|..||::|||.|
Human   849 PERYSVSTRIVCVIEAAETPFTGGVEVDVFGKLGRSPPNVQFTFQQPKPLSVEPQQGPQAGGTTL 913

  Fly   996 SLIGKFLNIGS--TMRAFLDEYECHID--------VT--QASSSQVSCTTSEATQP--------- 1039
            ::.|..|:.||  .:|..|:...|.:.        ||  ||:..|:....|....|         
Human   914 TIHGTHLDTGSQEDVRVTLNGVPCKVTKFGAQLQCVTGPQATRGQMLLEVSYGGSPVPNPGIFFT 978

  Fly  1040 ----------EPIRSLHLVIDGANRTLECQISTPSITNTNPTRSNFGSYQLRSLPRQPCSIFNYT 1094
                      ||:||.....||  .|....::.|.:...:...|...|...|..| .|......|
Human   979 YRENPVLRAFEPLRSFARNPDG--HTRGSTLTRPRVPPAHLRHSLVLSTSHRVAP-LPTETHTCT 1040

  Fly  1095 QDPRIMQIK-------------PL------RSFKSGGRVLTVHGIYLNSIQKPELEVFYDNERVN 1140
            ..||:::.:             |.      .:.:||||.:.|.|...:.||:             
Human  1041 WKPRVVRARVGGDGRAEAAGTTPASRAHEGTALRSGGRSINVTGQGFSLIQR------------- 1092

  Fly  1141 KTSCVVINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQNSSFQTETRYKNEYDRKKRRADFGD 1205
              ..:|:.:..::...||                                        |.|   :
Human  1093 --FAMVVIAEPLQSWQPP----------------------------------------REA---E 1112

  Fly  1206 TFRLYTNAGSSANYFVNNNMDV---TTFVKVHETQLNLQLSFVMDNVQ-LVRNLNKYFHDIRSTI 1266
            :.:..|..|:  :|..:|:..|   :..|.......||.:...||..: |:|.....|.      
Human  1113 SLQPMTVVGT--DYVFHNDTKVVFLSPAVPEEPEAYNLTVLIEMDGHRALLRTEAGAFE------ 1169

  Fly  1267 VYLADPKYLPFPNDGVKLYKGDSLVIEGELLNLAADEYDVNVTIGTSQCNITSLALNQLLCIPPE 1331
             |:.||.:..| ..|||......:...|..||.|....:....:|..:|.:.:|....|.|.|||
Human  1170 -YVPDPTFENF-TGGVKKQVNKLIHARGTNLNKAMTLQEAEAFVGAERCTMKTLTETDLYCEPPE 1232

  Fly  1332 QQPLPTDENGVDQSTDLPLVVVKVGRNLRFVIGYLKYDLNKPYVFSHALLVGILTVALLVVVFVI 1396
            .||.|......|.:.:||..:||.| :..:|:|.::||.....|....:|.  |.:..:|||..:
Human  1233 VQPPPKRRQKRDTTHNLPEFIVKFG-SREWVLGRVEYDTRVSDVPLSLILP--LVIVPMVVVIAV 1294

  Fly  1397 VLIIFRRKSTQAEREYKRIQIQMITLESNVRSECKQAFAELQTDMTDLTADLESTGIPTLDHVNY 1461
            .:..:.|||.||||||::|:.|:..||.:||..||:.|.:|..:|.|.|.|:...|||.||:..|
Human  1295 SVYCYWRKSQQAEREYEKIKSQLEGLEESVRDRCKKEFTDLMIEMEDQTNDVHEAGIPVLDYKTY 1359

  Fly  1462 IMKVFF-PGV-SDHPILNSPKFREGSPQTN-YDAAMVQFEQLIGNKYFLLMFIETLEAQRSSFSI 1523
            ..:||| |.. .|..::.:.|.....|:.. .:.|:.||..|:.:|.||:.||.|||.|| .||.
Human  1360 TDRVFFLPSKDGDKDVMITGKLDIPEPRRPVVEQALYQFSNLLNSKSFLINFIHTLENQR-EFSA 1423

  Fly  1524 RDRVNVASLIMVVLMNKMEYATEILKSLLLRLIDKSLASKHPQLMLRRTESVVEKMLTNYLAICM 1588
            |.:|..|||:.|.|..|:||.|:|:.:|.|.|:::.:.:|:|:|||||:|:|||:||:|:::||:
Human  1424 RAKVYFASLLTVALHGKLEYYTDIMHTLFLELLEQYVVAKNPKLMLRRSETVVERMLSNWMSICL 1488

  Fly  1589 YDYLKEYAGSNLFLLFKAIKHQIEKGLVDAITNDARYSLSEERLLHEQVTHS-VVILHILQDDLD 1652
            |.|||:.||..|:.||||||||:|||.|||:...|:|:|::..||.:.|.:: :.:..|:||:..
Human  1489 YQYLKDSAGEPLYKLFKAIKHQVEKGPVDAVQKKAKYTLNDTGLLGDDVEYAPLTVSVIVQDEGV 1553

  Fly  1653 EKVQCRVNDWDTISQVKLKILDAIFKNTPFSMRPSVNEVDLEWRHGRGGHLTLQDEDLTTKTVNG 1717
            :.:..:|.:.|||||||.||:|.:::..|.|..|..:.|.||||.|....: |.|.|||::....
Human  1554 DAIPVKVLNCDTISQVKEKIIDQVYRGQPCSCWPRPDSVVLEWRPGSTAQI-LSDLDLTSQREGR 1617

  Fly  1718 WKRLNTLAHYGVKESAVMSL----IARQNDNYHIPYSKNQNSAPYHNFYFINNSQSHIIINNDIE 1778
            |||:|||.||.|::.|.:.|    :::|.::       :|...|         .:.|.::.    
Human  1618 WKRVNTLMHYNVRDGATLILSKVGVSQQPED-------SQQDLP---------GERHALLE---- 1662

  Fly  1779 SGLQQPRVYHLVKP-NIPDHYMNIKNSVLSGGSPAFQSHVVNNCNDRVNKTIPEVYLTRLLATKG 1842
               ::.||:|||:| :..|...:.:.||..              .:| .|.|.|:||||||:.||
Human  1663 ---EENRVWHLVRPTDEVDEGKSKRGSVKE--------------KER-TKAITEIYLTRLLSVKG 1709

  Fly  1843 TIQKFVDDFFSIILTVNEELPPAVKWLFDLLDEAARRHDIADTDIVHAWKSNCLPLRFWVNFIKN 1907
            |:|:|||:||..:|.....:|||||:.||.|||.|.:|:|.|.|.:|.||:|.||||||||.:||
Human  1710 TLQQFVDNFFQSVLAPGHAVPPAVKYFFDFLDEQAEKHNIQDEDTIHIWKTNSLPLRFWVNILKN 1774

  Fly  1908 PDFIFDVNKTYSVDSCLSVIAQTFMDACSTSEHRLGKDSPSNKLLFAKDIPNYRIMVKEFYRDVS 1972
            |.|||||:....||:.||||||||||||:.:||:|.:||||||||:||:|..|:.||:::|:.:.
Human  1775 PHFIFDVHVHEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKEISTYKKMVEDYYKGIR 1839

  Fly  1973 RLPQISDQEMSTAMQQLSVRQNEEFDTISALKELYIYITKYKDQIMESLETDINCRKMHLSRKLG 2037
            ::.|:|||:|:|.:.::|....:..:|:.||.:||.|..||.|:|:.:||.|...:||.|:.:|.
Human  1840 QMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQYTQKYYDEIINALEEDPAAQKMQLAFRLQ 1904

  Fly  2038 NVAATLDGDCT 2048
            .:||.|:...|
Human  1905 QIAAALENKVT 1915

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexBNP_001245400.1 Sema_plexin_like 86..534 CDD:200497 123/483 (25%)
PSI 535..586 CDD:279745 21/50 (42%)
PSI 683..730 CDD:214655 13/52 (25%)
PSI 836..877 CDD:214655 17/42 (40%)
IPT_plexin_repeat1 888..976 CDD:238585 30/91 (33%)
IPT_plexin_repeat2 977..1095 CDD:238584 34/148 (23%)
IPT_plexin_repeat3 1097..1211 CDD:238586 16/132 (12%)
Plexin_cytopl 1452..2017 CDD:285529 242/573 (42%)
PLXNB2NP_001363793.1 Sema_plexin_B2 27..467 CDD:200537 124/487 (25%)
PSI 468..518 CDD:214655 21/50 (42%)
TIG_plexin 526..613 CDD:375449 19/88 (22%)
PSI 759..>799 CDD:366642 19/57 (33%)
IPT_plexin_repeat1 803..894 CDD:238585 30/91 (33%)
IPT_plexin_repeat2 895..981 CDD:238584 21/85 (25%)
Plexin_cytopl 1350..1883 CDD:369821 241/572 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 58 1.000 Domainoid score I10786
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D56043at33208
OrthoFinder 1 1.000 - - FOG0000391
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100269
Panther 1 1.100 - - O PTHR22625
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.820

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