DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PlexB and Plxnb1

DIOPT Version :9

Sequence 1:NP_001245400.1 Gene:PlexB / 43766 FlyBaseID:FBgn0025740 Length:2051 Species:Drosophila melanogaster
Sequence 2:NP_766363.2 Gene:Plxnb1 / 235611 MGIID:2154238 Length:2119 Species:Mus musculus


Alignment Length:2316 Identity:672/2316 - (29%)
Similarity:1030/2316 - (44%) Gaps:585/2316 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 YFTHMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQCHAGGCPEDI-ETSLVNNFN 149
            :..|::.|.....|:.||||.:.:|:..|::.|...|||::||..|.....|::. :....||.|
Mouse    34 HLQHLARDPTTGTLYVGATNFLFQLSPGLQLEAVVSTGPVNDSRDCLPPVIPDECPQAQPTNNPN 98

  Fly   150 KILVVSYAHDGILIACGSIRQGACEIYSL---------PRFPATPQFFAVPLAANDENASTYAFV 205
            ::|:||   ...|:.|||:.||.||:.||         |..|...|:    :||||...||   |
Mouse    99 QLLLVS---PEALVVCGSVHQGICELRSLGQIRQLLLRPERPGDTQY----VAANDPAVST---V 153

  Fly   206 GPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRLDDLN-YAEFSIQQS---IINIDVKYRDH 266
            |........|.:|:||..:|:.| ....:|.|::|.|...: .|.||.:::   .:....:|..|
Mouse   154 GLVAQGLVGEPLLFVGRGYTSRG-VGGGIPPITTRALRPPDPQAAFSYEETAKLAVGRLSEYSHH 217

  Fly   267 FLVDYIYGFNSSEYAYFIIVQKKSHLADEA--GYVTRLARICITDPNYDSYTEITVQCTATENNV 329
            |:..::.|.:    |||:.:::.......|  .||   :|:|:.|.:|.||.|:.:.|....   
Mouse   218 FVSAFVRGAS----AYFLFLRRDLKAPSRAFRAYV---SRVCLQDQHYYSYVELPLACQGGR--- 272

  Fly   330 DYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVFS----PSRE----ISNQPESKSAMCIYSIKD 386
             |.:::.|.|       |....:.:.| ||...||    |:.:    .|......|.:|.:.:.:
Mouse   273 -YGLIQAAAV-------ATSKEVARGD-VLFAAFSSVAPPTVDWPLSASTGASGTSVLCAFPLDE 328

  Fly   387 IEDMFIENIHLCF-------NGTTKDRNLGYISGTINDGRC--------------------PIVG 424
            ::.:.......|:       || ||..::.|  ..::|  |                    |:|.
Mouse   329 VDQLANYTRDACYTREGRAENG-TKVADIAY--DVLSD--CAQLPVDTPDAFPCGSDHTPSPMVS 388

  Fly   425 SLGNIYNFCSVGLKISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLS 489
            .:                 |:.|..:.....|.:|:|..  |.:..|::||||.:.|.:.:|.|.
Mouse   389 CV-----------------PLEATPILELPGVQLTAVAV--TMEDGHTIAFLGDSQGQLHRVYLG 434

  Fly   490 -GQSPGEYEEIVVDAGNRILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTNCSACLESRDPFC 553
             |:|...|.:..:..|:.:..:.......:.|||.:|..:.|:.:..|:.:.:|.:||..|||:|
Mouse   435 PGRSAAPYSKQSIQPGSPVNRDLTFDGTFEHLYVATQTTLVKVPVAPCAQHLDCDSCLAHRDPYC 499

  Fly   554 GWCSLEKRCTVRSTCQRDTSASRWL-----SLGSGQQCIEFESIIPEKIPISELSHLHLIIRTLP 613
            |||.|..||:.||.|.||....:||     .||    |:...::.|..|...|...:.|.:..||
Mouse   500 GWCVLLGRCSRRSECSRDQGPEQWLWSFQPELG----CLRVVAVSPANISREERREVFLSVPGLP 560

  Fly   614 EPF-NAKYRCVFGN-STPIDAEILENGLGCATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVS 676
            ..: ...|.|.||: .:|  |.:..:|:.|.:|...|.|::....|||.|.:.:|....  ...|
Mouse   561 SLWPGESYFCYFGDQQSP--ALLTSSGVMCPSPDPSEAPVLQRGADHISVNVELRFGAV--VIAS 621

  Fly   677 RNFAFFDC------SHHGNCQECLQSSWGCNWCIFDNKCVHKS---------------------- 713
            .:.:|:||      |....|:.|:.|.||||||::...|.||:                      
Mouse   622 TSLSFYDCVAVTASSPSAPCRACVSSRWGCNWCVWQQLCTHKASCDAGPMVASQQSPLLPLIPPA 686

  Fly   714 ---------------------------------------------------------LQCRNIEN 721
                                                                     |...:.|:
Mouse   687 RDELTPFPPTVPQTTVTPTPNSFPIEPRAPSTASDVLPGAKPSRLSLWGPWAGPGPILSPTSTES 751

  Fly   722 ----------------------------------------------------------------- 721
                                                                             
Mouse   752 PLHEKPLPPDPPTIPGTTVPAPTGLGPSTTPEDLLASYPFPSDAAAVSPAEPGPEALPSMVALDQ 816

  Fly   722 -------------------------------------------AVST------------------ 725
                                                       |.||                  
Mouse   817 PPGTVPDTTFPGAPGSMKPVLDWLTKGGGELPEADEWMGGDTPAFSTSTLLSGDGDSAEHEGPPA 881

  Fly   726 --------------------------VGHCPHLKKNRPEILLPVRVPIEIRLEIENL----PKPK 760
                                      |..||.::..:..:|:||.|..|::|...||    ..|:
Mouse   882 PLILLSSLDYQYDTPGLWELGEVNQRVSSCPCVETVQGSLLIPVHVEREVQLRGRNLWLFQDGPR 946

  Fly   761 SAHAGFLCTIHIEAAQMLLPAHVESNK------IVVCEKTPYFYEINTHEYQAKVVVTWNFQHYV 819
            |:.    |.:.:.:.::.:.|.||...      .:.|::..:.||....|.|..:.:.|.....|
Mouse   947 SSE----CVLELGSREVAVEAQVECAPPPDVWCHIKCQQHQFSYEALKPELQVGLFLRWAGGLRV 1007

  Fly   820 DTA---IVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWCSNS---CVYNETCIADKNSISSGSK 878
            |:|   .|.||.|.|     .|.|||.|.|..|:|.|.||...   ||..|.|         ...
Mouse  1008 DSADGLHVVLYDCSV-----GHGDCSRCQTAMPQYDCVWCEGERPRCVAREAC---------NEA 1058

  Fly   879 SAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIFIGSVPCELE--NYQISVK 941
            ..:..:||.|.|..:.||:||::|||.:||.|||||...:||...:.:..|||.::  .|.:|..
Mouse  1059 ETVATQCPAPLIHSVDPLTGPIDGGTRVTIRGSNLGQHVQDVLDMVRVAGVPCAVDAGEYDVSSS 1123

  Fly   942 IECRTGASLYEMSAPIKV-ANDAGFTESSVQFHFKNVLLTGLYPTIGPRSGGTQLSLIGKFLNIG 1005
            :.|.||||..|::..:.| ....|...|...|.:::..:..::|..|||:|||:|:|.|..|..|
Mouse  1124 LVCITGASGEEVTGTVAVEVPGRGHGVSEFSFAYQDPKVHSIFPARGPRAGGTRLTLHGSKLLTG 1188

  Fly  1006 --STMRAFLDEYECHIDVTQASSSQVSCTTSEATQPEPIRSLHLVIDGANRTLECQISTPSITNT 1068
              ..:|..:.:..||: :.:..|.|:.|.|.....|..:                          
Mouse  1189 RLEDIRVVVGDQPCHL-LLEQQSEQLHCETGPYPVPAEL-------------------------- 1226

  Fly  1069 NPTRSNFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSIQKPELEV- 1132
             |....||:.:.|....|    |.||.||.:..:.|.:||.||||.:.|.|..|:.:|:|.:.| 
Mouse  1227 -PVTVLFGATERRLQHGQ----FKYTSDPNVTSVGPSKSFFSGGREIWVRGQDLDVVQRPRIRVT 1286

  Fly  1133 ---------FYDNERV----NKTSCVVINSNQMEC-----PSPPVNYKFETFKKTNRKMDTELHL 1179
                     ....:.|    .:..|:|.:|:.:.|     |.||                     
Mouse  1287 VVPRQHGQGLAQKQHVVPEKFEEPCLVNSSHLLMCRTPALPGPP--------------------- 1330

  Fly  1180 QNSSFQTETRYKNEYDRKKRRADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSF 1244
            .:|..|.|                                |:.:|| |..|..:..|..:.:.. 
Mouse  1331 WDSGVQVE--------------------------------FILDNM-VFDFAALSPTPFSYEAD- 1361

  Fly  1245 VMDNVQLVRNLNKYFHDIRSTIVYLADPKYLPFPNDGVKLYKGDSLVIEGELLNLAADEYDVNVT 1309
                 ..:|:||.            .||. .||.:.     .|....:|||.|:||..:.:|...
Mouse  1362 -----PTLRSLNP------------EDPS-TPFRHK-----PGSVFSVEGENLDLAMSKEEVVAM 1403

  Fly  1310 IGTSQCNITSLALNQLLCIPPEQQPLPTDENGVDQSTD-LPLVVVKVGRNLRFVIGYLKYDLNKP 1373
            ||...|.:.:|..|.|.|.||.:|||| ..:.:.::.| ||...|::| ||||.:|:::||...|
Mouse  1404 IGDGPCVVKTLTRNHLYCEPPVEQPLP-HPHALREAPDALPEFTVQMG-NLRFSLGHVQYDGESP 1466

  Fly  1374 YVFSHALLVGI-LTVALLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESNVRSECKQAFAEL 1437
            ..|..|..||: :..:||.:..:|:::|:||||.||.|:||::|||:..|||:||..||:.|.:|
Mouse  1467 VAFPVAAQVGLGVGTSLLALGVIIIVLIYRRKSKQALRDYKKVQIQLENLESSVRDRCKKEFTDL 1531

  Fly  1438 QTDMTDLTADLESTGIPTLDHVNYIMKVFFPGVSDHPI---LNSPKFREGSPQTNYDAAMVQFEQ 1499
            .|:|||||:||..:|||.||:..|..:|||||..:.|:   |..|..|    :...:..:.|...
Mouse  1532 MTEMTDLTSDLLGSGIPFLDYKVYAERVFFPGYRESPLHRDLGVPDSR----RPTVEQGLGQLSN 1592

  Fly  1500 LIGNKYFLLMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSLLLRLIDKSLASKH 1564
            |:.:|.||..||.|||:|| :||.|||..||||:.|.|..|:||.|:||::||..|:.:.:| |:
Mouse  1593 LLNSKLFLTKFIHTLESQR-TFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVA-KN 1655

  Fly  1565 PQLMLRRTESVVEKMLTNYLAICMYDYLKEYAGSNLFLLFKAIKHQIEKGLVDAITNDARYSLSE 1629
            |:|||||||:||||:|||:::||:|.::::..|..|::||:.||||::||.||::|..|:|:|::
Mouse  1656 PKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLND 1720

  Fly  1630 ERLLHEQVTHSVVILHIL--QDDLDEKVQC---RVNDWDTISQVKLKILDAIFKNTPFSMRPSVN 1689
            .|||.|.|.:..:.|:.|  ......:.||   :|.|.|||||.|.|:||.::|..|.:.||...
Mouse  1721 NRLLREDVEYRPLTLNALLAVGPGAGEAQCVPVKVLDCDTISQAKEKMLDQLYKGVPLAQRPDSC 1785

  Fly  1690 EVDLEWRHGRGGHLTLQDEDLTTKTVNGWKRLNTLAHYGVKESAVMSL-------IARQNDNYHI 1747
            .:|:|||.|..|||.|.|||:|::....|:|||||.||.|.:.|.::|       |.|:|.:| :
Mouse  1786 TLDVEWRSGVAGHLILSDEDVTSELQGLWRRLNTLQHYKVPDGATVALVPCLTKHILRENQDY-V 1849

  Fly  1748 PYSKNQNSAPYHNFYFINNSQSHIIINNDIESGLQQPRVYHLVKPNIPDHYMNIKNSVLSGGSPA 1812
            |..:..                   :..|::.|..:|  :|||||:........:...|.||.  
Mouse  1850 PGERTP-------------------MLEDVDEGGIRP--WHLVKPSDEPEPPRPRRGSLRGGE-- 1891

  Fly  1813 FQSHVVNNCNDRVNKTIPEVYLTRLLATKGTIQKFVDDFFSIILTVNEELPPAVKWLFDLLDEAA 1877
                     .:|. |.|||:||||||:.|||:||||||.|.:||:.:..:|.|||:.||||||.|
Mouse  1892 ---------RERA-KAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQA 1946

  Fly  1878 RRHDIADTDIVHAWKSNCLPLRFWVNFIKNPDFIFDVNKTYSVDSCLSVIAQTFMDACSTSEHRL 1942
            ::|.|:|.|.:|.||:|.||||||:|.||||.|:|||..:.::|:.|.||||||||||:.::|:|
Mouse  1947 QQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKL 2011

  Fly  1943 GKDSPSNKLLFAKDIPNYRIMVKEFYRDVSRLPQISDQEMSTAMQQLSVRQNEEFDTISALKELY 2007
            |:|||.||||:|:|||.|:.||:.:|.|:.:....|||||::.:.:||...:.:.....||.|||
Mouse  2012 GRDSPINKLLYARDIPRYKQMVERYYADIRQTVPASDQEMNSVLAELSRNCSADLGARVALHELY 2076

  Fly  2008 IYITKYKDQIMESLETDINCRKMHLSRKLGNVAATLDGDCT 2048
            .||.||.|||:.:||.|...:||.|..:|..:||.::...|
Mouse  2077 KYINKYYDQIITALEEDGTAQKMQLGYRLQQIAAAVENKVT 2117

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexBNP_001245400.1 Sema_plexin_like 86..534 CDD:200497 121/499 (24%)
PSI 535..586 CDD:279745 23/55 (42%)
PSI 683..730 CDD:214655 21/283 (7%)
PSI 836..877 CDD:214655 15/43 (35%)
IPT_plexin_repeat1 888..976 CDD:238585 33/90 (37%)
IPT_plexin_repeat2 977..1095 CDD:238584 27/119 (23%)
IPT_plexin_repeat3 1097..1211 CDD:238586 25/132 (19%)
Plexin_cytopl 1452..2017 CDD:285529 252/579 (44%)
Plxnb1NP_766363.2 Sema 28..480 CDD:417757 121/499 (24%)
PSI 481..527 CDD:396154 21/45 (47%)
TIG_plexin 541..627 CDD:407808 23/89 (26%)
PSI 641..677 CDD:214655 12/35 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 683..724 0/40 (0%)
PHA03247 <713..851 CDD:223021 2/137 (1%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 741..818 2/76 (3%)
TIG_2 919..1018 CDD:407859 24/102 (24%)
PSI 1019..1066 CDD:214655 17/60 (28%)
IPT_plexin_repeat1 1068..1159 CDD:238585 33/90 (37%)
IPT 1160..1247 CDD:417750 26/118 (22%)
IPT 1250..1360 CDD:417750 31/163 (19%)
Plexin_cytopl 1546..2086 CDD:400574 252/579 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1867..1892 9/37 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 59 1.000 Domainoid score I10610
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H130508
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D56043at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100269
Panther 1 1.100 - - O PTHR22625
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
98.820

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