DRSC/TRiP Functional Genomics Resources

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Protein Alignment PlexB and PLXND1

DIOPT Version :10

Sequence 1:NP_524616.2 Gene:PlexB / 43766 FlyBaseID:FBgn0025740 Length:2051 Species:Drosophila melanogaster
Sequence 2:NP_055918.3 Gene:PLXND1 / 23129 HGNCID:9107 Length:1925 Species:Homo sapiens


Alignment Length:2127 Identity:633/2127 - (29%)
Similarity:990/2127 - (46%) Gaps:402/2127 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 IESVRDSQSKNYFTHMSFDFMHNVLFAGATNKILKLN-ENLRVLAEAVTGPLHDSPQCHAGGCPE 138
            :|..|...|.....:.:.|.....::..|.|::.:|: .||.:.|||..||:.|||.|||...|:
Human    47 LEIQRRFPSPTPTNNFALDGAAGTVYLAAVNRLYQLSGANLSLEAEAAVGPVPDSPLCHAPQLPQ 111

  Fly   139 ---DIETSLVNNFNKILVVSYAHDGILIACGSIRQGACEIYS-------LPRF-PATPQFFAVP- 191
               :....|.:|:||||.:. ...|:::.||||.||.|::..       ..|| ||.|.  |.| 
Human   112 ASCEHPRRLTDNYNKILQLD-PGQGLVVVCGSIYQGFCQLRRRGNISAVAVRFPPAAPP--AEPV 173

  Fly   192 --------LAANDENASTYAFVGPARYAWKEEDILYVGTTFTNVG-----------DYR-HDVPA 236
                    :|||..||||...|.|.. |......|.||.|:|..|           |:| .:.|.
Human   174 TVFPSMLNVAANHPNASTVGLVLPPA-AGAGGSRLLVGATYTGYGSSFFPRNRSLEDHRFENTPE 237

  Fly   237 ISSRRLD-----------DLNYAEFSIQQSIINIDVKYRDHFLVDYIYGF--------NSSEYAY 282
            |:.|.||           |||.::    .:|:.|....::...:.::..|        .:..|||
Human   238 IAIRSLDTRGDLAKLFTFDLNPSD----DNILKIKQGAKEQHKLGFVSAFLHPSDPPPGAQSYAY 298

  Fly   283 FIIVQKKSHLAD-EAGYVTRLARICITDPN---------YDSYTEITVQCTATENNVD-YNIVRD 336
             :.:..::...| |:...:.|||||:  |:         .:||.::.:||.......| |:  |.
Human   299 -LALNSEARAGDKESQARSLLARICL--PHGAGGDAKKLTESYIQLGLQCAGGAGRGDLYS--RL 358

  Fly   337 AKVTPASHKLAQKMGIKKDDHVLVTVFSPSREISNQPESK---SAMCIYSIKDIEDMFIENIHLC 398
            ..|.||..:|                |:........|.::   :|:|.:...|:..........|
Human   359 VSVFPARERL----------------FAVFERPQGSPAARAAPAALCAFRFADVRAAIRAARTAC 407

  Fly   399 FNGTTKDRNLGYISGTINDGRCPIVGSLGNIY--------NFCSVGLKISGVSPITAHALFHFDN 455
            |.....|  :..:..::..|..|......||.        ....:...:|.:.|:.|..:|... 
Human   408 FVEPAPD--VVAVLDSVVQGTGPACERKLNIQLQPEQLDCGAAHLQHPLSILQPLKATPVFRAP- 469

  Fly   456 VSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLSGQSPGEYEEIVVDAGNRILPNTMMSPKKD-- 518
             .:|||...|..:  ::..||||..|.:.|:.|:.........:|..|....:.:.|.....|  
Human   470 -GLTSVAVASVNN--YTAVFLGTVNGRLLKINLNESMQVVSRRVVTVAYGEPVHHVMQFDPADSG 531

  Fly   519 FLYVLSQRKITKLRIEHCSVYTNCSACLESRDPFCGWCSLEKRCTVRSTCQRDTSASRWLSLGSG 583
            :||:::..::.::::..|:|::.|..|:.:.|.:||||:||.|||::..|...:....|.|...|
Human   532 YLYLMTSHQMARVKVAACNVHSTCGDCVGAADAYCGWCALETRCTLQQDCTNSSQQHFWTSASEG 596

  Fly   584 QQCIEFESIIPEKIPISELSHLHLIIR---TLPEPFNAKYRCVFGNSTPIDAEILENGLG----- 640
            .......:::|.:|.:.: .:..:|::   :||.....:..|.:||:....|.:.....|     
Human   597 PSRCPAMTVLPSEIDVRQ-EYPGMILQISGSLPSLSGMEMACDYGNNIRTVARVPGPAFGHQIAY 660

  Fly   641 CATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSRNFAFFDCSH------HGNCQECLQSSWG 699
            |...|.|:.|..|.|.||:.|.:|||.:  .::.|..||..:|||.      |..|..||.:.|.
Human   661 CNLLPRDQFPPFPPNQDHVTVEMSVRVN--GRNIVKANFTIYDCSRTAQVYPHTACTSCLSAQWP 723

  Fly   700 CNWCIFDNKCVHKSLQCRNIENAVSTVGHCPHLKKNRPEILLPVRVPIEIRLEIENLPKPKSAHA 764
            |.||...:.||....:|....|        |...::.|..||....|:... ..:|:..|.:..|
Human   724 CFWCSQQHSCVSNQSRCEASPN--------PTSPQDCPRTLLSPLAPVPTG-GSQNILVPLANTA 779

  Fly   765 GFL-----CTIHIEAAQMLLPAHVESNKIVVCEKTPYFYEINTHEYQAKVVVTWNFQ------HY 818
            .|.     |:..:|.   :..|...:..:|.|:      ::..|..:...|...:.|      .:
Human   780 FFQGAALECSFGLEE---IFEAVWVNESVVRCD------QVVLHTTRKSQVFPLSLQLKGRPARF 835

  Fly   819 VDT---AIVTLYKCDVLGSHREHPDCSLCVTR-DPKYKCAWCSNSCVYNETCIADKNSISSGSKS 879
            :|:   ..|.:|.| .:||    ||||.|:.| |..:.|.| |:.|...            |...
Human   836 LDSPEPMTVMVYNC-AMGS----PDCSQCLGREDLGHLCMW-SDGCRLR------------GPLQ 882

  Fly   880 AIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIFIGSVPCE--LENYQISVKI 942
            .:...||.|.|..|:|||||::||||:||.|.|||.|..||...::||.|.||  .:.|.:|.:|
Human   883 PMAGTCPAPEIHAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAHGVWIGGVACEPLPDRYTVSEEI 947

  Fly   943 ECRTGASLYEMSAPIKV-ANDAGFTESSVQFHFKNVLLTGLYPTIGPRSGGTQLSLIGKFLNIGS 1006
            .|.||.:...:|..:.| |:..|  :|..:|.:...|:..|.||:||::|||::::.|..|::||
Human   948 VCVTGPAPGPLSGVVTVNASKEG--KSRDRFSYVLPLVHSLEPTMGPKAGGTRITIHGNDLHVGS 1010

  Fly  1007 TMRAFLDEYECHIDVTQASSSQVSCTTSEATQPEPIRSLHLVIDGANRTLECQISTPSITNTNPT 1071
            .::..:::.:...::.:..:| ::||..|...|.|:                           |.
Human  1011 ELQVLVNDTDPCTELMRTDTS-IACTMPEGALPAPV---------------------------PV 1047

  Fly  1072 RSNFGSYQLRSLPRQPC----SIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSIQKPELEV 1132
            ...|        .|:.|    ..|.|.|:|.|..|.|.||..||||.:||.|...:.:|...:.|
Human  1048 CVRF--------ERRGCVHGNLTFWYMQNPVITAISPRRSPVSGGRTITVAGERFHMVQNVSMAV 1104

  Fly  1133 FYDNERVNKTSCVVINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQNSSFQTETRYKNEYDRK 1197
            .:...  ..|.|.|:||..:.||||..                                      
Human  1105 HHIGR--EPTLCKVLNSTLITCPSPGA-------------------------------------- 1129

  Fly  1198 KRRADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFVMDNVQLVRNLNKYFHDI 1262
                        .:||.:..::|:|............|         ::|..:..|.       .
Human  1130 ------------LSNASAPVDFFINGRAYADEVAVAEE---------LLDPEEAQRG-------S 1166

  Fly  1263 RSTIVYLADPKYLPFPND-GVKLYKGD--SLVIEGELLNLAADEYDVNVTIGTSQCNITSLALNQ 1324
            |..:.||.:|::.....: .:|.:.|:  :|||..|..:|....::..|.||...|:|..::...
Human  1167 RFRLDYLPNPQFSTAKREKWIKHHPGEPLTLVIHKEQDSLGLQSHEYRVKIGQVSCDIQIVSDRI 1231

  Fly  1325 LLCIPPEQQPLPTDENGVDQST-----DLPLVVVKVGRNLRFVIGYLKYDLNKPYVFSHALLVGI 1384
            :.|             .|::|.     .|| :.::|| |....|..|:...::.     |::|.|
Human  1232 IHC-------------SVNESLGAAVGQLP-ITIQVG-NFNQTIATLQLGGSET-----AIIVSI 1276

  Fly  1385 LTVALLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESNVRSECKQAFAELQTDMTDLTADL- 1448
            :..::|:::.|:.|.:|..||.:|||.:::..:||..:||.:|.|.::.||||||||||||.:| 
Human  1277 VICSVLLLLSVVALFVFCTKSRRAERYWQKTLLQMEEMESQIREEIRKGFAELQTDMTDLTKELN 1341

  Fly  1449 ESTGIPTLDHVNYIMKVFFPGVSD------------------------HPILNSPKFREGSPQTN 1489
            .|.|||.|::.:::.:.|||..|.                        ||:|...|..| |.:.|
Human  1342 RSQGIPFLEYKHFVTRTFFPKCSSLYEERYVLPSQTLNSQGSSQAQETHPLLGEWKIPE-SCRPN 1405

  Fly  1490 YDAAMVQFEQLIGNKYFLLMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSLLLR 1554
            .:..:..|..|:.||:||::|:..|| |:..|::|||.::|||:.:.|..|:||.|.|:|.||:.
Human  1406 MEEGISLFSSLLNNKHFLIVFVHALE-QQKDFAVRDRCSLASLLTIALHGKLEYYTSIMKELLVD 1469

  Fly  1555 LIDKSLASKHPQLMLRRTESVVEKMLTNYLAICMYDYLKEYAGSNLFLLFKAIKHQIEKGLVDAI 1619
            |||.| |:|:|:||||||||||||||||:::||||..|:|..|...|||..|||.||.||.:|||
Human  1470 LIDAS-AAKNPKLMLRRTESVVEKMLTNWMSICMYSCLRETVGEPFFLLLCAIKQQINKGSIDAI 1533

  Fly  1620 TNDARYSLSEERLLHEQVTHSVVILHI-LQDDLDEKVQCRVNDWDTISQVKLKILDAIFKNTPFS 1683
            |..|||:||||.||.|.:......|:: .|....:.:..|..|.||::|||.|||:|..||.|:|
Human  1534 TGKARYTLSEEWLLRENIEAKPRNLNVSFQGCGMDSLSVRAMDTDTLTQVKEKILEAFCKNVPYS 1598

  Fly  1684 MRPSVNEVDLEWRHGRGGHLTLQDEDLTTKTVNGWKRLNTLAHYGVKESA--VMSLIARQNDNYH 1746
            ..|...:|||||.........|:|.|.|:...:|.|:|||||||.:.|.|  .||||.::::.  
Human  1599 QWPRAEDVDLEWFASSTQSYILRDLDDTSVVEDGRKKLNTLAHYKIPEGASLAMSLIDKKDNT-- 1661

  Fly  1747 IPYSKNQNSAPYHNFYFINNSQSHIIINNDIESGLQQPRVYHLVKPNIPDHYMNIKNSVLSGGSP 1811
            :...|:.::..|.          |:::..|   .|.:|:..|.                      
Human  1662 LGRVKDLDTEKYF----------HLVLPTD---ELAEPKKSHR---------------------- 1691

  Fly  1812 AFQSHVVNNCNDRVNKTIPEVYLTRLLATKGTIQKFVDDFFSIILTVNEELPP-AVKWLFDLLDE 1875
              |||        ..|.:||:||||||:||||:|||:||.|..||::.|:.|| |||:.||.|:|
Human  1692 --QSH--------RKKVLPEIYLTRLLSTKGTLQKFLDDLFKAILSIREDKPPLAVKYFFDFLEE 1746

  Fly  1876 AARRHDIADTDIVHAWKSNCLPLRFWVNFIKNPDFIFDVNKTYSVDSCLSVIAQTFMDACSTSEH 1940
            .|.:..|:|.|.:|.||:|.||||||||.:|||.|:||::||..:|:|||||||.|:||||.|:.
Human  1747 QAEKRGISDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIDKTDHIDACLSVIAQAFIDACSISDL 1811

  Fly  1941 RLGKDSPSNKLLFAKDIPNYRIMVKEFYRDVSRLPQISDQEMSTAMQQLSVRQNEEFDTISALKE 2005
            :||||||:||||:||:||.||.:|:.:|:.:..:..:|:|||:..:.:.|.:...||:|..|:.|
Human  1812 QLGKDSPTNKLLYAKEIPEYRKIVQRYYKQIQDMTPLSEQEMNAHLAEESRKYQNEFNTNVAMAE 1876

  Fly  2006 LYIYITKYKDQIMESLETDINCRKMHLSRKLGNVAATLDG---DCTS 2049
            :|.|..:|:.|||.:||.:...|:..|..|...|.|.::.   :|.|
Human  1877 IYKYAKRYRPQIMAALEANPTARRTQLQHKFEQVVALMEDNIYECYS 1923

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexBNP_524616.2 Sema_plexin_like 86..534 CDD:200497 123/523 (24%)
PSI 535..586 CDD:396154 18/50 (36%)
TIG_plexin 594..682 CDD:465588 25/95 (26%)
PSI 683..730 CDD:214655 15/52 (29%)
TIG_2 738..827 CDD:465619 17/102 (17%)
PSI 836..877 CDD:214655 11/41 (27%)
IPT_plexin_repeat1 888..976 CDD:238585 38/90 (42%)
IPT_plexin_repeat2 977..1095 CDD:238584 25/121 (21%)
IPT_plexin_repeat3 1097..1211 CDD:238586 24/113 (21%)
TIG 1277..>1334 CDD:460355 13/59 (22%)
Plexin_cytopl 1452..2012 CDD:462434 246/587 (42%)
PLXND1NP_055918.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
Sema_plexin_D1 49..547 CDD:200508 125/532 (23%)
PSI 549..601 CDD:396154 18/51 (35%)
TIG_plexin <627..700 CDD:465588 22/74 (30%)
PSI 711..753 CDD:214655 13/49 (27%)
IPT_plexin_repeat1 891..979 CDD:238585 38/89 (43%)
IPT_plexin_repeat2 981..1067 CDD:238584 25/121 (21%)
IPT_plexin_repeat3 1069..1174 CDD:238586 33/172 (19%)
Plexin_cytopl 1345..1883 CDD:462434 246/587 (42%)
Blue background indicates that the domain is not in the aligned region.

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