DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexB and Mst1r

DIOPT Version :9

Sequence 1:	NP_001245400.1	Gene:	PlexB / 43766	FlyBaseID:	FBgn0025740	Length:	2051	Species:	Drosophila melanogaster
Sequence 2:	XP_006511717.1	Gene:	Mst1r / 19882	MGIID:	99614	Length:	1406	Species:	Mus musculus

Alignment Length:	1826	Identity:	332/1826 - (18%)
Similarity:	535/1826 - (29%)	Gaps:	767/1826 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LCIIIILGSQHYCVNCIEELPAQALSPLNDIVAQFNLPSIPVQSTASSYGNRSIGNNIESVRDSQ 82
            |.::::|.......|...:.|....:...|...::.:||.            |.|..:::
Mouse    12 LLLMLLLRLSAASTNLNWQCPRIPYAASRDFSVKYVVPSF------------SAGGRVQA----- 59

  Fly    83 SKNYFTHMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQCHA--------GGCPED 139
                 |....|..::.:|....|.:..|..:|:.:....|||: .:|.|..        .|.|:|
Mouse    60 -----TAAYEDSTNSAVFVATRNHLHVLGPDLQFIENLTTGPI-GNPGCQTCASCGPGPHGPPKD 118

  Fly   140 IETSLVNNFNKILVVSYAHDGI--LIACGSIRQGACEIYSLPRFPATPQFFAVPLAA-------- 194
            .:|          :|.....|:  |::|||..||.|.::.|     .|:..|:.|||
Mouse   119 TDT----------LVLVMEPGLPALVSCGSTLQGRCFLHEL-----EPRGKALHLAAPACLFSAN 168

  Fly   195 -NDENASTYAFVGPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRLDDLNYAEFS------- 251
             |...|.|.....|            :||..| |.:..|......:..||....|.||
Mouse   169 NNKPEACTDCVASP------------LGTRVT-VVEQGHASYFYVASSLDPELAASFSPRSVSIR 220

  Fly   252 --------IQQSIINIDV--KYRDHFLVDYIYGFNSSEYAYFIIVQKKSHLADEAGYVTRLARIC 306
                    .|....::.|  ||...:|:.|:|.|:|.::.||:.||..|..:..:...|||.|:.
Mouse   221 RLKSDTSGFQPGFPSLSVLPKYLASYLIKYVYSFHSGDFVYFLTVQPISVTSPPSALHTRLVRLN 285

  Fly   307 ITDPNYDSYTEITVQC---------TATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTV 362
            ..:|....|.|:.:.|         .|.|....|.:::.|...|...|||.::.|.:...||..|
Mouse   286 AVEPEIGDYRELVLDCHFAPKRRRRGAPEGTQPYPVLQAAHSAPVDAKLAVELSISEGQEVLFGV 350

  Fly   363 FSPSREISNQPESKSAMCIYSIKDIEDMFIENIHLCFNGTTKDRNLGYISGTINDGRCPIVGSLG 427
            |...::..:.....|.:|.:.|..:..:..|.:..|.:.:...   ..:|..::..:.|
Mouse   351 FVTVKDGGSGMGPNSVVCAFPIYHLNILIEEGVEYCCHSSNSS---SLLSRGLDFFQTP------ 406

  Fly   428 NIYNFC--SVGLKISGVS------PITAHALFH--------FDNVSVTSVTATSTTDQQHSLAFL 476
               :||  ..|.:.||.|      |:..||.|.        ..:|.||::..|...:.  ::|.:
Mouse   407 ---SFCPNPPGGEASGPSSRCHYFPLMVHASFTRVDLFNGLLGSVKVTALHVTRLGNV--TVAHM 466

  Fly   477 GTNMGVIKKVLLSGQSPGEYEEIVVDAGNRILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTN 541
            ||                      ||  .|:|...:.......|||.:
Mouse   467 GT----------------------VD--GRVLQVEIARSLNYLLYVSN----------------- 490

  Fly   542 CSACLESRDPFCGWCSLEKRCTVRSTCQRDTSASRWLSLGSGQQCIEFESIIPEKIPISELSHLH 606
                                                .||||..|        |....:|.|
Mouse   491 ------------------------------------FSLGSSGQ--------PVHRDVSRL---- 507

  Fly   607 LIIRTLPEPFNAKYRCVFGNSTPIDAEILENGLGCATPPLDERPLIPTNTDHIL-VPLSVRSSET 670
                              ||.                       |:..:.|.:. ||:....
Mouse   508 ------------------GND-----------------------LLFASGDQVFKVPIQGPG--- 528

  Fly   671 NKDFVSRNFAFFDCSHHGNCQECL--QSSWGCNWCIFDNKCVHKSLQCRNIENAVSTVGHCPHLK 733
                         |.|...|..||  |...||.||  .::|..:.              .||.
Mouse   529 -------------CRHFLTCWRCLRAQRFMGCGWC--GDRCDRQK--------------ECPG-- 562

  Fly   734 KNRPEILLPVRVPIEIRLEIENLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKTPYFY 798

Mouse   563 ----------------------------------------------------------------- 562

  Fly   799 EINTHEYQAKVVVTWNFQHYVDTAIVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWCSNSCVYN 863
                         :|...|
Mouse   563 -------------SWQQDH---------------------------------------------- 568

  Fly   864 ETCIADKNSISSGSKSAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDV----RGKI 924
                                 || |.|....|.|||:.|.|.:|:.|||..:|.:||    ..:|
Mouse   569 ---------------------CP-PEISEFYPHSGPLRGTTRLTLCGSNFYLRPDDVVPEGTHQI 611

  Fly   925 FIGSVPCEL--------------ENYQISVKIECR-----------TGASLYEMSAPIKVANDAG 964
            .:|..||.|              |..|   ::||.           |..||...:.|      ||
Mouse   612 TVGQSPCRLLPKDSSSPRPGSLKEFIQ---ELECELEPLVTQAVGTTNISLVITNMP------AG 667

  Fly   965 ----FTESSVQ--FHFKNVLLTGLYPTIGPRSGGTQLSLIGKFLNIGSTMRAFLDEYECHIDVTQ 1023
                ....|||  |.|...:||.:.|..|||:|||.|:|.|:.|::|::....::..:|.::  |
Mouse   668 KHFRVEGISVQEGFSFVEPVLTSIKPDFGPRAGGTYLTLEGQSLSVGTSRAVLVNGTQCRLE--Q 730

  Fly  1024 ASSSQVSCTT--SEATQPEPIRSLHLVIDGANRTLECQISTPSITNTNPTRSNFGSYQLRSLPRQ 1086
            .:..|:.|.|  ...|...|   |||.|.||        ..|            ||:
Mouse   731 VNEEQILCVTPPGAGTARVP---LHLQIGGA--------EVP------------GSW-------- 764

  Fly  1087 PCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSIQKPELEVFYDNE-RVNKTSCV--VIN 1148
               .|:|.:||.::.|.|...: ||..:: :||.:|.|.....|. |:|.: .|....|.  .:.
Mouse   765 ---TFHYKEDPIVLDISPKCGY-SGSHIM-IHGQHLTSAWHFTLS-FHDGQSTVESRQCAGQFVE 823

  Fly  1149 SNQMECPSPPVNYKFETFKKTNRKMDTELHLQNSSFQTETRYKNEYDRKKRRADFGDTFRLYTNA 1213
            ..|..|..|
Mouse   824 QQQRRCRLP-------------------------------------------------------- 832

  Fly  1214 GSSANYFVNNNMDVTTFVKVHETQLNLQL------SFVMDNVQLVRNLNKYFHDIRSTIVYLADP 1272
                .|.|.|.....|.        ||.:      .|.:...
Mouse   833 ----EYVVRNPQGWATG--------NLSVWGDGAAGFTLPGF----------------------- 862

  Fly  1273 KYLPFPND---GVKLYKGD--SLVIEGELLNLAADEYDVNVTIGTSQCNITSLALNQLLC-IPPE 1331
            ::||.|:.   |:...|.:  |:.:|...|...||...||:|:|...|. ..|..:.::| :||.
Mouse   863 RFLPPPSPLRAGLVELKPEEHSVKVEYVGLGAVADCVTVNMTVGGEVCQ-HELRGDVVICPLPPS 926

  Fly  1332 QQ------PLPTDENGVDQSTDLPLVVVK--VGRNLRFVIGYLKYDLNKPYVFSHALLVGILTVA 1388
            .|      ||   :..||....:...||:  .||                 .....||:.:|.:.
Mouse   927 LQLGKDGVPL---QVCVDGGCHILSQVVRSSPGR-----------------ASQRILLIALLVLI 971

  Fly  1389 LLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESNVRSECKQAFA-----ELQTDMTDLTA-- 1446
            |||.|..:.||...|:        ::.|:...:|.....|:.....:     |..::..|.|:
Mouse   972 LLVAVLAVALIFNSRR--------RKKQLGAHSLSPTTLSDINDTASGAPNHEESSESRDGTSVP 1028

  Fly  1447 --DLESTGIPTLDH--VNYIMKVFFPGVSDHPILNSPKFREGSPQTNYDAAMVQFEQLIGNKYFL 1507
              ..||..:..||.  :..:..|..|                     ::..::..:|:||..:|.
Mouse  1029 LLRTESIRLQDLDRMLLAEVKDVLIP---------------------HEQVVIHTDQVIGKGHFG 1072

  Fly  1508 LMF---------------IETL----EAQRSSFSIRDRV--------NVASLIMVVLMNKMEYAT 1545
            :::               |::|    |.|.....:|:.:        |:.:||.::|      ..
Mouse  1073 VVYHGEYTDGAQNQTHCAIKSLSRITEVQEVEAFLREGLLMRGLHHPNILALIGIML------PP 1131

  Fly  1546 EILKSLLL----------------RLID-----KSLASKHPQL-----MLRRTESVVEKMLTNYL 1584
            |.|..:||                |:.|     :..||.||.|     :..:..:|.:.:.....
Mouse  1132 EGLPRVLLPYMRHGDLLHFIRSPQRVSDHCPGWEVSASTHPCLRSPVTLCPQNPTVKDLVSFGLQ 1196

  Fly  1585 AICMYDYL-------KEYAGSNLFLLFKAIKHQIEKGLVDAITNDARYSLSEERLLHEQVTHSVV 1642
            ..|..:||       ::.|..|..|.........:.||...:.:...||:.:.|  |.::....:
Mouse  1197 VACGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARGVLDKEYYSVRQHR--HARLPVKWM 1259

  Fly  1643 ILHILQ 1648
            .|..||
Mouse  1260 ALESLQ 1265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexB	NP_001245400.1	Sema_plexin_like	86..534	CDD:200497	110/508 (22%)
		PSI	535..586	CDD:279745	4/50 (8%)
		PSI	683..730	CDD:214655	11/48 (23%)
		PSI	836..877	CDD:214655	0/40 (0%)
		IPT_plexin_repeat1	888..976	CDD:238585	35/122 (29%)
		IPT_plexin_repeat2	977..1095	CDD:238584	32/119 (27%)
		IPT_plexin_repeat3	1097..1211	CDD:238586	17/116 (15%)
		Plexin_cytopl	1452..2017	CDD:285529	44/259 (17%)
Mst1r	XP_006511717.1	Sema_RON	29..525	CDD:200540	130/690 (19%)
		PSI	528..570	CDD:214655	15/220 (7%)
		IPT	571..685	CDD:387656	35/122 (29%)
		IPT_plexin_repeat2	686..770	CDD:238584	32/119 (27%)
		IPT	771..864	CDD:214657	25/186 (13%)
		PKc_like	1064..1352	CDD:389743	40/210 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I11936
eggNOG	1	0.900	-	-		E1_KOG3610
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810