DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PlexB and Plxna3

DIOPT Version :9

Sequence 1:NP_001245400.1 Gene:PlexB / 43766 FlyBaseID:FBgn0025740 Length:2051 Species:Drosophila melanogaster
Sequence 2:NP_032909.2 Gene:Plxna3 / 18846 MGIID:107683 Length:1872 Species:Mus musculus


Alignment Length:2040 Identity:677/2040 - (33%)
Similarity:1036/2040 - (50%) Gaps:298/2040 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 THMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQCHAGGCPEDIETSL-----VNN 147
            ||::...:...:|.||.|::.||..||..|...||||:.|:.:|:.   |..:....     |:|
Mouse    35 THLAVHRVTGEVFVGAVNRVFKLAPNLTELRAHVTGPIEDNARCYP---PPSMRVCSHRLVPVDN 96

  Fly   148 FNKILVVSYAHDGILIACGSIRQGACEIYSLPRFPATPQFFAVP---------LAANDENASTYA 203
            .||:|::.||... |:|||||.||.|:...|      ...|.:.         |:...|..|...
Mouse    97 VNKLLLIDYAARR-LVACGSIWQGICQFLRL------DDLFKLGEPHHRKEHYLSGAQEPDSMAG 154

  Fly   204 FV-----GPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRL-DDLNYAE-FSI--QQSIINI 259
            .:     ||::        |:|||......:|   .|.:|||:| ||.:..: ||:  |...::.
Mouse   155 VIVEQVQGPSK--------LFVGTAVDGKSEY---FPTLSSRKLIDDEDSGDMFSLVYQDEFVSS 208

  Fly   260 DVKYRDH-------FLVDYIYGFNSSEYAYFIIVQ--KKSHLADEAG---YVTRLARICITDPNY 312
            .:|....       |.:.|||||.|:.:.||:.:|  .:..|.|.||   :.:::.|:|..|..:
Mouse   209 QIKIPSDTLSLYPAFDIYYIYGFVSASFVYFLTLQLDTQQTLLDTAGEKFFTSKIVRMCAGDSEF 273

  Fly   313 DSYTEITVQCTATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVFSPSREISNQPESKS 377
            .||.|..:.|  :...|:|.:|:.|.:......|||.:|:..|:.||.|:||..::....|..::
Mouse   274 YSYVEFPIGC--SWRGVEYRLVQSAHLAKPGLLLAQALGVPADEDVLFTIFSQGQKNRANPPRQT 336

  Fly   378 AMCIYSIKDIEDMFIENIHLCFNGTTKDRNLGYISGTIN-----DGRCPIVGSLGNIY-NFCSVG 436
            .:|::::..|.......|..|:.|          .||:.     :...|.:.:...|. |||.:.
Mouse   337 ILCLFTLSSINAHIRRRIQSCYRG----------EGTLALPWLLNKELPCINTPLQINGNFCGLV 391

  Fly   437 LK--ISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLSGQSPGE-YEE 498
            |.  :.|:..|....|.......:.||.|  .|..|||:.|:||..|.:|||.:.|....: ||.
Mouse   392 LNQPLGGLHVIEGLPLLADSTDGMASVAA--YTYHQHSVVFIGTRSGNLKKVRVDGSQDAQLYET 454

  Fly   499 IVVDAGNRILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTNCSACLESRDPFCGWCSLEKRCT 563
            :.|..|:.||.:.:.||....:|:||::::::|.:|.|..|.:|:|||.|.||.||||.|:.||.
Mouse   455 VSVVQGSPILRDLLFSPDHRHIYLLSEKQVSQLPVETCEQYLSCAACLGSGDPHCGWCVLQHRCC 519

  Fly   564 VRSTCQRDTSASRWLSLGSGQQCIEFESIIPEKIPISELS-HLHLIIRTLPEPFNAKYRCVFGNS 627
            ....|...::...:....|  :||:.. :.|..:.::... .|.:.:|.:|: .:....|.|...
Mouse   520 REGACPGASAPHGFAEELS--KCIQVR-VRPNNVSVTSSGVQLTVAMRNVPD-LSVGVSCSFEEV 580

  Fly   628 TPIDAEILENG-LGCATPPLDERPLI-----PTNTDHILVPLSVRSSETNKDFVSRNFAFFDCSH 686
            |..:|.:|.:| |.|.:|.|.|...:     .|:|    |.|.:.|.||...|...:|.|::||.
Mouse   581 TESEAILLPSGELRCPSPSLQELQTLTRGHGATHT----VRLQLLSMETGVRFAGVDFVFYNCSA 641

  Fly   687 HGNCQECLQSSWGCNWCIFDNKCVHKSLQCRNIENAVSTVGHCPHLKKNRPEILLPVRVPIEIRL 751
            ..:|..|:.|.:.|:||.:.:.|.....:|...|..|.:...||.:.. :.::|:||.|...:.|
Mouse   642 LQSCMSCVGSPYPCHWCKYRHVCTSHPHECSFQEGRVHSPEGCPEILP-QGDLLIPVGVMQPLTL 705

  Fly   752 EIENLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKTPYFYEINTH-EYQAKVVVTWNF 815
            ..:|||:|:|....:.|.:.::..|..:||...::..|.|:...||||.:.. :.:....|.|:.
Mouse   706 RAKNLPQPQSGQKNYECVVRVQGRQHRVPAVRFNSSSVQCQNASYFYEGDEFGDTELDFSVVWDG 770

  Fly   816 QHYVD---TAIVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWC--SNSCVYNETCIADK-NSIS 874
            ...:|   :....||||     ..:.|.|.||:..||::.|.||  .:.|.....|.|.| |.:.
Mouse   771 DFPIDKPPSFRALLYKC-----WAQRPSCGLCLKADPRFNCGWCISEHRCQLRAHCPAPKSNWMH 830

  Fly   875 SGSKSAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIF---IGSVPCELENY 936
            ...|.|   .|..|||..|.||:||.||||.:||.|.|||:...:|..::.   ..|:|.|   |
Mouse   831 PSQKGA---RCSHPRITQIHPLTGPKEGGTRVTIVGENLGLTSREVGLRVAGVRCNSIPTE---Y 889

  Fly   937 QISVKIECRTGASLYEMSAP----IKVAN-DAGF-TESSVQFHFKNVLLTGLYPTIGPRSGGTQL 995
            ..:.:|.|....||.....|    :.|.: .|.| |:|...:.|.......:.|:.||.||||:|
Mouse   890 VSAERIVCEMEESLVPSPPPGPAELCVGDCSADFRTQSQQLYSFVTPTFDRVSPSRGPASGGTRL 954

  Fly   996 SLIGKFLNIGSTMRAFLDEYECHIDVTQASSSQVSCTTSEATQPEPIRSLHLVIDGANRTLECQI 1060
            ::.|..|:.||.:...:.:.||..  .:..:..:.|.:..:|.......:.|.||.||       
Mouse   955 TISGISLDAGSRVTVIIRDGECQF--VRRDAEAIVCISPVSTLGPSQSPITLAIDHAN------- 1010

  Fly  1061 STPSITNTNPTRSNFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSI 1125
                |:||.                   .|:.|||||.:..::|..|..:|...:||.|.:|.::
Mouse  1011 ----ISNTG-------------------VIYTYTQDPTVTHLEPTWSIINGSTSITVSGTHLLTV 1052

  Fly  1126 QKPELEVFYDNERVNKTSCVVINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQNSSFQTETRY 1190
            |:|.:...|.......| |.|||...|.|.:|.:                  .|.:...:.:..:
Mouse  1053 QEPRVRAKYRGIETTNT-CQVINDTAMLCKAPGI------------------FLGHPQPRAQGEH 1098

  Fly  1191 KNEYDRKKRRADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFVMDNVQLVRNL 1255
            .:|:                                                .|::|:||..|:|
Mouse  1099 PDEF------------------------------------------------GFLLDHVQAARSL 1115

  Fly  1256 NKYFHDIRSTIVYLADPKYLPFPNDGVKLYK-GDSLVIEGE-LLNLAADEYDVNVT--IGTSQCN 1316
            |      ||:..|..||.:.|....||...| |..:|::|: |:..||....:|.|  ||...|.
Mouse  1116 N------RSSFTYYPDPSFEPLGPSGVLDVKPGSHVVLKGKNLIPAAAGSSRLNYTVLIGGQPCA 1174

  Fly  1317 ITSLALNQLLCIPPEQ---QPLPTDENGVDQSTDLPLVVVKVGRNLRFVIGYLKYDLNKPYVFSH 1378
            :| ::..||||..|.|   ||                |:|.|| .|.|.:|.|....::  ..:.
Mouse  1175 LT-VSDTQLLCDSPSQTGRQP----------------VMVLVG-GLEFWLGTLHITADR--ALTL 1219

  Fly  1379 ALLVGILT-VALLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESNVRSECKQAFAELQTDMT 1442
            ..:||:.. ..||::...:||:.::||:..|:|..||:|:||..|||.|..|||:||||||||:.
Mouse  1220 PAMVGLAAGGGLLLLAITVVLVAYKRKTQDADRTLKRLQLQMDNLESRVALECKEAFAELQTDIN 1284

  Fly  1443 DLTADLESTGIPTLDHVNYIMKVFFPGVSDHPILNSPKFREGSPQTNYDAAMVQFEQLIGNKYFL 1507
            :||..::...||.||:..|.::|.|||:..||:|     :|.....|.:.|:..|.||:.::.||
Mouse  1285 ELTNHMDGVQIPFLDYRTYAVRVLFPGIEAHPVL-----KELDTPPNVEKALRLFGQLLHSRAFL 1344

  Fly  1508 LMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSLLLRLIDKSLASK-HPQLMLRR 1571
            |.||.||||| ||||:|||..||||.||.|.::::|||.:||.||..||:|:|.|| ||:|:|||
Mouse  1345 LTFIHTLEAQ-SSFSMRDRGTVASLTMVALQSRLDYATGLLKQLLADLIEKNLESKNHPKLLLRR 1408

  Fly  1572 TESVVEKMLTNYLAICMYDYLKEYAGSNLFLLFKAIKHQIEKGLVDAITNDARYSLSEERLLHEQ 1636
            ||||.||||||:....::.:|||.||..||||:.|||.|:|||.:||||.:|||||||::|:.:|
Mouse  1409 TESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQ 1473

  Fly  1637 VTHSVVILHIL--QDDLDEKVQCRVNDWDTISQVKLKILDAIFKNTPFSMRPSVNEVDLEWRHGR 1699
            :.:..:.||.:  :.:...:|..:|.:.|:|:|.|.|:||.::|..|:|.||...::|||||.||
Mouse  1474 IDYKTLTLHCVCPESEGSAQVPVKVLNCDSITQAKDKLLDTVYKGIPYSQRPKAEDMDLEWRQGR 1538

  Fly  1700 GGHLTLQDEDLTTKTVNGWKRLNTLAHYGVKESAVMSLIARQNDNYHI--PYSKNQNSAPYHNFY 1762
            ...:.|||||:|||....|||:|:||||.|.:.::::|:.:|...|::  .::..::.:.|.:..
Mouse  1539 MARIILQDEDITTKIECDWKRVNSLAHYQVTDGSLVALVPKQVSAYNMANSFTFTRSLSRYESLL 1603

  Fly  1763 FINNSQSHI-----IINNDIESGLQQPRVYHLVKPNIPDHYMNIKNSVLSGGSPAFQSHVVNNCN 1822
            ...:|...:     ::..|.|:|   .:::|||:    :|                 .|..:...
Mouse  1604 RAASSPDSLRSRAPMLTPDQEAG---TKLWHLVR----NH-----------------DHTDHREG 1644

  Fly  1823 DRVNKTIPEVYLTRLLATKGTIQKFVDDFFSIILTV---NEELPPAVKWLFDLLDEAARRHDIAD 1884
            ||.:|.:.|:|||||||||||:||||||.|..:.:.   ...||.|:|::||.|||.|.:..|:|
Mouse  1645 DRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRGSALPLAIKYMFDFLDEQADQRQISD 1709

  Fly  1885 TDIVHAWKSNCLPLRFWVNFIKNPDFIFDVNKTYSVDSCLSVIAQTFMDACSTSEHRLGKDSPSN 1949
            .|:.|.|||||||||||||.||||.|:||::|....|:||||:||||||:|||||||||||||||
Mouse  1710 PDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSN 1774

  Fly  1950 KLLFAKDIPNYRIMVKEFYRDVSRLPQISDQEMSTAMQQLSVRQNEEFDTISALKELYIYITKYK 2014
            |||:|||||||:..|:.:|||::::..||||:|...:.:.|.....:|:.:|||.|||.|:|||:
Mouse  1775 KLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYR 1839

  Fly  2015 DQIMESLETDINCRKMHLSRKLGNV 2039
            .:|:.||:.|.:|||..|.:||..:
Mouse  1840 QEILTSLDRDASCRKHKLRQKLEQI 1864

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexBNP_001245400.1 Sema_plexin_like 86..534 CDD:200497 136/489 (28%)
PSI 535..586 CDD:279745 18/50 (36%)
PSI 683..730 CDD:214655 12/46 (26%)
PSI 836..877 CDD:214655 14/43 (33%)
IPT_plexin_repeat1 888..976 CDD:238585 34/96 (35%)
IPT_plexin_repeat2 977..1095 CDD:238584 26/117 (22%)
IPT_plexin_repeat3 1097..1211 CDD:238586 21/113 (19%)
Plexin_cytopl 1452..2017 CDD:285529 267/577 (46%)
Plxna3NP_032909.2 Sema_plexin_A3 22..490 CDD:200534 136/489 (28%)
PSI 491..>531 CDD:279745 17/39 (44%)
PSI 638..685 CDD:214655 12/46 (26%)
PSI 789..830 CDD:214655 14/40 (35%)
IPT_plexin_repeat1 841..935 CDD:238585 34/96 (35%)
IPT_plexin_repeat2 936..1022 CDD:238584 26/117 (22%)
IPT_plexin_repeat3 1024..1124 CDD:238586 31/172 (18%)
IPT_PCSR 1126..1209 CDD:238337 32/100 (32%)
Plexin_cytopl 1295..1842 CDD:285529 267/576 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 54 1.000 Domainoid score I11157
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D56043at33208
OrthoFinder 1 1.000 - - FOG0000391
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100269
Panther 1 1.100 - - O PTHR22625
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.820

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