Protein Alignment PlexB and Plxna3

DIOPT Version :10

• Sequence 1: NP_524616.2
• Gene: PlexB / 43766
• FlyBaseID: FBgn0025740
• Length: 2051
• Species: Drosophila melanogaster
• Sequence 2: NP_032909.2
• Gene: Plxna3 / 18846
• MGIID: 107683
• Length: 1872
• Species: Mus musculus
• Alignment Length: 2040
• Identity: 677/2040 - (33%)
• Similarity: 1036/2040 - (50%)
• Gaps: 298/2040 - (14%)

  Fly    88 THMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQCHAGGCPEDIETSL-----VNN 147
            ||::...:...:|.||.|::.||..||..|...||||:.|:.:|:.   |..:....     |:|
Mouse    35 THLAVHRVTGEVFVGAVNRVFKLAPNLTELRAHVTGPIEDNARCYP---PPSMRVCSHRLVPVDN 96

  Fly   148 FNKILVVSYAHDGILIACGSIRQGACEIYSLPRFPATPQFFAVP---------LAANDENASTYA 203
            .||:|::.||... |:|||||.||.|:...|      ...|.:.         |:...|..|...
Mouse    97 VNKLLLIDYAARR-LVACGSIWQGICQFLRL------DDLFKLGEPHHRKEHYLSGAQEPDSMAG 154

  Fly   204 FV-----GPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRL-DDLNYAE-FSI--QQSIINI 259
            .:     ||::        |:|||......:|   .|.:|||:| ||.:..: ||:  |...::.
Mouse   155 VIVEQVQGPSK--------LFVGTAVDGKSEY---FPTLSSRKLIDDEDSGDMFSLVYQDEFVSS 208

  Fly   260 DVKYRDH-------FLVDYIYGFNSSEYAYFIIVQ--KKSHLADEAG---YVTRLARICITDPNY 312
            .:|....       |.:.|||||.|:.:.||:.:|  .:..|.|.||   :.:::.|:|..|..:
Mouse   209 QIKIPSDTLSLYPAFDIYYIYGFVSASFVYFLTLQLDTQQTLLDTAGEKFFTSKIVRMCAGDSEF 273

  Fly   313 DSYTEITVQCTATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVFSPSREISNQPESKS 377
            .||.|..:.|  :...|:|.:|:.|.:......|||.:|:..|:.||.|:||..::....|..::
Mouse   274 YSYVEFPIGC--SWRGVEYRLVQSAHLAKPGLLLAQALGVPADEDVLFTIFSQGQKNRANPPRQT 336

  Fly   378 AMCIYSIKDIEDMFIENIHLCFNGTTKDRNLGYISGTIN-----DGRCPIVGSLGNIY-NFCSVG 436
            .:|::::..|.......|..|:.|          .||:.     :...|.:.:...|. |||.:.
Mouse   337 ILCLFTLSSINAHIRRRIQSCYRG----------EGTLALPWLLNKELPCINTPLQINGNFCGLV 391

  Fly   437 LK--ISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLSGQSPGE-YEE 498
            |.  :.|:..|....|.......:.||.|  .|..|||:.|:||..|.:|||.:.|....: ||.
Mouse   392 LNQPLGGLHVIEGLPLLADSTDGMASVAA--YTYHQHSVVFIGTRSGNLKKVRVDGSQDAQLYET 454

  Fly   499 IVVDAGNRILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTNCSACLESRDPFCGWCSLEKRCT 563
            :.|..|:.||.:.:.||....:|:||::::::|.:|.|..|.:|:|||.|.||.||||.|:.||.
Mouse   455 VSVVQGSPILRDLLFSPDHRHIYLLSEKQVSQLPVETCEQYLSCAACLGSGDPHCGWCVLQHRCC 519

  Fly   564 VRSTCQRDTSASRWLSLGSGQQCIEFESIIPEKIPISELS-HLHLIIRTLPEPFNAKYRCVFGNS 627
            ....|...::...:....|  :||:.. :.|..:.::... .|.:.:|.:|: .:....|.|...
Mouse   520 REGACPGASAPHGFAEELS--KCIQVR-VRPNNVSVTSSGVQLTVAMRNVPD-LSVGVSCSFEEV 580

  Fly   628 TPIDAEILENG-LGCATPPLDERPLI-----PTNTDHILVPLSVRSSETNKDFVSRNFAFFDCSH 686
            |..:|.:|.:| |.|.:|.|.|...:     .|:|    |.|.:.|.||...|...:|.|::||.
Mouse   581 TESEAILLPSGELRCPSPSLQELQTLTRGHGATHT----VRLQLLSMETGVRFAGVDFVFYNCSA 641

  Fly   687 HGNCQECLQSSWGCNWCIFDNKCVHKSLQCRNIENAVSTVGHCPHLKKNRPEILLPVRVPIEIRL 751
            ..:|..|:.|.:.|:||.:.:.|.....:|...|..|.:...||.:.. :.::|:||.|...:.|
Mouse   642 LQSCMSCVGSPYPCHWCKYRHVCTSHPHECSFQEGRVHSPEGCPEILP-QGDLLIPVGVMQPLTL 705

  Fly   752 EIENLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKTPYFYEINTH-EYQAKVVVTWNF 815
            ..:|||:|:|....:.|.:.::..|..:||...::..|.|:...||||.:.. :.:....|.|:.
Mouse   706 RAKNLPQPQSGQKNYECVVRVQGRQHRVPAVRFNSSSVQCQNASYFYEGDEFGDTELDFSVVWDG 770

  Fly   816 QHYVD---TAIVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWC--SNSCVYNETCIADK-NSIS 874
            ...:|   :....||||     ..:.|.|.||:..||::.|.||  .:.|.....|.|.| |.:.
Mouse   771 DFPIDKPPSFRALLYKC-----WAQRPSCGLCLKADPRFNCGWCISEHRCQLRAHCPAPKSNWMH 830

  Fly   875 SGSKSAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIF---IGSVPCELENY 936
            ...|.|   .|..|||..|.||:||.||||.:||.|.|||:...:|..::.   ..|:|.|   |
Mouse   831 PSQKGA---RCSHPRITQIHPLTGPKEGGTRVTIVGENLGLTSREVGLRVAGVRCNSIPTE---Y 889

  Fly   937 QISVKIECRTGASLYEMSAP----IKVAN-DAGF-TESSVQFHFKNVLLTGLYPTIGPRSGGTQL 995
            ..:.:|.|....||.....|    :.|.: .|.| |:|...:.|.......:.|:.||.||||:|
Mouse   890 VSAERIVCEMEESLVPSPPPGPAELCVGDCSADFRTQSQQLYSFVTPTFDRVSPSRGPASGGTRL 954

  Fly   996 SLIGKFLNIGSTMRAFLDEYECHIDVTQASSSQVSCTTSEATQPEPIRSLHLVIDGANRTLECQI 1060
            ::.|..|:.||.:...:.:.||..  .:..:..:.|.:..:|.......:.|.||.||
Mouse   955 TISGISLDAGSRVTVIIRDGECQF--VRRDAEAIVCISPVSTLGPSQSPITLAIDHAN------- 1010

  Fly  1061 STPSITNTNPTRSNFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSI 1125
                |:||.                   .|:.|||||.:..::|..|..:|...:||.|.:|.::
Mouse  1011 ----ISNTG-------------------VIYTYTQDPTVTHLEPTWSIINGSTSITVSGTHLLTV 1052

  Fly  1126 QKPELEVFYDNERVNKTSCVVINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQNSSFQTETRY 1190
            |:|.:...|.......| |.|||...|.|.:|.:                  .|.:...:.:..:
Mouse  1053 QEPRVRAKYRGIETTNT-CQVINDTAMLCKAPGI------------------FLGHPQPRAQGEH 1098

  Fly  1191 KNEYDRKKRRADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFVMDNVQLVRNL 1255
            .:|:                                                .|::|:||..|:|
Mouse  1099 PDEF------------------------------------------------GFLLDHVQAARSL 1115

  Fly  1256 NKYFHDIRSTIVYLADPKYLPFPNDGVKLYK-GDSLVIEGE-LLNLAADEYDVNVT--IGTSQCN 1316
            |      ||:..|..||.:.|....||...| |..:|::|: |:..||....:|.|  ||...|.
Mouse  1116 N------RSSFTYYPDPSFEPLGPSGVLDVKPGSHVVLKGKNLIPAAAGSSRLNYTVLIGGQPCA 1174

  Fly  1317 ITSLALNQLLCIPPEQ---QPLPTDENGVDQSTDLPLVVVKVGRNLRFVIGYLKYDLNKPYVFSH 1378
            :| ::..||||..|.|   ||                |:|.|| .|.|.:|.|....::  ..:.
Mouse  1175 LT-VSDTQLLCDSPSQTGRQP----------------VMVLVG-GLEFWLGTLHITADR--ALTL 1219

  Fly  1379 ALLVGILT-VALLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESNVRSECKQAFAELQTDMT 1442
            ..:||:.. ..||::...:||:.::||:..|:|..||:|:||..|||.|..|||:||||||||:.
Mouse  1220 PAMVGLAAGGGLLLLAITVVLVAYKRKTQDADRTLKRLQLQMDNLESRVALECKEAFAELQTDIN 1284

  Fly  1443 DLTADLESTGIPTLDHVNYIMKVFFPGVSDHPILNSPKFREGSPQTNYDAAMVQFEQLIGNKYFL 1507
            :||..::...||.||:..|.::|.|||:..||:|     :|.....|.:.|:..|.||:.::.||
Mouse  1285 ELTNHMDGVQIPFLDYRTYAVRVLFPGIEAHPVL-----KELDTPPNVEKALRLFGQLLHSRAFL 1344

  Fly  1508 LMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSLLLRLIDKSLASK-HPQLMLRR 1571
            |.||.||||| ||||:|||..||||.||.|.::::|||.:||.||..||:|:|.|| ||:|:|||
Mouse  1345 LTFIHTLEAQ-SSFSMRDRGTVASLTMVALQSRLDYATGLLKQLLADLIEKNLESKNHPKLLLRR 1408

  Fly  1572 TESVVEKMLTNYLAICMYDYLKEYAGSNLFLLFKAIKHQIEKGLVDAITNDARYSLSEERLLHEQ 1636
            ||||.||||||:....::.:|||.||..||||:.|||.|:|||.:||||.:|||||||::|:.:|
Mouse  1409 TESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQ 1473

  Fly  1637 VTHSVVILHIL--QDDLDEKVQCRVNDWDTISQVKLKILDAIFKNTPFSMRPSVNEVDLEWRHGR 1699
            :.:..:.||.:  :.:...:|..:|.:.|:|:|.|.|:||.::|..|:|.||...::|||||.||
Mouse  1474 IDYKTLTLHCVCPESEGSAQVPVKVLNCDSITQAKDKLLDTVYKGIPYSQRPKAEDMDLEWRQGR 1538

  Fly  1700 GGHLTLQDEDLTTKTVNGWKRLNTLAHYGVKESAVMSLIARQNDNYHI--PYSKNQNSAPYHNFY 1762
            ...:.|||||:|||....|||:|:||||.|.:.::::|:.:|...|::  .::..::.:.|.:..
Mouse  1539 MARIILQDEDITTKIECDWKRVNSLAHYQVTDGSLVALVPKQVSAYNMANSFTFTRSLSRYESLL 1603

  Fly  1763 FINNSQSHI-----IINNDIESGLQQPRVYHLVKPNIPDHYMNIKNSVLSGGSPAFQSHVVNNCN 1822
            ...:|...:     ::..|.|:|   .:::|||:    :|                 .|..:...
Mouse  1604 RAASSPDSLRSRAPMLTPDQEAG---TKLWHLVR----NH-----------------DHTDHREG 1644

  Fly  1823 DRVNKTIPEVYLTRLLATKGTIQKFVDDFFSIILTV---NEELPPAVKWLFDLLDEAARRHDIAD 1884
            ||.:|.:.|:|||||||||||:||||||.|..:.:.   ...||.|:|::||.|||.|.:..|:|
Mouse  1645 DRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRGSALPLAIKYMFDFLDEQADQRQISD 1709

  Fly  1885 TDIVHAWKSNCLPLRFWVNFIKNPDFIFDVNKTYSVDSCLSVIAQTFMDACSTSEHRLGKDSPSN 1949
            .|:.|.|||||||||||||.||||.|:||::|....|:||||:||||||:|||||||||||||||
Mouse  1710 PDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSN 1774

  Fly  1950 KLLFAKDIPNYRIMVKEFYRDVSRLPQISDQEMSTAMQQLSVRQNEEFDTISALKELYIYITKYK 2014
            |||:|||||||:..|:.:|||::::..||||:|...:.:.|.....:|:.:|||.|||.|:|||:
Mouse  1775 KLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYR 1839

  Fly  2015 DQIMESLETDINCRKMHLSRKLGNV 2039
            .:|:.||:.|.:|||..|.:||..:
Mouse  1840 QEILTSLDRDASCRKHKLRQKLEQI 1864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PlexB	NP_524616.2	Sema_plexin_like	86..534	CDD:200497	136/489 (28%)
		PSI	535..586	CDD:396154	18/50 (36%)
		TIG_plexin	594..682	CDD:465588	24/94 (26%)
		PSI	683..730	CDD:214655	12/46 (26%)
		TIG_2	738..827	CDD:465619	23/92 (25%)
		PSI	836..877	CDD:214655	14/43 (33%)
		IPT_plexin_repeat1	888..976	CDD:238585	34/96 (35%)
		IPT_plexin_repeat2	977..1095	CDD:238584	26/117 (22%)
		IPT_plexin_repeat3	1097..1211	CDD:238586	21/113 (19%)
		TIG	1277..>1334	CDD:460355	21/63 (33%)
		Plexin_cytopl	1452..2012	CDD:462434	264/572 (46%)
Plxna3	NP_032909.2	Sema_plexin_A3	22..490	CDD:200534	136/489 (28%)
		PSI	491..>528	CDD:396154	17/36 (47%)
		TIG_plexin	547..637	CDD:465588	24/94 (26%)
		PSI	638..685	CDD:396154	12/46 (26%)
		TIG_2	691..785	CDD:465619	23/93 (25%)
		PSI	789..838	CDD:396154	16/51 (31%)
		IPT_plexin_repeat1	841..935	CDD:238585	34/96 (35%)
		IPT_plexin_repeat2	936..1022	CDD:238584	26/117 (22%)
		IPT_plexin_repeat3	1024..1124	CDD:238586	31/172 (18%)
		IPT_PCSR	1126..1209	CDD:238337	32/100 (32%)
		Plexin_cytopl	1294..1837	CDD:462434	264/572 (46%)