DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PlexB and Plxna2

DIOPT Version :9

Sequence 1:NP_001245400.1 Gene:PlexB / 43766 FlyBaseID:FBgn0025740 Length:2051 Species:Drosophila melanogaster
Sequence 2:XP_006497303.1 Gene:Plxna2 / 18845 MGIID:107684 Length:1901 Species:Mus musculus


Alignment Length:2062 Identity:703/2062 - (34%)
Similarity:1061/2062 - (51%) Gaps:320/2062 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 SQSKNY-FTHMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQCH----AGGCPEDI 140
            |::::: |.|::.......::.||.|::.||..||.:.....|||..|:..|:    ...|.|.:
Mouse    43 SENRDWTFNHLTVHRRTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKACYPPLIVQPCSEVL 107

  Fly   141 ETSLVNNFNKILVVSYAHDGILIACGSIRQGACEIYSLPRFPATPQFFAVP--------LAANDE 197
              :|.||.||:|::.|: :..|:||||:.||.|::..|...     |..|.        |::.::
Mouse   108 --TLTNNVNKLLIIDYS-ENRLLACGSLYQGVCKLLRLDDL-----FILVEPSHKKEHYLSSVNK 164

  Fly   198 NASTYAFVGPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRL----DDLNYAEFSIQQSIIN 258
            ..:.|..:..:.   .|:..|::||......||   .|.:|||:|    :.....::.:....::
Mouse   165 TGTMYGVIVRSE---GEDGKLFIGTAVDGKQDY---FPTLSSRKLPRDPESSAMLDYELHSDFVS 223

  Fly   259 IDVKYR-------DHFLVDYIYGFNSSEYAYFIIVQKKS------HLADEAGYVTRLARICITDP 310
            ..:|..       .||.:.|||||.|..:.||:.||.::      :.|.:..|.:|:.|:|..||
Mouse   224 SLIKIPSDTLALVSHFDIFYIYGFASGGFVYFLTVQPETPDGMAINSAGDLFYTSRIVRLCKDDP 288

  Fly   311 NYDSYTEITVQCTATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVFSPSREISNQPES 375
            .:.||..:...||..  .|:|.:::.|.:......|||...|..|:.||..:||..::..:.|..
Mouse   289 KFHSYVSLPFGCTRA--GVEYRLLQAAYLAKPGEALAQAFNISSDEDVLFAIFSKGQKQYHHPPD 351

  Fly   376 KSAMCIYSIKDIEDMFIENIHLCFNGTTKDRNLGYISGTINDGRC-----PIVGSLGNIYNFCSV 435
            .||:|.:.|:.|.....|.:..|::| ..:..|.::.|  .|.:|     ||..      |||.:
Mouse   352 DSALCAFPIRAINLQIKERLQSCYHG-EGNLELNWLLG--KDVQCTKAPVPIDD------NFCGL 407

  Fly   436 GLK--ISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLSGQSPG--EY 496
            .:.  :.|.:|:....|:......:|||  .|.....:|:.|:||..|.:||:...|...|  :|
Mouse   408 DINQPLGGSTPVEGLTLYTTSRDRLTSV--ASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQY 470

  Fly   497 EEI-VVDAGNRILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTNCSACLESRDPFCGWCSLEK 560
            |.: |...|:.||.:...|..:.:|||:|:|::|::.:|.|..||.|..||.|.||.||||:|..
Mouse   471 EMVSVFKDGSPILRDMAFSINQLYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALHN 535

  Fly   561 RCTVRSTCQRDTSASRWLSLGSGQQCIEFESIIPEKIPISELSH-LHLIIRTLPEPFNAKYRCVF 624
            .|:.|..|||...|:|:.:  |..||:..| :.|..|.:|:.|. |.|::...|. .:....|.|
Mouse   536 MCSRRDKCQRAWEANRFAA--SISQCMSLE-VHPNSISVSDHSRLLSLVVNDAPN-LSEGIACAF 596

  Fly   625 GNSTPIDAEILENGLGCATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSRNFAFFDCSHHGN 689
            ||.|.::.::..:.:.|.:|...:.|:||.:.|...:.|.:||.||.|.|||..|.|::||.|..
Mouse   597 GNLTEVEGQVSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVSTEFKFYNCSAHQL 661

  Fly   690 CQECLQSSWGCNWCIFDNKCVHKSLQCRNIENAVSTVGHCPHLKKNRPEILLPVRVPIEIRLEIE 754
            |..|:.|::.|:||.:.|.|.|....|...|..::....||.|.... |||:||.....|.|:..
Mouse   662 CLSCVNSAFRCHWCKYRNLCTHDPTTCSFQEGRINVSEDCPQLVPTE-EILIPVGEVKPITLKAR 725

  Fly   755 NLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKTPYFYE-INTHEYQAKVVVTWNFQHY 818
            |||:|:|...|:.|.:.|:.|...:||...::..|.|:.:.|.|: ::.........|.||....
Mouse   726 NLPQPQSGQRGYECVLSIQGAVHRVPALRFNSSSVQCQNSSYQYDGMDISNLAVDFAVVWNGNFI 790

  Fly   819 VDT---AIVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWCSNS--CVYNETCIADKNSISSGSK 878
            :|.   ..|.||||   .:.||  .|.||:..|.|::|.|||..  |..::.|.:..:.....|.
Mouse   791 IDNPQDLKVHLYKC---AAQRE--SCGLCLKADHKFECGWCSGERRCTLHQHCPSTSSPWLDWSS 850

  Fly   879 SAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIFIGSVPCE--LENYQISVK 941
            ..:  :|..|:|..|..:|||.||||.:||.|.|||:...::...:.:..|||.  ...|.|:.:
Mouse   851 HNV--KCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAGVPCTPIPGEYIIAEQ 913

  Fly   942 IECRTG-ASLYEMSAPIKV----ANDAGFTESSVQFHFKNVLLTGLYPTIGPRSGGTQLSLIGKF 1001
            |.|..| |.:...|.|:::    ......|:|..|:.|.|..:..|.|..||.||||.:::.|.:
Mouse   914 IVCEMGHAVIGTTSGPVRLCIGECKPEFMTKSHQQYTFVNPSVLSLSPIRGPESGGTMVTITGHY 978

  Fly  1002 LNIGSTMRAFLDEYECHIDVTQASSSQVSCTTSEATQPEPIRSLHLVIDGANRTLECQISTPSIT 1066
            |..||::..:|....|  :....|.:::.|                            :|.||..
Mouse   979 LGAGSSVAVYLGNQTC--EFYGRSMNEIVC----------------------------VSPPSSN 1013

  Fly  1067 NTNPTRSNFGSYQLRSLPRQPCSI------------FNYTQDPRIMQIKPLRSFKSGGRVLTVHG 1119
            ...|.               |.|:            |.|..|||:.:|:|..|..||...||:.|
Mouse  1014 GLGPV---------------PVSVSVDRARVDSSLQFEYIDDPRVQRIEPEWSITSGHTPLTITG 1063

  Fly  1120 IYLNSIQKPELEV-FYDNERVNKTSCVVINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQNSS 1183
            ..|:.||:|.:.| |...|.||  .|.|:|:..:.|.:|.:.                       
Mouse  1064 FNLDVIQEPRVRVKFNGKESVN--VCTVVNTTTLTCLAPSLT----------------------- 1103

  Fly  1184 FQTETRYKNEYDRKKRRADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFVMDN 1248
                :.|:...|..:|..:||                                       |:.:|
Mouse  1104 ----SDYRPGLDTVERPDEFG---------------------------------------FLFNN 1125

  Fly  1249 VQLVRNLNKYFHDIRSTIVYLADPKYLPFPNDGVKLYK---------GDSLVIEGELLNLAAD-- 1302
            ||             |.::| .|.|::.:||...:|..         |..::::|:.|...|.  
Mouse  1126 VQ-------------SLLIY-NDTKFIYYPNPTFELLSPTGILDQKPGSPIILKGKNLCPPASGG 1176

  Fly  1303 -EYDVNVTIGTSQCNITSLALNQLLCIPPEQQPLPTDENGVDQSTDLPLVVVKVGRNLRFVIGYL 1366
             :.:..|.||.:.|.:| ::..||||.||             ..|....|:|.|| .:.|..|.:
Mouse  1177 AKLNYTVMIGETPCTVT-VSETQLLCEPP-------------NLTGQHKVMVHVG-GMVFSPGSV 1226

  Fly  1367 KYDLNKPYVFSHALLV--GILTVA----LLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESN 1425
            .       |.|.:||.  .|:::|    ||:::.:||||.::|||.:.:...||:|:||..|||.
Mouse  1227 S-------VISDSLLTLPAIISIAAGGSLLLIIVIIVLIAYKRKSRENDLTLKRLQMQMDNLESR 1284

  Fly  1426 VRSECKQAFAELQTDMTDLTADLESTGIPTLDHVNYIMKVFFPGVSDHPILNSPKFREGSPQTNY 1490
            |..|||:||||||||:.:||:||:.:|||.||:..|.|:|.|||:.|||:|...:. :|:.|.:.
Mouse  1285 VALECKEAFAELQTDINELTSDLDRSGIPYLDYRTYAMRVLFPGIEDHPVLRELEV-QGNGQQHV 1348

  Fly  1491 DAAMVQFEQLIGNKYFLLMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSLLLRL 1555
            :.|:..|.|||.||.|||.||.|||.|| |||:|||.|||||||..|..::||||::||.||..|
Mouse  1349 EKALKLFAQLINNKVFLLTFIRTLELQR-SFSMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDL 1412

  Fly  1556 IDKSLASK-HPQLMLRRTESVVEKMLTNYLAICMYDYLKEYAGSNLFLLFKAIKHQIEKGLVDAI 1619
            |||:|.:| ||:|:|||||||.||||||:.|..::.:|||.||..||:|:.|||.|:|||.:|||
Mouse  1413 IDKNLENKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAI 1477

  Fly  1620 TNDARYSLSEERLLHEQVTHSVVILHILQDDLDE--KVQCRVNDWDTISQVKLKILDAIFKNTPF 1682
            |.:|||||||::|:.:|:.:..:||:.:..|.:.  ::..:|.:.|||:|||.|||||::||.|:
Mouse  1478 TGEARYSLSEDKLIRQQIEYKTLILNCVNPDNENSPEIPVKVLNCDTITQVKEKILDAVYKNVPY 1542

  Fly  1683 SMRPSVNEVDL-------EWRHGRGGHLTLQDEDLTTKTVNGWKRLNTLAHYGVKESAVMSLIAR 1740
            |.||...::||       |||.||...:.|||||:|||....|||||||.||.|.:.:|::|:.:
Mouse  1543 SQRPRAVDMDLATHPFHPEWRQGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPK 1607

  Fly  1741 QNDNYHIPYS---KNQNSAPYHNFYFINNSQSHI-----IINNDIESGLQQPRVYHLVKPNIPDH 1797
            |..:|:||.|   ...:.:.|.:.:....|...:     :|..|:|||:   :|:||||    :|
Mouse  1608 QTSSYNIPASASISRTSISRYDSSFRYTGSPDSLRSRVPMITPDLESGV---KVWHLVK----NH 1665

  Fly  1798 YMNIKNSVLSGGSPAFQSHVVNNCNDRVNKTIPEVYLTRLLATKGTIQKFVDDFFSIILTV---N 1859
                             .|......||.:|.:.|:|||||||||||:||||||.|..:.:.   .
Mouse  1666 -----------------DHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETLFSTVHRG 1713

  Fly  1860 EELPPAVKWLFDLLDEAARRHDIADTDIVHAWKSNCLPLRFWVNFIKNPDFIFDVNKTYSVDSCL 1924
            ..||.|:|::||.|||.|.||.|.|||:.|.|||||||||||||.||||.|:||::|....|:||
Mouse  1714 SALPLAIKYMFDFLDEQADRHSIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKGSITDACL 1778

  Fly  1925 SVIAQTFMDACSTSEHRLGKDSPSNKLLFAKDIPNYRIMVKEFYRDVSRLPQISDQEMSTAMQQL 1989
            ||:||||||:||||||||||||||||||:|||||:|:..|:.:|.|:::||.||||:|:..:.:.
Mouse  1779 SVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKNWVERYYADIAKLPAISDQDMNAYLAEQ 1843

  Fly  1990 SVRQNEEFDTISALKELYIYITKYKDQIMESLETDINCRKMHLSRKL 2036
            |.....||:.:|||.|:|.|::||.::::.:||.|...|:..|:.|:
Mouse  1844 SRLHATEFNMLSALNEIYSYVSKYSEELIGALEQDEQARRQRLAYKV 1890

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexBNP_001245400.1 Sema_plexin_like 86..534 CDD:200497 130/487 (27%)
PSI 535..586 CDD:279745 22/50 (44%)
PSI 683..730 CDD:214655 14/46 (30%)
PSI 836..877 CDD:214655 13/42 (31%)
IPT_plexin_repeat1 888..976 CDD:238585 31/94 (33%)
IPT_plexin_repeat2 977..1095 CDD:238584 24/129 (19%)
IPT_plexin_repeat3 1097..1211 CDD:238586 29/114 (25%)
Plexin_cytopl 1452..2017 CDD:285529 290/585 (50%)
Plxna2XP_006497303.1 Sema_plexin_A2 38..552 CDD:200533 152/535 (28%)
TIG_plexin 566..654 CDD:375449 28/88 (32%)
PSI 655..702 CDD:366642 14/46 (30%)
TIG_2 708..802 CDD:375492 27/94 (29%)
PSI 806..855 CDD:366642 14/52 (27%)
IPT_plexin_repeat1 858..953 CDD:238585 31/94 (33%)
IPT_plexin_repeat2 954..1037 CDD:238584 23/127 (18%)
IPT_plexin_repeat3 1041..1141 CDD:238586 37/181 (20%)
TIG 1143..1227 CDD:366832 23/98 (23%)
Plexin_cytopl 1311..1870 CDD:369821 290/584 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 54 1.000 Domainoid score I11157
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S4424
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000391
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100269
Panther 1 1.100 - - O PTHR22625
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.760

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