DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PlexB and Plxna1

DIOPT Version :9

Sequence 1:NP_001245400.1 Gene:PlexB / 43766 FlyBaseID:FBgn0025740 Length:2051 Species:Drosophila melanogaster
Sequence 2:NP_032907.1 Gene:Plxna1 / 18844 MGIID:107685 Length:1894 Species:Mus musculus


Alignment Length:2044 Identity:711/2044 - (34%)
Similarity:1064/2044 - (52%) Gaps:291/2044 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 THMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQCH----AGGCPEDIETSLVNNF 148
            ||:........::.||.|:|.||:.||.:|...||||:.|:.:|:    ...||..:.::  :|.
Mouse    50 THLVVHEQTGEVYVGAVNRIYKLSGNLTLLRAHVTGPVEDNEKCYPPPSVQSCPHGLGST--DNV 112

  Fly   149 NKILVVSYAHDGILIACGSIRQGACEIYSLPRF--PATPQFFAVPLAANDENASTYAFVGPARYA 211
            ||:|::.||.:. |:||||..||.|:...|...  ...|........::...|.:.|.|..|...
Mouse   113 NKLLLLDYAANR-LLACGSASQGICQFLRLDDLFKLGEPHHRKEHYLSSVREAGSMAGVLIAGPP 176

  Fly   212 WKEEDILYVGTTFTNVGDYRHDVPAISSRRL----DDLNYAEFSIQQSIINIDVKYRDH------ 266
            .:.:..|:|||......:|   .|.:|||||    :|.:...|..|...::..:|....      
Mouse   177 GQGQAKLFVGTPIDGKSEY---FPTLSSRRLMANEEDADMFGFVYQDEFVSSQLKIPSDTLSKFP 238

  Fly   267 -FLVDYIYGFNSSEYAYFIIVQKKSHLA--DEAG---YVTRLARICITDPNYDSYTEITVQCTAT 325
             |.:.|:|.|.|.::.|::.:|..:.|.  |.||   :.:::.|:|:.||.:.||.|..:.|  .
Mouse   239 AFDIYYVYSFRSEQFVYYLTLQLDTQLTSPDAAGEHFFTSKIVRLCVNDPKFYSYVEFPIGC--E 301

  Fly   326 ENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVFSPSREISNQPESKSAMCIYSIKDIEDM 390
            :..|:|.:|:||.::.....||:::|:.:|:.||.|||:..::...:|..:||:|:::::.|::.
Mouse   302 QAGVEYRLVQDAYLSRPGQALAKQLGLAEDEEVLFTVFAQGQKNRVKPPKESALCLFTLRAIKEK 366

  Fly   391 FIENIHLCFNGTTK-------DRNLGYISG--TINDGRCPIVGSLGNIYNFCSVGLKISGVSPIT 446
            ..|.|..|:.|..|       ::.||.|:.  .|:|..|      |..:|     ..:.|...|.
Mouse   367 IKERIQSCYRGEGKLSLPWLLNKELGCINSPLQIDDDFC------GQDFN-----QPLGGTVTIE 420

  Fly   447 AHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLL-----SGQSPGEYEEIVVDAGNR 506
            ...||......:|:|.|...  |..::.|.||..|.|:|:|:     ||:....||.:|...||.
Mouse   421 GTPLFVDKEDGLTAVAAYDY--QGRTVVFAGTRSGRIRKILVDLANPSGRPALAYESVVAQEGNP 483

  Fly   507 ILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTNCSACLESRDPFCGWCSLEKRCTVRSTCQRD 571
            ||.:.::||.:.:||.::::::|::.:|.|..||:|..||.||||.||||.|...|:.:..|:|.
Mouse   484 ILRDLVLSPNRQYLYAMTEKQVTQVPVE
SCVQYTSCELCLGSRDPHCGWCVLHSICSRQDACERA 548

  Fly   572 TSASRWLSLGSGQQCIEFESIIPEKIPISELSHLHLIIRTLPEP-FNAKYRCVFGNSTPIDAEIL 635
            ....|:.|  ...||::. ::.|..:.:: :|.:.|:::....| .:|...|.|.:.|..:: ||
Mouse   549 EEPQRFAS--DLLQCVQL-TVQPRNVSVT-MSQVPLVLQAWNVPDLSAGVNCSFEDFTETES-IL 608

  Fly   636 ENG-LGCATPPLDE-RPLIPTNTDHILVPLSVRSSETNKDFVSRNFAFFDCSHHGNCQECLQSSW 698
            |:| :.|.:|...| .|:.....|..:|.|.::|.||.|.|.|.:|.|::||.|.:|..|:..|:
Mouse   609 EDGRIHCHSPSAREVAPITQGQGDQRVVKLYLKSKETGKKFASVDFVFYNCSVHQSCLACVNGSF 673

  Fly   699 GCNWCIFDNKCVHKSLQCRNIENAVSTVGHCPHLKKNRPEILLPVRVPIEIRLEIENLPKPKSAH 763
            .|:||.:.:.|.:.:..|..:|..|:....||.:..: ..|.:||.|...|.|...|||:|:|..
Mouse   674 PCHWCKYRHVCTNNAADCAFLEGRVNMSEDCPQILPS-THIYVPVGVVKPITLAARNLPQPQSGQ 737

  Fly   764 AGFLCTIHIEAAQMLLPAHVESNKIVVCEKTPYFYEIN-THEYQAKVVVTWNFQHYVD---TAIV 824
            .|:.|..||..:...:.|...::..:.|:.:.|.||.| ..:....:.|.||....:|   ....
Mouse   738 RGYECLFHIPGSPARVTALRFNSSSLQCQNSSYSYEGNDVSDLPVNLSVVWNGNFVIDNPQNIQA 802

  Fly   825 TLYKCDVLGSHREHPDCSLCVTRDPKYKCAWC--SNSCVYNETCIADKNS----ISSGSKSAIEN 883
            .||||..|     ...|.||:..||:::|.||  ...|.....|.||..:    ...||     :
Mouse   803 HLYKCPAL-----RQSCGLCLKADPRFECGWCVAERRCSLRHHCPADSPASWMHAHHGS-----S 857

  Fly   884 ECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIFIGSVPCE-LENYQISV-KIECRT 946
            .|..|:|..:.|.:||.:|||.:||.|.|||:|.||||..:.:|.|.|. :|:..||. :|.|..
Mouse   858 RCTDPKILKLSPETGPRQGGTRLTITGENLGLRFEDVRLGVHVGKVLCSPVESEYISAEQIVCEI 922

  Fly   947 G--ASLYEMSAPIKV-ANDAGF---TESSVQFHFKNVLLTGLYPTIGPRSGGTQLSLIGKFLNIG 1005
            |  ::|....|.::| ..|...   ..|..:|.|.......:.|:.||.||||.:.:.|..||.|
Mouse   923 GDASTLRAHDALVEVCVRDCSLHYRALSPKRFTFVTPTFYRVSPSRGPLSGGTWIGIEGSHLNAG 987

  Fly  1006 STMRAFLDEYECHIDVTQASSSQVSCTTSEATQPEPIRSLHLVIDGANRTLECQISTPSITNTNP 1070
            |.:...:....|  ..:..:|.::.|.|.....|   .|..:||: .||   .|:|.|.:.    
Mouse   988 SDVAVSIGGRPC--SFSWRNSREIRCLTPPGHTP---GSAPIVIN-INR---AQLSNPEVK---- 1039

  Fly  1071 TRSNFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSIQKPELEVFYD 1135
                                :|||:||.|::|.|..|..|||.:|||.|..|.::::|.:...|.
Mouse  1040 --------------------YNYTEDPTILRIDPEWSINSGGTLLTVTGTNLATVREPRIRAKYG 1084

  Fly  1136 N-ERVNKTSCVVINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQNSSFQTETRYKNEYDRKKR 1199
            . ||.|  ||:|.|...|.|.:|.:                                   |..||
Mouse  1085 GIEREN--SCMVYNDTTMVCRAPSI-----------------------------------DNPKR 1112

  Fly  1200 -------RADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFVMDNVQLVRNLNK 1257
                   |.|                                      ::.|:||||:.:..||.
Mouse  1113 SPPELGERPD--------------------------------------EIGFIMDNVRTLLVLNS 1139

  Fly  1258 YFHDIRSTIVYLADPKYLPF-PNDGVKLYKGDSLVIEG-ELLNLAADEYDVNVT--IGTSQCNIT 1318
                  |:.:|..||...|. |...::|.....|:::| .||..|.....:|.|  ||::.| |.
Mouse  1140 ------SSFLYYPDPVLEPLSPTGLLELKPSSPLILKGRNLLPPAPGNSRLNYTVLIGSTPC-IL 1197

  Fly  1319 SLALNQLLCIPPEQQPLPTDENGVDQSTDLPLVVVKVGRNLRFVIGYLKYDLNKPYVFSHALLV- 1382
            :::..||||..|             ..|....|.|:.| ...|..|.|:       |:|.:||. 
Mouse  1198 TVSETQLLCEAP-------------NLTGQHKVTVRAG-GFEFSPGMLQ-------VYSDSLLTL 1241

  Fly  1383 -GILTV----ALLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESNVRSECKQAFAELQTDMT 1442
             .|:.:    .||::|.|.|||.::|||..|:|..||:|:||..|||.|..|||:||||||||:.
Mouse  1242 PAIVGIGGGGGLLLLVIVAVLIAYKRKSRDADRTLKRLQLQMDNLESRVALECKEAFAELQTDIH 1306

  Fly  1443 DLTADLESTGIPTLDHVNYIMKVFFPGVSDHPILNSPKFREGSPQTNYDAAMVQFEQLIGNKYFL 1507
            :||:||:..|||.||:..|.|:|.|||:.|||:|     :|...|.|.:.::..|.||:..|:||
Mouse  1307 ELTSDLDGAGIPFLDYRTYAMRVLFPGIEDHPVL-----KEMEVQANVEKSLTLFGQLLTKKHFL 1366

  Fly  1508 LMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSLLLRLIDKSLASK-HPQLMLRR 1571
            |.||.|||||| |||:|||.|||||||..|..:|||||.:||.||..||:|:|.|| ||:|:|||
Mouse  1367 LTFIRTLEAQR-SFSMRDRGNVASLIMTALQGEMEYATGVLKQLLSDLIEKNLESKNHPKLLLRR 1430

  Fly  1572 TESVVEKMLTNYLAICMYDYLKEYAGSNLFLLFKAIKHQIEKGLVDAITNDARYSLSEERLLHEQ 1636
            ||||.||||||:....:|.:|||.||..||:|:.|||.|:|||.:||||.:|||||||::|:.:|
Mouse  1431 TESVAEKMLTNWFTFLLYKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQ 1495

  Fly  1637 VTHSVVILHILQDDLDEKVQCRVN--DWDTISQVKLKILDAIFKNTPFSMRPSVNEVDLEWRHGR 1699
            :.:..:.|:.:..:.:...:..|.  :.||::|||.|:|||::|..|:|.||...::|||||.||
Mouse  1496 IDYKTLTLNCVNPEHENAPEVPVKGLNCDTVTQVKEKLLDAVYKGVPYSQRPKAGDMDLEWRQGR 1560

  Fly  1700 GGHLTLQDEDLTTKTVNGWKRLNTLAHYGVKESAVMSLIARQNDNYHIPYSK--NQNSAPYHNFY 1762
            ...:.|||||:|||..|.||||||||||.|.:.:.::|:.:|...|:|..|.  .::.:.|.:..
Mouse  1561 MARIILQDEDVTTKIDNDWKRLNTLAHYQVTDGSSVALVPKQTSAYNISNSSTFTKSLSRYESML 1625

  Fly  1763 FINNSQSHI-----IINNDIESGLQQPRVYHLVKPNIPDHYMNIKNSVLSGGSPAFQSHVVNNCN 1822
            ...:|...:     :|..|:|||   .:::||||    :|                 .|:.....
Mouse  1626 RTASSPDSLRSRTPMITPDLESG---TKLWHLVK----NH-----------------DHLDQREG 1666

  Fly  1823 DRVNKTIPEVYLTRLLATKGTIQKFVDDFFSIILTV---NEELPPAVKWLFDLLDEAARRHDIAD 1884
            ||.:|.:.|:|||||||||||:||||||.|..|.:.   ...||.|:|::||.|||.|.:|.|.|
Mouse  1667 DRGSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHQIHD 1731

  Fly  1885 TDIVHAWKSNCLPLRFWVNFIKNPDFIFDVNKTYSVDSCLSVIAQTFMDACSTSEHRLGKDSPSN 1949
            :|:.|.|||||||||||||.||||.|:||::|....|:||||:||||||:||||||:||||||||
Mouse  1732 SDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHKLGKDSPSN 1796

  Fly  1950 KLLFAKDIPNYRIMVKEFYRDVSRLPQISDQEMSTAMQQLSVRQNEEFDTISALKELYIYITKYK 2014
            |||:|||||||:..|:.:|.|::::|.||||:||..:.:.|.....:|:::|||.|:|.||.|||
Mouse  1797 KLLYAKDIPNYKSWVERYYADIAKMPAISDQDMSAYLAEQSRLHLSQFNSMSALHEIYSYIAKYK 1861

  Fly  2015 DQIMESLETDINCRKMHLSRKLGNVAATL 2043
            |:|:.:||.|...|:..|..||..|..|:
Mouse  1862 DEILVALEKDEQARRQRLRSKLEQVVDTM 1890

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexBNP_001245400.1 Sema_plexin_like 86..534 CDD:200497 134/481 (28%)
PSI 535..586 CDD:279745 20/50 (40%)
PSI 683..730 CDD:214655 13/46 (28%)
PSI 836..877 CDD:214655 12/46 (26%)
IPT_plexin_repeat1 888..976 CDD:238585 35/95 (37%)
IPT_plexin_repeat2 977..1095 CDD:238584 27/117 (23%)
IPT_plexin_repeat3 1097..1211 CDD:238586 30/121 (25%)
Plexin_cytopl 1452..2017 CDD:285529 285/577 (49%)
Plxna1NP_032907.1 Sema_plexin_A1 36..511 CDD:200532 134/481 (28%)
PSI 512..>554 CDD:279745 18/41 (44%)
PSI 658..705 CDD:279745 13/46 (28%)
PSI 809..860 CDD:279745 15/60 (25%)
IPT_plexin_repeat1 862..958 CDD:238585 35/95 (37%)
IPT_plexin_repeat2 959..1044 CDD:238584 27/117 (23%)
IPT_plexin_repeat3 1046..1146 CDD:238586 39/180 (22%)
TIG 1148..1232 CDD:280079 26/98 (27%)
Plexin_cytopl 1316..1864 CDD:285529 285/577 (49%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 54 1.000 Domainoid score I11157
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D56043at33208
OrthoFinder 1 1.000 - - FOG0000391
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100269
Panther 1 1.100 - - O PTHR22625
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.820

Return to query results.
Submit another query.