DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PlexB and Met

DIOPT Version :9

Sequence 1:NP_001245400.1 Gene:PlexB / 43766 FlyBaseID:FBgn0025740 Length:2051 Species:Drosophila melanogaster
Sequence 2:NP_032617.2 Gene:Met / 17295 MGIID:96969 Length:1379 Species:Mus musculus


Alignment Length:1758 Identity:328/1758 - (18%)
Similarity:582/1758 - (33%) Gaps:699/1758 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    99 LFAGATNKILKLNE-NLRVLAEAVTGPLHDSPQC-----------HAGGCPEDIETSLVNNFNKI 151
            ::.||||.|..||: :|:.::|..|||:.:.|.|           .:||..:|       |.|..
Mouse    62 IYLGATNYIYVLNDKDLQKVSEFKTGPVLEHPDCLPCRDCSSKANSSGGVWKD-------NINMA 119

  Fly   152 LVVSYAHDGILIACGSIRQGACEIYSLPRFPATPQFFAVPLAANDENASTYAFVGP--------- 207
            |:|...:|..||:|||:.:|.|:.:.||           |..:.|..:..:....|         
Mouse   120 LLVDTYYDDQLISCGSVNRGTCQRHVLP-----------PDNSADIQSEVHCMFSPEEESGQCPD 173

  Fly   208 -------ARYAWKEED---ILYVGTTFTNVGDYRHDVPAISSRRLDDLNYA-EFSIQQSIINIDV 261
                   |:....|:|   ..:||.|..:.....:.:.:||.|||.:.... :|...||.|::..
Mouse   174 CVVSALGAKVLLSEKDRFINFFVGNTINSSYPPGYSLHSISVRRLKETQDGFKFLTDQSYIDVLP 238

  Fly   262 KYRDHFLVDYIYGFNSSEYAYFIIVQKKSHLADEAGYVTRLARICITDPNYDSYTEITVQCTATE 326
            :::|.:.:.||:.|.|:.:.||:.|||::  .|...:.||:.|.|..|....||.|:.::|..||
Mouse   239 EFQDSYPIKYIHAFESNHFIYFLTVQKET--LDAQTFHTRIIRFCSVDSGLHSYMEMPLECILTE 301

  Fly   327 NNVD-------YNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVFSPSREISNQPESKSAMCIYSI 384
            ....       :||::.|.|:.....||:::|....|.:|..||:.|:..|.:|.::||:|.:.|
Mouse   302 KRRKRSTREEVFNILQAAYVSKPGANLAKQIGASPSDDILFGVFAQSKPDSAEPVNRSAVCAFPI 366

  Fly   385 KDIEDMFIE----------------NIHLCFNGTTKDRNLGYISGTINDGRCPIVGSLGNIYNFC 433
            |.:.|.|.:                |...|||.|.. ||........::.|.....:|..:..| 
Mouse   367 KYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLL-RNSSGCEARSDEYRTEFTTALQRVDLF- 429

  Fly   434 SVGLKISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLSGQSPGEYEE 498
                            :...:.|.:||::.....|.  ::|.|||:.|...:|:||         
Mouse   430 ----------------MGRLNQVLLTSISTFIKGDL--TIANLGTSEGRFMQVVLS--------- 467

  Fly   499 IVVDAGNRILPNTMMSPKKDFLYVLSQRKIT-KLRIEHCSVYTNCSACLESRDPFCGWCSLEKRC 562
                      ....::|..:||  |....:: ::.:||.|.....:..:..           |:.
Mouse   468 ----------RTAHLTPHVNFL--LDSHPVSPEVIVEHPSNQNGYTLVVTG-----------KKI 509

  Fly   563 TVRSTCQRDTSASRWLSLGSGQQCIEFESIIPEKIPISELSHLHLIIRTLPEPFNAKYRCVFGNS 627
            |                                |||:                            
Mouse   510 T--------------------------------KIPL---------------------------- 514

  Fly   628 TPIDAEILENGLGCATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSRNFAFFDCSHHGNCQE 692
                     ||||                                           |.|..:|.:
Mouse   515 ---------NGLG-------------------------------------------CGHFQSCSQ 527

  Fly   693 CLQSSWGCNWCIFDNKCVHKSLQCRNIENAVSTVGHCPHLKKNRPEILLPVRVPIEIRLEIENLP 757
            ||.:                                                             
Mouse   528 CLSA------------------------------------------------------------- 531

  Fly   758 KPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKTPYFYEINTHEYQAKVVVTWNFQHYVDTA 822
                                                 |||.:                       
Mouse   532 -------------------------------------PYFIQ----------------------- 536

  Fly   823 IVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWCSNSCVYNETCIADKNSISSGSKSAIENECPL 887
                                          |.||.|.||..:.|       .||:.:   .|..|
Mouse   537 ------------------------------CGWCHNQCVRFDEC-------PSGTWT---QEICL 561

  Fly   888 PRIDIIKPLSGPVEGGTLITIEGSNLGIREE---DVR-GKIFIGSVPCELENYQISVK-IECRTG 947
            |.:..:.|.|.|:||||::||.|.:.|.|:.   |:| .|:.:|:..|.|...:.:.. ::|..|
Mouse   562 PAVYKVFPTSAPLEGGTVLTICGWDFGFRKNNKFDLRKTKVLLGNESCTLTLSESTTNTLKCTVG 626

  Fly   948 ASLYE-MSAPIKVANDAGFTESSVQFHFKNVLLTGLYPTIGPRSGGTQLSLIGKFLNIGSTMRAF 1011
            .::.| .:..:.::|....|:.|. |.:.:.::|.:.|..||::|||.|:|.||:||.|::....
Mouse   627 PAMSEHFNVSVIISNSRETTQYSA-FSYVDPVITSISPRYGPQAGGTLLTLTGKYLNSGNSRHIS 690

  Fly  1012 LDEYECHIDVTQASSSQVSC-TTSEATQPE-PIRSLHLVIDGANRTLECQISTPSITNTNPTRSN 1074
            :....|  .:...|.|.:.| |.::.|..| |::   |.||.|||                    
Mouse   691 IGGKTC--TLKSVSDSILECYTPAQTTSDEFPVK---LKIDLANR-------------------- 730

  Fly  1075 FGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSIQKPELEVFYDNERV 1139
                        ..|.|:|.:||.:.:|.|.:||.|||..:|..|..|||:..|:|.:......|
Mouse   731 ------------ETSSFSYREDPVVYEIHPTKSFISGGSTITGIGKTLNSVSLPKLVIDVHEVGV 783

  Fly  1140 NKT-SCVVINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQNSSFQTETRYKNEYDRKKRRADF 1203
            |.| :|...:::::.|.:.|          :.:::..:|.|:..:|                   
Mouse   784 NYTVACQHRSNSEIICCTTP----------SLKQLGLQLPLKTKAF------------------- 819

  Fly  1204 GDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFVMDNVQLVRNLNKYFHDIRSTIVY 1268
                                                    |::|.:     |:|:|     .:.|
Mouse   820 ----------------------------------------FLLDGI-----LSKHF-----DLTY 834

  Fly  1269 LADPKYLPFP--------NDGVKLYKGDSL---VIEGELLNLAADEYDVNVTIGTSQCNITSLAL 1322
            :.:|.:.||.        |:.|...||:::   .::||:|.           :|...|.......
Mouse   835 VHNPVFEPFEKPVMISIGNENVVEIKGNNIDPEAVKGEVLK-----------VGNQSCESLHWHS 888

  Fly  1323 NQLLCIPPEQQPLPTDENGVD-----QSTDLPLVVVKVGRNLRFVIGYLKYDLNKPYVFSHALLV 1382
            ..:||..|........|..::     .||.|..|:|:..:|..                  .|::
Mouse   889 GAVLCTVPSDLLKLNSELNIEWKQAVSSTVLGKVIVQPDQNFA------------------GLII 935

  Fly  1383 GILTVALLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESNVRSECKQAFAELQ-----TDM- 1441
            |.:::: :||:.:..|.::.||     |::|.:..:::..::.|.:.........:     |:| 
Mouse   936 GAVSIS-VVVLLLSGLFLWMRK-----RKHKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMV 994

  Fly  1442 ----TDLTADLESTGIPTLDHVNYIMKVFFPGVSDHPILNSPKFREGSP----QTNYD------- 1491
                .|..|.......|.........:|.:|.....|||.|......||    ..:.|       
Mouse   995 SNESVDYRATFPEDQFPNSSQNGACRQVQYPLTDLSPILTSGDSDISSPLLQNTVHIDLSALNPE 1059

  Fly  1492 -------------AAMVQFEQLIGNKYFLLMFIETL---EAQRSSFSIRDRVNVASLIMVVLMNK 1540
                         :.:|.|.::||..:|..::..||   :.::...:::.            :|:
Mouse  1060 LVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKS------------LNR 1112

  Fly  1541 MEYATEILKSLLLRLIDKSLASKHPQLMLRRTESVVEKMLTNYLAICMYDYLKEYAGSNLFLLFK 1605
            :....|:.:.|...:|.|..:  ||.::             :.|.||:     ...||.|.:| .
Mouse  1113 ITDIEEVSQFLTEGIIMKDFS--HPNVL-------------SLLGICL-----RSEGSPLVVL-P 1156

  Fly  1606 AIKH------------------------QIEKGLVDAITNDARYSLSEERLLHEQVTHSVVILHI 1646
            .:||                        |:.||:        :| |:.::.:|..:.....:   
Mouse  1157 YMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGM--------KY-LASKKFVHRDLAARNCM--- 1209

  Fly  1647 LQDDLDEKVQCRVNDWDTISQVKLKILDAIFKNTPFSMRPSVNEVDLEWRHGRGGHLTLQDEDLT 1711
                ||||...:|.|:.....:..|...::...|  ..:..|..:.||         :||.:..|
Mouse  1210 ----LDEKFTVKVADFGLARDMYDKEYYSVHNKT--GAKLPVKWMALE---------SLQTQKFT 1259

  Fly  1712 TKT 1714
            ||:
Mouse  1260 TKS 1262

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexBNP_001245400.1 Sema_plexin_like 86..534 CDD:200497 118/490 (24%)
PSI 535..586 CDD:279745 4/50 (8%)
PSI 683..730 CDD:214655 5/46 (11%)
PSI 836..877 CDD:214655 8/40 (20%)
IPT_plexin_repeat1 888..976 CDD:238585 26/93 (28%)
IPT_plexin_repeat2 977..1095 CDD:238584 31/119 (26%)
IPT_plexin_repeat3 1097..1211 CDD:238586 24/114 (21%)
Plexin_cytopl 1452..2017 CDD:285529 55/314 (18%)
MetNP_032617.2 Sema 25..515 CDD:387663 126/593 (21%)
PSI 518..560 CDD:214655 19/245 (8%)
IPT_plexin_repeat1 562..655 CDD:238585 26/93 (28%)
IPT_plexin_repeat2 656..739 CDD:238584 31/119 (26%)
IPT 741..836 CDD:387656 30/173 (17%)
IPT_PCSR 838..917 CDD:238337 16/89 (18%)
PTKc_Met_Ron 1080..1341 CDD:270649 43/243 (18%)
Interaction with RANBP9. /evidence=ECO:0000250 1210..1379 16/64 (25%)
Interaction with MUC20. /evidence=ECO:0000250 1318..1357
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 47 1.000 Domainoid score I11936
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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