Protein Alignment PlexB and Plxnb3

DIOPT Version :10

• Sequence 1: NP_524616.2
• Gene: PlexB / 43766
• FlyBaseID: FBgn0025740
• Length: 2051
• Species: Drosophila melanogaster
• Sequence 2: NP_062533.2
• Gene: Plxnb3 / 140571
• MGIID: 2154240
• Length: 1902
• Species: Mus musculus
• Alignment Length: 2070
• Identity: 657/2070 - (31%)
• Similarity: 1032/2070 - (49%)
• Gaps: 313/2070 - (15%)

  Fly    79 RDSQSKNYFTHMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQC----HAGGCPED 139
            |.|.....|.|:........|:.||.|.:.:|:..|::.:.|||||:.|||.|    ....||
Mouse    36 RFSVPNTSFNHLVLAPDQGKLYVGAVNHLFQLSPELKMESVAVTGPVIDSPDCVPFRDLAECP-- 98

  Fly   140 IETSLVNNFNKILVVSYAHDGILIACGSIRQGACE----------IYSLPRFPATPQFFAVPLAA 194
             :..|.:|.|::|:|| :....|:|||.::||.||          :|. ...|...||    :||
Mouse    99 -QAQLTDNANQLLLVS-SRTQELVACGQVKQGVCEKRRLGDVTQVLYQ-AEDPGDGQF----VAA 156

  Fly   195 NDENASTYAFVGPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRL-DDLNYAEFSIQQSIIN 258
            |....:|...|.|.    ...|:|.|....  .|.....||.::.|:| ....::...:.:.::.
Mouse   157 NTLGVTTVGLVVPL----PGRDLLLVARGL--AGKLSAGVPPLTVRQLAGPQPFSSEGLGRLVVG 215

  Fly   259 IDVKYRDHFLVDYIYGFNSSEYAYFIIVQKKSHLADEAGYVTRLARICITDPNYDSYTEITVQCT 323
            ....|.:    .|:..|:.:..|||:..::.:....|  |.:.:||:|:.|.|..||.|:.:.|.
Mouse   216 DFSDYNN----SYVGAFSDAHSAYFVFRRRGARAQTE--YRSYVARVCLRDVNLYSYVEMPLTCH 274

  Fly   324 ATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVFSPSREISNQPESKSAMCIYSIKDIE 388
            .      ..:::.|.:||               ..|:..||     :...::::|:|.:.:.|::
Mouse   275 G------QGLIQAAFLTP---------------DTLLGAFS-----AGTSQAQAALCAFPLADLD 313

  Fly   389 DMFIENIHLCFNGTTKDRN-LGYISGTINDG---RC-------PIVGSLGNIYNFCSVGLKISGV 442
            ....:...||:  ||..:. .|....|:..|   ||       |.....|:.:    ....|:|.
Mouse   314 RSMEQARRLCY--TTGGQGPSGMEEATVEYGVTSRCVTLPPDSPESYPCGDEH----TPSPIAGR 372

  Fly   443 SPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLSGQSPGE--YEEIVVDAGN 505
            .|:.|..|..... |:::|.|..|  ..|::||||...|.:.||.|: .|.|:  :.:.|...|:
Mouse   373 QPLEAQPLLQLGQ-SISAVAALQT--DGHTIAFLGDTQGQLHKVFLN-SSHGQVYHSQQVGPPGS 433

  Fly   506 RILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTNCSACLESRDPFCGWCSLEKRCTVRSTCQR 570
            .|.|:.::....|.||||:.:::.::.:..|..:.||:.||::|||.||||.|:.|||.|..|.|
Mouse   434 AISPDLLVDSNGDHLYVLTAQQVDRILVAACPQFPNCTTCLQARDPLCGWCILQGRCTRRGECGR 498

  Fly   571 DTSASRWLSLGSGQQCIEFESIIPEKIPISELSHLHLIIRTLPE-PFNAKYRCVFGNSTPIDAEI 634
            ....:.||.......|...:|::|.:.|..|...:.|.:..||. ..:..:.|.||....: |::
Mouse   499 AAQPNHWLWSYEDNHCPYIQSLLPAQHPRQEQGQIILSVPRLPTLAMDEYFHCAFGGYNSL-AQV 562

  Fly   635 LENGLGCATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSRNFAFFDCSH------HGNCQEC 693
            .|..:.|.|||.|:.|..|..:||:.:||::...:.  ...:..|:|:|||.      ...|:.|
Mouse   563 EEPHVVCTTPPQDQMPPNPPGSDHVTLPLALMFEDV--VLTATTFSFYDCSAVQALEVAAPCRAC 625

  Fly   694 LQSSWGCNWCIFDNKCVHKSLQCRNIENAVSTVGH----------CPHLKKNRPEILLPVRVPIE 748
            :.|.|.|:||...:.|::.. .|...|.||.:...          ||.::......|:||.....
Mouse   626 VSSLWRCHWCPQSSHCIYGE-HCPEGEKAVYSAQEVDILVRGPEACPQVEGLASPQLVPVGWESH 689

  Fly   749 IRLEIENLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNK----IVVCEKTPYFYEINTHEYQAKV 809
            :.|.|:||...:...|.:.|.:.:......|||.:|...    ::.|:...::..::..|....:
Mouse   690 VTLHIQNLHYFQGLPALYHCWLELPGKLQKLPASLEETSRDSGLIHCQAQQFYPSMSQWELPVPI 754

  Fly   810 VVTWNFQHYVDTA---IVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWCSN---SCVYNETCIA 868
            .||......:|.|   .||||.| .:|    |||||.|...:....|.||.:   :|.|...|
Mouse   755 YVTRGEIQRLDNAGDLHVTLYDC-AMG----HPDCSHCQAANGSLSCLWCGDGQPACRYGPLC-- 812

  Fly   869 DKNSISSGSKSAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIFIGSVPCEL 933
                    ...|:|..||:|.||:|:||:||.|||..|||.|||||....|||..:.:...||..
Mouse   813 --------PPGAVEQLCPIPSIDVIEPLTGPPEGGLAITILGSNLGQAFNDVRNAVTVAGQPCNP 869

  Fly   934 EN--YQISVKIECRTGASLYEMSAPIKVA---NDAGFTESSVQFHFKNVLLTGLYPTIGPRSGGT 993
            :.  |:||.:|.|.|..:....:.|::||   ...|.  |:..|.:::.:|..|.|..||::|||
Mouse   870 DPSLYRISARIVCVTSPAPNGTAGPVQVAIKSRPPGI--STQNFTYQDPVLLSLNPQWGPQAGGT 932

  Fly   994 QLSLIGKFLNIGSTMRAFLDEYECHIDVTQASSSQVSCTTSEATQPEPIRSLHLVIDG-ANRTLE 1057
            ||::.|::|..|..:..|:.:..|.|. .......:.|.|  ..|.||..::.|::.| ..|.|
Mouse   933 QLTIHGQYLQTGGNISVFVGDQPCPIQ-EPVCPEAIICHT--MPQTEPGEAVVLIVFGHVERKL- 993

  Fly  1058 CQISTPSITNTNPTRSNFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYL 1122
              ::||                           |.||.:|::::.:|..||:.||||:.|.|..|
Mouse   994 --LTTP---------------------------FRYTANPQLVEAEPSVSFRGGGRVIRVRGTGL 1029

  Fly  1123 NSIQKPELEVFYDNE-RVNKTSCVVINSN-QMECPSPPVNYKFETFKKTNRKMDTE--LHLQNSS 1183
            :.:.:|.|.|:.::| :|........::| :..|.:|..              |.:  :||::..
Mouse  1030 DVVWQPLLSVWLEDEPKVKALGVQAQDANPRRSCGAPAA--------------DPQACIHLESGL 1080

  Fly  1184 FQTETRYKNEYDRKKRRADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFVMDN 1248
            .|..|                     ..:..||:....::       ..|.:..|..::.|.:||
Mouse  1081 LQCST---------------------LCSVNSSSLLLCHS-------PAVPDGALPKRVFFALDN 1117

  Fly  1249 VQLVRNLNKYFHDIRST-----IVYLADPKYLPFPNDGV----KLYKGDSLVIEGELLNLAADEY 1304
            :|:         |..|.     .:|..:|:..|..::|:    .|..|..|.:|||.|||...:.
Mouse  1118 MQV---------DFASASGGQGFLYQPNPRLAPLSHEGITHPYHLKPGHVLDVEGEGLNLGISKE 1173

  Fly  1305 DVNVTIGTSQCNITSLALNQLLCIPPEQQPLPTDENGVDQSTDLPLVVVKVGRNLRFVIGYLKYD 1369
            :|.|.||..:|.:.:|.|..|.|.||.|.|.||:.:|.     ||..||::| |||..:|.::|:
Mouse  1174 EVQVHIGDGECLVKTLTLTHLYCEPPPQAPQPTNGSGT-----LPQFVVQMG-NLRLALGPVQYE 1232

  Fly  1370 LNKPY-VFSHALLVGI-LTVALLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESNVRSECKQ 1432
            ..... .|.....:|: :..|:|:...:::.:::|.||.:|.|:|:::.:|:..||:.|..:|::
Mouse  1233 AESMMSTFPVEAQLGLGMGAAVLIAAVLLLTLMYRHKSKKALRDYQKVLVQLENLETGVGDQCRK 1297

  Fly  1433 AFAELQTDMTDLTADLESTGIPTLDHVNYIMKVFFPGVSDHPIL----------NSPKFREGSPQ 1487
            .|.:|.|:|||||:|||::|||.||:..|..:.||||....|:.          .|...|:|
Mouse  1298 EFTDLMTEMTDLTSDLEASGIPFLDYRTYAERAFFPGHVGCPLQPGLEGLGEEGRSVTVRQG--- 1359

  Fly  1488 TNYDAAMVQFEQLIGNKYFLLMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSLL 1552
                  :.|...|:.:|.|||..|.|||.| .|||.|||.:||||:.:.|.:|:||.|:|:::||
Mouse  1360 ------LTQLSNLLNSKLFLLTLIHTLEEQ-PSFSQRDRCHVASLLSLALHSKLEYLTDIMRTLL 1417

  Fly  1553 LRLIDKSLAS----KHPQLMLRRTESVVEKMLTNYLAICMYDYLKEYAGSNLFLLFKAIKHQIEK 1613
                 ..||:    |:|:|||||||::|||:|||:|:||:|.:|||.||..|::||:|||:|::|
Mouse  1418 -----GDLAAHYVHKNPKLMLRRTETMVEKLLTNWLSICLYTFLKEVAGEPLYMLFRAIKYQVDK 1477

  Fly  1614 GLVDAITNDARYSLSEERLLHEQVT-HSVVILHILQDDLD--------EKVQCRVNDWDTISQVK 1669
            |.|||:|..|:.:|::..||.|.|. ..:.::.::..:.|        .:|..||.|.|||:|||
Mouse  1478 GPVDAVTGKAKRTLNDSHLLREDVEFQPLTLMALVGPEADRAAGNSGVHRVPARVLDTDTITQVK 1542

  Fly  1670 LKILDAIFKNTPFSMRPSVNEVDLEWRHGRGGHLTLQDEDLTTKTVNGWKRLNTLAHYGVKESAV 1734
            .|:||.|:|.||||.||||:.:|||||.|..|||||.|||||:.|.|.|||||||.||.|.:.|.
Mouse  1543 EKVLDQIYKGTPFSQRPSVHSLDLEWRSGLAGHLTLSDEDLTSVTQNHWKRLNTLQHYKVPDGAT 1607

  Fly  1735 MSLIARQNDNYHIPYSKNQNSAPYHNFYFINNSQSHIIINNDIESGLQQPRVYHLVKPNIPDHYM 1799
            :.||.:.::...:..|..|...|        :.::..::.:..|.|:   |::||||........
Mouse  1608 VVLIPQVHNGGTVSQSLGQTGCP--------SGENTPMLEDGEEGGV---RLWHLVKATEEAEGA 1661

  Fly  1800 NIKNSVLSGGSPAFQSHVVNNCNDRVN-----KTIPEVYLTRLLATKGTIQKFVDDFFSIILTVN 1859
            .::.|.|               .||..     |.|||:||||||:.|||:||||||.|..||::|
Mouse  1662 KVRRSSL---------------RDRERERSRAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSMN 1711

  Fly  1860 EELPPAVKWLFDLLDEAARRHDIADTDIVHAWKSNCLPLRFWVNFIKNPDFIFDVNKTYSVDSCL 1924
            ..:|.|||:|||.|||.|.:|.|.|.:.:|.||:|.|.||||||.:|||..||||..:.:.|:.|
Mouse  1712 RPVPIAVKYLFDFLDELAEKHGIEDPETLHIWKTNSLLLRFWVNVLKNPQLIFDVQVSDNEDAIL 1776

  Fly  1925 SVIAQTFMDACSTSEHRLGKDSPSNKLLFAKDIPNYRIMVKEFYRDVSRLPQISDQEMSTAMQQL 1989
            :||||||:|:|..|||::|:|||.||||:|::||.|:.||:::|.|:.:....|.|||::|:.:|
Mouse  1777 AVIAQTFIDSCMVSEHKVGRDSPVNKLLYAREIPRYKQMVEKYYADIRQSSPASYQEMNSALAEL 1841

  Fly  1990 SVRQNEEFDTISALKELYIYITKYKDQIMESLETDINCRKMHLSRKLGNVAATLD 2044
            |...:.....:.||:|||.:|.:|.|||:.:||.|...:||.|:.:|..|||.::
Mouse  1842 SGNYSSAPHCLEALRELYNHIHRYYDQIISALEEDPVAQKMQLACRLQQVAALVE 1896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PlexB	NP_524616.2	Sema_plexin_like	86..534	CDD:200497	117/475 (25%)
		PSI	535..586	CDD:396154	21/50 (42%)
		TIG_plexin	594..682	CDD:465588	23/88 (26%)
		PSI	683..730	CDD:214655	15/62 (24%)
		TIG_2	738..827	CDD:465619	21/95 (22%)
		PSI	836..877	CDD:214655	12/43 (28%)
		IPT_plexin_repeat1	888..976	CDD:238585	36/92 (39%)
		IPT_plexin_repeat2	977..1095	CDD:238584	29/118 (25%)
		IPT_plexin_repeat3	1097..1211	CDD:238586	24/117 (21%)
		TIG	1277..>1334	CDD:460355	22/60 (37%)
		Plexin_cytopl	1452..2012	CDD:462434	254/587 (43%)
Plxnb3	NP_062533.2	Sema_plexin_B3	37..462	CDD:200538	118/481 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	353..372		3/22 (14%)
		PSI	464..515	CDD:396154	21/50 (42%)
		TIG_plexin	522..608	CDD:465588	23/88 (26%)
		PSI	622..658	CDD:214655	12/36 (33%)
		TIG_2	678..775	CDD:465619	21/96 (22%)
		IPT_plexin_repeat1	824..915	CDD:238585	36/92 (39%)
		IPT_plexin_repeat2	916..1001	CDD:238584	28/117 (24%)
		IPT	1004..1135	CDD:472823	35/181 (19%)
		TIG	<1165..1232	CDD:460355	28/72 (39%)
		Plexin_cytopl	1317..1864	CDD:462434	254/587 (43%)