DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexB and Plxnb2

DIOPT Version :9

Sequence 1:	NP_001245400.1	Gene:	PlexB / 43766	FlyBaseID:	FBgn0025740	Length:	2051	Species:	Drosophila melanogaster
Sequence 2:	NP_001152993.1	Gene:	Plxnb2 / 140570	MGIID:	2154239	Length:	1842	Species:	Mus musculus

Alignment Length:	2083	Identity:	641/2083 - (30%)
Similarity:	995/2083 - (47%)	Gaps:	355/2083 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 GNRSIGNNIESVRDS--QSKNYFTHMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSP 129
            |...:|.::.|.:..  :|:....|::.|.:..|::.||.|.:.:|:.:|.|....||||..|:.
Mouse    12 GLTGLGLSLRSRKPESFRSETELNHLAVDEVTGVVYVGAVNALYQLSADLHVQQHVVTGPFMDNK 76

  Fly   130 QC----HAGGCPEDIETSLVNNFNKILVVSYAHDGILIACGSIRQGACEIYSLPRFP-------- 182
            :|    .|..|.|.:   |.:|||::|::. .....|:.|||:.:|.|.:.::....
Mouse    77 KCTPPIEASQCHEAV---LTDNFNQLLLLD-PPGKRLVECGSLFKGICALRAMSNISVRLFYEDG 137

  Fly   183 ATPQFFAVPLAANDENASTYAFVGPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRLDDLNY 247
            :..:.|   :|:|||..:|...|...|.  ..|.:|:||.     |:..||...|.|.||.|...
Mouse   138 SGEKSF---VASNDERVATVGLVTSTRP--DGERVLFVGK-----GNGPHDNGIIVSTRLLDRAE 192

  Fly   248 AEFSIQQSIINIDVKYRDH--FLVDY--------IYGFNSSEYAYFIIVQKKSHLADEAGYVTRL 302
            ...:.:        .|.||  |...|        :..|....|.:|:...:..|.|...   |.|
Mouse   193 GREAFE--------AYSDHTTFKAGYLSTNTQQFVAAFEDDFYVFFVFNHQDKHPAKNR---TLL 246

  Fly   303 ARICITDPNYDSYTEITVQCTATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVFSPSR 367
            ||:|..||:|.||.|:.:||....         |.:.:.....||..:........|..|||...
Mouse   247 ARMCKDDPSYYSYVEMDLQCQDPS---------DPQDSAFGTCLAASVATSGAGRALYAVFSRDG 302

  Fly   368 EISNQPESKSAMCIYSIKDIEDMFIENIHLCFNGTTK-DRNLGY--ISGTINDGRCPIVGSL-GN 428
            ..:..|  .:.:|::.:..:.:....|.:.|:.|..: .|.:.|  ..|.|..|     |.| |.
Mouse   303 RSTGGP--GAGLCVFPLDKVREKIEANRNACYTGAREAGRTIFYKPFHGEIQCG-----GHLIGA 360

  Fly   429 IYNF-CS---VGLKISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLS 489
            ..:| |.   :...:.....:.|.|:.|...:::|:||.|:..|  |::|||||:.|.|.||.|:
Mouse   361 SESFPCGSEHLPYPLGSRDGLVATAVLHRGGLNLTAVTVTAEND--HTVAFLGTSDGRILKVYLA 423

  Fly   490 --GQSPGEYEEIVVDAGNRILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTNCSACLESRDPF 552
              |.| .||..|.||...:|..:..:|.....||.::|.|:.:|.::.|..|..|:.|.:|:||:
Mouse   424 PDGTS-AEYGSIPVDINKKIKQDLALSGNLSSLYAMTQDKVFRLPVQECLSYVTCAQCRDSQDPY 487

  Fly   553 CGWCSLEKRCTVRSTCQRDTSASRWLSLGSGQQCIEFESIIPEKIPISELSHLHLIIRTLPE-PF 616
            ||||.:|.|||.:|.|.|......|| ....:.|:......|:.:.......:.|.:..||. ..
Mouse   488 CGWCVIEGRCTRKSECSRAEETGHWL-WSREKSCVAITDAFPQNMSRRAQGEVRLSVSPLPTLTE 551

  Fly   617 NAKYRCVFGNSTPIDAEILENGLGCATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSRNFAF 681
            :.:..|:||:|.|..|.:.::.:.|.:|  ...|..|...||:.|.:.:.....:....|..:.|
Mouse   552 DDELLCLFGDSPPHPARVEDDTVICNSP--SSIPSTPPGQDHVDVSIQLLLKSGSVFLTSHQYPF 614

  Fly   682 FDCSHHGN------CQECLQSSWGCNWCIFDNKCVHKSLQCR----NIENAVSTVGHCPHLKKNR 736
            :||....:      |..|..:.|.|.|.:       :..:||    |.|..:...    |::.|.
Mouse   615 YDCREAMSLVENLPCISCASNRWTCQWDL-------QYYECREASPNPEEGIIRA----HMEDNC 668

  Fly   737 PEILLPVRVPIEIRLEIENLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKTPYFYEIN 801
            |:.|.|..:.|.:..|.|...:.|:.....:.::::            .::::..|:|...:|.:
Mouse   669 PQFLAPDPLVIPMNHETEVTFQGKNLETVKVSSLYV------------GSELLNFEETVTMHESD 721

  Fly   802 THEYQAKV------------VVTWNFQHYVDTAI-VTLYKCDVLGSHREHPDCSLCVTRDPKYKC 853
            |..::...            :...:|...:|:.: ||||.|....|     |||||:..||.|:|
Mouse   722 TFSFRTPKLSHDGNETLPLHLYVKSFGKNIDSKLQVTLYNCSFGRS-----DCSLCLAADPAYRC 781

  Fly   854 AWC--SNSCVYNETCIADKNSISSGSKSAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIR 916
            .||  .|.|||...|            |.:.:|||.|.|..|:|.:||:.||.|:||.|||||::
Mouse   782 VWCRGQNRCVYEALC------------SNVTSECPPPVITRIQPETGPLGGGILVTIHGSNLGVK 834

  Fly   917 EEDVRGKIFIGSVPCELE--NYQISVKIECRTGASLYEMSAPIK--VANDAGFTESSVQFHFKNV 977
            .:||: ||.:....|..|  .|.:|.:|.|...||....:..|:  |....|.:...|||.::..
Mouse   835 ADDVK-KITVAGQNCAFEPRGYSVSTRIVCAIEASEMPFTGGIEVDVNGKLGHSPPHVQFTYQQP 898

  Fly   978 LLTGLYPTIGPRSGGTQLSLIGKFLNIGS--TMRAFLDEYECHIDVTQASSSQVSCTTSEATQPE 1040
            ....:.|..||::|||.|::.|..|:.||  .:|..|::..|  :||: ..:|:.|.|.:...|.
Mouse   899 QPLSVEPRQGPQAGGTTLTINGTHLDTGSKEDVRVTLNDVPC--EVTK-FGAQLQCVTGQQLAPG 960

  Fly  1041 PIRSLHLVIDGANRTLECQISTPSITNTNPTRSNFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPL 1105
            .: :|.:...|:      ::.:|.|:                        |.|.::|.|...:||
Mouse   961 QV-TLEIYYGGS------RVPSPGIS------------------------FTYCENPMIRAFEPL 994

  Fly  1106 RSFKSGGRVLTVHGIYLNSIQKPELEVFYDNER----------------VNKTSCVVINSNQMEC 1154
            |||.||||.:.|.|...:.|||..:.|..:..|                |.....|..|..::..
Mouse   995 RSFVSGGRSINVTGQGFSLIQKFAMVVIAEPLRSWRRRRREAGALERVTVEGMEYVFYNDTKVVF 1059

  Fly  1155 PSPPVNYKFETFKKTNR-KMDTELHLQNSSFQTETRYKNEYDRKKRRADFGDTFRLYTNAGSSAN 1218
            .||.|..:.|.:..|.. :||                             |....|.|.||
Mouse  1060 LSPAVPEEPEAYNLTVLIRMD-----------------------------GHCAPLRTEAG---- 1091

  Fly  1219 YFVNNNMDVTTFVKVHETQLNLQLSFVMDNVQLVRNLNKYFHDIRSTIVYLADPKYLPFPNDGVK 1283
                          |.|                                |:|||.:..| ..|||
Mouse  1092 --------------VFE--------------------------------YVADPTFENF-TGGVK 1109

  Fly  1284 LYKGDSLVIEGELLNLAADEYDVNVTIGTSQCNITSLALNQLLCIPPEQQPLPTDENGVDQSTDL 1348
            ......:...|..||.|....:....:|..:|.:.:|....|.|.|||.||.|......|.:.:|
Mouse  1110 KQVNKLIHARGTNLNKAMTLEEAEAFVGAERCIMKTLTETDLYCEPPEVQPPPKRRQKRDTAHNL 1174

  Fly  1349 PLVVVKVGRNLRFVIGYLKYDLNKPYVFSHALLVGILTVALLVVVFVIVLII--FRRKSTQAERE 1411
            |..:||.| :..:|:|.::||...    |...|..||.:.::.:||:||:.|  :.|||.|||||
Mouse  1175 PEFIVKFG-SREWVLGRVEYDTRA----SDVPLSLILPLVMVPMVFIIVVSIYCYWRKSQQAERE 1234

  Fly  1412 YKRIQIQMITLESNVRSECKQAFAELQTDMTDLTADLESTGIPTLDHVNYIMKVFF----PGVSD 1472
            |::|:.|:..||.:||..||:.|.:|..:|.|.|.|:...||||||:..|..:|||    .|..|
Mouse  1235 YEKIKSQLEGLEESVRDRCKKEFTDLMIEMEDQTNDVHEAGIPTLDYKTYTDRVFFLPSKDGDKD 1299

  Fly  1473 HPI---LNSPKFREGSPQTNYDAAMVQFEQLIGNKYFLLMFIETLEAQRSSFSIRDRVNVASLIM 1534
            ..|   |:.|:.|    :...:.|:.||..|:.:|.||:.||.|||.|| .||.|.:|..|||:.
Mouse  1300 VMITGKLDIPESR----RPIVEQALYQFSNLLNSKSFLINFIHTLENQR-EFSARAKVYFASLLT 1359

  Fly  1535 VVLMNKMEYATEILKSLLLRLIDKSLASKHPQLMLRRTESVVEKMLTNYLAICMYDYLKEYAGSN 1599
            |.|..|:||.|:|:::|.|.|:::.:.:|:|:|||||:|:|||:||:|:::||:|.|||:.||..
Mouse  1360 VALHGKLEYYTDIMRTLFLELMEQYVVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEP 1424

  Fly  1600 LFLLFKAIKHQIEKGLVDAITNDARYSLSEERLLHEQVTHS-VVILHILQDDLDEKVQCRVNDWD 1663
            |:.||||||||:|||.|||:...|:|:|::..||.:.|.:: :.:..|:||:..:.:..:|.:.|
Mouse  1425 LYKLFKAIKHQVEKGPVDAVQKKAKYTLNDTGLLGDDVEYAPLTVSVIVQDEGIDAIPVKVLNCD 1489

  Fly  1664 TISQVKLKILDAIFKNTPFSMRPSVNEVDLEWRHGRGGHLTLQDEDLTTKTVNGWKRLNTLAHYG 1728
            ||||||.||:|.:::..|.|..|..:.|.||||.|....: |.|.|||::....|||:|||.||.
Mouse  1490 TISQVKEKIIDQVYRTQPCSCWPKPDSVVLEWRPGSTAQI-LSDLDLTSQREGRWKRINTLMHYN 1553

  Fly  1729 VKESAVMSL----IARQNDNYHIPYSKNQNSAPYHNFYFINNSQSHIIINNDIESGLQQPRVYHL 1789
            |::.|.:.|    :::|.::       :|...|         .:.|.::.       ::.||:||
Mouse  1554 VRDGATLILSKVGVSQQPED-------SQQDLP---------GERHALLE-------EENRVWHL 1595

  Fly  1790 VKPNIPDHYMNIKNSVLSG----GSPAFQSHVVNNCNDRVNKTIPEVYLTRLLATKGTIQKFVDD 1850
            |:|.         :.|..|    ||...:..         .|.|.|:||||||:.|||:|:|||:
Mouse  1596 VRPT---------DEVDEGKSKRGSMKEKER---------TKAITEIYLTRLLSVKGTLQQFVDN 1642

  Fly  1851 FFSIILTVNEELPPAVKWLFDLLDEAARRHDIADTDIVHAWKSNCLPLRFWVNFIKNPDFIFDVN 1915
            ||..:|.....:|||||:.||.|||.|.:|||.|.|.:|.||:|.||||||||.:|||.|||||:
Mouse  1643 FFQSVLAPGHAVPPAVKYFFDFLDEQAEKHDIRDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVH 1707

  Fly  1916 KTYSVDSCLSVIAQTFMDACSTSEHRLGKDSPSNKLLFAKDIPNYRIMVKEFYRDVSRLPQISDQ 1980
            ....||:.||||||||||||:.:||:|.:||||||||:||:|..|:.||:::|:.:.::.|:|||
Mouse  1708 VHEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQ 1772

  Fly  1981 EMSTAMQQLSVRQNEEFDTISALKELYIYITKYKDQIMESLETDINCRKMHLSRKLGNVAATLDG 2045
            :|:|.:.::|....:..:|:.||.:||.|..||.|:|:.:||.|...:||.|:.:|..:||.|:.
Mouse  1773 DMNTHLAEISRAHTDSLNTLVALHQLYQYTQKYYDEIINALEEDPAAQKMQLAFRLQQIAAALEN 1837

  Fly  2046 DCT 2048
            ..|
Mouse  1838 KVT 1840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexB	NP_001245400.1	Sema_plexin_like	86..534	CDD:200497	127/479 (27%)
		PSI	535..586	CDD:279745	20/50 (40%)
		PSI	683..730	CDD:214655	11/56 (20%)
		PSI	836..877	CDD:214655	16/42 (38%)
		IPT_plexin_repeat1	888..976	CDD:238585	34/91 (37%)
		IPT_plexin_repeat2	977..1095	CDD:238584	26/119 (22%)
		IPT_plexin_repeat3	1097..1211	CDD:238586	30/130 (23%)
		Plexin_cytopl	1452..2017	CDD:285529	246/580 (42%)
Plxnb2	NP_001152993.1	Sema	27..469	CDD:417757	128/485 (26%)
		PSI	471..519	CDD:396154	20/48 (42%)
		TIG_plexin	528..615	CDD:407808	18/88 (20%)
		PSI	761..>803	CDD:396154	19/58 (33%)
		IPT_plexin_repeat1	806..897	CDD:238585	34/91 (37%)
		IPT_plexin_repeat2	898..984	CDD:238584	26/119 (22%)
		IPT	986..>1069	CDD:417750	24/82 (29%)
		Plexin_cytopl	1275..1809	CDD:400574	246/580 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10610
eggNOG	1	0.900	-	-		E1_KOG3610
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D56043at33208
OrthoFinder	1	1.000	-	-		FOG0000391
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100269
Panther	1	1.100	-	-	O	PTHR22625
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.820