Protein Alignment PlexB and PlexB

DIOPT Version :10

• Sequence 1: NP_524616.2
• Gene: PlexB / 43766
• FlyBaseID: FBgn0025740
• Length: 2051
• Species: Drosophila melanogaster
• Sequence 2: XP_061515858.1
• Gene: PlexB / 1270788
• VectorBaseID: AGAMI1_000329
• Length: 2147
• Species: Anopheles gambiae
• Alignment Length: 2152
• Identity: 1259/2152 - (58%)
• Similarity: 1567/2152 - (72%)
• Gaps: 221/2152 - (10%)

  Fly    44 PLNDIVAQFNLPSIPVQSTASSYGNRSIGNNIESVRDSQSKNYFTHMSFDFMHNVLFAGATNKIL 108
            ||:||:|:::||:                          ..:.|||:::|....:.:|||||::|
Mosquito    59 PLDDIIARYSLPN--------------------------GTSRFTHLTYDPTRRLFYAGATNRVL 97

  Fly   109 KLNENLRVLAEAVTGPLHDSPQCHAGGCPEDIETSL-VNNFNKILVVSYAHDG-ILIACGSIRQG 171
            :|||||.:|.||:|||..||.||||.|||.|:..|: .:|.||:|:  |..|| .||||||:.||
Mosquito    98 QLNENLTLLREAITGPKLDSAQCHAAGCPPDVLDSVETDNVNKVLL--YNRDGDTLIACGSVHQG 160

  Fly   172 ACEIYSLP-RFPATPQFFAVPLAANDENASTYAFVGPARY-AWKEEDILYVGTTFTNVGDYRHDV 234
            ||:||.|. |||.:.:...|.||||||.:|||||:||:|| :||.|||:||||||||||||||||
Mosquito   161 ACDIYYLSGRFPESSKPIEVALAANDERSSTYAFIGPSRYQSWKREDIMYVGTTFTNVGDYRHDV 225

  Fly   235 PAISSRRLDDLNYAEFSIQQSIINIDVKYRDHFLVDYIYGFNSSEYAYFIIVQKKSHLADEAGYV 299
            |||||||||||.|||||||||.|||||||||||||:|:|||||:|||||::||||||||||||||
Mosquito   226 PAISSRRLDDLTYAEFSIQQSNINIDVKYRDHFLVNYVYGFNSTEYAYFVLVQKKSHLADEAGYV 290

  Fly   300 TRLARICITDPNYDSYTEITVQCTATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVFS 364
            |||||||:.|||||||||:|:.|..  |..||||:||||:..|..||:..||||::|::||.|||
Mosquito   291 TRLARICVNDPNYDSYTEVTITCMV--NGTDYNILRDAKLAQAGQKLSNDMGIKREDYLLVAVFS 353

  Fly   365 PSREISNQPESKSAMCIYSIKDIEDMFIENIHLCFNGTTKDRNLGYISGTINDGRCPIVGSLGNI 429
            ||:||:::|:::||:|:||:||||::|.||||.|||||.|||||||||||||||:||:.||||||
Mosquito   354 PSKEITDEPQNRSAICMYSLKDIEEVFNENIHSCFNGTIKDRNLGYISGTINDGKCPVAGSLGNI 418

  Fly   430 YNFCSVGLKISGVSPITAHALFHF-DNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLSGQSP 493
            ::||.||||||||:|:.|.|.|.| :.||:||:..||.  ..|:|||:|:|.|.|:||||||:..
Mosquito   419 FSFCHVGLKISGVTPVIASARFAFGEGVSLTSIAVTSI--GPHTLAFVGSNDGWIRKVLLSGREA 481

  Fly   494 GEYEEIVVDA-GNRILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTNCSACLESRDPFCGWCS 557
            ||||.::||. |:.|||::|.:|..|.||||::|||.|:::|||..:.|||||||||||:|||||
Mosquito   482 GEYERMLVDEDGSAILPDSMFAPTNDHLYVLTERKIIKMKVEHCGTFGNCSACLESRDPYCGWCS 546

  Fly   558 LEKRCTVRSTCQRDTSASRWLSLGSGQQCIEFESIIPEKIPISELSHLHLIIRTLPE-PFNAKYR 621
            ||||||||:.||:||||:||||:|:|||||:||.:.|:::|:.::|.:.|:|:|||| |.||:||
Mosquito   547 LEKRCTVRTACQKDTSAARWLSIGTGQQCIDFEMVAPDRVPVGQMSVVRLVIKTLPELPHNAQYR 611

  Fly   622 CVFGNSTPIDAEILENGLGCATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSRNFAFFDCSH 686
            |||||:|||||.:.:.||.|:|||::|||.:|...||:||||||||||||||||||:|||:||:.
Mosquito   612 CVFGNATPIDANVTKEGLICSTPPVNERPALPDGQDHVLVPLSVRSSETNKDFVSRSFAFYDCTR 676

  Fly   687 HGNCQECLQSSWGCNWCIFDNKCVHKSLQCRNIENAVSTVGHCPHLKKNRPEILLPVRVPIEIRL 751
            |..|::||.|:|||:|||:||:|...:..|||..|.|.....||.||.....||||.:||.||||
Mosquito   677 HDTCRKCLVSNWGCHWCIYDNRCAFNTTACRNSANIVQNEASCPRLKHRAGPILLPNKVPKEIRL 741

  Fly   752 EIENLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKTPYFYEINTHEYQAKVVVTWNFQ 816
            ||||||:|:|||.||||||:||.|.|:|||.||:||.:|||||.|.||..|:||:|.|.|.||..
Mosquito   742 EIENLPRPQSAHTGFLCTINIEGAHMVLPARVEANKYIVCEKTLYSYEAATNEYEATVDVNWNRN 806

  Fly   817 HYVDTAIVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWCSNSCVYNETCIADKNSISSGSKSAI 881
            ||:||..|.||||::|||||:|.||||||||||||:|.||...|.|||:|      |..|:.|.:
Mosquito   807 HYIDTVTVILYKCEILGSHRDHADCSLCVTRDPKYQCTWCGQQCSYNESC------IDGGAGSMM 865

  Fly   882 ------ENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIFIGSVPCELENYQISV 940
                  |..||.||||:|||||||:|||||:||||||||||||||||:|.||.||||||.|:|||
Mosquito   866 LRGRSEEGGCPRPRIDLIKPLSGPIEGGTLVTIEGSNLGIREEDVRGRIHIGEVPCELERYEISV 930

  Fly   941 KIECRTGASLYEMSAPIKVANDAGFTESSVQFHFKNVLLTGLYPTIGPRSGGTQLSLIGKFLNIG 1005
            :||||||....|||||:||.|:||:|.|||:|.:::|.|.||.||:||:||||:||:|||.||:|
Mosquito   931 RIECRTGPVRSEMSAPVKVGNEAGYTMSSVEFRYRDVRLEGLSPTMGPQSGGTKLSIIGKHLNVG 995

  Fly  1006 STMRAFLDEYECHIDVTQASSSQVSCTTSEATQPEPIRSLHLVIDGANRTLECQISTPSITNTNP 1070
            :...|:||:|||.|:.||||||:::|.||.|..||.||.|.|.||||||||.|  ||.:.|:...
Mosquito   996 TAAIAYLDDYECRINRTQASSSRLTCVTSAARSPEHIRVLTLRIDGANRTLAC--STSAGTSGER 1058

  Fly  1071 TR-----SNFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSIQKPEL 1130
            .|     .:.|:|..|   .:.||::|||.||:|||||||:||.||||::||||..|::||.||:
Mosquito  1059 VRGSSAYGSAGTYHSR---YETCSVYNYTVDPKIMQIKPLKSFLSGGRMMTVHGTNLDAIQLPEI 1120

  Fly  1131 EVFYDNERVNKTSCVVINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQNSSFQTETRYKNEYD 1195
            ||:.::||:|::.|.|:||||||||||.|...:...::      .::.|:|.|.....  ..:|.
Mosquito  1121 EVYLNDERLNRSICAVLNSNQMECPSPSVREAWTLLQQ------QQIQLRNLSVAGVG--AGDYS 1177

  Fly  1196 RKKRRADF----GDTFRL-----------------YTNAGSSANYFVNNNMDVTTF-VKVHETQL 1238
            ..:..:.|    |.|..:                 |:.:.:|.......:..::.| ....:.||
Mosquito  1178 PPRMLSGFVSADGRTVPIQQQQPPTAAVPMLLPSQYSLSPTSGPLVTAASAPLSPFHPSEQQLQL 1242

  Fly  1239 NLQLSFVMDNVQLVRNLNKYFHDIRSTIVYLADPKYLPFPNDGVKLYKGDSLVIEGELLNLAADE 1303
            .||::|:||:|..||||.|:|.::||.|||:.||.|.|||| .|||||||:||||||.||.|:||
Mosquito  1243 LLQINFLMDSVLSVRNLPKHFQNLRSAIVYVEDPVYQPFPN-AVKLYKGDTLVIEGEHLNAASDE 1306

  Fly  1304 YDVNVTIGTSQCNITSLALNQLLCIPPEQQPLPTDENGVDQSTDLPLVVVKVGRNLRFVIGYLKY 1368
            .||||||||:|||:||||..||:|.||.:||..||||||..:.|||||||:|||||||.||::||
Mosquito  1307 TDVNVTIGTAQCNVTSLAPTQLVCTPPLEQPEATDENGVPTANDLPLVVVRVGRNLRFPIGFIKY 1371

  Fly  1369 DLNKPYVFSHALLVGILTVALLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESNVRSECKQA 1433
            ||.|||.|||.|...|::....|:..:.:|.|:|||||.||||||||||||.|||||||.|||||
Mosquito  1372 DLIKPYAFSHVLFGVIVSGIFFVLSLLAILFIYRRKSTLAEREYKRIQIQMDTLESNVRMECKQA 1436

  Fly  1434 FAELQTDMTDLTADLESTGIPTLDHVNYIMKVFFPGVSDHPIL--NSPKFREGS----------- 1485
            |||||||||||||||||:|.||||.|||:||||||||:|||:|  |..|...|.
Mosquito  1437 FAELQTDMTDLTADLESSGTPTLDLVNYVMKVFFPGVADHPVLLANGAKLHGGGGGGGHHHHGHG 1501

  Fly  1486 -------PQTNYDAAMVQFEQLIGNKYFLLMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEY 1543
                   .:.|||.|||.|||||.|:.|||:||:|||||: :|:|||:||||||:|:||||:|:|
Mosquito  1502 THHGHPHQRNNYDQAMVMFEQLINNRVFLLLFIDTLEAQK-TFTIRDKVNVASLLMIVLMNQMDY 1565

  Fly  1544 ATEILKSLLLRLIDKSLASKHPQLMLRRTESVVEKMLTNYLAICMYDYLKEYAGSNLFLLFKAIK 1608
            .|:|||||||||||||:.:|||||||||||||||||||||:|:||||||:.|||::||||:||||
Mosquito  1566 VTDILKSLLLRLIDKSVMTKHPQLMLRRTESVVEKMLTNYMALCMYDYLRNYAGNSLFLLYKAIK 1630

  Fly  1609 HQIEKGLVDAITNDARYSLSEERLLHEQVTHSVVILHILQDDLDEKVQCRVNDWDTISQVKLKIL 1673
            ||||||||||:|:||||||||:|||.||:.||||.|||:||||||||||:|.|.|||||||.|:|
Mosquito  1631 HQIEKGLVDAVTHDARYSLSEDRLLREQIVHSVVTLHIIQDDLDEKVQCKVLDCDTISQVKSKVL 1695

  Fly  1674 DAIFKNTPFSMRPSVNEVDLEWRHGRGGHLTLQDEDLTTKTVNGWKRLNTLAHYGVKESAVMSLI 1738
            ||:|||||||:||||:::||||||||||||.|:|||:|||:|:|||||||||||||||||||||:
Mosquito  1696 DALFKNTPFSLRPSVHDLDLEWRHGRGGHLVLRDEDVTTKSVHGWKRLNTLAHYGVKESAVMSLV 1760

  Fly  1739 ARQNDNYHIPYSKNQNSAPYHNFYFINNSQSHIIINNDIESGLQQPR------------------ 1785
            ||.:|.|:.|   .::..||  .|:|||..|.   |:.:.|....|.
Mosquito  1761 ARPHDGYNTP---GRHIFPY--CYYINNPPSS---NHHLSSSATLPHGGSGSAASGPGSCGSSGT 1817

  Fly  1786 -----------------------------------------------------------VYHLVK 1791
                                                                       |:||||
Mosquito  1818 MGPAHTTDTLLAGSASHHHHHHPHLHPHHVHQQHAAQAAQAAAAAAAAAAQQQQQSQVGVFHLVK 1882

  Fly  1792 PNIPDHYMNIK------------NSVLSGGSPAFQSHVVNNCNDRVNKTIPEVYLTRLLATKGTI 1844
            | :.|.:..:.            :..|.||.|...||         :|.|||::|||||||||||
Mosquito  1883 P-LDDRFSTLSSYDQHGSSSSSAHGALYGGGPGSGSH---------HKAIPEIFLTRLLATKGTI 1937

  Fly  1845 QKFVDDFFSIILTVNEELPPAVKWLFDLLDEAARRHDIADTDIVHAWKSNCLPLRFWVNFIKNPD 1909
            ||||||.|:.||||||.||||||||:||||.|||.|.|.|.:::||||||.||||||||||||||
Mosquito  1938 QKFVDDLFATILTVNEALPPAVKWLYDLLDAAARHHGIHDPEVIHAWKSNGLPLRFWVNFIKNPD 2002

  Fly  1910 FIFDVNKTYSVDSCLSVIAQTFMDACSTSEHRLGKDSPSNKLLFAKDIPNYRIMVKEFYRDVSRL 1974
            ||||:.||.|||.|||||||||||||||:|:||||||||||||||||:|.||.||..||.|::.:
Mosquito  2003 FIFDIYKTPSVDVCLSVIAQTFMDACSTTEYRLGKDSPSNKLLFAKDLPQYREMVSNFYADIAMM 2067

  Fly  1975 PQISDQEMSTAMQQLSVRQNEEFDTISALKELYIYITKYKDQIMESLETDINCRKMHLSRKLGNV 2039
            ||||||||.:|||:||:.| ::|||::||||||:|::||:.||.|.||.|:...|:||:.||..|
Mosquito  2068 PQISDQEMRSAMQRLSIHQ-QQFDTLAALKELYVYVSKYRLQIKEVLEMDLTASKLHLAHKLDLV 2131

  Fly  2040 AATLDGD 2046
            ||||:.|
Mosquito  2132 AATLEDD 2138

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PlexB	NP_524616.2	Sema_plexin_like	86..534	CDD:200497	293/453 (65%)
		PSI	535..586	CDD:396154	39/50 (78%)
		TIG_plexin	594..682	CDD:465588	56/88 (64%)
		PSI	683..730	CDD:214655	21/46 (46%)
		TIG_2	738..827	CDD:465619	58/88 (66%)
		PSI	836..877	CDD:214655	23/40 (58%)
		IPT_plexin_repeat1	888..976	CDD:238585	66/87 (76%)
		IPT_plexin_repeat2	977..1095	CDD:238584	63/122 (52%)
		IPT_plexin_repeat3	1097..1211	CDD:238586	48/134 (36%)
		TIG	1277..>1334	CDD:460355	41/56 (73%)
		Plexin_cytopl	1452..2012	CDD:462434	388/668 (58%)
PlexB	XP_061515858.1	None