DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PlexB and PLXNC1

DIOPT Version :9

Sequence 1:NP_001245400.1 Gene:PlexB / 43766 FlyBaseID:FBgn0025740 Length:2051 Species:Drosophila melanogaster
Sequence 2:NP_005752.1 Gene:PLXNC1 / 10154 HGNCID:9106 Length:1568 Species:Homo sapiens


Alignment Length:1984 Identity:476/1984 - (23%)
Similarity:751/1984 - (37%) Gaps:617/1984 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 AGGCPEDIETSLV--------NNFNKILVVSYAH-----DGILIACGSIRQGACEIYSLPRFPAT 184
            ||.|.|.:  ||.        ::|:|:| :.|..     .|:|:...:..:||||:..|......
Human    84 AGNCTEPV--SLAPPARPRPGSSFSKLL-LPYREGAAGLGGLLLTGWTFDRGACEVRPLGNLSRN 145

  Fly   185 PQFFAVPLAANDENASTYAFVGPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRLDDLNYAE 249
            .......:.:.....||...|    |.....:..|:....|    |....|..:||    .|.|.
Human   146 SLRNGTEVVSCHPQGSTAGVV----YRAGRNNRWYLAVAAT----YVLPEPETASR----CNPAA 198

  Fly   250 FSIQQSIINIDVKYRD------------------HFLVDYIYGFNSSEYAYFIIVQKKSHLADEA 296
            .....:|...|.:.|.                  ||:..:::  |.|.|..:......|..|  .
Human   199 SDHDTAIALKDTEGRSLATQELGRLKLCEGAGSLHFVDAFLW--NGSIYFPYYPYNYTSGAA--T 259

  Fly   297 GYVTRLARICITDPNYDSYTEITVQCTATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVT 361
            |:.: :|||.       ..||:..|..|:        :......|...:|.....:.:...|...
Human   260 GWPS-MARIA-------QSTEVLFQGQAS--------LDCGHGHPDGRRLLLSSSLVEALDVWAG 308

  Fly   362 VFSPSREISNQPES--KSAMCIYSIKDIEDMFIENIHLCFNGTTKDRNLGYISGTINDGRCPIVG 424
            |||.:.....:..|  .:|:|::.:.:|:              .:.:.:.:...|..        
Human   309 VFSAAAGEGQERRSPTTTALCLFRMSEIQ--------------ARAKRVSWDFKTAE-------- 351

  Fly   425 SLGNIYNFCSVGLKISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLS 489
                  :.|..|.:...|.||.:..|.|.|   :|||..|...::  ::.||||..|.:.||:|.
Human   352 ------SHCKEGDQPERVQPIASSTLIHSD---LTSVYGTVVMNR--TVLFLGTGDGQLLKVILG 405

  Fly   490 GQSPGEYEEIVVDAGN------RILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTNCSACLES 548
            ........|::.:...      :::|:.:   |..::|:.:.:::.::|:.:|:.:.:||.||.:
Human   406 ENLTSNCPEVIYEIKEETPVFYKLVPDPV---KNIYIYLTAGKEVRRIRVANCNKHKSCSECLTA 467

  Fly   549 RDPFCGWCSLEKRCTVRSTCQRDTSASRWLSLGSG-QQCIEFESI--IPEKIPISELSHLHLIIR 610
            .||.||||...:|||.:..|....:...||.:.|| ::|.:.:.|  ..||..:           
Human   468 TDPHCGWCHSLQRCTFQGDCVHSENLENWLDISSGAKKCPKIQIIRSSKEKTTV----------- 521

  Fly   611 TLPEPFNAKY-RCVFGNSTPIDA--EILENGLGCATPPLDERPLIPTNTDHILVPLSVRSSETNK 672
            |:...|:.:: :|:..|   :|:  |:.:|.   :.|.......|||...:..|      |..|.
Human   522 TMVGSFSPRHSKCMVKN---VDSSRELCQNK---SQPNRTCTCSIPTRATYKDV------SVVNV 574

  Fly   673 DF------VSRNFAFFDCSHHGNCQECLQSSWGCNWCIFDNKCVHKSLQC------RNIENAVST 725
            .|      :|..|.|.:||....|..|:::  ||.||....:|:|....|      ||.|     
Human   575 MFSFGSWNLSDRFNFTNCSSLKECPACVET--GCAWCKSARRCIHPFTACDPSDYERNQE----- 632

  Fly   726 VGHCPHLKKNRPEILLPVRVPIEIRLEIENLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVV 790
              .||              |.:| :......||....:.      ..:|.|:.....:|..|:..
Human   633 --QCP--------------VAVE-KTSGGGRPKENKGNR------TNQALQVFYIKSIEPQKVST 674

  Fly   791 CEKTPYFYEINTHEYQAKVVVTW-NFQHYVDTAIVT--LYKCD---VLGSHREHPDCSLCVTRDP 849
            ..|             :.|:||. ||....:..::.  ...||   :..||         |..|.
Human   675 LGK-------------SNVIVTGANFTRASNITMILKGTSTCDKDVIQVSH---------VLNDT 717

  Fly   850 KYKCAWCSNSCVYNETCIA-DKNSISS-GSKSAIENECPLPRIDIIKPLSGPVEGGTLITIEGSN 912
            ..|.:..|:.....:.||. |..:.|| ||.|.|    .||...:|.|.:..:.||..||:.|.|
Human   718 HMKFSLPSSRKEMKDVCIQFDGGNCSSVGSLSYI----ALPHCSLIFPATTWISGGQNITMMGRN 778

  Fly   913 LGIREEDVRGKIFIGSVPCELENYQISVKIECRTGASLYEMSAPIKVANDAGFTESSVQFHFKNV 977
            ..:                 ::|..||.:::.....|.|      .||...||...|::      
Human   779 FDV-----------------IDNLIISHELKGNINVSEY------CVATYCGFLAPSLK------ 814

  Fly   978 LLTGLYPTIGPRSGGTQLSLIGKFLNIGSTMRAFLDEYECHIDVTQASSSQVSCTTSEATQPEPI 1042
                                                            ||:|.            
Human   815 ------------------------------------------------SSKVR------------ 819

  Fly  1043 RSLHLVIDGANRTLECQISTPSITNTNPTRSNFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRS 1107
                     .|.|::.::....:                     .|....|.:|||.        
Human   820 ---------TNVTVKLRVQDTYL---------------------DCGTLQYREDPRF-------- 846

  Fly  1108 FKSGGRVLTVHGIYLNSIQKPELEVFYDNERVNKTSCVVINSNQMECPSPPVNYKFETFKKTNRK 1172
              :|.||        .|....||||....|                      |..|...||    
Human   847 --TGYRV--------ESEVDTELEVKIQKE----------------------NDNFNISKK---- 875

  Fly  1173 MDTELHL-------QNSSFQTETRYKNEYDRKKRRADFGDTFRLYTNAGSSANYFVNNNMDVTTF 1230
             |.|:.|       .|.||:..||                                  |.|:||.
Human   876 -DIEITLFHGENGQLNCSFENITR----------------------------------NQDLTTI 905

  Fly  1231 V-KVHETQLNLQLSFVMDNVQLVRNLNKYFHDIRSTIVYLADPKYLPFPNDGVKLYKGDSLVIEG 1294
            : |:                                              .|:|...        
Human   906 LCKI----------------------------------------------KGIKTAS-------- 916

  Fly  1295 ELLNLAADEYDVNVTIGTSQCNITSLALNQLLCIPPEQQPLPTDENGVDQSTDLPLVVVKVGRNL 1359
               .:|.....|.|.:|..:..:             ||:.:|        ||...|:|:.|    
Human   917 ---TIANSSKKVRVKLGNLELYV-------------EQESVP--------STWYFLIVLPV---- 953

  Fly  1360 RFVIGYLKYDLNKPYVFSHALLVGILTVALLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLES 1424
                                         |||:|....:.:.|.||.:..|:..:   |:..|||
Human   954 -----------------------------LLVIVIFAAVGVTRHKSKELSRKQSQ---QLELLES 986

  Fly  1425 NVRSECKQAFAELQTDMTDLTADLESTG-IPTLDHVNYIMKVFFP--GVSDHPILNSPKFREGSP 1486
            .:|.|.:..|||||.|..|:   ::|.| :|.||:.::.::.|||  |...|........|:.:.
Human   987 ELRKEIRDGFAELQMDKLDV---VDSFGTVPFLDYKHFALRTFFPESGGFTHIFTEDMHNRDAND 1048

  Fly  1487 QTNYDAAMVQFEQLIGNKYFLLMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSL 1551
            :   :.::...:.||.||.||:..|.|||.|: :||::||...||.:.:.|..|:.|.|.||: :
Human  1049 K---NESLTALDALICNKSFLVTVIHTLEKQK-NFSVKDRCLFASFLTIALQTKLVYLTSILE-V 1108

  Fly  1552 LLRLIDKSLASKHPQLMLRRTESVVEKMLTNYLAICMYDYLKEYAGSNLFLLFKAIKHQIEKGLV 1616
            |.|.:.:..::..|:||||||||||||:|||::::|:..:|:|..|...:||...:..:|.||.|
Human  1109 LTRDLMEQCSNMQPKLMLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKINKGPV 1173

  Fly  1617 DAITNDARYSLSEERLLHEQVTHSVVILHILQDDLDEKVQ---CR-----VNDWDTISQVKLKIL 1673
            |.||..|.|:|:|:.||.:....|.|.|:::.:.:.|...   ||     |.|.|||.|.|.||.
Human  1174 DVITCKALYTLNEDWLLWQVPEFSTVALNVVFEKIPENESADVCRNISVNVLDCDTIGQAKEKIF 1238

  Fly  1674 DA-IFKN-TPFSMRPSVNEVDLEWRHGRGGHLTLQDE--DLTTKTV---NGWKRLNTLAHYGVKE 1731
            .| :.|| :|:.::  :||:.||.:.|     |.|.|  |:.:.:|   :|..:|||:.||.:..
Human  1239 QAFLSKNGSPYGLQ--LNEIGLELQMG-----TRQKELLDIDSSSVILEDGITKLNTIGHYEISN 1296

  Fly  1732 SAVMSLIARQNDNYHIPYSKNQNSAPYHNFYFINNSQSHIIINNDIESGLQQPRVYHLVKPNIPD 1796
            .:.:.:                       |..|.|..|.:..::|         ..||:.|:   
Human  1297 GSTIKV-----------------------FKKIANFTSDVEYSDD---------HCHLILPD--- 1326

  Fly  1797 HYMNIKNSVLSGGSPAFQSHVVNNCNDRVNKTIPEVYLTRLLATKGTIQKFVDDFFSIILTV-NE 1860
                         |.|||.........:....:.|:|||:||:||..|...::..|..|.:: |.
Human  1327 -------------SEAFQDVQGKRHRGKHKFKVKEMYLTKLLSTKVAIHSVLEKLFRSIWSLPNS 1378

  Fly  1861 ELPPAVKWLFDLLDEAARRHDIADTDIVHAWKSNCLPLRFWVNFIKNPDFIFDVNKTYSVDSCLS 1925
            ..|.|:|:.||.||..|....|.|.|:||.||:|.||||||||.:|||.|:||:.||..:|.|||
Human  1379 RAPFAIKYFFDFLDAQAENKKITDPDVVHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHIDGCLS 1443

  Fly  1926 VIAQTFMDACSTSEHRLGKDSPSNKLLFAKDIPNYRIMVKEFYRDVSRLPQISDQEMSTAMQQLS 1990
            ||||.||||.|.:|.:|||::|:||||:|||||.|:..||.:|:.:..||.:|..||...:.|.|
Human  1444 VIAQAFMDAFSLTEQQLGKEAPTNKLLYAKDIPTYKEEVKSYYKAIRDLPPLSSSEMEEFLTQES 1508

  Fly  1991 VRQNEEFDTISALKELYIYITKYKDQIMESLETD 2024
            .:...||:...||.|:|.||.||.|:|:..||.:
Human  1509 KKHENEFNEEVALTEIYKYIVKYFDEILNKLERE 1542

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexBNP_001245400.1 Sema_plexin_like 86..534 CDD:200497 83/439 (19%)
PSI 535..586 CDD:279745 19/51 (37%)
PSI 683..730 CDD:214655 14/52 (27%)
PSI 836..877 CDD:214655 9/42 (21%)
IPT_plexin_repeat1 888..976 CDD:238585 19/87 (22%)
IPT_plexin_repeat2 977..1095 CDD:238584 7/117 (6%)
IPT_plexin_repeat3 1097..1211 CDD:238586 23/120 (19%)
Plexin_cytopl 1452..2017 CDD:285529 210/583 (36%)
PLXNC1NP_005752.1 Sema_plexin_C1 44..453 CDD:200507 83/439 (19%)
PSI 454..507 CDD:279745 19/52 (37%)
PSI 591..635 CDD:214655 14/52 (27%)
TIG 664..750 CDD:280079 23/107 (21%)
IPT 753..841 CDD:214657 26/206 (13%)
Plexin_cytopl 1012..1535 CDD:285529 209/582 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147254
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D90434at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR22625
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.850

Return to query results.
Submit another query.