Protein Alignment PlexB and LOC100496572

DIOPT Version :10

• Sequence 1: NP_524616.2
• Gene: PlexB / 43766
• FlyBaseID: FBgn0025740
• Length: 2051
• Species: Drosophila melanogaster
• Sequence 2: NP_001415012.1
• Gene: LOC100496572 / 100496572
• XenbaseID: XB-GENE-29083231
• Length: 1368
• Species: Xenopus tropicalis
• Alignment Length: 1814
• Identity: 341/1814 - (18%)
• Similarity: 581/1814 - (32%)
• Gaps: 693/1814 - (38%)

  Fly    14 VLHVLCIIIILGSQHYCVNCIEELPAQALSPLNDIVAQFNLPSIPVQSTASSYGNRSIGNNIESV 78
            :|.:|.:..|..||     |....|:..|    |...::..|:.    |||    |.| .|:.|.
 Frog     8 LLSLLLLPTITTSQ-----CPSLPPSLTL----DTKVRYQFPNF----TAS----RPI-QNLVSF 54

  Fly    79 RDSQSKNYFTHMSFDFMHNVLFAGATNK--ILKLNENLRVLAEAVTGPLHDS-----PQCHAGGC 136
            .||                 ||...||.  :||.|| |.:|....|||. ||     .:|..|..
 Frog    55 EDS-----------------LFLTTTNHLYVLKGNE-LHLLQNITTGPT-DSQCTLCSKCQLGEA 100

  Fly   137 ----PEDIETSLVNNFNKILVVSYAHDGILIACGSIRQGACEIYSLPRFPATPQFFAVPLAANDE 197
                |||       ..:::|.|. ..:.::.:|||...|.|.::.:..............:.|..
 Frog   101 LPKQPED-------TVSQVLAVD-PEESVIYSCGSSLHGLCYMHIIASSKIVESECLFRQSGNSA 157

  Fly   198 NASTYAFVGPARYAWKEEDILYVGTTFTNV----GDYRHDVPAISSRRLDDLNYAEFSIQQSI-- 256
            ::.......|            :||..:.|    |.|.:...::.||..:..:....||::.:
 Frog   158 SSCPDCIASP------------LGTLLSVVTQSRGVYFYTASSLDSRIAESYSPTSISIRRLLGS 210

  Fly   257 ----------INIDVKYRDHFLVDYIYGFNSSEYAYFIIVQKKSHLADEAGYVTRLARICITDPN 311
                      :::...|||.:.:.|::.|.|..|.||:.||.:..|::.  |.:|:.|:...:..
 Frog   211 QDGFSPGFHSLSVLESYRDSYPIHYVHTFVSGSYVYFLTVQPEHPLSNT--YHSRVVRLSKNEEE 273

  Fly   312 YDSYTEITVQC----------TATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVFSPS 366
            ..||.|:.::|          ...|..: :|:::.|.|......||.::.|.:.|.||..||:.|
 Frog   274 MRSYRELILECRLEPKRRRRRRRAEPKI-FNVLKAAHVATVGSTLAGELDISEKDPVLFAVFAQS 337

  Fly   367 REISNQPESKSAMCIYSIKDIEDMFIENIHLCFNGTTK---DRNLGYISGTI--------NDGRC 420
            ...|.||...||:|.:.::.|:....:.::.|.:.|..   .|.|.:....:        :|..|
 Frog   338 EPKSAQPRYNSAVCAFPLRLIDLSIEDGMNACCSNTNSVRLTRGLNFFQPEMDCPQKDNQSDTSC 402

  Fly   421 PIVGSLGNIYNFCSVGLKISGVSPITAHALFH--FDNVSVTSVTATSTTDQQHSLAFLGTNMGVI 483
            ..|.:|              .:.|:....:|:  .|.|.:|||..:...|.  ::.||||:.|.:
 Frog   403 KNVPTL--------------VLPPLRRVDIFNGQLDGVLLTSVYVSPQEDL--TIGFLGTSAGRL 451

  Fly   484 KKVLLSGQSPGEYEEIVVDAGNRILPNTMMSPK----------KDFLYVLSQRKITKLRI--EHC 536
            .:|:|...|           ..|.|.|..:|..          .|.|:.::..::||:.|  ..|
 Frog   452 LQVVLQRNS-----------NPRTLSNFSISDNYPVSREVTQIGDSLFFVTGNQVTKVNITGPGC 505

  Fly   537 SVYTNCSACLES-RDPFCGWCSLEKRCTVRSTCQRDTSASRWLSLGSGQQCIEFESIIPEKIPIS 600
            ..:..||.||.: |...|.||
 Frog   506 RHFLTCSRCLRAPRFMGCSWC-------------------------------------------- 526

  Fly   601 ELSHLHLIIRTLPEPFNAKYRCVFGNSTPIDAEILENGLGCATPPLDERPLIPTNTDHILVPLSV 665
                                                                             
 Frog   527 ----------------------------------------------------------------- 526

  Fly   666 RSSETNKDFVSRNFAFFDCSHHGNCQ-ECLQSSWGCNWCIFDNKCVHKSLQCRNIENAVSTVGHC 729
                       :|.    |...|.|: ||.|           |.|
 Frog   527 -----------KNV----CCQQGECEGECAQ-----------NTC-------------------- 545

  Fly   730 PHLKKNRPEILLPVRVPIEIRLEIENLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKT 794
                       ||.....          .||:|                 |....:| |.:|.:
 Frog   546 -----------LPAITDF----------YPKTA-----------------PLRGNTN-ITLCGR- 570

  Fly   795 PYFYEINTHEYQAKVVVTWNFQHYVDTAIVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWCSNS 859
                     ::|:.||     .:....|.:|      .|:||        |:..|:
 Frog   571 ---------DFQSSVV-----YNAPPKAKIT------AGTHR--------VSVGPR--------- 598

  Fly   860 CVYNETCIADKNSISSGSKSAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKI 924
                 |||     ::.|..::....|.|           ..||
 Frog   599 -----TCI-----VNPGKSNSTSLVCTL-----------QTEG---------------------- 620

  Fly   925 FIGSVPCELENYQISVKI-ECRTGASLYEMSAPIKVANDAGFTESSVQFHFKNVLLTGLYPTIGP 988
                :|.......|::.| |..||...|     ||      .|.|:..|:|....:|.:.|..||
 Frog   621 ----LPDTASTADIALTIDENLTGTPYY-----IK------GTISAAGFNFVEPAITSIEPNFGP 670

  Fly   989 RSGGTQLSLIGKFLNIGSTMRAFLDEYECHIDVTQASSSQVSCTTSEATQPEPIRSLHLVIDGAN 1053
            .:|||.|:|.|:.|..|.|.|.|:...||.|..:...:..:.|.:..:....|: ::..::|||
 Frog   671 LAGGTMLTLKGQNLRSGETQRVFISGAECMISGSLCPAEVLCCVSPRSLSLGPL-NVSALLDGA- 733

  Fly  1054 RTLECQISTPSITNTNPTRSNFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVH 1118
                 :||:|                         :.|.|..||.:..|:|..|..||.| ||:.
 Frog   734 -----EISSP-------------------------AQFQYKPDPLVSVIRPNCSLASGTR-LTIQ 767

  Fly  1119 GIYLNSIQKPELEVFYDNERVNKTSCV-VINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQNS 1182
            |..|:|:.  .:::.|..::...:.|. ..:|:::.|.||...|
 Frog   768 GSNLDSVS--SIKISYSGQKTVSSDCQGTFSSDRIVCRSPEYPY--------------------- 809

  Fly  1183 SFQTETRYKNEYDRKKRRADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFVMD 1247
                                ||....| |.|..:.||
 Frog   810 --------------------FGRPGNL-TLALDAVNY---------------------------- 825

  Fly  1248 NVQLVRNLNKY-FHDIRSTIVYLADPKYLPFPNDGV-KLYKG-DSLVIEGELLNLAADEYDVNVT 1309
                   :..| |..:::.:::...||   .|:.|: ||.|| |.:....|.|...|....|::|
 Frog   826 -------IYPYRFRYLQNYVIHPFRPK---DPDGGILKLKKGEDEIETHQENLEQVATCLKVSMT 880

  Fly  1310 IGTSQCNITSLALNQLLCIPPEQQPLPTDENGV-----DQSTDLPLVVVKVGRNLRFVIGYLKYD 1369
            :|..:||.|.|. |::.|..|:...:|::.:.|     |..|.:.||::.  ..|..|:|
 Frog   881 VGGRECNPTVLK-NEITCRIPKGMVIPSEGSIVQVCVDDDCTTVGLVMIV--NMLDPVLG----- 937

  Fly  1370 LNKPYVFSHALLVGILTVALLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESNVRSECKQAF 1434
                      :::|.:...|:|.|.:.:|:..:||      :.|:..::.:.|.||...|
 Frog   938 ----------IVLGSVASVLVVAVLIFLLLKHQRK------KKKKPAVEALELLSNNNRE----- 981

  Fly  1435 AELQTDMTDLTADLESTGIPTLDHVNYIMKVFFPGVSDH--------------PILNSPKFREGS 1485
             .:.:.::.|..|..::.||:.:.         .|:..|              |||.:.......
 Frog   982 -PVLSPISLLHVDYRTSYIPSSNS---------GGMLSHGAGYSGGSLGGGSMPILLTSLLDSLR 1036

  Fly  1486 PQTNYDAAMVQF---------EQLIGNKYFLLMFIETLE---------AQRSSFSIRDRVNVASL 1532
            |:...:...|..         :::||..:|..::..|..         |.:|...|.|...|...
 Frog  1037 PELLEEVKDVLIPERCLTTHRDRIIGKGHFGSVYHGTYVDEDQQEVHCAVKSLNRITDLEEVEEF 1101

  Fly  1533 IMVVLMNKMEYATEILKSLLLRLIDKSLA------SKHPQLMLRRTESVVEKMLTNYLAICMYDY 1591
            :...::.|..:...:|..:.:.|..:.|.      .||..  ||......|:..|
 Frog  1102 LREGILMKSFHHPNVLSLIGIFLPQEGLPLVVLPFMKHGD--LRHFIRCQERNPT---------- 1154

  Fly  1592 LKEYAGSNLFLLFKAIKHQIEKGLVDAITNDARYSLSEERLLHEQVTHSVVILHILQDDLDEKVQ 1656
            :|:..|..|         |:.:|:        .| |:..:.:|..:.....:       |||...
 Frog  1155 VKDLVGFGL---------QVSRGM--------EY-LANRKFVHRDLAARNCM-------LDETFH 1194

  Fly  1657 CRVNDWDTISQVKLKILDAIFKNTPFSMRPSVN-EVDLEWRHGRGGHLTLQDEDLTTKT 1714
            .:|.|:.....|        |....:|:|...| .:.::|.    ...:||.:..|||:
 Frog  1195 VKVADFGLARDV--------FDKEYYSVRRHKNARLPVKWM----ALESLQTQKFTTKS 1241

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PlexB	NP_524616.2	Sema_plexin_like	86..534	CDD:200497	110/509 (22%)
		PSI	535..586	CDD:396154	9/51 (18%)
		TIG_plexin	594..682	CDD:465588	1/87 (1%)
		PSI	683..730	CDD:214655	8/47 (17%)
		TIG_2	738..827	CDD:465619	14/88 (16%)
		PSI	836..877	CDD:214655	6/40 (15%)
		IPT_plexin_repeat1	888..976	CDD:238585	15/88 (17%)
		IPT_plexin_repeat2	977..1095	CDD:238584	28/117 (24%)
		IPT_plexin_repeat3	1097..1211	CDD:238586	22/114 (19%)
		TIG	1277..>1334	CDD:460355	20/58 (34%)
		Plexin_cytopl	1452..2012	CDD:462434	52/302 (17%)
LOC100496572	NP_001415012.1	None