Protein Alignment PlexB and met

DIOPT Version :10

• Sequence 1: NP_524616.2
• Gene: PlexB / 43766
• FlyBaseID: FBgn0025740
• Length: 2051
• Species: Drosophila melanogaster
• Sequence 2: XP_002935001.1
• Gene: met / 100485823
• XenbaseID: XB-GENE-481272
• Length: 1375
• Species: Xenopus tropicalis
• Alignment Length: 1801
• Identity: 345/1801 - (19%)
• Similarity: 595/1801 - (33%)
• Gaps: 732/1801 - (40%)

  Fly    70 SIGNNIES-VRDSQSKNYFTHMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQC-H 132
            :|.:|::| ..|:..:|......:      ::.||.|||..|||||..::|..||||.....| .
 Frog    34 NIKHNLQSFTTDTPIQNIIMFKGY------IYVGAVNKIYVLNENLTKVSEYKTGPLLVHSHCLP 92

  Fly   133 AGGCPEDI---ETSLVNNFNKILVVSYAHDGILIACGSIRQGACEIYSL----PRFPATPQ--FF 188
            ...|.::.   ..:..:|.|..|.|...:|..||:||:||:|.|:.::|    |...|:..  .:
 Frog    93 CKNCTDNFLSPNGTWKDNVNMALFVEDFYDDQLISCGNIRRGECQRHTLHSDKPWDIASNVHCLY 157

  Fly   189 AVPLAANDEN-----ASTYA----------FVGPARYAWKEEDILYVGTTFTNVGDYRHDVPAIS 238
            :..:..:.:|     .||..          ||.           .:||:|.|......|   ::|
 Frog   158 SSQMIEDKDNCPDCIVSTTGSKILVTVRDRFVK-----------FFVGSTLTGQPSTIH---SVS 208

  Fly   239 SRRLDDLNYA-EFSIQQSIINIDVKYRDHFLVDYIYGFNSSEYAYFIIVQKKSHLADEAGYVTRL 302
            .|||.:.... |:...||.|::..:.||.:.:.|||.|.|:.:.||:.||::|  .|...|.||:
 Frog   209 VRRLKETQDGFEYLTDQSYIDVLPQLRDIYPIKYIYTFESNNFVYFLTVQRES--IDSQAYHTRI 271

  Fly   303 ARICITDPNYDSYTEITVQCTATEN-------NVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLV 360
            .|:|.:|....||.|:.::|..||.       ...:||::.|.:..|...||::||:|.||.:|.
 Frog   272 VRVCSSDSELRSYIEMPLECIFTEKRRKRSTAGAVFNILQAAYLGRAGEDLAEEMGVKPDDDILY 336

  Fly   361 TVFSPSREISNQPESKSAMCIYSIKDIEDMF-----------IENIH-----LCFNGTTKDRNLG 409
            .||:.|:..|::..::||:|..|:|.|.:.|           :|:.:     ||.|.....||..
 Frog   337 AVFAQSKLDSSEANNRSAVCAVSVKTINEFFNNAADKQNTKCLEHFYEKDNRLCINNKKFLRNAS 401

  Fly   410 YISGTINDGRCPIVGSLGNIYNFCSVGLKISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLA 474
            |.|..|::.|..:...|..:..|                 :..|.||.:||::.  .|..:.::|
 Frog   402 YCSTPIDEYRVEVTTVLRRLDLF-----------------MDQFRNVLLTSISV--FTQGRLTIA 447

  Fly   475 FLGTNMGVIKKVLLS--GQSPGEYEEIVVDAGNRILPNTMMSPKKDFLYVLSQRKITKLRIEHCS 537
            .|||:.|...:|::|  ||                       ||....::|..|.::
 Frog   448 NLGTSEGRFMQVVISRTGQ-----------------------PKPHVNFLLEPRPVS-------- 481

  Fly   538 VYTNCSACLESRDPFCGWCSLEKRCTVRSTCQRDTSASRWLSLGSGQQCIEFESIIPEKI--PIS 600
                                                                    ||.:  |.|
 Frog   482 --------------------------------------------------------PEVVINPAS 490

  Fly   601 ELSHLHLIIRTLPEPFNAKYRCVFGNSTPIDAEILENGLGCATPPLDERPLIPTNTDHILVPLSV 665
            |                                  |:|.          .|:.|......|||.|
 Frog   491 E----------------------------------ESGY----------TLVNTGMQLTKVPLVV 511

  Fly   666 RSSETNKDFVSRNFAFFDCSHHGNCQECLQSSWGCNWCIFDNKCVHKSLQCRNIENAVSTVGHCP 730
                            ..|.|..:|..||.|
 Frog   512 ----------------LTCGHLKSCSHCLSS---------------------------------- 526

  Fly   731 HLKKNRPEILLPVRVPIEIRLEIENLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKTP 795
                                                                             
 Frog   527 ----------------------------------------------------------------- 526

  Fly   796 YFYEINTHEYQAKVVVTWNFQHYVDTAIVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWCSNSC 860
                                                                 |...|.||.|.|
 Frog   527 -----------------------------------------------------PSVNCGWCKNRC 538

  Fly   861 VYNETCIADKNSISSGSKSAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREE---DVRG 922
            ...:.|:         ::..|:..|| |.:..:.|.|.|:||||.:||.||:..:.:.   |::.
 Frog   539 TRKQECL---------NEEWIQETCP-PAVYEVFPSSAPLEGGTQLTICGSDFVLSKNNNFDLKN 593

  Fly   923 -KIFIGSVPCELE-NYQISVKIECR---TGASLYEMSAPI----KVANDAGFTESSVQFHFKNVL 978
             .:.||...|::| .:....|:.||   :.:|::.:|:.:    :|.|   ||    .|.:.|.:
 Frog   594 TMVIIGKKRCKIEGKFSNQNKLVCRIDSSASSVFNISSSVSNGKQVVN---FT----TFSYVNPI 651

  Fly   979 LTGLYPTIGPRSGGTQLSLIGKFLNIGSTMRAFLDEYECHIDVTQASSSQVSCTTSEATQPEPIR 1043
            :|.:.|:.||::|.|.:::.|::||.|...:..:.:..|.|  ...||:.:.|.|
 Frog   652 ITSIMPSHGPKAGRTLITMKGQYLNSGKEQKVIIGKEMCKI--KSVSSAAIECYT---------- 704

  Fly  1044 SLHLVIDGANRTLECQISTPSITNTNPTRSNFGSY----QLRSLPRQPCSIFNYTQDPRIMQIKP 1104
                                      |.:...|:|    ::.:..|:..:.|.|.:||.:..|||
 Frog   705 --------------------------PVQRTTGTYLVALKIDNADRESSTRFTYMEDPSVSNIKP 743

  Fly  1105 LRSFKSGGRVLTVHGIYLNSIQKPELEVFYDNERVNK------TSCVVINSNQMECPSPPVNYKF 1163
            ::||.|||..:|.:|..||::..|::.:     |::|      .||:..:::::.|.|.|
 Frog   744 VKSFLSGGSSITAYGRNLNAVASPQMVI-----RLSKPELSYNMSCIHRSTSELICCSTP----- 798

  Fly  1164 ETFKKTNRKMDTELHLQNSSFQTETRYKNEYDRKKRRADFGDTFRLYTNAGSSANYFVNNNMDVT 1228
             :.|        ||:|
 Frog   799 -SLK--------ELNL------------------------------------------------- 805

  Fly  1229 TFVKVHETQLNLQLSFVMDNVQLVRNLNKYFHDIRSTIVYLADPKY--------LPFPNDGVKLY 1285
                  |..:..|:.|::|.|     ::.||.     :.|:.:|.:        .|..|..:...
 Frog   806 ------EPPITTQVFFILDGV-----ISNYFE-----LSYVNNPIFETFEKPVVFPIGNKNILEI 854

  Fly  1286 KG---DSLVIEGELLNLAADEYDVNVTIGTSQCNITSLALNQLLCIPPEQQPLPTDENGVDQSTD 1347
            ||   ||..:.||:|.           :|...|.|.....:.:.|      .:|||
 Frog   855 KGDHIDSEAVRGEVLK-----------VGNKSCEIIQSKSDSVSC------SVPTD--------- 893

  Fly  1348 LPLVVVKVGRNLR--FVIGYLKYDLNKPYVFSHALLVGILT-----VALLVVVFVIVLIIFRRKS 1405
                :.|....|:  |:.|.....:.|..|.......||:|     |.||:::|.:::.:.:||
 Frog   894 ----LFKSNSELKIEFLQGVSSIIIGKVMVTQDQNFTGIITGVVSCVVLLLIIFGVLIWMKKRK- 953

  Fly  1406 TQAEREYKRIQIQMITLESNVRSECKQAFAELQTDMTDLTADLESTGIPTLDHVNYIMKVFFPGV 1470
                 :.|.:...|:..:..|.:.........::    ::...|.....::|:.:.:.:..||..
 Frog   954 -----QLKDLGGDMVLYDGRVHTPHLDRLVSARS----ISPTTEMVSSESVDYRSTVQEDPFPNS 1009

  Fly  1471 SDH--------------PILNSPKFREGSPQTN------------------------YDAAMVQF 1497
            |.:              |||:|......||..:                        .|..:|.|
 Frog  1010 SQNGSCRPAQYAHRDLSPILSSGDSDIASPLLHSYVHIDISALSTDLMKEVEHMVIRVDRLIVHF 1074

  Fly  1498 EQLIGNKYFLLMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSLLLRLIDKSLAS 1562
            .::||..:|..::..||      ..| |..||.  ..|..:|::....|:.:.|...:|.|..:
 Frog  1075 NKVIGRGHFGCVYHGTL------LDI-DGKNVH--CAVKSLNRITDIEEVSQFLKEGIIMKDFS- 1129

  Fly  1563 KHPQLMLRRTESVVEKMLTNYLAICMYDYLKEYAGSNLFLLFKAIKH------------------ 1609
             ||.::             :.|.||:.:     .||.|.:| ..:||
 Frog  1130 -HPNVL-------------SLLGICLPN-----EGSPLVVL-PFMKHGDLRNFIRNETHNPTVKD 1174

  Fly  1610 ------QIEKGLVDAITNDARYSLSEERLLHEQVTHSVVILHILQDDLDEKVQCRVNDWDTISQV 1668
                  |:.||:        .| |:.::.:|..:.....:       |||....:|.|:.....|
 Frog  1175 LIGFGLQVAKGM--------EY-LASKKFVHRDLAARNCM-------LDEHFTVKVADFGLARDV 1223

  Fly  1669 KLKILDAIFKNTPFSMRPSVNEVDLEWRHGRGGHLTLQDEDLTTKT 1714
            ..|...::...|  ..:..|..:.||         :||.:..|||:
 Frog  1224 YDKEYYSVHNKT--GAKLPVKWMALE---------SLQTQKFTTKS 1258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PlexB	NP_524616.2	Sema_plexin_like	86..534	CDD:200497	130/498 (26%)
		PSI	535..586	CDD:396154	0/50 (0%)
		TIG_plexin	594..682	CDD:465588	13/89 (15%)
		PSI	683..730	CDD:214655	6/46 (13%)
		TIG_2	738..827	CDD:465619	0/88 (0%)
		PSI	836..877	CDD:214655	7/40 (18%)
		IPT_plexin_repeat1	888..976	CDD:238585	27/99 (27%)
		IPT_plexin_repeat2	977..1095	CDD:238584	22/121 (18%)
		IPT_plexin_repeat3	1097..1211	CDD:238586	25/119 (21%)
		TIG	1277..>1334	CDD:460355	12/59 (20%)
		Plexin_cytopl	1452..2012	CDD:462434	61/325 (19%)
met	XP_002935001.1	Sema_MET	21..510	CDD:200539	146/647 (23%)
		PSI	513..555	CDD:396154	14/202 (7%)
		IPT_plexin_repeat1	556..649	CDD:238585	27/99 (27%)
		IPT_plexin_repeat2	650..734	CDD:238584	22/121 (18%)
		IPT_plexin_repeat3	736..831	CDD:238586	33/178 (19%)
		IPT_PCSR	833..926	CDD:238337	23/122 (19%)
		PTKc_Met_Ron	1076..1337	CDD:270649	48/240 (20%)