DRSC/TRiP Functional Genomics Resources

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Protein Alignment PlexB and met

DIOPT Version :9

Sequence 1:NP_001245400.1 Gene:PlexB / 43766 FlyBaseID:FBgn0025740 Length:2051 Species:Drosophila melanogaster
Sequence 2:NP_001007125.1 Gene:met / 100150664 ZFINID:ZDB-GENE-041014-1 Length:1382 Species:Danio rerio


Alignment Length:1960 Identity:352/1960 - (17%)
Similarity:607/1960 - (30%) Gaps:816/1960 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 IHVLHVLCIIIILGSQHYCVNCIEELPAQALSPLNDIVAQFNLP----SIPVQSTASSYGNRSIG 72
            ||......|:|||.|..:.:||..|.|.:: |.| |:...::||    ..|:|....        
Zfish     3 IHYSEAASILIILQSLWWGLNCQCEEPIES-SKL-DLSVTYDLPYFVSDTPIQKLLE-------- 57

  Fly    73 NNIESVRDSQSKNYFTHMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQC-----H 132
                                  ::..::.||.|::..|:::|:...|..|||:|:.|.|     .
Zfish    58 ----------------------INGTVYVGAVNRLYALSKDLKKKHEYKTGPVHEGPDCKTPTDQ 100

  Fly   133 AGGC---PEDIETSLVNNFNKILVVSYAHDGILIACGSIRQGACEIYSLPRFPATPQFFAVPLAA 194
            ..||   |.:|     ||.|..|::...:|..|.:|||:..|.|..:.|...|...:...:....
Zfish   101 CSGCENKPRNI-----NNTNMALLMETFYDLELFSCGSVGNGVCSRHVLEDGPLGAEVTCMYTKK 160

  Fly   195 ND--ENASTYAFVGPARYAWKEEDILYVGTTFTNV-------------------GDYRHDVPAIS 238
            |:  .:.......|||            ||...|:                   |...|.  .||
Zfish   161 NEGSSHGCPDCLAGPA------------GTQILNIMSGRVVRFFVANSEPLESNGPRLHH--TIS 211

  Fly   239 SRRLDDLNYA-EFSIQQSIINIDVKYRDHFLVDYIYGFNSSEYAYFIIVQKKSHLADEAGYVTRL 302
            .|::.:.... ||..:||.:::....|.::.:.|:|.|.|..|.||:.||::.  .:...:.||:
Zfish   212 IRKMRETQDGFEFFSEQSYMDLAPSLRGNYPLHYVYSFQSGPYVYFLTVQREG--GNSKAFHTRI 274

  Fly   303 ARICITDPNYDSYTEITVQCTATEN-------NVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLV 360
            .|:|.:|.....|.|:..:|..:|.       .|.:|:::.|.|....:...|:||:|:.:.||.
Zfish   275 VRMCSSDSEILRYVEMPFECIYSERRRKKRSAQVVFNVLQAAHVAKVGYDFQQEMGLKEGEDVLF 339

  Fly   361 TVFSPSREISNQPESKSAMCIYSIKDIEDMFIENIHLCFNGTTKDRNLGYISGTINDGRCPIVGS 425
            ..|:.|:..|.:|.:.||:|:.||.||.:.|...|.   .|.|  |.|.:..           ||
Zfish   340 AAFARSKPDSPEPTASSAVCLISITDINEFFKVFIQ---KGYT--RKLHHFP-----------GS 388

  Fly   426 LGNIYNFCSVG-------------LKISGVSPITAHALFH--FDNVSVTSVTATSTTDQQHSLAF 475
            ....:|...||             |:::..:|  ....||  |.||.:||:.....  |.|::..
Zfish   389 EEKTFNQTFVGDSFSCGKHERGYRLEVTSTNP--RRDYFHGRFRNVLLTSIAVVPI--QNHTVVS 449

  Fly   476 LGTNMGVIKKVLLS--GQSPGEYEEIVVDAGNRILP----NTMMSPK--KDFLYVLSQRKITKLR 532
            |||..|.:.:|::|  |::     |..||....:||    ..::||:  ...|.:::..|::||.
Zfish   450 LGTAEGRVIQVVVSRFGKT-----EPHVDFRLDMLPVSSEMALLSPQHHNGSLLLITGDKVSKLP 509

  Fly   533 I--EHCSVYTNCSACLESRDPF-CGWCSLEKRCTVRSTCQRDTSASRWLSLGSGQQCIEFESIIP 594
            :  ..|.....||:||.:.... ||||....|||                               
Zfish   510 VIGPGCEQLWTCSSCLLAPGFMGCGWCRTSNRCT------------------------------- 543

  Fly   595 EKIPISELSHLHLIIRTLPEPFNAKYRCVFGNSTPIDAEILENGLGCATPPLDERPLIPTNTDHI 659
                                                                             
Zfish   544 ----------------------------------------------------------------- 543

  Fly   660 LVPLSVRSSETNKDFVSRNFAFFDCSHHGNCQECLQSSWGCNWCIFDNKCVHKSLQCRNIENAVS 724
                                         ....|.||.|                          
Zfish   544 -----------------------------RAPRCPQSQW-------------------------- 553

  Fly   725 TVGHCPHLKKNRPEILLPVRVPIEIRLEIENLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIV 789
                                                                             
Zfish   554 ----------------------------------------------------------------- 553

  Fly   790 VCEKTPYFYEINTHEYQAKVVVTWNFQHYVDTAIVTLYKCDVLGSHREHPDCSLCVTRDPKYKCA 854
                                                                             
Zfish   554 ----------------------------------------------------------------- 553

  Fly   855 WCSNSCVYNETCIADKNSISSGSKSAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREED 919
                                      |::.||| .|..|.|.|.|:.|.|.|||.|.|.|..::|
Zfish   554 --------------------------IQDSCPL-LITSISPSSAPLRGQTNITICGKNFGFNKKD 591

  Fly   920 ----VRGKIFIGSVPCELE-----NYQISVKIECRTGASLYEMSAPIKVANDAGFTESSVQ---- 971
                ....:.:....|:||     |.::...::....:||           |:..|..|.:    
Zfish   592 RFDTKLVDVVVAGTKCKLERKDSNNNRLVCGLDYVNWSSL-----------DSVITVRSGKEQAQ 645

  Fly   972 ---FHFKNVLLTGLYPTIGPRSGGTQLSLIGKFLNIGSTMRAFLDEYECHIDVTQASSSQVSCTT 1033
               |.|.|.::..::|..||:||||.|::.|.||:.|:.....:....|.:.  ..|::.::|  
Zfish   646 KDGFSFVNPVIIEIFPEFGPQSGGTMLTISGSFLDSGNVQTVTVGNATCVLQ--SVSATMLTC-- 706

  Fly  1034 SEATQPEPIRSLHLV---IDGANRTLECQISTPSITNTNPTRSNFGSYQLRSLPRQPCSIFNYTQ 1095
              .|.|:|..|.|.|   |||.  ..|..:|                             :.|.:
Zfish   707 --RTPPQPSPSQHKVQLHIDGV--IFEAPVS-----------------------------YTYNK 738

  Fly  1096 DPRIMQIKPLRSFKSGGRVLTVHGIYLNSIQKPELEVFYDNERVNKTSCVVINSNQMECPSPPVN 1160
            :|.|..::|..||.|||..:||:|.||:|..:|::.:         |:.......|:.|      
Zfish   739 NPHISSVQPKHSFISGGSTVTVNGFYLHSALQPQMVL---------TAATEGKLFQVTC------ 788

  Fly  1161 YKFETFKKTNRKMDTELHLQNSSFQTETRYKNEYDRKKRRADFGDTFRLYTNAGSSANYFVNNNM 1225
                                            .:|..||                       |.:
Zfish   789 --------------------------------SHDEDKR-----------------------NIL 798

  Fly  1226 DVTTFVKVHETQ--LNLQLSFVMDNVQLVRNLNKYFHDIRSTIVYLADPKYLPFPNDGVKLYKGD 1288
            .:|..:|....|  :..:::||:|.          |...:..::|:.|||:..|....| ..:|.
Zfish   799 CITPSLKGLSVQPPVATKMTFVLDG----------FSTDQYDLLYVEDPKFEEFQKPTV-TPRGK 852

  Fly  1289 SLVIEGEL--LNLAADEYDVNVTIGTSQCNITSLALNQLLCIPPEQQPLPTDENGVD--QSTDLP 1349
            ..::|.::  :|..|.:....:.:....|...:|..|.|.|..|.:......|..|:  |:|.  
Zfish   853 KNILEIKVPPVNQEAVKNGEVLRVSNRTCESVTLVGNTLECTVPMELQTAAKELEVEWKQATS-- 915

  Fly  1350 LVVVKVGRNLRFVIGYLKYDLNKPYVFSHALLVGILTVALLVVVFVIVLIIFRRKS--------- 1405
                      ..::|.:....::.|   ..|:.|.:.|::|:::.:.|.:..:||.         
Zfish   916 ----------SVILGRVILAQDQDY---RILITGGVCVSILLLLLIAVFVWIKRKKHIDDLAKTM 967

  Fly  1406 ----------------------------TQAEREYKRIQIQMITLESNVRSECK-QAFAELQTDM 1441
                                        :....:|:...::...|..:....|: ..:|....|:
Zfish   968 VWYDGRAHIPHLDMLANARSVSPTDEMVSHESVDYRTTLLEDQNLPLSQTESCRPHLYAHSHVDL 1032

  Fly  1442 T----DLTADLESTGIPT---LD----HVNYIMKVFFPGVSDHPILNSPKFREGSPQTNYDAAMV 1495
            :    .:..||.|..:|:   :|    |...:. |      .|.::    .||.        .::
Zfish  1033 SPMLGPMEGDLASPLLPSTAPIDLGSLHPELLKXV------QHVVI----ARED--------LLL 1079

  Fly  1496 QFEQLIGNKYFLLMFIETL---EAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSLLLRLID 1557
            ...::||..:|..:|..||   :.|:...:|:.            :|::....|:.:.|...:|.
Zfish  1080 HVNEIIGRGHFGCVFHGTLLEPDGQKQHCAIKS------------LNRITDIEEVSQFLKEGIIV 1132

  Fly  1558 KSLASKHPQLMLRRTESVVEKMLTNYLAICMYDYLKEYAGSNLFLLFKAIKH------------- 1609
            |..:  ||.::             :.|.||:     ...||.|.:| ..:||             
Zfish  1133 KDFS--HPNVL-------------SLLGICL-----PSEGSPLVVL-PYMKHGDLRNFIRDESHN 1176

  Fly  1610 -----------QIEKGLVDAITNDARYSLSEERLLHEQVTHSVVILHILQDDLDEKVQCRVNDWD 1663
                       |:.||:        .| |:.::.:|..:.....:       |||....:|.|..
Zfish  1177 PTVKDLMGFGLQVAKGM--------EY-LASKKFVHRDLAARNCM-------LDESYTVKVADVG 1225

  Fly  1664 TISQVKLKILDAIFKNTPFSMRPSVNEVDLEWRHGRGGHLTLQDEDLTTKTVNGWKRLNTLAHYG 1728
            ....|..|...::  :....::..|..:.||         :||....|||: :.|.       :|
Zfish  1226 LARDVYDKEYYSV--HNKHGVKLPVKWMALE---------SLQTHKFTTKS-DVWS-------FG 1271

  Fly  1729 VKESAVMSLIARQNDNYHIPYSKNQNSAPYHNFYFINNSQSHIIINN-DIESGLQQPRVYHLVKP 1792
            |   .:..|:.|             .:.||.:            :|: ||...|.|.|  .|::|
Zfish  1272 V---LLWELMTR-------------GAPPYSD------------VNSFDITVFLLQGR--RLLQP 1306

  Fly  1793 NI-PDHYMNI 1801
            .. ||...|:
Zfish  1307 EFCPDALYNV 1316

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlexBNP_001245400.1 Sema_plexin_like 86..534 CDD:200497 125/509 (25%)
PSI 535..586 CDD:279745 12/51 (24%)
PSI 683..730 CDD:214655 4/46 (9%)
PSI 836..877 CDD:214655 0/40 (0%)
IPT_plexin_repeat1 888..976 CDD:238585 25/103 (24%)
IPT_plexin_repeat2 977..1095 CDD:238584 27/120 (23%)
IPT_plexin_repeat3 1097..1211 CDD:238586 21/113 (19%)
Plexin_cytopl 1452..2017 CDD:285529 70/386 (18%)
metNP_001007125.1 Sema_MET_like 43..511 CDD:200509 129/543 (24%)
PSI 514..559 CDD:214655 17/351 (5%)
IPT 562..653 CDD:301692 25/101 (25%)
IPT_plexin_repeat2 654..736 CDD:238584 26/118 (22%)
IPT 740..823 CDD:301692 27/152 (18%)
Pkinase_Tyr 1079..1338 CDD:285015 63/336 (19%)
PTKc_Met_Ron 1083..1344 CDD:270649 63/332 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 41 1.000 Domainoid score I12490
eggNOG 1 0.900 - - E1_KOG3610
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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