Protein Alignment PlexB and mst1rb

DIOPT Version :10

• Sequence 1: NP_524616.2
• Gene: PlexB / 43766
• FlyBaseID: FBgn0025740
• Length: 2051
• Species: Drosophila melanogaster
• Sequence 2: XP_073773053.1
• Gene: mst1rb / 100134855
• ZFINID: ZDB-GENE-071218-3
• Length: 1374
• Species: Danio rerio
• Alignment Length: 1992
• Identity: 373/1992 - (18%)
• Similarity: 635/1992 - (31%)
• Gaps: 765/1992 - (38%)

  Fly    29 YCVNC--IEELPAQALS---PLNDIVAQFNLP-SIPVQSTASSYGNRSIGNNIESVRDSQSKNYF 87
            :.|.|  |:.|.:.||.   |...|...|::| .:|..                     |::|..
Zfish     7 HLVTCVWIQALMSSALDTCPPTAPISVDFSVPYPMPYY---------------------QTRNPI 50

  Fly    88 THMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQCH-AGGCPEDIETSLVNNFNKI 151
            .::..:..:..::..:.|.|..||.:|..|.:..|||: .||:|. ...|..|.:....:..|::
Zfish    51 QNIVTNSFYKEVYVASQNVIEALNNSLDKLWKLRTGPV-GSPECEICDLCDIDRDPFHEDTDNEV 114

  Fly   152 LVVS----YAHDGILIACGSIRQGACEIYSL-----PRFPA---------TPQF--------FAV 190
            |::.    |     |.:|||.:.|.|..:.|     |..|:         :|||        |..
Zfish   115 LLLDTFLMY-----LYSCGSTQYGVCYFHQLRENGNPPGPSKCLFRKKFNSPQFCPDCIASPFGT 174

  Fly   191 PLAANDENASTYAFVGPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRR---LDDLNYAEF-- 250
            .::..:|..:.|.|               |..|..|....::...:||.||   .:|..|.:.
Zfish   175 KVSMVEEGQTVYFF---------------VAATVNNSVTQKYGRMSISVRRPVATEDGFYTDVRG 224

  Fly   251 -----SIQQSIINIDVKYRDHFLVDYIYGFNSSEYAYFIIVQKKSHLADEAGYVTRLARICITDP 310
                 ::||:           :.::|:|.|.:.::.||:.||::....|.:.:.|||.|:    |
Zfish   225 LTVLPALQQT-----------YGIEYVYSFYTQDFVYFLSVQREKTNLDSSPFQTRLGRL----P 274

  Fly   311 NYD----SYTEITVQC----------TATE--NNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVL 359
            .::    .|.||.::|          ..:|  .:|.||:|:.|....|..:||.::|.:::|.:|
Zfish   275 RHEWEMRRYREIVLECRFEPKRRRRSNVSEPFKDVVYNVVQAAHFGKAGRELADELGAEEEDDIL 339

  Fly   360 VTVFSPSREISNQPESKSAMCIYSIKDIEDMFIENIHLCFNGTTKDRNLGYISGTINDGRCPIVG 424
            ..||:.:.: |..||..||:|.:.:..:.....:.:..|.....:..:.|.......:. ||
Zfish   340 YGVFAVTDD-SGVPEHDSALCAFPMDTVNTAIDDGVEDCCKSGPEQLSRGLCHFQPCES-CP--- 399

  Fly   425 SLGNIYNFCSVGLKISGVSPITAHALFHFD-------NVSVTSVTATSTTDQQHSLAFLGTNMGV 482
                 :......:.......:.|...:..|       .|.:||:..||.  :..::|.:||:.|.
Zfish   400 -----HESMEHNMTCRDHPTLVAQPYYRVDLFNRQMRGVLLTSLLVTSI--ENKTVAHIGTSDGR 457

  Fly   483 IKKVLLSGQSPGEYEEIVVDAGNRILPNTMMS------PKKDFLYVLSQRKI-TKLRIEHCSVYT 540
            :.:::|...||      ::.|...::.|..:|      .:...|:|:..:.| ...|...|..:.
Zfish   458 LLQLVLRRSSP------IIFANYSLVENQKVSSTAAVLSQNHLLFVVGDKMIRVPQRGPGCRHFL 516

  Fly   541 NCSACLES-RDPFCGWCSLEKRCTVRSTCQRDTSASRWLSLGSGQQCIEFESIIPEKIPISELSH 604
            .|:.||.: :...|||||  .:||..|.|:     :.|::........||   .|:..|....|.
Zfish   517 TCAMCLTAPKFMGCGWCS--GQCTWASECR-----AHWVNESCPPVITEF---FPKTAPPDGQSE 571

  Fly   605 LHLIIRTLPEPFNAKYRCVFGNSTPIDAEILENGLGCATPPLDERPLIPTNTDHILVPLSVRSSE 669
            :.|              |.:...:|:                  ||.|.|.|.      .||..|
Zfish   572 MTL--------------CGWEFQSPL------------------RPAITTRTH------EVRLGE 598

  Fly   670 TNKDFVSRNFAFFDCSHHGNCQECLQSSWGCNWCIFDNKCV---HKSLQCRNIENAVSTVGHCPH 731
            |                                     .||   |||              :|.|
Zfish   599 T-------------------------------------ACVVQPHKS--------------NCTH 612

  Fly   732 LKKNRPEILLPVRVPIEIRLEIENLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKTPY 796
            |                                  ||.|.
Zfish   613 L----------------------------------LCKIR------------------------- 618

  Fly   797 FYEINTHEYQAKVVVTWNFQHYVDTAIVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWCSNSCV 861
                                   ...|.||:|             .|.||
Zfish   619 -----------------------SGTIETLFK-------------PLNVT--------------- 632

  Fly   862 YNETCIADKNSISSGSKSAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIFI 926
                                           .|...|.|||.  .:|:||
Zfish   633 -------------------------------AKVHEGQVEGH--YSIDGS--------------- 649

  Fly   927 GSVPCELENYQISVKIECRTGASLYEMSAPIKVANDAGFTESSVQFHFKNVLLTGLYPTIGPRSG 991
                                             |...|||     |...|:  |.:.|..||..|
Zfish   650 ---------------------------------AEMPGFT-----FVVPNI--TEVQPDYGPVDG 674

  Fly   992 GTQLSLIGKFLNIGSTMRAFLDEYEC---HIDVTQASSSQVSCTTSEATQPEPIRSLHLVIDGAN 1053
            ||.:::.|.:|:.|...:..||...|   .:.|.:.:.|.:.|.:...|:.:.:
Zfish   675 GTLITITGPYLDSGKNRKVTLDGESCPVQSVSVARGNLSSIVCLSQPVTEVKDV----------- 728

  Fly  1054 RTLECQISTPSITNTNPTRSNFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVH 1118
             .|...|....:..|                    .:|.|.:.|.|:.:.|..||.||.|:: :.
Zfish   729 -VLRVYIDKSRVVTT--------------------KVFRYKKTPEILAVLPDCSFDSGSRII-IE 771

  Fly  1119 GIYLNSIQKPELEVFYDNERVNKTSCVVINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQNSS 1183
            |..|:|:.:   .|.|...:                                     |.||:..|
Zfish   772 GRNLDSVYR---TVVYFQPK-------------------------------------ESHLKPVS 796

  Fly  1184 FQTETRYKNEYDRKKRRADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFVMDN 1248
              ||.|.|.:..|                            |:..|.|...:.....:|||.||.
Zfish   797 --TECRGKAKPTR----------------------------MECITPVFPRDETEEGELSFDMDG 831

  Fly  1249 VQLVRNLNKYFHDIRSTIVYLADPKYLPFPNDG--VKLYKG-DSLVIEGELLNLAADEYDVNVTI 1310
            |     |..:.||..    |....:.:||..:|  ::||.| |.:.:..:.|||.:....:.:|:
Zfish   832 V-----LGLWKHDFS----YHPYGRPIPFETEGHILRLYPGFDEVSLHHQKLNLVSSCMSITMTV 887

  Fly  1311 GTSQCNITSLALNQLLCIPPEQQPLPTDENGVDQSTDLPLVVVKVGRNLRFVIGYLKYDLNKPYV 1375
            |...|....|. |::.|..|....:|        |..||   |||..|     || .:::....:
Zfish   888 GDVDCGGKVLD-NEITCRIPNNLTIP--------SEGLP---VKVTVN-----GY-THNVGTVIL 934

  Fly  1376 FSHALLVGIL--TVALLVVVFVIVLIIFR-----RKSTQAER-----EYKRIQIQMITLESNVRS 1428
            .|:..:|||:  .:|.||...|:..|:.:     :|::|.|.     .:.|.:...:.|.|.|
Zfish   935 VSNHYMVGIVLGILAALVTGAVLAFIVLKNLRKQKKASQTENRLSYFSHSRSRSNSVDLSSLV-- 997

  Fly  1429 ECKQAFAELQTD--MTDLTADLESTGIPTLDHVNYIMKVFFPGVSDHPILNSPKFREGSPQTNYD 1491
                   :.:.|  :|.:||...:...|.|.:...:.....|.:....| :...||....:...|
Zfish   998 -------DYRRDLPLTSITAPTGALAFPGLAYTGTLDTTLTPLMPPENI-SITSFRPELLEEVKD 1054

  Fly  1492 AAM------VQFEQLIGNKYFLLMFIETLE---------AQRSSFSIRDRVNVASLIMVVLMNKM 1541
            ..:      |...|:||..:|..::...|.         |.:|...|.|...|...:...::.|.
Zfish  1055 VLIPASTLKVHHHQIIGKGHFGTVYHGYLTDHNNREIHCAVKSLNRITDVEEVEQFLKEGILMKG 1119

  Fly  1542 EYATEILKSLLLRLIDKSLA------SKHPQL--MLR---RTESVVEKMLTNYLAICMYDYLKEY 1595
            .:.:.:|..|.:.|.::.|.      .||..|  .:|   |..:|                 |:.
Zfish  1120 FHHSNVLSLLGILLPEEGLPLVVLPYMKHGDLRHFIRCENRNPTV-----------------KDL 1167

  Fly  1596 AGSNLFLLFKAIKHQIEKGLVDAITNDARYSLSEERLLHEQVTHSVVILHILQDDLDEKVQCRVN 1660
            .|..|         |:.||:        .| |::::.:|..:.....:       |||....:|.
Zfish  1168 IGFGL---------QVAKGM--------EY-LAQKKFVHRDLAARNCM-------LDESYTVKVA 1207

  Fly  1661 DW----DTISQVKLKILDAIFKNTPFSMRPSVNEVDLEWRHGRGGHLTLQDEDLTTKTVNGWKRL 1721
            |:    |.:.:....:.|......|      |..:.:|         :||.:..|||: :.|.
Zfish  1208 DFGMARDVLEKEYYSVQDHRKAKLP------VKWMAIE---------SLQTQKFTTKS-DVWS-- 1254

  Fly  1722 NTLAHYGVKESAVMSLIARQNDNYHIPYSKNQNSAPYHNFYFINNSQSHIIINNDIESGLQQPRV 1786
                 :||   .:..::.|...    ||.:..   ||...:|:...:.           |.||:.
Zfish  1255 -----FGV---LMWEMLTRGAS----PYPEVD---PYDVTHFLLKGRR-----------LPQPQY 1293

  Fly  1787 YHLVKPNIPDHYMNIKNSVLSGGSPAFQSHVVNNCND-----RVN-KTIPEVYLTRLLATKGTIQ 1845
                   .||              |.|.  ::..|.|     |.: .|:....::.|.:.:|
Zfish  1294 -------CPD--------------PLFA--ILLQCWDPDPEKRPSFSTLVSAVMSILSSLEG--- 1332

  Fly  1846 KFVDDFFSIILT-VNEELPPAVKWLFDLLDEAARRHDIADTD 1886
               :.:.|:.:| ||.:.|.....|.|..||    :|.:|.|
Zfish  1333 ---EHYISLKVTYVNLDQPRPYPALTDSADE----YDSSDAD 1367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PlexB	NP_524616.2	Sema_plexin_like	86..534	CDD:200497	106/514 (21%)
		PSI	535..586	CDD:396154	14/51 (27%)
		TIG_plexin	594..682	CDD:465588	15/87 (17%)
		PSI	683..730	CDD:214655	5/49 (10%)
		TIG_2	738..827	CDD:465619	5/88 (6%)
		PSI	836..877	CDD:214655	3/40 (8%)
		IPT_plexin_repeat1	888..976	CDD:238585	13/87 (15%)
		IPT_plexin_repeat2	977..1095	CDD:238584	22/120 (18%)
		IPT_plexin_repeat3	1097..1211	CDD:238586	22/113 (19%)
		TIG	1277..>1334	CDD:460355	16/59 (27%)
		Plexin_cytopl	1452..2012	CDD:462434	87/472 (18%)
mst1rb	XP_073773053.1	None