Protein Alignment PlexB and plxna1

DIOPT Version :10

• Sequence 1: NP_524616.2
• Gene: PlexB / 43766
• FlyBaseID: FBgn0025740
• Length: 2051
• Species: Drosophila melanogaster
• Sequence 2: XP_031755564.1
• Gene: plxna1 / 100037845
• XenbaseID: XB-GENE-5819524
• Length: 1931
• Species: Xenopus tropicalis
• Alignment Length: 2128
• Identity: 701/2128 - (32%)
• Similarity: 1073/2128 - (50%)
• Gaps: 392/2128 - (18%)

  Fly    80 DSQSKNYFTHMSFDF------MHN---VLFAGATNKILKLNENLRVLAEAVTGPLHDSPQCH--- 132
            |...|::.|....|:      :||   .::.||.|:|.||:.||.::...||||:.|:.:|:
 Frog    28 DGTPKSFRTFTGTDWSLTHLVVHNKTGEVYLGAINRIYKLSNNLTLMRTHVTGPVEDNEKCYPPP 92

  Fly   133 -AGGCPEDIETSLVNNFNKILVVSYAHDGILIACGSIRQGACEIYSLPRFPATPQFFAVP----- 191
             ...||..:.::  ||.||:|::.|: :..||||||..||.|:...|      ...|.:.
 Frog    93 SVQSCPHGLVST--NNVNKLLLIDYS-ENRLIACGSASQGICQFLRL------DDLFKLGEPHHR 148

  Fly   192 ----LAANDENASTYAFV-----GPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRL----D 243
                |::.:|:.:....:     |        ::.|:|||......:|   .|.:|||:|    :
 Frog   149 KEHYLSSVNESGTMSGVIIEVPNG--------QNKLFVGTPIDGKSEY---FPTLSSRKLMGNEE 202

  Fly   244 DLNYAEFSIQQSIINIDVKYRDH-------FLVDYIYGFNSSEYAYFIIVQKKSHLA--DEAG-- 297
            :.....|..|...::..:|....       |.:.|:|.|:|.::.|::.:|..:.|.  |..|
 Frog   203 NAEMFGFVYQDEFVSSQLKIPSDTLSKFPTFDIYYVYSFSSEQFVYYLTLQLDTQLTSPDSTGEQ 267

  Fly   298 -YVTRLARICITDPNYDSYTEITVQCTATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVT 361
             :.:::.|:|:.||.:.||.|..:.|  .::.|:|.:::||.::....:||:::||.:.:.:|.|
 Frog   268 FFTSKIVRLCVDDPKFYSYVEFPIGC--IKDGVEYRLIQDAYLSKPGKRLAKELGISEREDILFT 330

  Fly   362 VFSPSREISNQPESKSAMCIYSIKDIEDMFIENIHLCFNGTTK-------DRNLGYISG--TIND 417
            |||..::...:|..:|.||::::|.|:|...|.|..|:.|..|       ::.||.|:.  .|:|
 Frog   331 VFSQGQKNRIKPPKESVMCLFTLKKIKDKIKERIQSCYRGDGKLSLPWLLNKELGCINSPLQIDD 395

  Fly   418 GRCPIVGSLGNIYNFCSVGLK--ISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNM 480
                         |||.....  :.|...|....||......:|||.|...  :.|::.|.||..
 Frog   396 -------------NFCGQDFNQPLGGTVTIEGTPLFLDKEDGMTSVAAYDY--RGHTVVFAGTRS 445

  Fly   481 GVIKKVLL----SGQSPGEYEEIVVDAGNRILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTN 541
            |.:||:|:    |.....:||.:||..||.||.:.::||.:.::|.::::::|::.:|.|..|..
 Frog   446 GRMKKILVDLSASSHMAQQYENVVVHEGNAILRDLVLSPDRQYIYAMTEKQVTRVPVESCEQYET 510

  Fly   542 CSACLESRDPFCGWCSLEKRCTVRSTCQRDTSASRWLSLGSGQQCIEFESIIPEKIPISELSHLH 606
            |.|||.||||.||||.|...|:.:..|:|.....|:.|  ..:||::. ::.|..|.:: :|.:.
 Frog   511 CDACLGSRDPHCGWCVLHNMCSRKDKCERADELHRFTS--DQRQCVQL-TVHPRNISVT-VSEVP 571

  Fly   607 LIIRTLPEP-FNAKYRCVFGNSTPIDAEILENGLGCATPPL-DERPLIPTNTDHILVPLSVRSSE 669
            ::::....| .:|...|.|.:.|.::..||:..:.|.:|.. |..|:...:.|..::.|.::|.|
 Frog   572 MVLQAWNVPDLSAGVNCSFEDFTEMEGRILDGKIYCTSPSTKDVIPITRGHGDKRVLKLYLKSKE 636

  Fly   670 TNKDFVSRNFAFFDCSHHGNCQECLQSSWGCNWCIFDNKCVHKSLQCRNIENAVSTVGHCPHLKK 734
            |.|.|.|.:|.|::||.|.:|..|:..|:.|:||.:.:.|.|.:..|...|..|:....||.:..
 Frog   637 TGKKFASVDFVFYNCSVHQSCLSCVNGSFPCHWCKYRHVCTHNAADCSFQEGRVNMSEDCPQILP 701

  Fly   735 NRPEILLPVRVPIEIRLEIENLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKTPYFYE 799
            : .:|.:||.|...|.|..:|||:|:|....:.|..||..:...:.|...::..:.|:.|.|.||
 Frog   702 S-TQIYIPVGVVKPITLTAKNLPQPQSGQRNYECIFHIPGSVTRVTALRFNSTSIQCQNTSYNYE 765

  Fly   800 IN-THEYQAKVVVTWNFQHYVD---TAIVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWC--SN 858
            .| ..:....:.|.||....:|   .....||||..|   ||  .|.||:..|.:::|.||  ..
 Frog   766 GNDISDLPVNLSVVWNGHFVIDNPQNIQAHLYKCSAL---RE--SCGLCLKSDQRFECGWCVSEK 825

  Fly   859 SCVYNETCIADKNSISSGSKSAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGK 923
            .|...:.|.|.:|.....  |.:.:.|..|:|..:.|.:||.:||||:||.|.|||:|.||:|..
 Frog   826 KCTLRQNCPAYENPWMHA--STVNSRCTDPKITKLFPETGPKQGGTLLTITGENLGLRFEDIRFG 888

  Fly   924 IFIGSVPC-ELENYQISV-KIECRTGASLYEMSAPIKVANDAGFTESSVQ--------------- 971
            :.:|.|.| .:||..||. :|.|.           ||.|......|:.|:
 Frog   889 VRVGHVMCVPIENEYISAEQIVCE-----------IKDAGKMRVHEAQVEVCVKDCSQDYRAISP 942

  Fly   972 --FHFKNVLLTGLYPTIGPRSGGTQLSLIGKFLNIGSTMRAFLDEYECHIDVTQASSSQVSCTTS 1034
              |.|.......:.|:.||.||||.:|:.|.:||.||.:...:....|..  :..::.::.|.|.
 Frog   943 KSFTFVVPSFNRVTPSRGPLSGGTWISIEGSYLNSGSDVSVDIGGRPCMF--SWRTAKEIRCKTP 1005

  Fly  1035 EATQPEPIRSLHLVIDGANRTLECQISTPSITNTNPTRSNFGSYQLRSLPRQPCSIFNYTQDPRI 1099
            :....            ....::..|:..::.|:...                   :|||:||.:
 Frog  1006 QGPST------------GKAEIQIHINRATLYNSEVH-------------------YNYTEDPTV 1039

  Fly  1100 MQIKPLRSFKSGGRVLTVHGIYLNSIQKPELEVFY-DNERVNKTSCVVINSNQMECPSPPVNYKF 1163
            .:|:|..|..|||..|.|.|:.|.:|::|::...| |.||.|  :|.|.|...|.|.:|.|....
 Frog  1040 QKIEPEWSIASGGTPLIVTGLNLATIKEPKIRAKYGDAEREN--NCTVYNDTTMVCLAPSVENPL 1102

  Fly  1164 ETFKKTNRKMDTELHLQNSSFQTETRYKNEYDRKKRRADFGDTFRLYTNAGSSANYFVNNNMDVT 1228
            .:..:...:.|
 Frog  1103 RSPPENGDRPD------------------------------------------------------ 1113

  Fly  1229 TFVKVHETQLNLQLSFVMDNVQLVRNLNKYFHDIRSTIVYLADPKYLPFPNDG-VKLYKGDSLVI 1292
                        ::.|:||||..:..:|      .::.:|..||.:.|....| ::|.....|:|
 Frog  1114 ------------EIGFIMDNVLALLIVN------TTSFLYYPDPVFEPLTASGNLELKPSSPLII 1160

  Fly  1293 EG-ELLNLAADEYDVNVT--IGTSQCNITSLALNQLLCIPPEQQPLPTDENGVDQSTDLPLVVVK 1354
            :| .|:..|...:.:|.|  ||.:.|.:| ::..||||..|             ..|....|.:|
 Frog  1161 KGRNLIPAAPGNFRLNYTVLIGDTPCALT-VSETQLLCESP-------------NLTGQHKVTIK 1211

  Fly  1355 VGRNLRFVIGYLKYDLNKPYVFSHALLV--GILTV----ALLVVVFVIVLIIFRRKSTQAEREYK 1413
            .|       |: :|......::|.:||.  .|:.:    .||:::.:||||.::|||..|:|..|
 Frog  1212 AG-------GF-EYSPGTLQIYSDSLLTLPAIIGIGGGGGLLLLIIIIVLIAYKRKSRDADRTLK 1268

  Fly  1414 RIQIQMITLESNVRSECKQAFAELQTDMTDLTADLESTGIPTLDHVNYIMKVFFPGVSDHPILNS 1478
            |:|:||..|||.|..|||:||||||||:.:||.||:..|||.||:..|.|:|.|||:.|||:|
 Frog  1269 RLQLQMDNLESRVALECKEAFAELQTDIHELTNDLDGAGIPFLDYRTYAMRVLFPGIEDHPVL-- 1331

  Fly  1479 PKFREGSPQTNYDAAMVQFEQLIGNKYFLLMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEY 1543
               :|...|.|.:.::..|.||:..|:|||.||.|||||| |||:|||.|||||||..|..:|||
 Frog  1332 ---KEMEVQANVEKSLTLFGQLLTKKHFLLTFIRTLEAQR-SFSMRDRGNVASLIMTALQGEMEY 1392

  Fly  1544 ATEILKSLLLRLIDKSLASK-HPQLMLRRTESVVEKMLTNYLAICMYDYLKEYAGSNLFLLFKAI 1607
            ||.:||.||..||:|:|.|| ||:|:|||||||.||||||:....:|.:|||.||..||:|:.||
 Frog  1393 ATGVLKQLLSDLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFMLYCAI 1457

  Fly  1608 KHQIEKGLVDAITNDARYSLSEERLLHEQVTHSVVILHILQDDL---DE---------------- 1653
            |.|:|||.:||||.:|||||||::|:.:|:.:..  |:...||:   ||
 Frog  1458 KQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKT--LNPCADDVGLSDESCCRSPQTLNCVNPEN 1520

  Fly  1654 ----KVQCRVNDWDTISQVKLKILDAIFKNTPFSMRPSVNEVDLEWRHGRGGHLTLQDEDLTTKT 1714
                ::..:|.:.|||:|||.|:|||::|..|:|.||...::|||||.||...:.|||||:|||.
 Frog  1521 ENAPEIPVKVLNCDTITQVKEKLLDAVYKGVPYSQRPKAGDMDLEWRQGRMARIILQDEDVTTKI 1585

  Fly  1715 VNGWKRLNTLAHYGVKESAVMSLIARQNDNYHI--------------------------PYSKNQ 1753
            .|.||||||||||.|.:.:.::|:.:||..|:|                          |..:.|
 Frog  1586 DNDWKRLNTLAHYQVTDGSSVALVPKQNSAYNISNSSTFTKSLSRYGHQLDHHTVGLRRPVGRGQ 1650

  Fly  1754 N--------------SAPYHNFYFINNSQSHI-IINNDIESGLQQPRVYHLVKPNIPDHYMNIKN 1803
            :              |:|       ::.:|.. :|..|:|||   .:::||||    :|
 Frog  1651 HQQADFWPESMLRTASSP-------DSLRSRTPMITPDLESG---TKLWHLVK----NH------ 1695

  Fly  1804 SVLSGGSPAFQSHVVNNCNDRVNKTIPEVYLTRLLATKGTIQKFVDDFFSIILTV---NEELPPA 1865
                       .|:.....||.:|.:.|:|||||||||||:||||||.|..|.:.   ...||.|
 Frog  1696 -----------DHLDQREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSALPLA 1749

  Fly  1866 VKWLFDLLDEAARRHDIADTDIVHAWKSNCLPLRFWVNFIKNPDFIFDVNKTYSVDSCLSVIAQT 1930
            :|::||.|||.|.:|.|.|.|:.|.|||||||||||||.||||.|:||::|....|:||||:|||
 Frog  1750 IKYMFDFLDEQADKHQITDYDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQT 1814

  Fly  1931 FMDACSTSEHRLGKDSPSNKLLFAKDIPNYRIMVKEFYRDVSRLPQISDQEMSTAMQQLSVRQNE 1995
            |||:||||||:|||||||||||:|||||||:..|:.:|.|::::..||||:||..:.:.|.....
 Frog  1815 FMDSCSTSEHKLGKDSPSNKLLYAKDIPNYKSWVERYYADIAKMSVISDQDMSAYLAEQSRLHLS 1879

  Fly  1996 EFDTISALKELYIYITKYKDQIMESLETDINCRKMHLSRKLGNVAATL 2043
            :|:::|||.|:|.|||||:|:|:.:||.|...|:..|..||..|..|:
 Frog  1880 QFNSMSALHEIYSYITKYRDEILTALEKDEQARRQRLRSKLEQVIDTM 1927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PlexB	NP_524616.2	Sema_plexin_like	86..534	CDD:200497	133/505 (26%)
		PSI	535..586	CDD:396154	20/50 (40%)
		TIG_plexin	594..682	CDD:465588	23/89 (26%)
		PSI	683..730	CDD:214655	14/46 (30%)
		TIG_2	738..827	CDD:465619	25/92 (27%)
		PSI	836..877	CDD:214655	13/42 (31%)
		IPT_plexin_repeat1	888..976	CDD:238585	35/106 (33%)
		IPT_plexin_repeat2	977..1095	CDD:238584	20/117 (17%)
		IPT_plexin_repeat3	1097..1211	CDD:238586	26/114 (23%)
		TIG	1277..>1334	CDD:460355	18/60 (30%)
		Plexin_cytopl	1452..2012	CDD:462434	288/627 (46%)
plxna1	XP_031755564.1	Sema_plexin_A1	31..503	CDD:200532	134/508 (26%)
		PSI	504..554	CDD:396154	21/51 (41%)
		TIG_plexin	559..649	CDD:465588	23/90 (26%)
		PSI	650..697	CDD:396154	14/46 (30%)
		TIG_2	703..797	CDD:465619	25/93 (27%)
		PSI	799..851	CDD:396154	16/58 (28%)
		IPT_plexin_repeat1	853..948	CDD:238585	34/105 (32%)
		IPT_plexin_repeat2	950..1035	CDD:238584	20/117 (17%)
		IPT_plexin_repeat3	1037..1137	CDD:238586	33/173 (19%)
		TIG	1156..1223	CDD:460355	22/88 (25%)
		Plexin_cytopl	1307..1896	CDD:462434	288/627 (46%)