DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PlexB and mst1ra

DIOPT Version :9

Sequence 1:	NP_001245400.1	Gene:	PlexB / 43766	FlyBaseID:	FBgn0025740	Length:	2051	Species:	Drosophila melanogaster
Sequence 2:	XP_005166175.1	Gene:	mst1ra / 100002448	ZFINID:	ZDB-GENE-071218-2	Length:	1356	Species:	Danio rerio

Alignment Length:	1851	Identity:	355/1851 - (19%)
Similarity:	597/1851 - (32%)	Gaps:	680/1851 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 QSKNYFTHMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQCHAGGCPEDIE----T 142
            |:.|...::.|:...:.::..:.|.:..|::||..|.|..|||: .||.|....|  |||    |
Zfish    45 QTTNAIQNIVFNEYFDEVYVASQNVVEALDKNLTKLWELKTGPV-GSPDCQTCNC--DIENEPGT 106

  Fly   143 SLVNNFNKILVVS-YAHDGILIACGSIRQGACEIYSLPR----------------FPA-TPQFFA 189
            || :..|::||:. ..|...|..|||.:.|.|.:..|.:                .|: .|...|
Zfish   107 SL-DTDNQVLVLEPQQHLDFLYICGSTQYGVCNMLELDKGNIASSPECLFNKKANSPSDCPDCVA 170

  Fly   190 VPLAAN----DENASTYAFVGPARYAWKEEDILYVGTTFTNVGDY-RHDVPAISSRRLDDLNYAE 249
            .||...    ||..|||.|....           |.:|.  .|.: :|   ::|.|||.:.....
Zfish   171 SPLGTKVTVVDEGYSTYFFTAAT-----------VNSTI--AGSFGKH---SLSIRRLLNTENGF 219

  Fly   250 FSIQQSIINIDV--KYRDHFLVDYIYGFNSSEYAYFIIVQKKSHLADEAGYVTRLARICITDPNY 312
            ..::    |:.|  |::|.|.:||||.|:::||.||:.||.:|.:...|...|.|.|:.|.|...
Zfish   220 HDVK----NLTVLPKFQDVFTIDYIYTFSTTEYVYFLSVQWESLMKPNAKLQTHLGRLPIKDSEL 280

  Fly   313 DSYTEITVQC-------TATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVFSPSREIS 370
            ..|.||.::|       ..:..:|.||.|:.|..:.|..:||..:|::.|..:|..||:.:.:..
Zfish   281 WMYREIILECRFEPKRRRRSFRDVVYNSVQAAHFSTAGKELADDLGVRIDSPILYGVFAVTDQKG 345

  Fly   371 NQPESKSAMCIYSIKDIEDMFIENIHLCFNGTTKDRNLGYISGTINDGRC---PIVGSLGNIYNF 432
            | |..:||:|.:.:..:.....:.:..|.:..|:.         |:.|.|   |.  .:..:.|.
Zfish   346 N-PMRQSALCAFPLDYVNSAIEKGVDACCSSLTEQ---------ISRGLCHFQPC--EMCPVENS 398

  Fly   433 CSVGLKISGVSPITAHALFHFDNVSVTSVTATS---TTDQQHSLAFLGTNMGVIKKVLLSGQSPG 494
            .|:..|.:.......:....|.|..:::|..||   ||.:..::|.:||:.|.:.:::||...|.
Zfish   399 DSLTCKTTPTMVSKPYYRVDFFNGQMSNVLFTSILVTTIETKTVAHIGTDHGRLLQIILSRSIPV 463

  Fly   495 EYE--EIVVDAGNRILPNTMMSPKKDFLYVLSQRKI-TKLRIEHCSVYTNCSACLES-RDPFCGW 555
            .:.  .:|.||........:.|..:..|:|:..:.| ...|...||.:.||||||.: |...|||
Zfish   464 VFANYSLVEDAQKVSRIAAIHSSLESLLFVVGNKLINVSPRGPGCSHFLNCSACLAAPRFMGCGW 528

  Fly   556 CSLEKRCTVRSTCQRDTSASRWLSLGSGQQCIEFESIIPEKIPISELSHLHLIIRTLPEPFNAKY 620
            |.  :.|:.:..|:     .:|    ||..|   ..:|.:..|           ||:|
Zfish   529 CG--EVCSQQHQCE-----DQW----SGDSC---PPVITQFFP-----------RTVP------- 561

  Fly   621 RCVFGNSTPIDAEILENGLGCATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSRNFAFFDCS 685
                           .||                 |..:::
Zfish   562 ---------------SNG-----------------TSELIL------------------------ 570

  Fly   686 HHGNCQECLQSSWGCNWCIFDNKCVHKSLQCRNIENAVSTVGHCPHLKKNRPEILLPVRVPIEIR 750
                          |.|               |.::|            :||.|
Zfish   571 --------------CGW---------------NFQSA------------SRPAI----------- 583

  Fly   751 LEIENLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKTPYFYEINTHE-YQAKVVVTWN 814
                                                               |.| :|.:|
Zfish   584 ---------------------------------------------------TQESHQVRV----- 592

  Fly   815 FQHYVDTAIVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWCSNSCVYNETCIADKNSISSGSKS 879
                                  .:.||                       |.:.:|.|.|.
Zfish   593 ----------------------GNSDC-----------------------TVVPEKTSSSL---- 608

  Fly   880 AIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIFIGSVPCELENYQISVKIEC 944
                                    .:..|.|...|:.                 ::..|::::..
Zfish   609 ------------------------LVCRIVGEESGLH-----------------QSVNITIQVNE 632

  Fly   945 RTGASLYEMSAPIKVANDAGFTESSVQ-FHFKNVLLTGLYPTIGPRSGGTQLSLIGKFLNIGSTM 1008
            :...|.|.:|.           ::.:| |.|....:|.:.|:.||:.|||.::|.||.|:.|.:.
Zfish   633 KKAGSGYFISG-----------KAGIQGFSFVTPEITDISPSFGPKIGGTLITLSGKHLDAGGSR 686

  Fly  1009 RAFLDEYECHIDVTQASSSQVSCTTSEATQPEPIRSLHLVIDGANRTLECQISTPSITNTNPTRS 1073
            ...|.:..|.::...:..:.:.| .||..:......:.:||||         ||.|.|.|
Zfish   687 TISLGDRNCPVESVSSDGTSIVC-RSEGVKDTLEVDVKVVIDG---------STISSTKT----- 736

  Fly  1074 NFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSIQKPELEVFYDNER 1138
                             |:|..:|.:..:.|...|:.|.::: :.|..|:|:.:..::.....:.
Zfish   737 -----------------FSYRVNPEVTGVNPNCGFRRGSKII-ITGQNLDSVSQAVIKYKGGYKD 783

  Fly  1139 VNKTSCV-VINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQNSSFQTETRYKNEYDRKKRRAD 1202
            ..:|.|. ..|..||||.||
Zfish   784 PVETVCSGQGNPTQMECMSP--------------------------------------------- 803

  Fly  1203 FGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFVMDNVQLVRNLNKYFHDIRS-TI 1266
                                          |.|....: ||..:|..:          |::| |.
Zfish   804 ------------------------------VCEESTGI-LSVDLDGAK----------DLQSQTF 827

  Fly  1267 VYLADPKYLPFPNDG--VKLYKG-DSLVIEGELLNLAADEYDVNVTIGTSQCNITSLALNQLLCI 1328
            ...|:.:.:||..:.  ::|..| |.:.:..:.|.|.:...::.:|:....||...|. |::.|.
Zfish   828 TCHANGEPIPFETEDRVLELSPGQDEVSLHHKKLALVSGCMEIIMTVNGVDCNAKVLD-NEITCR 891

  Fly  1329 PPEQQPLPTDENGVD-----QSTDLPLVVVKVGRNLRFVIGYLKYDLNKPYVFSHALLVGILTVA 1388
            .|:...:|.....|.     :..|:.:||:|   |...::|               :::|||...
Zfish   892 IPKNLTIPRQGAPVKVLVNREEHDIGMVVMK---NSNLIVG---------------VVLGILAAV 938

  Fly  1389 LLVVVFVIVLIIFRRKSTQAEREYKRIQI--QMITLESNVRSE--------------CKQAFAEL 1437
            .:....|.|.:...||..:|.....|:.:  ...|.|:..||.              ....|...
Zfish   939 GVGAAIVYVAMAQERKKKKAALVEVRLSMHSNRTTAENYDRSPDGDYRRETVRPAGLSVSPFHGS 1003

  Fly  1438 QTDMTDL--TADLESTGIPTLDHVNYIMKVFFPGVSDH--PILNSPKFREGSPQTNYDAAMVQFE 1498
            .|..|.|  ...::|...|.:.. ...|....|.:.:.  .:|.||           |...:|.|
Zfish  1004 GTTFTSLPYAGSMDSAAAPLMRR-QVSMSALRPDLLEEVKNVLISP-----------DKIKIQHE 1056

  Fly  1499 QLIGNKYFLLMF---------IETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSLLLR 1554
            |:||..:|..::         .||..|.:|...|.|...|...:...|..|..:.:.:|..|.:.
Zfish  1057 QIIGKGHFGTVYHGYLTDSDNKETHCAVKSLNRITDLEEVEQFLREGLFMKAFHHSHVLSLLGIV 1121

  Fly  1555 LIDKSLA------SKHPQLMLRRTESVVEKMLTNYLAICMYDYLKEYAGSNLFLLFKAIKHQIEK 1613
            |....|.      .||..  ||......|:..|          :|:..|..|         |:.|
Zfish  1122 LPSDGLPLVILPYMKHGD--LRHFIRSPERSPT----------VKDLIGFGL---------QVAK 1165

  Fly  1614 GLVDAITNDARYSLSEERLLHEQVTHSVVILHILQDDLDEKVQCRVNDWDTISQVKLKILDAIFK 1678
            |:        .| |:.::.:|..:.....:       |||....:|.|:.....|        :.
Zfish  1166 GM--------EY-LANKKFVHRDLAARNCM-------LDESFTVKVADFGMARDV--------YD 1206

  Fly  1679 NTPFSMRPSVN-EVDLEWRHGRGGHLTLQDEDLTTKTVNGWKRLNTLAHYGVKESAVMSLIAR-- 1740
            ...:|::.|.. ::.::|.    ...:||.:..|||: :.|.       |||   .:..|:.|
Zfish  1207 KEYYSIQDSKKAKLPVKWM----ALESLQTQKFTTKS-DVWS-------YGV---LMWELLTRGA 1256

  Fly  1741 ----QNDNYHI-PYSKNQNSAPYHNFYFINNSQSHIIIN-------------------NDIES-- 1779
                ..|.|.| ||.......|...:.|  :|...:::.                   .||.|
Zfish  1257 SPYPDVDPYDITPYLMQGRRLPQPQYCF--DSLWSVLMQCWHPEPEKRPGFTTLVQAVQDIHSSL 1319

  Fly  1780 -------------GLQQPRVYHLVKPNIPDH 1797
                         .|.|||.|..:.|..|.|
Zfish  1320 DGEHYINLQITYVNLDQPRPYPSLCPATPAH 1350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PlexB	NP_001245400.1	Sema_plexin_like	86..534	CDD:200497	126/492 (26%)
		PSI	535..586	CDD:279745	18/51 (35%)
		PSI	683..730	CDD:214655	4/46 (9%)
		PSI	836..877	CDD:214655	6/40 (15%)
		IPT_plexin_repeat1	888..976	CDD:238585	10/88 (11%)
		IPT_plexin_repeat2	977..1095	CDD:238584	28/117 (24%)
		IPT_plexin_repeat3	1097..1211	CDD:238586	16/114 (14%)
		Plexin_cytopl	1452..2017	CDD:285529	80/405 (20%)
mst1ra	XP_005166175.1	Sema_MET_like	41..504	CDD:200509	127/494 (26%)
		PSI	507..>547	CDD:307546	18/50 (36%)
		IPT	550..654	CDD:326624	35/386 (9%)
		IPT_plexin_repeat2	655..740	CDD:238584	27/116 (23%)
		IPT	742..828	CDD:214657	24/172 (14%)
		PTKc_Met_Ron	1057..1318	CDD:270649	62/322 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3610
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810