DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mod and CG3335

DIOPT Version :9

Sequence 1:	NP_001247401.1	Gene:	mod / 43764	FlyBaseID:	FBgn0002780	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_648337.1	Gene:	CG3335 / 39119	FlyBaseID:	FBgn0036018	Length:	918	Species:	Drosophila melanogaster

Alignment Length:	645	Identity:	138/645 - (21%)
Similarity:	244/645 - (37%)	Gaps:	163/645 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QKKAVTVKGKKATNGEEKPLA---------KRVTKSTKVQEEETVVPQSPSKKSRKQPVKEVPQF 58
            |...|.|:...|...|:||.:         |.:.|..:.:.|.....:...||.:|..|.:|.|.
  Fly    68 QTSRVRVESCAALGSEDKPQSWSKYAKDSKKNLDKLKEKEREAAAKAKESEKKKKKDKVDKVDQI 132

  Fly    59 SEEDESDVE-----EQNDEQP-------GDDSDFETEEAAGLIDDEAEEDEEYNSDDEEDDDDDE 111
            ....:.|.|     |.:|:..       |.:.:.|.||.    |||.:|:.....||...|.|..
  Fly   133 LSRHKDDPEFQEFLEAHDKSRTLWGNDLGINKNRENEEE----DDEEQEESRAARDDSGVDADAG 193

  Fly   112 LEPGEVSKSEGADEVDESDDDEEAPVEKPVS-----------------KKSEKANSEKSEENRGI 159
            .|.|      ..||.||.:|.::. .|||:|                 .|..||.::||  |..:
  Fly   194 DEDG------SGDEADEEEDTDKL-AEKPISDLEYMKSLMATTSGEATAKKPKAKADKS--NLEL 249

  Fly   160 PKVKVGKIPLGTPKNQIV--------FVTNLPNEYLHKDLVALFAKFGRLSALQRFTNLNGNKSV 216
            ..:|:..:|..|.:.:::        :...||::      |..|...|..:.......:..|||.
  Fly   250 FTIKIHNVPYNTKRQEVLKFFKPLKPYSVRLPSK------VHGFCYVGFKTEKDMAKGMLKNKSF 308

  Fly   217 L----IAFDTSTGAEAVLQAK-------PKALTLGDNVLSVSQPR-NKEENNERT--VVVGLIGP 267
            :    :.|...|....|.:|.       |.|:..|:......|.. :||::...:  :....:..
  Fly   309 IKGKQVFFSDFTEKNKVTKASKSGQPLAPAAVDAGNAKWKHQQDSLSKEDDISESGRIFFRNLAY 373

  Fly   268 NITKDDLKTFFEKVAPVEAVTISSNRL-------------MPRAFVRLASVDDIPKALK----LH 315
            ..|::||:..||:..||..|.:..::|             ||.            .|||    |.
  Fly   374 TTTEEDLRKLFEQFGPVVEVNLPLDKLTRKIKGFGTVTYMMPE------------HALKAFNTLD 426

  Fly   316 STELFSRFITVRRISQESISRTSELTLVVENVGKHESYSSDALEKIFKKFGDVEE---------- 370
            .|:...|.:.:  :..:.|.:..:     |::.::::..|...:|..|...:.::
  Fly   427 GTDFHGRLLHL--LPSKDIEKNPK-----EDLDENDASLSFKEKKALKLKKNAQKPIGWNTLFLG 484

  Fly   371 IDVVCSKAVLAFVTFKQ-----SDAATKALAQLD-GKTVNKFEWK---------LHRFE---RST 417
            .:.|.......|.|.|:     ||..:.|..:|. |:|....|.|         |..|:   :..
  Fly   485 ANAVAEILAKQFKTSKERILDTSDGGSSAAVRLALGETQVVIEMKRFLEEEGVRLDAFDEPAKKR 549

  Fly   418 SGRAILVTNLTSDATEADLRKVFNDSGEIESIIM--LGQKAVVKFKDD----EGFCKSFLANESI 476
            |...||..||.:....:::..:|:..|.|..|::  .|..|::::.|.    :.|.|  || .|.
  Fly   550 SNTVILAKNLPAATEISEITPIFSRFGPIGRIVLPPSGVTALIEYCDPLEARQAFKK--LA-YSK 611

  Fly   477 VNNAPIFIEPNSLLKHRLLKKRLAIGQTRAPR---KFQKDTKPNFGKKPF--NKRPAQEN 531
            ..|||:::|   ....::..|.|: |:...|:   |.:::.||.  :||.  :.:|.:|:
  Fly   612 FKNAPLYLE---WAPEQVFTKTLS-GEPVIPKSEPKPKEEVKPE--EKPIVNDAKPDEED 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mod	NP_001247401.1	RRM_SF	177..244	CDD:302621	15/85 (18%)
		RRM_SF	260..327	CDD:240668	17/83 (20%)
		RRM_SF	342..411	CDD:240668	16/93 (17%)
		RRM_SF	422..>465	CDD:302621	11/48 (23%)
CG3335	NP_648337.1	RRM1_RBM19	2..77	CDD:241008	3/8 (38%)
		RRM_SF	250..314	CDD:302621	11/69 (16%)
		RRM3_RBM19	362..440	CDD:241011	17/91 (19%)
		RRM4_RBM19	552..623	CDD:241013	20/76 (26%)
		RRM	<638..845	CDD:223796	8/30 (27%)
		RRM5_RBM19_like	679..760	CDD:240764
		RRM6_RBM19	785..864	CDD:241015
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23147
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100