DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mod and Ncl

DIOPT Version :9

Sequence 1:	NP_001247401.1	Gene:	mod / 43764	FlyBaseID:	FBgn0002780	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_035010.3	Gene:	Ncl / 17975	MGIID:	97286	Length:	707	Species:	Mus musculus

Alignment Length:	649	Identity:	157/649 - (24%)
Similarity:	255/649 - (39%)	Gaps:	160/649 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KKAVTVKGKKATNGEEKPLAKRVTKSTKV--------QEEETVVPQSPSKKSRKQPVKEVPQFSE 60
            |||....||||.   ..|..|.:|.:..:        .:.:.:|| :|.||....|.|.......
Mouse    79 KKAAVTPGKKAV---ATPAKKNITPAKVIPTPGKKGAAQAKALVP-TPGKKGAATPAKGAKNGKN 139

  Fly    61 EDESDVEEQNDEQPGDDSD----------FETEEAAGL---------------IDDEAEEDEEYN 100
            ..:.|.:|..||:..||||          ||.....|:               .|||.|:|||
Mouse   140 AKKEDSDEDEDEEDEDDSDEDEDDEEEDEFEPPIVKGVKPAKAAPAAPASEDEEDDEDEDDEE-- 202

  Fly   101 SDDEEDDDDDELEPGEVSKSEGA--------------------------------DEVDESDDDE 133
            .||||::||.|.|..|::.::|.                                :|.|:.||||
Mouse   203 DDDEEEEDDSEEEVMEITTAKGKKTPAKVVPMKAKSVAEEEDDEEEDEDDEDEDDEEEDDEDDDE 267

  Fly   134 EAPVEKPVSKKSEKANSEKSEENRGIPKVKVGKI----PLGTPKNQIVFVTNL-PNEYLHK---D 190
            |...|:||.....|...|.:::... |:.|..|:    |. ||.|  :|:.|| ||:.:::   .
Mouse   268 EEEEEEPVKAAPGKRKKEMTKQKEA-PEAKKQKVEGSEPT-TPFN--LFIGNLNPNKSVNELKFA 328

  Fly   191 LVALFAKFGRLSALQRFTNLNGNKSVLIAFDTSTGAEAVLQAKPKALTLGDNVLSVSQPRNKEEN 255
            :..|||| ..|:.:...|..| .|...:.|:::...|..|:.  ..|.:..|.:.:.:|:.::..
Mouse   329 ISELFAK-NDLAVVDVRTGTN-RKFGYVDFESAEDLEKALEL--TGLKVFGNEIKLEKPKGRDSK 389

  Fly   256 N---ERTVVVGLIGPNITKDDLKTFFEKVAPVEAVTISSNRLMPRAFVRLASVDDIPKAL-KLHS 316
            .   .||::...:..|||:|:||..||....:..|: ...:....|::...|..|..|.| :...
Mouse   390 KVRAARTLLAKNLSFNITEDELKEVFEDAMEIRLVS-QDGKSKGIAYIEFKSEADAEKNLEEKQG 453

  Fly   317 TELFSRFITV-----RRISQESISRTS-----ELTLVVENVGKHESYSS--DALEKIFKK--FGD 367
            .|:..|.:::     :...||...:||     ..|||:.|:    |||:  :.||::|:|  |..
Mouse   454 AEIDGRSVSLYYTGEKGQRQERTGKTSTWSGESKTLVLSNL----SYSATKETLEEVFEKATFIK 514

  Fly   368 VEEIDVVCSKAVLAFVTFKQSDAATKAL-----AQLDGKTVNKFEWKLHRFE------RSTSGRA 421
            |.:......|. .||:.|...:.|.:||     .:::|:|:        |.|      ||...:.
Mouse   515 VPQNPHGKPKG-YAFIEFASFEDAKEALNSCNKMEIEGRTI--------RLELQGSNSRSQPSKT 570

  Fly   422 ILVTNLTSDATEADLRKVFNDSGEIESIIMLGQKAVVKFKDDEGFCKSFLANESIVNNAPIFIEP 486
            :.|..|:.|.||..|::.|  .|.:.:.|:..:        :.|..|.|           .|::.
Mouse   571 LFVKGLSEDTTEETLKESF--EGSVRARIVTDR--------ETGSSKGF-----------GFVDF 614

  Fly   487 NSLLKHRLLKKRLAIGQTRAPRKFQKDTKP---------NFGKKPFNKRPAQENGGKSFVKRAR 541
            ||....:..|:.:..|:....:......||         ..|:..|..|.....|...|..|.|
Mouse   615 NSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGFGGRGGGRGGRGGFGGRGR 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mod	NP_001247401.1	RRM_SF	177..244	CDD:302621	18/70 (26%)
		RRM_SF	260..327	CDD:240668	16/72 (22%)
		RRM_SF	342..411	CDD:240668	21/77 (27%)
		RRM_SF	422..>465	CDD:302621	9/42 (21%)
Ncl	NP_035010.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..308		61/236 (26%)
		8 X 8 AA tandem repeats of X-T-P-X-K-K-X-X	58..135		17/59 (29%)
		RRM1_NCL	309..383	CDD:240849	19/79 (24%)
		RRM2_NCL	392..467	CDD:240850	18/75 (24%)
		RRM3_NCL	486..558	CDD:240851	23/84 (27%)
		RRM4_NCL	569..646	CDD:240852	19/97 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..707		9/40 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910