DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2003 and MFS15

DIOPT Version :9

Sequence 1:	NP_651903.2	Gene:	CG2003 / 43761	FlyBaseID:	FBgn0039886	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_611375.2	Gene:	MFS15 / 37168	FlyBaseID:	FBgn0034392	Length:	497	Species:	Drosophila melanogaster

Alignment Length:	495	Identity:	192/495 - (38%)
Similarity:	287/495 - (57%)	Gaps:	22/495 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NDMEEIPKTVPRLGLRHLQAGLLFYGLAANTVLQLNVSVAVVAMTNETTSNNSDPPHYNWSEEKK 66
            |..::|..|.||.|:||||..|:|:|||....|::|:|||:||||:...| |.|.|.::|:|..|
  Fly    12 NGYQQIGNTGPRFGVRHLQCILVFFGLAVAYSLRVNLSVAIVAMTDRNAS-NPDFPEFDWNESTK 75

  Fly    67 SYILSSYYWGCALAQFPAGYLCKRFGSKAVLFWGTLGSSLLSALTTYGVYAGGWKAYCAIRLLQG 131
            ||:|||::||..:.|.|.|||...:|:|.:||:|.|..|.|:.||.:....|||.....:|.:||
  Fly    76 SYLLSSFFWGYVVTQIPGGYLSAIYGAKYMLFYGVLICSCLALLTPFCAVNGGWTVVVVLRAVQG 140

  Fly   132 LCQ-VTWPCIHQHLANWCPTAERTRLGAFAYTGFDCGNVLAMYGAGMIASSSLGWPGISYSAAGL 195
            ||| |.:|..|..|:.|.|..||.||..:.|:|...|.|:.:..:|.|||||||||...|....:
  Fly   141 LCQGVIFPSTHTFLSKWAPAEERGRLVGYTYSGSQFGTVVMLSVSGYIASSSLGWPSTFYIPGCV 205

  Fly   196 GLIWCGLWLLLGAN--------KASDARFIGEAEKAYIVGDIQRSERKGPKKMEIPWKGIFTSVP 252
            |::|..:||.|.::        ..::.|||..:.:|....|..|.|:..|   ..||..||||||
  Fly   206 GIVWSFVWLYLCSSTPAQHPTITPNERRFIESSGQARRPSDAGREEQPRP---PTPWWRIFTSVP 267

  Fly   253 VYALLCARCADSWGLTTMQTELPTYLSGVLKLDMKSNAVFSALPFLLMWVMCYVYLIIADVL-LR 316
            ...|:.|.||::||..|:.||:||::..||.:|:|:|...||||:..|.::..|::.::|.| .|
  Fly   268 FLVLVLAHCANNWGFWTLLTEIPTFMKNVLGMDIKNNGPLSALPYFAMILLTCVFIWLSDTLKQR 332

  Fly   317 KKWMSLTTLRKTYTSIALWAP--ASIMLSLVIVGEGQKTLVLVLVTLSVGVSSAATIGSELNTID 379
            ...:.|...||.:.::.:|.|  |.|.|..:..||....|.:.|:|.:|..:||..:|..:|.||
  Fly   333 GTVIPLGFSRKFFNTLGMWLPMLALIGLGYITEGEANVRLAIGLLTAAVATNSATYLGFHVNHID 397

  Fly   380 LSPNHAGILAGLMSSFTNLMALLTPLVVGVLVTDPSQRSQWQIVFSLAAGVLFTGNVIFLIWGTA 444
            ||||:||.|.|:.:...|.|::|.||:||::|.|.:..:||:|||...|.|.|.||::|:::|..
  Fly   398 LSPNYAGTLMGITNCAANFMSILAPLIVGLIVWDETNPAQWRIVFFFTAFVYFIGNLLFMLFGRT 462

  Fly   445 VTQPWNESKESRRELEPEEKPFHRAKLEIGTDNTDGNVVG 484
            ..||||....:|     ...|....:.:.||::. |.::|
  Fly   463 RVQPWNSRPTTR-----TPSPGGGGERDEGTEDR-GPLIG 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2003	NP_651903.2	2A0114euk	23..456	CDD:129972	176/444 (40%)
CG2003	NP_651903.2	MFS	58..441	CDD:119392	153/394 (39%)
MFS15	NP_611375.2	2A0114euk	18..469	CDD:129972	183/454 (40%)
MFS15	NP_611375.2	MFS	31..459	CDD:119392	171/431 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442715
Domainoid	1	1.000	42	1.000	Domainoid score	I12425
eggNOG	1	0.900	-	-		E1_KOG2532
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I245
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		mtm14983
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X142
	9	8.890