DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2003 and MFS12

DIOPT Version :9

Sequence 1:	NP_651903.2	Gene:	CG2003 / 43761	FlyBaseID:	FBgn0039886	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_610332.3	Gene:	MFS12 / 35745	FlyBaseID:	FBgn0033234	Length:	477	Species:	Drosophila melanogaster

Alignment Length:	467	Identity:	176/467 - (37%)
Similarity:	262/467 - (56%)	Gaps:	8/467 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LGLRHLQAGLLFYGLAANTVLQLNVSVAVVAMTNETTSNNSDPPHYNWSEEKKSYILSSYYWGCA 78
            ||:||.||.|||.|:..|...::|:|.|:|.||..|    :..|.|.|....||.||||::||..
  Fly    15 LGVRHWQAVLLFVGMMINYFQRVNISAAIVPMTQST----AGAPFYTWDTSDKSLILSSFFWGYV 75

  Fly    79 LAQFPAGYLCKRFGSKAVLFWGTLGSSLLSALTTYGVYAGGWKAYCAIRLLQGLCQVT-WPCIHQ 142
            ::|.|||.|.||||:|.||...|....:|........ ..||::.|.:|:|.||.|.| :||:|.
  Fly    76 VSQVPAGLLAKRFGAKLVLGLATAIGGILCFFHPIAA-KSGWQSICVLRVLTGLVQGTVYPCVHT 139

  Fly   143 HLANWCPTAERTRLGAFAYTGFDCGNVLAMYGAGMIASSSLGWPGISYSAAGLGLIWCGLWLLLG 207
            .||.|.|..||..|....|:|...|..:.:..:|.|..||:||||:.|.:.||.|.|..|:....
  Fly   140 LLAKWVPRTERGLLTTGVYSGAQFGTAVILVTSGFIFESSMGWPGLFYLSGGLSLAWALLFFWQA 204

  Fly   208 ANKASDARFIGEAEKAYIVGDIQRSERKGPKKMEIPWKGIFTSVPVYALLCARCADSWGLTTMQT 272
            ||:...|..|.:.|..||  :.........:.|.:||..||.|...|.||.|.|..:||..|:.|
  Fly   205 ANEPVTASRISKGEVEYI--ESLTGSNSSSQSMPVPWMSIFRSPAFYGLLAAHCGFTWGFYTLLT 267

  Fly   273 ELPTYLSGVLKLDMKSNAVFSALPFLLMWVMCYVYLIIADVLLRKKWMSLTTLRKTYTSIALWAP 337
            |:|||:|.||:|::||||..|:||:..|.::|:|...|:|:|:.:..:|:||.||.:.||..|.|
  Fly   268 EMPTYMSMVLQLNVKSNAFLSSLPYFAMGLLCFVVSPISDLLINRGTISITTARKLFNSIGQWGP 332

  Fly   338 ASIMLSLVIVGEGQKTLVLVLVTLSVGVSSAATIGSELNTIDLSPNHAGILAGLMSSFTNLMALL 402
            .:.::.|..:...:||..::|:||:||:::..:.|..:|.||||||.||.:.|:.:....:.:::
  Fly   333 MACLIGLGYMTADEKTWAILLLTLAVGINAGCSCGYLINHIDLSPNFAGPMMGVTNGIAGVTSII 397

  Fly   403 TPLVVGVLVTDPSQRSQWQIVFSLAAGVLFTGNVIFLIWGTAVTQPWNESKESRRELEPEEKPFH 467
            .|||||.:|:|....|||::||.:..|:....|.||:|:|.|..|.|||...:...:.......:
  Fly   398 APLVVGAIVSDEEDPSQWRMVFFITGGIYLVCNTIFVIFGKATIQIWNEPPSTSSTMTLRSHQEN 462

  Fly   468 RAKLEIGTDNTD 479
            .:|..:.|.:.|
  Fly   463 DSKSIVPTSDKD 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2003	NP_651903.2	2A0114euk	23..456	CDD:129972	167/433 (39%)
CG2003	NP_651903.2	MFS	58..441	CDD:119392	147/383 (38%)
MFS12	NP_610332.3	MFS	23..436	CDD:119392	160/419 (38%)
MFS12	NP_610332.3	2A0114euk	25..447	CDD:129972	165/428 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442723
Domainoid	1	1.000	42	1.000	Domainoid score	I12425
eggNOG	1	0.900	-	-		E1_KOG2532
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I245
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47714
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		mtm14983
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X142
	10	9.900