DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2003 and Slc17a8

DIOPT Version :9

Sequence 1:	NP_651903.2	Gene:	CG2003 / 43761	FlyBaseID:	FBgn0039886	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_714947.1	Gene:	Slc17a8 / 266767	RGDID:	628870	Length:	588	Species:	Rattus norvegicus

Alignment Length:	504	Identity:	142/504 - (28%)
Similarity:	230/504 - (45%)	Gaps:	50/504 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IPKTVPRLGLRHLQAGLLFYGLAANTVLQLNVSVAVVAMTNETTSNNSDPP-----HYNWSEEKK 66
            |||       |::.|.:...|...:..::.|:.||:|.|.|.:|......|     .:||..|..
  Rat    72 IPK-------RYIIAVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETV 129

  Fly    67 SYILSSYYWGCALAQFPAGYLCKRFGSK-----AVLFWGTLGSSLLSALTT-YGVYAGGWKAYCA 125
            ..|..|::||..:.|.|.|::..:|.:.     |:....||...:.||... ||       ....
  Rat   130 GLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYG-------CVMC 187

  Fly   126 IRLLQGLCQ-VTWPCIHQHLANWCPTAERTRLGAFAYTGFDCGNVLAMYGAGMIASSSLGWPGIS 189
            :|:||||.: ||:|..|...:.|.|..||:||...::.|...|.|:||..||::. ..:||..:.
  Rat   188 VRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLV-QYIGWASVF 251

  Fly   190 YSAAGLGLIWCGLWLLLGANKASDARFIGEAEKAYIVGDI-QRSERKGPKKMEIPWKGIFTSVPV 253
            |.....|:||...|||......:....|...|:.||...| :.:......|...||:..|||:||
  Rat   252 YIYGMFGIIWYMFWLLQAYECPAVHPTISNEERTYIETSIGEGANLASLSKFNTPWRRFFTSLPV 316

  Fly   254 YALLCARCADSWGLTTMQTELPTYLSGVLKLDMKSNAVFSALPFLLMWVMCYVYLIIADVLLRKK 318
            ||::.|....||....:....|.|...|....:....:.||:|.::|.::..:...:||.|..:|
  Rat   317 YAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRK 381

  Fly   319 WMSLTTLRKTYTSIALWAPASIMLSLVIVG-EGQKTLVLVLVTLSVGVSSAATIGSELNTIDLSP 382
            .::.|.:||..........|:::|   :|| ...|.:.:..:.|:||.|..|..|..:|.:|::|
  Rat   382 ILTTTAVRKIMNCGGFGMEATLLL---VVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAP 443

  Fly   383 NHAGILAGLMSSFTNLMALLTPLVVGVLVTDPSQRSQWQIVFSLAAGVLFTGNVIFLIWGTAVTQ 447
            .:|.||.|:.:....|..::.||:||.: |....|.:||.||.:||.|.::|.:.:.::.:...|
  Rat   444 RYASILMGISNGVGTLSGMVCPLIVGAM-TKHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQ 507

  Fly   448 PW----NESKE-----SRRELEPEEKPFH------RAKLEIG--TDNTD 479
            .|    |.|:|     .:.||..|.:..|      |.|:..|  |.|.:
  Rat   508 DWADPENLSEEKCGIIDQDELAEETELNHEAFVSPRKKMSYGATTQNCE 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2003	NP_651903.2	2A0114euk	23..456	CDD:129972	128/455 (28%)
CG2003	NP_651903.2	MFS	58..441	CDD:119392	114/391 (29%)
Slc17a8	NP_714947.1	MFS_SLC17A6_7_8_VGluT	79..502	CDD:340940	124/434 (29%)
Slc17a8	NP_714947.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..588		5/18 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342505
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740