DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2003 and slc-17.6

DIOPT Version :9

Sequence 1:	NP_651903.2	Gene:	CG2003 / 43761	FlyBaseID:	FBgn0039886	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_490947.2	Gene:	slc-17.6 / 171781	WormBaseID:	WBGene00017398	Length:	546	Species:	Caenorhabditis elegans

Alignment Length:	511	Identity:	130/511 - (25%)
Similarity:	228/511 - (44%)	Gaps:	38/511 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NDMEEIPKTVPRL----GLRHLQAGLLFYGLAANTVLQLNVSVAVVAMTNETTSNNS--DPP-HY 59
            |.:..:|..:|.|    .:| .|..||.  .||..|..|..:...:||.:...|.|.  .|. |.
Worm     7 NSVRSLPSPIPPLWTLQSIR-FQTALLI--SAACVVFGLMRTCFGMAMVDIVRSGNGTFHPDLHM 68

  Fly    60 NWSEEKKSYILSSYYWGCALAQFPAGYLCKRFGSKAVLFWGTLGSSLLSALTTY-GVYAGGWKAY 123
            .||.::::.|.:|:|.|..:|.||:.:|.|:.|.|.:|.:..|.:...|.||.: .:|...:...
Worm    69 EWSGDEQANIHTSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSAIYLRSYFPV 133

  Fly   124 CAIRLLQGL-CQVTWPCIHQHLANWCPTAERTRLGAFAYTGFDCGNVLAMYGAGMIASSSL--GW 185
            .||||:.|. .....|.....:::|.|.:|::...|...||...|..::|:....:.....  ||
Worm   134 AAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHFFEGW 198

  Fly   186 PGISYSAAGLGLIWCGLWLLLGANKASDARFIGEAEKAYIVGDIQRSERKGPKKMEIPWKGIFTS 250
            |.:......:|.::..:|.:..|:|..::::|...|..||.|..||..|........|:..|..:
Worm   199 PLVFIVYGLIGAVFLVIWHVRLADKPRESKYITATELTYIKGGKQRRNRAETIVRATPYMKIILN 263

  Fly   251 VPVYALLCARCADSWGLTTMQTELPTYLSGVLKLDMKSNAVFSALPFLLMWVMCYVYLIIADVLL 315
            ..|.|:.....|.|:.|..:.|.||.|.....|:::..|.::|:|||.:..:...::.||||.:.
Worm   264 GCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVK 328

  Fly   316 RKKWMSLTTLRKTYTSIALWAPASIMLSLVIVGEG---QKTLVLVLVTLSVGVSSAATIGSELNT 377
            ::| ::.|.:.|...:||.:|.|   :.:||...|   ...||.:.:.:|:...||...|...:.
Worm   329 QRK-VNATAVTKVSNAIASFASA---IFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVPGYNTSI 389

  Fly   378 IDLSPNHAGILAGLMSSFTNLMALLTPLVVGVLVTDPSQRSQWQIVFSLAAGVLFTGNVIFLIWG 442
            :.::|.....::.....:..:.:.|.|:|:| .:|......:|:..|...||||....:||.|:|
Worm   390 VTVAPQFTAFISSYAQLYAQIASTLAPIVIG-RITSHGTIYEWKCAFYSLAGVLAVTGLIFQIFG 453

  Fly   443 TAVTQPWNES----------------KESRRELEPEEKPFHRAKLEIGTDNTDGNV 482
            ...|:||.|:                ::...:|...||..|..:.|....:..||:
Worm   454 HGRTEPWGETPSNATSARLSTSVTMCEDGMCKLTLLEKHNHEFRTESKISSGSGNL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2003	NP_651903.2	2A0114euk	23..456	CDD:129972	117/458 (26%)
CG2003	NP_651903.2	MFS	58..441	CDD:119392	100/389 (26%)
slc-17.6	NP_490947.2	MFS	30..453	CDD:391944	112/429 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D619250at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X142
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020