Protein Alignment RhoGAP100F and BEM2

DIOPT Version :10

• Sequence 1: NP_001163786.1
• Gene: RhoGAP100F / 43758
• FlyBaseID: FBgn0039883
• Length: 1866
• Species: Drosophila melanogaster
• Sequence 2: NP_011082.3
• Gene: BEM2 / 856899
• SGDID: S000000957
• Length: 2167
• Species: Saccharomyces cerevisiae
• Alignment Length: 598
• Identity: 121/598 - (20%)
• Similarity: 215/598 - (35%)
• Gaps: 153/598 - (25%)

  Fly   602 VDENDGNTSAPEFDVRRGRDLRQRITASPSIFTADE-----YRAWLRRAPSSSAIAEQMRMTRDM 661
            ::.:|.|.|             :|.|....:|...|     ||...::...|.||:|:.: .:.:
Yeast  1672 IEMSDENPS-------------KRTTFGRILFNNFEDVNKVYRKKTKKVSESEAISERFQ-EQGV 1722

  Fly   662 FAQPRAQRFSCSAENIHDALRNTESIYSSRNHILGTGTLDRNMGLTRPISALPVRSMSSQHIGGA 726
            |.:......    |.|....|..|.:......:..:..|.:         |:|.::..|..|.|.
Yeast  1723 FNEILVNEI----EKIKREARKLEVLLDQEKILKNSAALHQ---------AVPKKNRKSVIISGT 1774

  Fly   727 GSIRSPSIRRMRQLLELSAGPASPSGSILSTGGHQSPAPTPSATLPRPHRQIDINPAEFAKYKLD 791
            .|....|..     :..:.|.....||::.:..        ||...|..|         |.:..:
Yeast  1775 HSDNDHSYN-----INKNTGQTPSLGSVMESNN--------SARNRRDSR---------ASFSTN 1817

  Fly   792 KPIV----DIGGISGMLWIHLLAGRGLRTAPEGAAGTATQGQTRDLYCVIECDRVHKARTVVRS- 851
            :..|    ...|:|..:       .|....|....|..|......|..::. ..|...::::.|
Yeast  1818 RSSVVSNSSHNGVSKKI-------GGFFRRPFSIGGFNTSSSNYSLNSILS-QEVSSNKSILPSI 1874

  Fly   852 ---------GDLQFDWD-ESFE----LDLVGNKQLDVLVYSWD--PQHRHKLCYRGAIS--LSSI 898
                     .||:..:. ::||    ::::.::.:....|::.  .|:.|:...:.|.|  |:..
Yeast  1875 LPEVDSMQLHDLKPSYSLKTFEIKSIMEIINHRNIPAYYYAFKIVMQNGHEYLIQTASSSDLTEW 1939

  Fly   899 LRQSPLHQLALKVEPRGTIYIRMRHTDPLALYKRRGLPSLRAGYPTLFGADLETVVNRESKNAPG 963
            ::.       :|...|.:.:.:.        ||.:       .:..:||..||.|..||
Yeast  1940 IKM-------IKASKRFSFHSKK--------YKGK-------THNKIFGVPLEDVCERE------ 1976

  Fly   964 SAPVPIVLRRCVEEVERRGLDIIGLYRLCGSATKKRLLREAFER---NSRAVELTPEHVPDINVI 1025
            :..:|.::.:.:||:|.||||.:||||:.||......|:.||:.   ...:..|..:...::|.|
Yeast  1977 NTLIPTIVVKLLEEIELRGLDEVGLYRIPGSIGSINALKNAFDEEGATDNSFTLEDDRWFEVNAI 2041

  Fly  1026 TGVLKDYLRELPEPLFTRCLFQMTVDALAVCLPDDP---EGNAKLMLSILDCLPRANRATLVFLL 1087
            .|..|.||||||:.||:..:.....| ||:......   |...::|..:|..||.....||..::
Yeast  2042 AGCFKMYLRELPDSLFSHAMVNDFTD-LAIKYKAHAMVNEEYKRMMNELLQKLPTCYYQTLKRIV 2105

  Fly  1088 DHLSLVVSNSERNKMSAQALATVMGPPLMLHSASAQPGADIDHAQPIAVLKYLLQIWPQPQAQHQ 1152
            .||:.|..:...|||.|..||.|..                        :.::.|         :
Yeast  2106 FHLNKVHQHVVNNKMDASNLAIVFS------------------------MSFINQ---------E 2137

  Fly  1153 QMAQHMGGAAGAM 1165
            .:|..||...||:
Yeast  2138 DLANSMGSRLGAV 2150

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP100F	NP_001163786.1	PDZ_Par6-like	178..261	CDD:467202
		C2	804..905	CDD:175973	17/119 (14%)
		RhoGAP_SYD1	946..1144	CDD:239844	58/203 (29%)
		DUF5585	1349..>1604	CDD:465521
BEM2	NP_011082.3	RasGEF	592..860	CDD:214539
		REM	1120..1291	CDD:470601
		PH	<1877..1948	CDD:459697	11/77 (14%)
		RhoGAP	1981..2134	CDD:459875	50/177 (28%)