DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP100F and SYDE1

DIOPT Version :9

Sequence 1:	NP_001163786.1	Gene:	RhoGAP100F / 43758	FlyBaseID:	FBgn0039883	Length:	1866	Species:	Drosophila melanogaster
Sequence 2:	NP_149014.3	Gene:	SYDE1 / 85360	HGNCID:	25824	Length:	735	Species:	Homo sapiens

Alignment Length:	477	Identity:	177/477 - (37%)
Similarity:	247/477 - (51%)	Gaps:	68/477 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   700 LDRNMGLTRPIS------ALPVRSMSSQH-----IGGAGSIRSPSIRRMRQLLELSAGPASPSGS 753
            |.|.:.|..|.:      |.|..|:.|::     :||.|....|            .|..||...
Human   176 LRRRLSLRGPRAGRERERAAPAGSVISRYHLDSSVGGPGPAAGP------------GGTRSPRAG 228

  Fly   754 ILSTG-GHQSPAPTPSATLPRPHRQIDINPAEFAKYKLDKPIVDIGGISGMLWIHLLAGRGLRTA 817
            .||.| ..:.||..||.|..||:   ::.||..|     .|    ..:.|.|.:||....|||.|
Human   229 YLSDGDSPERPAGPPSPTSFRPY---EVGPAARA-----PP----AALWGRLSLHLYGLGGLRPA 281

  Fly   818 PEGAAGTATQGQTRDLYCVIECDRVHKART-VVRSGDLQFDWDESFELDLVGNKQLDVLVYSWDP 881
            | ||.       .|||.|:::.|...:||| .:|.|......|.:|.|:|...:.|..||.:|||
Human   282 P-GAT-------PRDLCCLLQVDGEARARTGPLRGGPDFLRLDHTFHLELEAARLLRALVLAWDP 338

  Fly   882 -QHRHKLCYRGAISLSSILRQSPLHQLALKVEPRGTIYIRMRHTDPLALYKRRGLPSLRAGYPTL 945
             ..||:.|.:|.:.|.::.|.....|||:::||:|.:|.:      |.|.:::..|:  ...|.:
Human   339 GVRRHRPCAQGTVLLPTVFRGCQAQQLAVRLEPQGLLYAK------LTLSEQQEAPA--TAEPRV 395

  Fly   946 FGADLETVVNRESKNAPGSAPVPIVLRRCVEEVERRGLDIIGLYRLCGSATKKRLLREAFERNSR 1010
            ||..|..:|.||  ..||.  ||:::::||.::|||||.::|||||||||..|:.||:||||:|.
Human   396 FGLPLPLLVERE--RPPGQ--VPLIIQKCVGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSA 456

  Fly  1011 AVELTPEHVPDINVITGVLKDYLRELPEPLFTRCLFQMTVDALAVCLPDDPEGNAKLMLSILDCL 1075
            ||.|:.:..||||||||:|||||||||.||.|:.|:::.::|:|...|:......:....:|.||
Human   457 AVCLSEDLYPDINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCL 521

  Fly  1076 PRANRATLVFLLDHLSLVVSNSERNKMSAQALATVMGP--------PLMLHSASAQPG--ADIDH 1130
            |...||||..|||||.||.|....|:|:.|.||...||        |....:.|:.||  :.:|.
Human   522 PDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLPARQAPTRPRARSSGPGLASAVDF 586

  Fly  1131 AQPIAVLKYLLQIWPQPQAQHQ 1152
            ...|.||.||||.||.|:...|
Human   587 KHHIEVLHYLLQSWPDPRLPRQ 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP100F	NP_001163786.1	PDZ_signaling	177..260	CDD:238492
		C2	804..905	CDD:175973	36/102 (35%)
		RhoGAP_SYD1	946..1144	CDD:239844	96/207 (46%)
SYDE1	NP_149014.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..253		25/91 (27%)
		RhoGAP	396..601	CDD:295372	96/208 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	608..651		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..696
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143517
Domainoid	1	1.000	160	1.000	Domainoid score	I4050
eggNOG	1	0.900	-	-		E1_KOG1452
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5666
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004214
OrthoInspector	1	1.000	-	-		otm40849
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46150
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2831
SonicParanoid	1	1.000	-	-		X2962
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.780