DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP100F and SYDE2

DIOPT Version :9

Sequence 1:NP_001163786.1 Gene:RhoGAP100F / 43758 FlyBaseID:FBgn0039883 Length:1866 Species:Drosophila melanogaster
Sequence 2:XP_016857972.1 Gene:SYDE2 / 84144 HGNCID:25841 Length:1262 Species:Homo sapiens


Alignment Length:1289 Identity:308/1289 - (23%)
Similarity:459/1289 - (35%) Gaps:465/1289 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   253 RRLVLAIRQRRGNRGTGSPGPPTLSRPEQKPPPVVVIKRDLRDEDLDETDRMPRPRSSRDRRTGD 317
            ||.:..:|.|||.||||..|....:      ...|........:.....|.:||..:.     |.
Human     6 RRTLSRLRGRRGPRGTGGLGLRAAA------AAAVAASSAAAGDAWGAADTLPREHAG-----GH 59

  Fly   318 GREM--------------------TESRSRLG---LGLNNYSPQSEQL----------------- 342
            ||.:                    .|....||   .|....:|||..|                 
Human    60 GRSLQQPSPSPEAWGPGARVPGGHPEQLGALGPRPRGGQEAAPQSHGLAHAPPHSPEGSEDSGEE 124

  Fly   343 ------------DMYYNTRGGG------GGAMGEPPNWGYKPPPPP---SSVITE---------- 376
                        |.|.|..||.      .||..|     .:|||||   ||:..|          
Human   125 EEDDKDEDDYDADYYENLPGGSQSAPEPEGAEAE-----RRPPPPPAAGSSLGAEGGRLETGRLR 184

  Fly   377 -QPTKA--------HAFAPSHAYYQNAGTLESLAEKVHAFYPGQPGGPPVGPSRRMST----GTG 428
             |..:|        |...|.....:....|...:....|..||||  |..|.:.|.:.    ..|
Human   185 TQLREAYYLLIQAMHDLPPDSGARRGGRGLADHSFPAGARAPGQP--PSRGAAYRRACPRDGERG 247

  Fly   429 NVGLAQQHARFPRS------GSDQHLPRVEYSDYSNSL-----------------------GRH- 463
            ..|..:|....|||      |.....||:..| .|.||                       |.| 
Human   248 GGGRPRQQVSPPRSPQREPRGGQLRTPRMRPS-CSRSLESLRVGAKPPPFQRWPSDSWIRCGAHR 311

  Fly   464 ---------------------SLLRSSLKP------GTTGGAPMQVGVGGTLGRYGRYDQQRAGV 501
                                 :...:.|:|      |.:.|:|.:...|.::.|.|:.|:|. |.
Human   312 DWDEPPPRGGRMDGWSGDRARAAAPTGLQPPGCKDHGCSSGSPFRDPAGSSVIRSGKGDRQE-GP 375

  Fly   502 SKYGPPSGGAQSLTRRSRPNLDYSSDTEATIGPRPSYYYYNR-PAIGSMSRGSGGAGGGVGAAST 565
            |...||:                     .|:.....:.|..| .::|...|..|.|....| ...
Human   376 SFLRPPA---------------------VTVKKLQKWMYKGRLLSLGMKGRARGTAPKVTG-TQA 418

  Fly   566 AALLAGAADL--NKFNSLPRERPGTRL-------QGIRSRMGDRLVDENDGN------------- 608
            |:...||..:  |:..|:|   |..|:       ....|.|..|.::|...|             
Human   419 ASPNVGALKVRENRVLSVP---PDQRITLTDLFENAYGSSMKGRELEELKDNIEFRGHKPLNSIT 480

  Fly   609 -----------TSAP---EFDVRRGRDLRQRITASP----------SIFTA-------------- 635
                       |..|   |.:.::.:| |..::.||          |...:              
Human   481 VSKKRNWLYQSTLRPLNLEEENKKCQD-RSHLSISPVSLPKHQLSQSFLKSSKEYCTYVVCNATN 544

  Fly   636 ------------------DEYRAWLRRAP---------------SSSAIAEQMRMTRDMFAQP-- 665
                              ||...|....|               :.||:.:...:...|.:..  
Human   545 SSLSKNCALDFNEENDADDEGEIWYNPIPEDDDLGISSALSFGEADSAVLKLPAVNLSMLSGSDL 609

  Fly   666 -RAQRFS----CSAEN--------------IHDALRNTESIYSSRNHI----------------- 694
             :|:|.:    ||:|:              ||.| .:||.:...:..:                 
Human   610 MKAERHTEDSLCSSEHAGDIQTTRSNGMNPIHPA-HSTEFVQQYKQKLGHKTQEGIMVEDSPMLK 673

  Fly   695 ---LGTGTL----DRNMGLTRPIS--ALPVRSMSSQHIGGAGSIRSP-SIR----RMRQLLELSA 745
               .|:|.|    ...:|:..|.|  ..||:..||.:......|:|| ::|    :|::|.|.|.
Human   674 SPFAGSGILAATNSTELGIMEPSSPNPSPVKKGSSINWSLPDKIKSPRTVRKLSMKMKKLPEFSR 738

  Fly   746 ------------GPAS------------------PSGSILST----------------------- 757
                        .|.:                  |||:..:.                       
Human   739 KLSVKGTLNYINSPDNTPSLSKYNCREVHHTDILPSGNTTTAAKRNVISRYHLDTSVSSQQSYQK 803

  Fly   758 -----------GGHQSPAPTPSATLPR--------------------PHRQIDINPAEFAKYKL- 790
                       ||:.|...:|..|...                    ...:|||:  .|..|.. 
Human   804 KNSMSSKYSCKGGYLSDGDSPELTTKASKHGSENKFGKGKEIISNSCSKNEIDID--AFRHYSFS 866

  Fly   791 DKPIVDIGGISGMLWIHLLAGRGLRTAPEGAAGTATQGQTRDLYCVIECDRVHKARTVVRSGDLQ 855
            |:|... ..|||::.:|......|:         ..:..::|::|.|:.|.|:||||.:.:....
Human   867 DQPKCS-QYISGLMSVHFYGAEDLK---------PPRIDSKDVFCAIQVDSVNKARTALLTCRTT 921

  Fly   856 F-DWDESFELDLVGNKQLDVLVYSWDPQHR-HKLCYRGAISLSSILRQSPLHQLALKVEPRGTIY 918
            | |.|.:|.:::...:.|.::|:||:|..| :::|..|.:.|.::.|.:..||||:|:||||.||
Human   922 FLDMDHTFNIEIENAQHLKLVVFSWEPTPRKNRVCCHGTVVLPTLFRVTKTHQLAVKLEPRGLIY 986

  Fly   919 IRMRHTDPLALYKRRGLPSLRAGY-PTLFGADLETVVNRESKNAPGSAPVPIVLRRCVEEVERRG 982
            :::    .|.......|..|.... |.:||.|::.||.:|:.    ...||:::::|:.|:|:||
Human   987 VKV----TLMEQWENSLHGLDINQEPIIFGVDIQKVVEKENI----GLMVPLLIQKCIMEIEKRG 1043

  Fly   983 LDIIGLYRLCGSATKKRLLREAFERNSRAVELTPEHVPDINVITGVLKDYLRELPEPLFTRCLFQ 1047
            ..::|||||||||..|:.|||||||:|:||.|.....||||||||||||||||||.||.|:.|::
Human  1044 CQVVGLYRLCGSAAVKKELREAFERDSKAVGLCENQYPDINVITGVLKDYLRELPSPLITKQLYE 1108

  Fly  1048 MTVDALAV---------CLPDDPEGNAKLMLSILDCLPRANRATLVFLLDHLSLVVSNSERNKMS 1103
            ..:||:|.         | .:|| |::|..:.:|||||...:|||..|||||.||.|..|.|||:
Human  1109 AVLDAMAKSPLKMSSNGC-ENDP-GDSKYTVDLLDCLPEIEKATLKMLLDHLKLVASYHEVNKMT 1171

  Fly  1104 AQALATVMGPPLM------------LHSASAQPGADIDHAQPIAVLKYLLQIWP 1145
            .|.||...||.|:            :.:.|.:..:.:|..:.|.||.||||:||
Human  1172 CQNLAVCFGPVLLSQRQEPSTHNNRVFTDSEELASALDFKKHIEVLHYLLQLWP 1225

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP100FNP_001163786.1 PDZ_signaling 177..260 CDD:238492 2/6 (33%)
C2 804..905 CDD:175973 25/102 (25%)
RhoGAP_SYD1 946..1144 CDD:239844 99/218 (45%)
SYDE2XP_016857972.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143516
Domainoid 1 1.000 160 1.000 Domainoid score I4050
eggNOG 1 0.900 - - E1_KOG1452
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0004214
OrthoInspector 1 1.000 - - otm40849
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR46150
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2831
SonicParanoid 1 1.000 - - X2962
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.830

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