Protein Alignment RhoGAP100F and abr

DIOPT Version :9

• Sequence 1: NP_001163786.1
• Gene: RhoGAP100F / 43758
• FlyBaseID: FBgn0039883
• Length: 1866
• Species: Drosophila melanogaster
• Sequence 2: XP_012812699.1
• Gene: abr / 779766
• XenbaseID: XB-GENE-5797083
• Length: 1019
• Species: Xenopus tropicalis
• Alignment Length: 1041
• Identity: 223/1041 - (21%)
• Similarity: 349/1041 - (33%)
• Gaps: 364/1041 - (34%)

  Fly   358 EPPN-----WGYKPPPPPSSVITEQPTKAHAFAPSHAYYQNAGT-----LESLAEKVHAFYPGQP 412
            |||.     ...|||||      ..|.:|....|...|....|:     |::|........||..
 Frog    67 EPPKPFPRVRSNKPPPP------VPPQRAPPPLPDRDYEDERGSTERFVLDNLLSPAGELRPGGG 125

  Fly   413 GGPPVGPSRRMSTGTGNVGL-------AQQHARFPRSGSDQHLPRVEYSDYSNSLGRHSLLRS-S 469
            |........|.|.......|       :.:|:. |..|||.:|.    ||....       || .
 Frog   126 GEEETAGRERGSRAEKRRDLLTVPGWDSPRHSS-PERGSDDYLS----SDLEED-------RSID 178

  Fly   470 LKPGTTGGAPMQVGVGGTLGRYGRYDQQRAGVSKYGPPSGGAQSLTRRSRPNLDYSSDTEATIGP 534
            ...||.|                 ||.:  |..::.....|::::     |.:|.|    .|:.|
 Frog   179 FNYGTDG-----------------YDAE--GNEEHKSSREGSETM-----PYIDES----PTMSP 215

  Fly   535 RPSYYYYNRPAIGSMSRGSGGAGGGVGAASTAALLAGAADLNKFNSLPRERPGTRLQGIRSRMGD 599
            :             :|..|..:..||....|..||.|....:....|.|:   ..|.|:
 Frog   216 Q-------------LSARSQDSVDGVSPTPTEVLLPGGESESDKGLLMRK---LVLSGV------ 258

  Fly   600 RLVDEN------------------DGNTSAPEFDVRRGRD------------------------- 621
             |..|.                  ..:||.|...:::..|
 Frog   259 -LASEEIYINQLEALLLPMKPLKATASTSQPVLTLQQINDIFYKIEDIYQMHKDFYDKLCPIVLQ 322

  Fly   622 ---------LRQRITASPSIFTA--DEYRAWLRRAPSSS-------AIAEQMRM--TRDMFAQPR 666
                     |.|::.:...::.|  |.|:..|..|...|       .|:|.:::  .:|...||:
 Frog   323 FDNKTTVGHLFQKLASQLGVYKAFVDNYKFALETAEKCSQCNVQFFKISEDLKVKGPKDSKEQPQ 387

  Fly   667 A-----------QRFSCSAENIHDALRNT-----------ESIYSSRNHILGTG-TLD-RNMGLT 707
            :           .|.:.|...:||.|::|           :::..|:|.:.... .:| |...:|
 Frog   388 SVTMEALLYKPIDRVTRSTLVLHDLLKHTPTDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVT 452

  Fly   708 RPISALPVRSMSSQHIGGAGSIR-SPSIRRMRQLLELSAGPASPSGSILSTGGHQS--------- 762
            .|      :....|.:.....:. |.:.|::|.|...:...........:.|.||.
 Frog   453 TP------KGEPRQLVKDGFLVELSENSRKLRHLFLFTDLLLCAKLKKTTVGKHQQYDCKWYIPL 511

  Fly   763 -----PAPTPSATLPRPH-----------RQIDINPAEFAK------------------------ 787
                 |:|..|..:|:.|           .:|.:..:|..|
 Frog   512 ADLVFPSPEESEPIPQLHATPDHEIEEMKAKISVLKSEIQKERKSNKGSSRTIERLKKKMFEYES 576

  Fly   788 --------------------------------------YKLDK---------------------- 792
                                                  .||.|
 Frog   577 WLLLYSPTIPFRIHNKNGKSYFFLLSSDYERSEWREAIQKLQKKDLQALALSPFELQVLTASCFK 641

  Fly   793 -------PIV------DIGGISGMLWIHLLAGRGLRTAPEGAAGTATQGQTRDLYCVIECDR--- 841
                   ||:      :..|:.|.|.:.:.:.:|.             ..:.:|||.:|.|.
 Frog   642 LRTVHNVPIISHKDDDESPGLYGFLHVIVKSAKGF-------------SHSSNLYCTLEVDSFGY 693

  Fly   842 -VHKARTVVRSGDLQFDWDESFELDLVGNKQLDVLVYS--WDPQHRH--------KLCYRGAISL 895
             |.||:|.|.....:.:|:|.||::|.|::.|.:|.|.  :|....:        |:..:|.|.|
 Frog   694 FVSKAKTRVFRDTTEPEWNEEFEIELEGSQCLRILCYEKCYDKSKLNKDNNEIVDKIMGKGQIQL 758

  Fly   896 SSILRQSP------LHQLALKVEPRGTIYIRMRHTDPLALYKRRGLPSLRAGYPTLFGADLETVV 954
            ...:.||.      :....:|||      ..|:.:......||  .||.:  ...:||..:..|.
 Frog   759 DPQVVQSKNWHDDVIEMNGIKVE------FSMKFSSRDMSLKR--TPSKK--QTGVFGVKISVVT 813

  Fly   955 NRESKNAPGSAPVPIVLRRCVEEVERRGLDIIGLYRLCGSATKKRLLREAFERNSRAVELTPEHV 1019
            .||      .:.||.::|:|:||||:||::.:|:||:.|.||..:.|:.:|:.||:.:.:....:
 Frog   814 KRE------RSKVPYIVRQCIEEVEKRGIEEVGIYRISGVATDIQALKASFDANSKDILMMLSDM 872

  Fly  1020 PDINVITGVLKDYLRELPEPLFTRCLFQMTVDALAVCLPDDPEGNAKLMLSILDCLPRANRATLV 1084
             |||.|.|.||.|.|||||||.|..|:...::.:|:   .||......|:.:|..||..|..|.:
 Frog   873 -DINAIAGTLKLYFRELPEPLLTDRLYLAFMEGIAL---SDPAAKENCMMHLLRSLPDPNLMTFL 933

  Fly  1085 FLLDHLSLVVSNSERNKMSAQALATVMGPPLMLHSASAQPG-----ADI---DHAQPIAVLKYLL 1141
            |||.||..|......||||...||||.||.|:..|.....|     :||   |....:.||.|.|
 Frog   934 FLLQHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKGHMNLASDIWSHDVMAQVQVLLYYL 998

  Fly  1142 Q 1142
            |
 Frog   999 Q 999

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP100F	NP_001163786.1	PDZ_signaling	177..260	CDD:238492
		C2	804..905	CDD:175973	28/120 (23%)
		RhoGAP_SYD1	946..1144	CDD:239844	78/205 (38%)
abr	XP_012812699.1	Bcr-Abl_Oligo	3..65	CDD:312543
		RhoGEF	254..442	CDD:214619	29/194 (15%)
		PH_ABR	436..620	CDD:270172	22/189 (12%)
		C2_ABR	666..786	CDD:176068	32/138 (23%)
		RhoGAP_Bcr	805..1000	CDD:239852	78/205 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D332603at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920