Protein Alignment RhoGAP100F and Syde1

DIOPT Version :10

• Sequence 1: NP_001163786.1
• Gene: RhoGAP100F / 43758
• FlyBaseID: FBgn0039883
• Length: 1866
• Species: Drosophila melanogaster
• Sequence 2: NP_082151.1
• Gene: Syde1 / 71709
• MGIID: 1918959
• Length: 737
• Species: Mus musculus
• Alignment Length: 744
• Identity: 230/744 - (30%)
• Similarity: 324/744 - (43%)
• Gaps: 189/744 - (25%)

  Fly   439 FPRSGSDQHLPRVEYSDYSNSLGR-HSLLRSSLKP---------GTTGGAPM----QVGVGGTLG 489
            |.|....:.|||.:    |.:..| |...||..||         |:..||.:    :.....|.|
Mouse    10 FSRLRGREKLPRKK----SEAKDRGHPAQRSEPKPPEPEPRVLEGSQAGAEVPPSPETPRSPTRG 70

  Fly   490 RYGRYDQQRAGVSKYGPPS-----GGAQSLTRRSRPNLDYSSDTEATIGPR-PSYYYYNRPAIGS 548
            .|         :....|.|     |||:             ...|.::||| ||
Mouse    71 AY---------LQSLEPSSRRWVLGGAK-------------PPEEISLGPRTPS----------- 102

  Fly   549 MSRGSGGAGGGVGAASTAALLAGAADLNKFNSLPRERPGTRLQGIRSRMGDRLVDENDGNTSAPE 613
                ||...|.:.                :|.:|.|.|                     ...|||
Mouse   103 ----SGEPAGEIW----------------YNPIPEEDP---------------------RPPAPE 126

  Fly   614 FDVRRGRDLRQRITASPSIFTADEYRAWLRRAPSSSAIAEQMRMTRDMFAQPRAQRFSCSAENIH 678
               ..|..|.......|:|..|         ||:|    ...:.:|.....| |:|.|...:.:.
Mouse   127 ---PLGSQLASSEPEGPNIQGA---------APTS----PPTKTSRTKSPGP-ARRLSMKMKKLP 174

  Fly   679 DALRNTESIYSSRNHILGTGTLDRNMGLTRPISALPVRSMSSQHIGGAGSIRSPSIRRMRQLLEL 743
            : ||...|:.|:|     ||   |:...|.|..::..|......:|..|.            ..:
Mouse   175 E-LRRRLSLRSTR-----TG---RDRERTAPAGSVISRYHLDSSVGTPGQ------------ASV 218

  Fly   744 SAGPASPSGSILSTG-GHQSPAPTPSATLPRPHRQIDINPAEFAKYKLDKPIVDIGGISGMLWIH 807
            :.|..||.|..||.| ..:.|...||.|..||:   ::.|:  |:       .....:.|.|.:|
Mouse   219 AGGSRSPRGGYLSDGDSPERPGGPPSPTAFRPY---EVGPS--AR-------TPPAALWGRLSLH 271

  Fly   808 LLAGRGLRTAPEGAAGTATQGQTRDLYCVIECDRVHKART-VVRSGDLQFDWDESFELDLVGNKQ 871
            |....|||.:| ||.       .|||.|:::.|.|.:||| .:|||......|.:|.|:|...:.
Mouse   272 LYGLGGLRPSP-GAT-------PRDLCCLLQVDGVARARTGPLRSGPDFLRLDHTFHLELEAARL 328

  Fly   872 LDVLVYSWDP-QHRHKLCYRGAISLSSILRQSPLHQLALKVEPRGTIYIRMRHTDPLALYKRRGL 935
            |..||.:||| ..||:.|.:|.:.|.:|.|.....|||:::||:|.:|.:      |.|.:::..
Mouse   329 LRALVLAWDPGVRRHRPCAQGTVLLPTIFRGCQAQQLAVRLEPQGLLYAK------LTLSEQQEA 387

  Fly   936 PSLRAGYPTLFGADLETVVNRESKNAPGSAPVPIVLRRCVEEVERRGLDIIGLYRLCGSATKKRL 1000
            |:  ...|.:||..|:.:|.||  .:||.  ||:::|:||.::|.|||.::|||||||||..|:.
Mouse   388 PA--TAEPRVFGLPLQLLVERE--QSPGQ--VPLIIRKCVGQIECRGLRVVGLYRLCGSAAVKKE 446

  Fly  1001 LREAFERNSRAVELTPEHVPDINVITGVLKDYLRELPEPLFTRCLFQMTVDALAVCLPD----DP 1061
            ||:|||::|.||.|:.:..||||||||:|||||||||.||.|:.|:|:.::|:|...|.    .|
Mouse   447 LRDAFEQDSAAVCLSEDVYPDINVITGILKDYLRELPTPLITQPLYQVVLEAMAQGHPSRASLGP 511

  Fly  1062 EGNAKLMLSILDCLPRANRATLVFLLDHLSLVVSNSERNKMSAQALATVMGPPLM---------- 1116
            ||..    .:|.|||...||||..|||||.||.|....|:|:.|.||...||.|:
Mouse   512 EGTR----GLLRCLPDVERATLTLLLDHLRLVSSFHTHNRMTPQNLAVCFGPVLLPARQTPSRPR 572

  Fly  1117 LHSASAQPGADIDHAQPIAVLKYLLQIWP 1145
            |.|:.....:.:|..:.|.||.||||.||
Mouse   573 LRSSGPGVTSAVDFKRHIEVLHYLLQSWP 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP100F	NP_001163786.1	PDZ_Par6-like	178..261	CDD:467202
		C2	804..905	CDD:175973	38/102 (37%)
		RhoGAP_SYD1	946..1144	CDD:239844	98/211 (46%)
		DUF5585	1349..>1604	CDD:465521
Syde1	NP_082151.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..255		78/363 (21%)
		PHA03247	<57..263	CDD:223021	65/329 (20%)
		RhoGAP	396..601	CDD:470621	98/212 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	601..654		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	675..708