Protein Alignment RhoGAP100F and RhoGAP1A

DIOPT Version :10

• Sequence 1: NP_001163786.1
• Gene: RhoGAP100F / 43758
• FlyBaseID: FBgn0039883
• Length: 1866
• Species: Drosophila melanogaster
• Sequence 2: NP_001284725.1
• Gene: RhoGAP1A / 5740235
• FlyBaseID: FBgn0025836
• Length: 1404
• Species: Drosophila melanogaster
• Alignment Length: 616
• Identity: 157/616 - (25%)
• Similarity: 249/616 - (40%)
• Gaps: 118/616 - (19%)

  Fly   578 FNSLPRERPGTRLQGIRSRMGDRLVDE--NDGNTSAPEFDVRRGRDLRQRITASPSIFTADEYRA 640
            ||.|.||.|.........|...:::..  |..|.......:...|:||:.:..|..:...|.:|.
  Fly   825 FNDLLRETPNAHPDHQPLRQAQKIIQMFLNQFNVVNQRLPIESNRNLRRMVRNSFIVELVDGHRK 889

  Fly   641 WLRRA---PSSSAIAEQMRMTRDMF------------------AQPRAQRFSCSAENIHDALRNT 684
             ||..   ....|.|:...:.||..                  |.|..:....|..||....||.
  Fly   890 -LRHLFLFNDVIACAKYKALGRDRIDYELKWFIPLKDVSIYEEADPAVELKESSPANISQVKRNL 953

  Fly   685 ESIYSSRNHILGTGTLDRNMGLTRPISALPVRSMSSQHIGGAGSIRSPSIRRMRQLLELSAGPAS 749
            .|:                    |...|:.|.:      .|:|:.||....| |:|.:|.:....
  Fly   954 RSV--------------------RDQLAMEVAN------SGSGAFRSGDKYR-RKLADLESQLVL 991

  Fly   750 PSGSILSTGGHQSPAPTPSATLPRPHRQID-INPAEFAKYKLDKPIVD-IGGISGMLWIHLLAGR 812
            .:.:::...|:::...|.:..|.....:.. |:.....|.|.:.|..: |..:....:| :...:
  Fly   992 ATPNLVLRLGNKANNKTITFFLSSDFERTQWIDSILSLKQKCNLPGANTINSLEVTAFI-VAMQK 1055

  Fly   813 GLRTAP-------------------EGAAGTATQGQTRDLYCVIECDR----VHKART--VVRSG 852
            |::|..                   .|..|.....|..|||..:|.|.    ..||.|  :.||.
  Fly  1056 GMKTEMGSYLMRNTNDESLLVGDLYMGVHGLEGLEQANDLYICVEVDSYGHYFRKATTKKICRSQ 1120

  Fly   853 DLQFDWDESFELDLVGNKQLDVLVYSWDPQHRHKLCYRGAISLSSILRQSPLHQLALKVEPRGTI 917
            ...  |:|||.|:|.|::.:.:|:|  :.:.|..|..:..:.||       |..|....:|:.
  Fly  1121 TPL--WNESFMLELEGSQNVRILLY--EAKERPLLKAKHILKLS-------LSWLTETTQPKS-- 1172

  Fly   918 YIRMRHTDPLALYKR-------RGLPSLRAGYPTLFGADLETVVNRESKNAPGSAPVPIVLRRCV 975
             |::..|..|....|       ||  |.:.|  .||||.:..|:.||.::      :|.::..|:
  Fly  1173 -IKLTETLELGCSFRFIPGELFRG--STKPG--ALFGAKMSQVLKREKRD------IPFIIGACI 1226

  Fly   976 EEVERRGLDIIGLYRLCGSATKKRLLREAFERNSRAVELTPEHVPDINVITGVLKDYLRELPEPL 1040
            .||||||:..:|.||:.|||:....|::|||.::...|.....| ||:.:||:||.:||||||.|
  Fly  1227 REVERRGMLEVGCYRVSGSASDLAKLKKAFESDAYEAEQLLREV-DIHSVTGILKTFLRELPEAL 1290

  Fly  1041 FTRCLFQMTVDALAVCLPDDPEGNAKLMLSILDCLPRANRATLVFLLDHLSLVVSNSERNKMSAQ 1105
            ||..|:....|..:....::.......:|.:.:.||:||:|::..:||||..|......||||..
  Fly  1291 FTDQLYPRFFDTFSAFSNNNESTRINELLKVFEELPQANKASITSILDHLIRVHEKETDNKMSLH 1355

  Fly  1106 ALATVMGPPLMLHSASAQPG-ADIDHAQPIA 1135
            .||.|.||.|:      :|| ..:....|:|
  Fly  1356 NLAMVFGPTLL------RPGQTQVKQKDPLA 1380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP100F	NP_001163786.1	PDZ_Par6-like	178..261	CDD:467202
		C2	804..905	CDD:175973	29/125 (23%)
		RhoGAP_SYD1	946..1144	CDD:239844	68/191 (36%)
		DUF5585	1349..>1604	CDD:465521
RhoGAP1A	NP_001284725.1	RhoGEF	675..857	CDD:214619	8/31 (26%)
		PH_BCR_arthropod	851..1037	CDD:270174	39/213 (18%)
		C2	1079..1187	CDD:472691	32/121 (26%)
		RhoGAP	1203..1398	CDD:470621	68/191 (36%)