DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP100F and si:dkey-91m11.5

DIOPT Version :9

Sequence 1:	NP_001163786.1	Gene:	RhoGAP100F / 43758	FlyBaseID:	FBgn0039883	Length:	1866	Species:	Drosophila melanogaster
Sequence 2:	XP_021333943.1	Gene:	si:dkey-91m11.5 / 560226	ZFINID:	ZDB-GENE-060503-932	Length:	1312	Species:	Danio rerio

Alignment Length:	398	Identity:	127/398 - (31%)
Similarity:	195/398 - (48%)	Gaps:	54/398 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   783 AEFAKYKLDKPIVDIGGISGMLWIHLLAGRGLRTAPEGAAGTATQGQTRDLYCVIECDR----VH 843
            |.|....::|...:..|:.|.|.:.:.:..||:             |:.:|||.:|.|.    |:
Zfish   937 ALFCPLTVNKDDDESTGLCGFLNVIVHSATGLK-------------QSLNLYCTLEVDSFGYFVN 988

  Fly   844 KARTVVRSGDLQFDWDESFELDLVGNKQLDVLVYSW------DPQHRHKLCYRGAISLSSILRQS 902
            ||:|.|.....:.:|:|.||::|.|::.|.:|.||.      |.::..::..:|.|.|.....|.
Zfish   989 KAKTRVYRDTTEPNWNEEFEIELEGSQTLRLLCYSKIKQCRDDGENIDRVMAKGQIQLDPQSLQG 1053

  Fly   903 PLHQLALKVEPRG-TIYIRMRHTDPLALYKRRGLPSLRAGYPTLFGADLETVVNRESKNAPGSAP 966
            ...|..: :...| .:.:.||.|......||  :||.:..  .:||..:..|..||      .:.
Zfish  1054 KDWQRTV-ISMNGIEVKLSMRFTSREFSLKR--MPSRKQS--GVFGVKIGAVTKRE------HSK 1107

  Fly   967 VPIVLRRCVEEVERRGLDIIGLYRLCGSATKKRLLREAFERNSRAVELTPEHVPDINVITGVLKD 1031
            ||:::|:||||:||||::.:|:||:.|.||..:.|:.||:.|::.|.:....: |:|.|.|.||.
Zfish  1108 VPLIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDANNKDVSVIMSEM-DVNAIAGTLKL 1171

  Fly  1032 YLRELPEPLFTRCLFQMTVDALAVCLPDDPEGNAKLMLSILDCLPRANRATLVFLLDHLSLVVSN 1096
            |.|||||||||..|:....:.:|:   .|.......||::|..||..|..|.:||||||..|..|
Zfish  1172 YFRELPEPLFTDELYINFTEGIAL---SDSVAKESCMLNLLLSLPEPNLLTFLFLLDHLKRVAEN 1233

  Fly  1097 SERNKMSAQALATVMGPPLM--------LHSASAQP-----GADIDHAQPIAVLKYLLQI--WPQ 1146
            ...||||...||||.||.|:        :.|...||     ...::....:.||.|.||:  .|.
Zfish  1234 EIVNKMSFHNLATVFGPTLLRPSEKDSKIPSNPTQPISMSDSWSLEVMSQVQVLLYFLQLEAIPT 1298

  Fly  1147 PQAQHQQM 1154
            |.::.|.|
Zfish  1299 PDSKRQSM 1306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP100F	NP_001163786.1	PDZ_signaling	177..260	CDD:238492
		C2	804..905	CDD:175973	29/110 (26%)
		RhoGAP_SYD1	946..1144	CDD:239844	80/212 (38%)
si:dkey-91m11.5	XP_021333943.1	Bcr-Abl_Oligo	3..75	CDD:312543
		RhoGEF	527..714	CDD:238091
		PH_BCR_vertebrate	709..901	CDD:270173
		C2_ABR	958..1074	CDD:176068	32/129 (25%)
		RhoGAP_Bcr	1093..1293	CDD:239852	79/209 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D332603at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920