DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP100F and Syde1

DIOPT Version :9

Sequence 1:	NP_001163786.1	Gene:	RhoGAP100F / 43758	FlyBaseID:	FBgn0039883	Length:	1866	Species:	Drosophila melanogaster
Sequence 2:	NP_001178805.1	Gene:	Syde1 / 362842	RGDID:	1305857	Length:	735	Species:	Rattus norvegicus

Alignment Length:	747	Identity:	231/747 - (30%)
Similarity:	329/747 - (44%)	Gaps:	195/747 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   439 FPRSGSDQHLPRVEYSDYSNSLGRHSLLRSSLKP---------GTTGGAPMQVGVGGTLGRYGRY 494
            |.|....:.||| :.|| :...||.: .||..||         |:..||.:.
  Rat    10 FSRLRGREKLPR-KKSD-AKDRGRPA-QRSEPKPPEPEPRVLEGSQAGAEVP------------- 58

  Fly   495 DQQRAGVSKYGP--PSGGA--QSLTRRSR---------PNLDYSSDTEATIGPR-PSYYYYNRPA 545
                  :|...|  |:.||  |||...||         |.       |.::||| ||
  Rat    59 ------LSPETPRSPARGAYLQSLEPSSRRWVLGGAKPPE-------EISLGPRTPS-------- 102

  Fly   546 IGSMSRGSGGAGGGVGAASTAALLAGAADLNKFNSLPRERPGTRLQGIRSRMGDRLVDENDGNTS 610
                   ||...|.:.                :|.:|.|.|.....   ..:|.:|.      :|
  Rat   103 -------SGEPAGEIW----------------YNPIPEEDPRPPAP---EPVGSQLA------SS 135

  Fly   611 APEFDVRRGRDLRQRITASPSIFTADEYRAWLRRAPSSSAIAEQMRMTRDMFAQPRAQRFSCSAE 675
            .||..:.:|                        .||:|    ...:.:|.....| |:|.|...:
  Rat   136 EPEGPILQG------------------------AAPTS----PPTKTSRTKSPGP-ARRLSMKMK 171

  Fly   676 NIHDALRNTESIYSSRNHILGTGTLDRNMGLTRPISALPVRSMSSQHIGGAGSIRSPSIRRMRQL 740
            .:.: ||...|:.|:|.        .|....|.|..::    :|..|:.  .|:.:|.      .
  Rat   172 KLPE-LRRRLSLRSTRT--------SRERERTAPAGSV----ISRYHLD--SSVATPG------Q 215

  Fly   741 LELSAGPASPSGSILSTG-GHQSPAPTPSATLPRPHRQIDINPAEFAKYKLDKPIVDIGGISGML 804
            ..::.|..||.|..||.| ..:.|...||.|..||:   ::.|:..|     .|    ..:.|.|
  Rat   216 ASVAGGTRSPRGGYLSDGDSPERPGGPPSPTAFRPY---EVGPSARA-----PP----AALWGRL 268

  Fly   805 WIHLLAGRGLRTAPEGAAGTATQGQTRDLYCVIECDRVHKART-VVRSGDLQFDWDESFELDLVG 868
            .:||....|||..| ||.       .|||.|:::.|.|.:||| .:|||......|.:|.|:|..
  Rat   269 SLHLYGLGGLRPTP-GAT-------PRDLCCLLQVDGVARARTGPLRSGPDFLRLDHTFHLELEA 325

  Fly   869 NKQLDVLVYSWDP-QHRHKLCYRGAISLSSILRQSPLHQLALKVEPRGTIYIRMRHTDPLALYKR 932
            .:.|..||.:||| ..||:.|.:|.:.|.:|.|.....|||:::||:|.:|.:      |.|.::
  Rat   326 ARLLRALVLAWDPGVRRHRPCAQGTVLLPTIFRGCQAQQLAVRLEPQGLLYAK------LTLSEQ 384

  Fly   933 RGLPSLRAGYPTLFGADLETVVNRESKNAPGSAPVPIVLRRCVEEVERRGLDIIGLYRLCGSATK 997
            :..|:  ...|.:||..|:.:|.||  .:||.  ||:::|:||.::|.|||.::|||||||||..
  Rat   385 QEAPA--TVEPRVFGLPLQLLVERE--QSPGQ--VPLIIRKCVGQIECRGLRVVGLYRLCGSAAV 443

  Fly   998 KRLLREAFERNSRAVELTPEHVPDINVITGVLKDYLRELPEPLFTRCLFQMTVDALAVCLPD--- 1059
            |:.||:|||::|.||.|:.:..||||||||:|||||||||.||.|:.|:|:.::|:|...|.
  Rat   444 KKELRDAFEQDSAAVCLSEDVYPDINVITGILKDYLRELPTPLITQPLYQVVLEAMAQGHPSRAS 508

  Fly  1060 -DPEGNAKLMLSILDCLPRANRATLVFLLDHLSLVVSNSERNKMSAQALATVMGPPLM------- 1116
             .|||..    .:|.|||...||||..|||||.||.|....|:|:.|.||...||.|:
  Rat   509 LGPEGTR----GLLSCLPDVERATLTLLLDHLRLVSSFHTHNRMTPQNLAVCFGPVLLPARQTPS 569

  Fly  1117 ---LHSASAQPGADIDHAQPIAVLKYLLQIWP 1145
               |..:.....:.:|..:.|.||.||||.||
  Rat   570 RTRLRGSGPGVSSAVDFKRHIEVLHYLLQSWP 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP100F	NP_001163786.1	PDZ_signaling	177..260	CDD:238492
		C2	804..905	CDD:175973	38/102 (37%)
		RhoGAP_SYD1	946..1144	CDD:239844	97/211 (46%)
Syde1	NP_001178805.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..253		79/364 (22%)
		PHA03247	<48..263	CDD:223021	69/342 (20%)
		RhoGAP	396..601	CDD:413382	97/212 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	601..655		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	669..706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337259
Domainoid	1	1.000	152	1.000	Domainoid score	I4226
eggNOG	1	0.900	-	-		E1_KOG1452
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004214
OrthoInspector	1	1.000	-	-		otm44991
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46150
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2962
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.800