DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP100F and RhoGAP5A

DIOPT Version :9

Sequence 1:	NP_001163786.1	Gene:	RhoGAP100F / 43758	FlyBaseID:	FBgn0039883	Length:	1866	Species:	Drosophila melanogaster
Sequence 2:	NP_727007.1	Gene:	RhoGAP5A / 31473	FlyBaseID:	FBgn0029778	Length:	494	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	130/521 - (24%)
Similarity:	195/521 - (37%)	Gaps:	145/521 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   682 RNTESIYSSRNHILGTGTLDRNMGLTRPISALPVRSMSSQHIGGAGSIRSPSIRRMR-QLLELSA 745
            ||||:         |.|  :.|.|             .|..:|||....||..:..: :|.:|..
  Fly     3 RNTEA---------GAG--NANTG-------------GSGGVGGAPEPSSPVQKVWKPELYKLQL 43

  Fly   746 GPASPSGSILSTGGHQSPAPTP---SATLPRPHRQIDINPAEFAKYKLDKPIVDIGGISGMLW-- 805
                           ::|||.|   ..|||.|       ||     |.....|:...::|.|:
  Fly    44 ---------------EAPAPCPLRCQRTLPLP-------PA-----KSTAEAVEANNLAGRLYGS 81

  Fly   806 ------IHLLAGRGLRTAPEGAAGTATQGQTRDLYCV-IECDRVHKARTV---------VRSGDL 854
                  .||.|.:.|..|.:|:.......|:...|.: :..::..|...:         :|..|.
  Fly    82 EYHGLMGHLEAEQLLANARDGSYFVRRSPQSDGYYTLSLRFNKRPKHYKLLYKPGVGHYLRGQDK 146

  Fly   855 QFDWDESFELDLVGN--KQLDVLVYSWDPQHRHKLCY----------RGAISLSSIL-------- 899
            :||.......|.:.|  .||...........:.|.||          |...:||:.|
  Fly   147 RFDTVHDMVADGLINFHMQLHASPIIQQINQQTKNCYQQSPYMTLNGRKLRALSNELGKAAAKES 211

  Fly   900 RQSPLHQLALK--------VEPRGTIYIRMRH---------------TDPLALYKRRGLPSLRAG 941
            ::||..:...|        |:|...:|.:..|               .:.|..:..:|:.....|
  Fly   212 KESPAEEKEQKQEEPPPPAVDPMPLVYEKPHHFKVHTFKGLNWCEFCANFLWGFTAQGVKCEACG 276

  Fly   942 Y---------------PTL------FGADLETVVNRESKNAPGSAPVPIVLRRCVEEVERRGLDI 985
            :               |.|      ||.||.|:|..|..:     .:|.|:||||||||.||:..
  Fly   277 FVAHSKCSELVPPKCVPDLKRIRGVFGTDLTTMVQLEPHH-----QIPFVVRRCVEEVEARGMLQ 336

  Fly   986 IGLYRLCGSATKKRLLREAFERNSRAVELTPEHVPDINVITGVLKDYLRELPEPLFTRCLFQMTV 1050
            .|:||:.|.|.:...|:.|.:|.....:::.....::|||.|.||.|||.||.||.|   ||...
  Fly   337 EGIYRVSGFADEIEALKLALDREGEKTDMSETAYGNVNVIAGTLKLYLRLLPVPLIT---FQAYP 398

  Fly  1051 DALAVCLPDDPEGNAKLMLSILDCLPRANRATLVFLLDHLSLVVSNSERNKMSAQALATVMGPPL 1115
            ..:|...........:||...:..||.|:.:.|.::|:||..|.|:...|||:...||||..|.|
  Fly   399 SFMAAGRTGKQAEQRQLMAEAVRRLPPAHHSCLQYMLEHLKRVASHYAVNKMNEHNLATVFAPTL 463

  Fly  1116 M 1116
            :
  Fly   464 I 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP100F	NP_001163786.1	PDZ_signaling	177..260	CDD:238492
		C2	804..905	CDD:175973	27/138 (20%)
		RhoGAP_SYD1	946..1144	CDD:239844	64/171 (37%)
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215	17/90 (19%)
		C1_1	242..294	CDD:278556	4/51 (8%)
		RhoGAP_chimaerin	302..491	CDD:239837	64/171 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443409
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46684
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840