DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP100F and Bcr

DIOPT Version :9

Sequence 1:	NP_001163786.1	Gene:	RhoGAP100F / 43758	FlyBaseID:	FBgn0039883	Length:	1866	Species:	Drosophila melanogaster
Sequence 2:	XP_038955099.1	Gene:	Bcr / 309696	RGDID:	1307993	Length:	1270	Species:	Rattus norvegicus

Alignment Length:	1232	Identity:	261/1232 - (21%)
Similarity:	412/1232 - (33%)	Gaps:	430/1232 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 GTGSPG---PPTLSRP---------EQKPPPVVVIKRDLRDEDLDETDRMPRPRSSRDR------ 313
            |.|||.   |.|..||         ::.||..|...|    .:.::..:.|....|.|.
  Rat   119 GEGSPSKGRPATARRPAAAAPADRDDRGPPTSVAALR----SNFEKIRKGPAQPGSADAEKPFYV 179

  Fly   314 -----------RTGDGREMTESRSRLGLGLNNYSPQSEQLDMYYNTRGGGGGAMGEPP------- 360
                       :..| :|:::..|.||       .|:.|::...:.:..|.| :||.|
  Rat   180 NVEFHHERGLVKVND-KEVSDRISSLG-------SQAMQMERKKSQQSAGQG-LGEAPRPHYRGR 235

  Fly   361 -----------------------------NWGYKPPPPP---------------------SSVIT 375
                                         |.|.:||.||                     |.::.
  Rat   236 SSESSCGLDGDYEDAELNPRFLKDNLINANGGNRPPWPPLEYQPYQSIYVGGMMVEGEGKSPLLR 300

  Fly   376 EQPTK---------AHAFAP------SHAYYQNAGTLESLAEKVHAFYPGQPGGPPVGPSRRMST 425
            .|.|.         ..:::|      ...|..:..:.|:|......|..||        |.|:|.
  Rat   301 SQSTSEQEKRLTWPRRSYSPRSFEDSGGGYTPDCSSNENLTSSEEDFSSGQ--------SSRVSP 357

  Fly   426 GTGNVGLAQQHARFPRSGSDQHL-------PRVEYSDYSNSLGRHSLLRSSLKPGTTGGAPMQVG 483
            ......:.:..:|.|...|.|..       |:.:        .||...:..:...|.      ||
  Rat   358 SPTTYRMFRDKSRSPSQNSQQSFDSSSPPTPQCQ--------KRHRQCQVVVSEATI------VG 408

  Fly   484 VGGTLGRY----GRYDQQRAGVSKYGPPSG-----GAQSLTRRSRPNLDYSSDTEATIGPRPSYY 539
            |..| |:.    |....|....|.:|.|.|     ......||.:..|.|..|:       ||
  Rat   409 VRKT-GQIWPSDGDSTFQGEADSSFGTPPGYGCAADQAEEQRRHQDGLPYIDDS-------PS-- 463

  Fly   540 YYNRPAIGSMSRGSGGAG-----------------------GGVGAASTAAL------------L 569
              :.|.:.|..|||..:|                       .|:.|:....|            |
  Rat   464 --SSPHLSSKGRGSPASGALEPTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPL 526

  Fly   570 AGAADLNK-----------FNSLP----------------------RERPGTRLQGIRSRMG-DR 600
            ..||..::           |..:|                      ::|.|...|.:.|::| .|
  Rat   527 KAAATTSQPVLTSQQIETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYR 591

  Fly   601 LVDENDG------------NTSAPEFD----VRRGRDLR----------------QRITASPSIF 633
            ...:|.|            |....|..    .|..:|::                .|:|.|..:.
  Rat   592 AFVDNYGVAMETAEKCCQANAQFAEISENLRARSNKDVKDSTTKNSLETLLYKPVDRVTRSTLVL 656

  Fly   634 TADEYRAWLRRAPSS----SAIAEQMRMTRDMFAQ------PRAQRFSCSAENIHDALRNT---E 685
                 ...|:..|||    |.:.:.:|::::..:.      ||.|..:.........|:::   |
  Rat   657 -----HDLLKHTPSSHPDHSLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVE 716

  Fly   686 SIYSSR--NHI-------LGTGTLDRNMGLTRPISA---LPVRSMSSQHIG-------------- 724
            .:..:|  .||       |.|....::.|.|:....   :|:..:|.|.:.
  Rat   717 LVEGARKLRHIFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEALPNIPLVPDE 781

  Fly   725 -------GAGSIRSPSIRRMR-----QLLELSAGPASPSGSIL------------STGG------ 759
                   ....|:|...|..|     :::|......|...|:|            |..|
  Rat   782 ELDALKIKISQIKSDIQREKRANKGSKVMERLRKKLSEQESLLLLMSPSMAFRVHSRNGKSYTFL 846

  Fly   760 ---------------HQSPAPTPSATLPRPHRQIDIN-----------PAEFAKYKLDKPIVDIG 798
                           .|......|.:|.....|:..|           |....|...:.|
  Rat   847 ISSDYERAEWRESIREQQKKCFKSFSLTSVELQMLTNSCVKLQTVHHIPLTINKEDDESP----- 906

  Fly   799 GISGMLWIHLLAGRGLRTAPEGAAGTATQGQTRDLYCVIECDR----VHKARTVVRSGDLQFDWD 859
            |:.|.|...:.:..|.:             |:.:|||.:|.|.    |:||:|.|.....:.:|:
  Rat   907 GLYGFLHAIVHSATGFK-------------QSSNLYCTLEVDSFGYFVNKAKTRVYRDTTEPNWN 958

  Fly   860 ESFELDLVGNKQLDVLVY----------SWDPQHRHKLCYRGAISLSSILRQSPLHQLALKVEPR 914
            |.||::|.|::.|.:|.|          ..|.:...||..:|.:.|.....|....|..: ::..
  Rat   959 EEFEIELEGSQTLRILCYEKCYNKMKMAKEDGESADKLMGKGQVQLDPQTLQDRDWQRTV-IDMN 1022

  Fly   915 G-TIYIRMRHTDPLALYKRRGLPSLRAGYPTLFGADLETVVNRESKNAPGSAPVPIVLRRCVEEV 978
            | .:.:.::.|......||  :||.:  ...:||..:..|..||      .:.||.::|:||||:
  Rat  1023 GIEVKLSVKFTSREFSLKR--MPSRK--QTGVFGVKIAVVTKRE------RSKVPYIVRQCVEEI 1077

  Fly   979 ERRGLDIIGLYRLCGSATKKRLLREAFERNSRAVELTPEHVPDINVITGVLKDYLRELPEPLFTR 1043
            ||||::.:|:||:.|.||..:.|:.||:.|::.|.:....: |:|.|.|.||.|.|||||||||.
  Rat  1078 ERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEM-DVNAIAGTLKLYFRELPEPLFTD 1141

  Fly  1044 CLFQMTVDALAVCLPDDPEGNAKLMLSILDCLPRANRATLVFLLDHLSLVVSNSERNKMSAQALA 1108
            ..:....:.:|:   .||......||::|..||.||..|.:||||||..|......||||...||
  Rat  1142 EFYPNFAEGIAL---SDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKETVNKMSLHNLA 1203

  Fly  1109 TVMGPPLMLHSASAQPGADIDHAQPIA--------------VLKYLLQI--WPQPQAQHQQM 1154
            ||.||.| |..:..:.....:.:|||.              ||.|.||:  .|.|.::.|.:
  Rat  1204 TVFGPTL-LRPSEKESKLPANPSQPITMTDSWSLEVMSQVQVLLYFLQLEAIPAPDSKRQSI 1264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP100F	NP_001163786.1	PDZ_signaling	177..260	CDD:238492
		C2	804..905	CDD:175973	28/114 (25%)
		RhoGAP_SYD1	946..1144	CDD:239844	81/213 (38%)
Bcr	XP_038955099.1	Bcr-Abl_Oligo	3..75	CDD:401106
		RhoGEF	501..688	CDD:395496	29/191 (15%)
		PH-like	683..876	CDD:418428	28/192 (15%)
		C2_ABR	912..1032	CDD:176068	30/133 (23%)
		RhoGAP_Bcr	1051..1251	CDD:239852	80/210 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D332603at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920