Protein Alignment RhoGAP100F and Syde2

DIOPT Version :9

• Sequence 1: NP_001163786.1
• Gene: RhoGAP100F / 43758
• FlyBaseID: FBgn0039883
• Length: 1866
• Species: Drosophila melanogaster
• Sequence 2: XP_017446301.2
• Gene: Syde2 / 308021
• RGDID: 1564206
• Length: 1281
• Species: Rattus norvegicus
• Alignment Length: 1161
• Identity: 288/1161 - (24%)
• Similarity: 440/1161 - (37%)
• Gaps: 364/1161 - (31%)

  Fly   264 GNRGTGSPGPPTLSRPEQKPPPVVVIKRDLRDEDLDETDRMPRP---------RSSRDRRTGDGR 319
            |..|:|..|                     .||..|..:.:|..         |:|..:..|...
  Rat    41 GTEGSGDDG---------------------EDEGADYYENLPAGCAPEGAEALRASPSQAAGSSP 84

  Fly   320 EMTESRSRLGLGLNNYSPQSEQLDMYY--------------NTRGGGGGAMGE------------ 358
            .|...|...|      ..|::..:.||              ..|||..||..:
  Rat    85 GMEGGRQETG------RLQTQLREAYYLLIQAMHDLPPDSGTRRGGPAGAQAQGQQPPLPRGAAV 143

  Fly   359 ----PPNWGYKPP----PPPSSVITEQPTKAHAFAPSHAYYQ--NAGTLESLAEKVHAFYP---- 409
                .|..|.:||    ||.||     ||::....|.....|  :..:||||  :|....|
  Rat   144 RRACSPRGGDRPPQQVSPPRSS-----PTESRVGRPPSPRMQLSSCRSLESL--RVSPQPPLFQR 201

  Fly   410 -----------------GQPGG--------------------PPV--GPSR------RMSTGTGN 429
                             .||.|                    ||.  .|||      :...||..
  Rat   202 WASDSWIRCGAHRDREEPQPRGGGMDGWSRGSHRAATSAALLPPFCQDPSRSSGRPFKDPAGTSV 266

  Fly   430 VGLAQQHARFPRSGSDQHLPRVEYSDYSNSLGRHSLLRSSLKPGTTGGAPMQVGVGGTLGRYGRY 494
            :..:|:.  .|........|.|........:.:..||...:|....|.||...|...|....|.:
  Rat   267 ISCSQED--HPEELPLLKPPAVTVKKLQKWMYKGRLLSLGMKGRAHGTAPKVPGAQATSPNLGSW 329

  Fly   495 ------------DQQ------------RAGVSKYGPPSG-------GAQSLTR------------ 516
                        ||:            .:.:.|..|..|       |.|:|..
  Rat   330 KVHENHVLSVTADQRITLTADLFENVCGSPLKKRDPGGGRGNTELSGHQALNNITVSKKRNWLYQ 394

  Fly   517 ---RSRPNLD--YSSDTEATIG----PRPSYYYYNRPAIGSMSRGSGGAGGGVGAAS-------- 564
               || |:||  |||.:..:..    |:|....:..|.:.::...:|......|:::
  Rat   395 SPLRS-PSLDRHYSSLSPVSPPRHRLPQPFCKPHREPCMHAVCNAAGSPSSRNGSSAFSEDDADD 458

  Fly   565 ------------TAALLAGAADLNKFNSLPRERPGTRLQGIRSR------------------MGD 599
                        .:..:|....|.:.|:...:.|..|:..:.:|                  .||
  Rat   459 EGEIWYNPIPEDDSLGIAHVLSLEEANAAALKLPAVRVSMLSARDLAKAETRSEDLLCPTQHRGD 523

  Fly   600 RLVDENDGNTSAPEF---DV------RRGRDLRQRITA--SP---SIFTA---------DEYRAW 641
            ....:::|..|....   |:      |.|...::.:||  ||   |.||.         .|.||.
  Rat   524 VQTSQSNGINSVDSIHSTDIVQPCRQRLGHRTQESLTAEDSPGLKSAFTGPGILVSTNRTELRAL 588

  Fly   642 LRRAPSSSAIAEQMRMT---RDMFAQPR-AQRFSCSAENIHDALRNTESIYSSRNHILGTGTLDR 702
            ...:||.|.:.:...:|   .|....|| .::.|...:.:.:..|..    .:|..:..|.:.||
  Rat   589 EPPSPSPSPVKKGSSITWSLPDKIKSPRTVRKLSMKMKRLPEFSRKR----GARGALHYTNSPDR 649

  Fly   703 NMGLTR----------------PISALPVR-----SMSSQHI---GGAGSIRSPSIRRMRQLLEL 743
            ...|::                |.|.:..|     ::||||.   ...||.|.|.
  Rat   650 TPPLSKWYYGEGPQSVLLPSGNPASNVISRYHLDTTVSSQHSYQKKPLGSSRYPC---------- 704

  Fly   744 SAGPASPSGSILSTGGHQSP-APTPSATLPRPHR---------------QIDINPAEFAKYKL-D 791
                   .|..||.|  .|| ..|.|:.....||               :||:  ..|..|.. |
  Rat   705 -------KGGYLSDG--DSPELRTRSSKHGSEHRLGKGREAVPSGCSKNEIDV--GAFRHYSFSD 758

  Fly   792 KPIVDIGGISGMLWIHLLAGRGLRTAPEGAAGTATQGQTRDLYCVIECDRVHKARTVVRSGDLQF 856
            :|... ..|||::.:|.....||:         ..:..::|::|.|:.|.|:||||.:.:....|
  Rat   759 QPKCS-QYISGLMSVHFYGAEGLK---------PPRIDSKDVFCAIQVDSVNKARTALLTCRTTF 813

  Fly   857 -DWDESFELDLVGNKQLDVLVYSWDP-QHRHKLCYRGAISLSSILRQSPLHQLALKVEPRGTIYI 919
             |.|.:|.:::...:.|.::|:||:| ..|:::|..|.:.|.::.|.:..||||:|:||||.||:
  Rat   814 LDLDHTFNIEIENAQHLKLVVFSWEPTPRRNRVCCHGTVVLPALFRVTRTHQLAVKLEPRGLIYV 878

  Fly   920 RMRHTDPLALYKR-----RGLPSLRAGYPTLFGADLETVVNRESKNAPGSAPVPIVLRRCVEEVE 979
            :      :.|.::     .||...|..  .:||.|::.||.:|:    ....||:::::|:.|:|
  Rat   879 K------VTLMEQWENSLHGLDKNRES--VMFGVDIQKVVEKEN----AGLMVPLLIQKCIMEIE 931

  Fly   980 RRGLDIIGLYRLCGSATKKRLLREAFERNSRAVELTPEHVPDINVITGVLKDYLRELPEPLFTRC 1044
            :||..::|||||||||..|:.||||||::|:.|.|..:..||||||||||||||||||.||.|:.
  Rat   932 KRGCQVVGLYRLCGSAAVKKELREAFEKDSKTVGLCEDQYPDINVITGVLKDYLRELPSPLITKQ 996

  Fly  1045 LFQMTVDALAVCLP--------DDPEGNAKLMLSILDCLPRANRATLVFLLDHLSLVVSNSERNK 1101
            |:|..:||: |..|        ::...:::..:.:|:|||...:|||..|||||.||.|..|.||
  Rat   997 LYQAVLDAM-VKSPLKMSSNGCENESSDSRFTVDLLNCLPDVEKATLKMLLDHLKLVASYHEVNK 1060

  Fly  1102 MSAQALATVMGPPLM------------LHSASAQPGADIDHAQPIAVLKYLLQIWP 1145
            |:.|.||...||.|:            :.|.|.:..:.:|..:.|.||.||||:||
  Rat  1061 MTCQNLAVCFGPVLLNQRQETSTHNNRVFSDSEELASALDFKKHIEVLHYLLQLWP 1116

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP100F	NP_001163786.1	PDZ_signaling	177..260	CDD:238492
		C2	804..905	CDD:175973	26/102 (25%)
		RhoGAP_SYD1	946..1144	CDD:239844	94/217 (43%)
Syde2	XP_017446301.2	PHA03247	<115..324	CDD:223021	45/217 (21%)
		C2	767..882	CDD:417471	39/129 (30%)
		RhoGAP	902..1116	CDD:413382	94/218 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337258
Domainoid	1	1.000	152	1.000	Domainoid score	I4226
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004214
OrthoInspector	1	1.000	-	-		otm44991
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46150
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2962
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.030