Protein Alignment RhoGAP100F and ABR

DIOPT Version :9

• Sequence 1: NP_001163786.1
• Gene: RhoGAP100F / 43758
• FlyBaseID: FBgn0039883
• Length: 1866
• Species: Drosophila melanogaster
• Sequence 2: XP_016880028.1
• Gene: ABR / 29
• HGNCID: 81
• Length: 1137
• Species: Homo sapiens
• Alignment Length: 1177
• Identity: 261/1177 - (22%)
• Similarity: 391/1177 - (33%)
• Gaps: 419/1177 - (35%)

  Fly   304 MPRPRSSRDRRTGDGREMTESRSRLGLGLNNYSPQSEQLDMYYNTRG---GGGGAMGEP--PNWG 363
            :||..|.||..    ||:  .|.||.|.........|||........   ||||..|||  |:..
Human    22 VPRLESVRDAE----REL--ERRRLNLERLQQVLAEEQLKASLPQAALARGGGGDSGEPGRPDPE 80

  Fly   364 YKPP------PPPSSVITEQPTKAHAFAPSHAYYQNAGTLESLAEKVH--AFYP----------- 409
            .:.|      |.|.:   |.|.......|..|  ..||...|.|:.||  ...|
Human    81 AESPRGDPGRPDPEA---ESPRGDLPAGPGAA--GEAGGGRSWADAVHRQLLQPQLRFRAREDDA 140

  Fly   410 --GQPGGPP----------------------------VGP---------------------SRRM 423
              |.|...|                            |.|                     .||.
Human   141 PLGDPQAAPGTDEGGDGGDHDFEMVDFNEKFILSHWLVAPCRFGTRERARSPRRWMHLIPGGRRP 205

  Fly   424 STGTGNVGLAQQHARFPRSGSD---------QHLP--------RVEYSDYSNSLGRHSLLRSSLK 471
            ..||.::...:..|: .|.||.         :|||        ||...|   |.|..|..|.|
Human   206 QRGTRDLEQREAEAK-GRPGSPLAAEETPGREHLPPWRRRRFLRVPERD---SPGHSSPERDS-- 264

  Fly   472 PGTTGGAPMQVGVGGTLGRYG--RYDQQRAGVSKYGPPSGGAQSLTRRSRPNLDYSSDTEATIGP 534
            .|:...:..:........ ||  .||.: ....:.|||.|.      .:.|.:|.|        |
Human   265 DGSRHSSDREDDFSADFS-YGTDEYDGE-GNEEQKGPPEGS------ETMPYIDES--------P 313

  Fly   535 RPSYYYYNRPAIGSMSRGSG-------------GAGGGVGAASTAALLAG--AAD---LNKFNSL 581
            ..|      |.:.:.|:|.|             |...|.|......:|:|  |::   :|:..:|
Human   314 TMS------PQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEAL 372

  Fly   582 -----PRERPGTRLQ-------------------GIRSRMGDRL---VDENDGNTSAPEFDVRRG 619
                 |.:...|..|                   .|.....|.|   |.:.|.       .|..|
Human   373 LLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDS-------QVTMG 430

  Fly   620 RDLRQRITASPSIFTA--DEYRAWLRRAPSSS-------AIAEQMR-------------MTRDMF 662
            . |.|::.:...::.|  |.|:..|..|...|       .|:|:::             :|.:..
Human   431 H-LFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEAL 494

  Fly   663 AQPRAQRFSCSAENIHDALRNT-----------ESIYSSRNHILGTG-TLD-RNMGLTRPISALP 714
            ......|.:.|...:||.|::|           :::..|:|.:.... .:| |...:|.|
Human   495 LYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTP----- 554

  Fly   715 VRSMSSQHIGGAGSIR-SPSIRRMRQLLELSAGPASPSGSILSTGGHQS--------------PA 764
             :..:.|.:.....:. |.|.|::|.:...:...........|.|.||.              |:
Human   555 -KGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPS 618

  Fly   765 PTPSATLPRPH-----------RQIDINPAEFAKYK------------------------LDKPI 794
            |..|...|:.|           .:|....:|..|.|                        |:.|.
Human   619 PEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPT 683

  Fly   795 VD--IGGISGMLWIHLLAG---------------------------------------RGLRTAP 818
            :.  |...:|..::.||:.                                       |.:...|
Human   684 IPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIP 748

  Fly   819 ----------EGAAG------TATQG--QTRDLYCVIECDR----VHKARTVVRSGDLQFDWDES 861
                      .|..|      .:.:|  |:.:|||.:|.|.    |.||:|.|.....:..|||.
Human   749 VTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTAEPKWDEE 813

  Fly   862 FELDLVGNKQLDVLVYSWDPQHRHKLCYRGAISLSSILRQSPLHQLALKVEPRG-------TIYI 919
            ||::|.|::.|.:            |||......:.:.:.:  :::..|:..:|       |:..
Human   814 FEIELEGSQSLRI------------LCYEKCYDKTKVNKDN--NEIVDKIMGKGQIQLDPQTVET 864

  Fly   920 RMRHTDPLAL----------YKRRGLPSLRAGYPT-----LFGADLETVVNRESKNAPGSAPVPI 969
            :..|||.:.:          :..|.:...|.  |:     :||..:..|..||      .:.||.
Human   865 KNWHTDVIEMNGIKVEFSMKFTSRDMSLKRT--PSKKQTGVFGVKISVVTKRE------RSKVPY 921

  Fly   970 VLRRCVEEVERRGLDIIGLYRLCGSATKKRLLREAFERNSRAVELT---------PEHVP----- 1020
            ::|:||||||:||::.:|:||:.|.||..:.|:..|:.:.:..:||         |.:..
Human   922 IVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDASKQLQKLTRADSLAQDDPTYNKDILLM 986

  Fly  1021 ----DINVITGVLKDYLRELPEPLFTRCLFQMTVDALAVCLPDDPEGNAKLMLSILDCLPRANRA 1081
                |||.|.|.||.|.|||||||.|..|:...::.:|:   .||......|:.:|..||..|..
Human   987 LSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIAL---SDPAAKENCMMHLLRSLPDPNLI 1048

  Fly  1082 TLVFLLDHLSLVVSNSERNKMSAQALATVMGPPLM--------LHSASAQPGADI---DHAQPIA 1135
            |.:|||:||..|......||||...||||.||.|:        .|..||   |||   |....:.
Human  1049 TFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSA---ADIWSHDVMAQVQ 1110

  Fly  1136 VLKYLLQ 1142
            ||.|.||
Human  1111 VLLYYLQ 1117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP100F	NP_001163786.1	PDZ_signaling	177..260	CDD:238492
		C2	804..905	CDD:175973	29/161 (18%)
		RhoGAP_SYD1	946..1144	CDD:239844	82/226 (36%)
ABR	XP_016880028.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D332603at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920