Protein Alignment RhoGAP100F and syd-1

DIOPT Version :10

• Sequence 1: NP_001163786.1
• Gene: RhoGAP100F / 43758
• FlyBaseID: FBgn0039883
• Length: 1866
• Species: Drosophila melanogaster
• Sequence 2: NP_001022146.1
• Gene: syd-1 / 174230
• WormBaseID: WBGene00006363
• Length: 987
• Species: Caenorhabditis elegans
• Alignment Length: 1200
• Identity: 334/1200 - (27%)
• Similarity: 486/1200 - (40%)
• Gaps: 367/1200 - (30%)

  Fly    21 RMLCCGRRKENGRSVPDVTASPGRAPPGPLPANQMPAMGNQQHHGNQQHHGNQQQHHGNQHSNHR 85
            |:|||       .|..|.|||..|     :.|:|.|.
 Worm    50 RLLCC-------CSPVDQTASRSR-----MNASQPPP---------------------------- 74

  Fly    86 GQSGSLSNAAGVKDPVMLQGDFRKVSGISSEIFRQIEAVENDHDPNTAAALEAV-------ERRG 143
            |..|.|.:                      |:||:|.||:......|.:.::.:       |.||
 Worm    75 GGGGRLPD----------------------EVFRKITAVDQGQSTLTQSGIQGLSARTLSSEPRG 117

  Fly   144 EMIVRVLEPRCMGSKQAVDAAHKLMNKADARHTVQLVEIVKRPGQTLGLYIREGNGADRTDGVFI 208
            :::                              .|||||:|:|||:||||:|||||.||:||||:
 Worm   118 DLV------------------------------FQLVEIIKKPGQSLGLYLREGNGKDRSDGVFV 152

  Fly   209 SRIALESAVYNSG-CLRVGDEILAVNLVDVTHMSLDDVVIIMSIPRRLVLAIRQRRGNRGTGSPG 272
            ||....|.:...| .:|.|||||.:|.|:|:.||:||||:|:||||||:|.||..:..|     .
 Worm   153 SRFGDNSELAKYGEVMRPGDEILTINNVEVSMMSIDDVVLILSIPRRLLLRIRYSKSMR-----H 212

  Fly   273 PPTLSRPEQKPPPVVVIKR--DLRDEDLDETDR--MPRPRSSRDRRTG--DGREMTESR-----S 326
            ....||..:...||||..:  |.||   .||:.  :.:|.|:.:...|  ..::|.|.|     |
 Worm   213 EIISSRSRESERPVVVFHKYDDRRD---SETNAPILSQPTSTANTWLGKKSRQQMEEMRNATTSS 274

  Fly   327 RLGLGLNNYSPQSEQLDMYYNTRGGGGGAMGEPPNWGYKPPPPPSSVITEQPTKAHAFAPSHAYY 391
            .|....:..||::.......|   |...::|.|                ...|.:|    .|.|.
 Worm   275 TLRTHASTSSPRNHFAPRLVN---GHSHSIGVP----------------SASTTSH----DHQYQ 316

  Fly   392 QNAGTLESLAEKVHAFYPGQPGGPPVGPSRRMSTGTGNVGLAQQHARFPRSGSDQHLPRVEYSDY 456
            :.|..                      ||..:|          :.||.|.       ||:.
 Worm   317 RFASE----------------------PSDSVS----------RTARVPP-------PRLA---- 338

  Fly   457 SNSLGRHSLLRSSLKPGTTGGAPMQVGVGGTLGRYGRYDQQRAGVSKYGPPSGG-----AQSLTR 516
            |.::.|.....|:  ||.:..|||             |...|:..:...|...|     |:....
 Worm   339 SATVRRTESFNSA--PGVSTSAPM-------------YTLPRSSTAVPPPDILGSIPYSARDPLM 388

  Fly   517 RSRPNLDYSSDTEATIGPRPSYYYYNRPAIGSMSRGSGGAGGGVGAASTAALLA----------- 570
            ||..:|.|.                  |..|.:|          .:..|..||:
 Worm   389 RSSADLPYD------------------PMTGRLS----------SSVPTDPLLSRSLCSPILPRT 425

  Fly   571 --GAADLNKFNSLPRERPGTRLQGIRSR-----MGDRLVDENDGNTSAPEFDVRRGRDLRQR--- 625
              .|.|.||.|||||.|..|..:.::.|     ..|...:|:||..||||:.......|.|:
 Worm   426 LRQANDSNKSNSLPRRRIMTGGRNVKWRNDVVSTSDLCGEESDGAISAPEYSSPPFSRLTQQQQF 490

  Fly   626 --ITASP-----SIFTADEYRAWLRRAPSSSAIAEQMRMTRDMFAQ----PRAQRFSCSAENIHD 679
              ...||     .||:|.|||.|  ..|..         .|.|:..    .||.|:|
 Worm   491 RLSNGSPGRTVNDIFSAAEYRNW--AGPYD---------PRGMYGPFPPGQRATRWS-------- 536

  Fly   680 ALRNTESIYSSRNHILGTGTLDRNMGLTRPISALPVRSMSSQHIGGAGSIRSPSIRRMRQLLELS 744
                         |..|.....|.       |:||.|::.:|.:.|     ||.:.|
 Worm   537 -------------HTYGEQRAPRT-------SSLPGRTVLAQSLVG-----SPVLPR-------- 568

  Fly   745 AGPASPSGSILSTGGHQSP--APTPSATLPRPHRQIDIN---PAEFAKYKLDKPIVDIGGISGML 804
                           |..|  ...|||...|.|....:|   |...|...::...:.:..::|:|
 Worm   569 ---------------HPPPIVQDRPSAVFDRYHVSPLMNRRAPLRAAGPGINVDRLSVSSLTGIL 618

  Fly   805 WIHLLAGRGLRTAPEGAAGTATQGQTRDLYCVIECDRVHKARTVVRSGDLQFDWDESFELDLVGN 869
            ::|::.||||: .||     ..:|.|.::|||:|.|..|:|||.|.:.:.:|.|.|:|.:|:|..
 Worm   619 YVHIVEGRGLK-IPE-----KQKGLTEEMYCVLEVDEQHRARTGVSTIEQKFKWRETFHIDVVNA 677

  Fly   870 KQLDVLVYSWDPQHRHKLCYRGAISLSSILRQSPLHQ---LALKVEPRGTIYIRMRHTDPLALYK 931
            ...:..||||.||.|||||::|::.|........|:.   .||.:||||.:.:|:...|..|:::
 Worm   678 TVSNFFVYSWHPQFRHKLCHKGSLKLLEAFVVDQLNDDRVFALNLEPRGQLIVRIGFHDLQAVFR 742

  Fly   932 RRGLPSLRAGYPTLFGADLETVVNRESKNAPGSAPVPIVLRRCVEEVERRGLDIIGLYRLCGSAT 996
            |...|.|..    :||..|..:|.||.::      .||||.|.::|:|:||:|..|||.||||..
 Worm   743 RTVNPRLNG----VFGISLSRLVQRERRD------TPIVLTRLIQEIEKRGVDYSGLYVLCGSVE 797

  Fly   997 KKRLLREAFERNSRAVELTPEHVPDINVITGVLKDYLRELPEPLFTRCLFQMTVDALAVCLPDDP 1061
            ||::||...|.|....||..|.:||.|||..::||:||||||||.:..:..|.::|.:|.||:|.
 Worm   798 KKKMLRAELESNPLGTELAAESIPDTNVIACLIKDFLRELPEPLISPQIHGMLLEAASVALPNDV 862

  Fly  1062 EGNAKLMLSILDCLPRANRATLVFLLDHLSLVVSNSERNKMSAQALATVMGP----------PLM 1116
            :.|..|:|.|:|||..:.:..|:.:|||||.|:.:|..|.::...|:.:..|          |..
 Worm   863 QTNRHLVLKIIDCLQLSAKNCLLLVLDHLSTVLCSSPHNGLTPTRLSLIFAPLLFFCLDTFSPYT 927

  Fly  1117 LHSASAQPGA-DIDHAQPIAVLKYLLQIWP 1145
            :...|..... .:|..|..:.|:.:|.|||
 Worm   928 ISPTSKMAAVRTLDINQASSSLQMILSIWP 957

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP100F	NP_001163786.1	PDZ_Par6-like	178..261	CDD:467202	52/83 (63%)
		C2	804..905	CDD:175973	39/100 (39%)
		RhoGAP_SYD1	946..1144	CDD:239844	77/208 (37%)
		DUF5585	1349..>1604	CDD:465521
syd-1	NP_001022146.1	PDZ_Par6-like	122..206	CDD:467202	52/83 (63%)
		C2	617..705	CDD:214577	39/93 (42%)
		RhoGAP_SYD1	753..957	CDD:239844	78/209 (37%)