DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP100F and Abr

DIOPT Version :9

Sequence 1:	NP_001163786.1	Gene:	RhoGAP100F / 43758	FlyBaseID:	FBgn0039883	Length:	1866	Species:	Drosophila melanogaster
Sequence 2:	NP_932135.1	Gene:	Abr / 109934	MGIID:	107771	Length:	871	Species:	Mus musculus

Alignment Length:	879	Identity:	198/879 - (22%)
Similarity:	314/879 - (35%)	Gaps:	290/879 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   491 YGRYDQQRAG-VSKYGPPSGGAQSLTRRSRPNLDYSSDTEATIGPRPSYYYYNRPAIGSMSRGSG 554
            ||..|....| ..:.|||.|.      .:.|.:|.|        |..|      |.:.:.|:|.|
Mouse    36 YGAEDYDAEGHEEQKGPPEGS------ETMPYIDES--------PTMS------PQLSARSQGGG 80

  Fly   555 -------------GAGGGVGAASTAALLAG--AAD---LNKFNSL-----PRERPGTRLQ----- 591
                         |...|.|......:|:|  |::   :|:..:|     |.:...|..|
Mouse    81 DSVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTI 145

  Fly   592 --------------GIRSRMGDRL---VDENDGNTSAPEFDVRRGRDLRQRITASPSIFTA--DE 637
                          .|.....|.|   |.:.|.       .|..|. |.|::.:...::.|  |.
Mouse   146 QQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDS-------QVTMGH-LFQKLASQLGVYKAFVDN 202

  Fly   638 YRAWLRRAPSSS-------AIAEQMR-------------MTRDMFAQPRAQRFSCSAENIHDALR 682
            |:..|..|...|       .|:|:::             :|.:........|.:.|...:||.|:
Mouse   203 YKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLK 267

  Fly   683 NT-----------ESIYSSRNHILGTG-TLD-RNMGLTRPISALPVRSMSSQHIGGAGSIR-SPS 733
            :|           :::..|:|.:.... .:| |...:|.|      :..:.|.:.....:. |.|
Mouse   268 HTPVDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTP------KGETRQLVKDGFLVEMSES 326

  Fly   734 IRRMRQLLELSAGPASPSGSILSTGGHQS--------------PAPTPSATLPRPH--------- 775
            .|::|.:...:...........|.|.||.              |:|..|...|:.|
Mouse   327 SRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSPEESEASPQVHPFPDHELED 391

  Fly   776 --RQIDINPAEFAKYK------------------------LDKPIVD--IGGISGMLWIHLLAG- 811
              .:|....:|..|.|                        |:.|.:.  |...:|..::.||:.
Mouse   392 MKTKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSD 456

  Fly   812 --------------------------------------RGLRTAP----------EGAAG----- 823
                                                  |.:...|          .|..|
Mouse   457 YERSEWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVI 521

  Fly   824 -TATQG--QTRDLYCVIECDR----VHKARTVVRSGDLQFDWDESFELDLVGNKQLDVLVYSWDP 881
             .:.:|  |:.:|||.:|.|.    |.||:|.|.....:..|||.||::|.|::.|.:
Mouse   522 VHSAKGFKQSANLYCTLEVDSFGYFVSKAKTRVFRDTTEPKWDEEFEIELEGSQSLRI------- 579

  Fly   882 QHRHKLCYRGAISLSSILRQSPLHQLALKVEPRG-------TIYIRMRHTDPLAL---------- 929
                 |||......:.:.:.:  :::..|:..:|       |:..:..|||.:.:
Mouse   580 -----LCYEKCYDKTKVNKDN--NEIVDKIMGKGQIQLDPQTVESKNWHTDVIEMNGIKVEFSMK 637

  Fly   930 YKRRGLPSLRAGYPT-----LFGADLETVVNRESKNAPGSAPVPIVLRRCVEEVERRGLDIIGLY 989
            :..|.:...|.  |:     :||..:..|..||      .:.||.::|:|:||||:||::.:|:|
Mouse   638 FTSRDMSLKRT--PSKKQTGVFGVKISVVTKRE------RSKVPYIVRQCIEEVEKRGIEEVGIY 694

  Fly   990 RLCGSATKKRLLREAFERNSRAVELTPEHVPDINVITGVLKDYLRELPEPLFTRCLFQMTVDALA 1054
            |:.|.||..:.|:..|:.|::.:.|....: |||.|.|.||.|.|||||||.|..|:...::.:|
Mouse   695 RISGVATDIQALKAVFDANNKDILLMLSDM-DINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIA 758

  Fly  1055 VCLPDDPEGNAKLMLSILDCLPRANRATLVFLLDHLSLVVSNSERNKMSAQALATVMGPPLM--- 1116
            :   .||......|:.:|..||..|..|.:|||:||..|......||||...||||.||.|:
Mouse   759 L---SDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPS 820

  Fly  1117 -----LHSASAQPGADI---DHAQPIAVLKYLLQ 1142
                 .|..||   |||   |....:.||.|.||
Mouse   821 EVESKAHLTSA---ADIWSHDVMAQVQVLLYYLQ 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP100F	NP_001163786.1	PDZ_signaling	177..260	CDD:238492
		C2	804..905	CDD:175973	29/161 (18%)
		RhoGAP_SYD1	946..1144	CDD:239844	80/208 (38%)
Abr	NP_932135.1	RhoGEF	104..294	CDD:238091	34/197 (17%)
		PH_ABR	289..472	CDD:270172	28/188 (15%)
		C2_ABR	518..638	CDD:176068	29/133 (22%)
		RhoGAP_Bcr	657..852	CDD:239852	80/208 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D332603at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920