DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FeCH and FC2

DIOPT Version :9

Sequence 1:	NP_524613.1	Gene:	FeCH / 43757	FlyBaseID:	FBgn0266268	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_001189639.1	Gene:	FC2 / 817589	AraportID:	AT2G30390	Length:	522	Species:	Arabidopsis thaliana

Alignment Length:	359	Identity:	128/359 - (35%)
Similarity:	201/359 - (55%)	Gaps:	34/359 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 KTAILMLNMGGPTHTDQVHDYLLRIMTDRDMIQLP-----VQSRLGPWIAQRRTPEVQKKYKEIG 87
            |..:|:||:|||...|.|..:|..:..|.|:|:||     :|..|..:|:..|.|:.::.|..||
plant   100 KIGVLLLNLGGPETLDDVQPFLFNLFADPDIIRLPPVFQFLQKPLAQFISVARAPKSKEGYASIG 164

  Fly    88 GGSPILKWTELQGQLMCEQLDR-ISPETAPHKHYVGFRYVNPLTENTLAEIEKDKPERVVLFSQY 151
            ||||:...|:.|    .|:|.: :..:..|.|.|||.||.:|.||..:.:|::|...::|:...|
plant   165 GGSPLRHITDAQ----AEELRKCLWEKNVPAKVYVGMRYWHPFTEEAIEQIKRDGITKLVVLPLY 225

  Fly   152 PQYSCATSGSSFNSIFTHYRSNNLPSDIKWSIIDRWGTHPLLIKTFAQRIRDELAKFVETKRN-- 214
            ||:|.:|||||...:...:|.:....:::.::|..|......||..|..|:.||.||....:.
plant   226 PQFSISTSGSSLRLLERIFREDEYLVNMQHTVIPSWYQREGYIKAMANLIQSELGKFGSPNQTCF 290

  Fly   215 ------DVVILFTAHSLPLKAVNR-GDAYPSEIGASVHMVMQELGQ---TNPYSLAWQSKVGPLP 269
                  .|||.|:||.:||..|.. ||.|.:|:...|.::|:||.:   ||.|:||:||:|||:.
plant   291 KPKYMLQVVIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEELDKRKITNAYTLAYQSRVGPVE 355

  Fly   270 WLAPATDDAIKGYVKQGLKNFILVPIAFVNEHIETLHELDIEYCDELAKEVGVEEIRRAATPNDH 334
            ||.|.|::||....|:|::|.:.|||:||:||||||.|:|:|| .|||.:.|::...|.......
plant   356 WLKPYTEEAITELGKKGVENLLAVPISFVSEHIETLEEIDVEY-KELALKSGIKNWGRVPALGTE 419

  Fly   335 PLFIDALTNVVAD-----------HLKSQQAVNP 357
            |:||..|.:.|.:           :|:::|::.|
plant   420 PMFISDLADAVVESLPYVGAMAVSNLEARQSLVP 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FeCH	NP_524613.1	Ferrochelatase	29..349	CDD:279146	124/348 (36%)
		Ferrochelatase_N	29..190	CDD:239504	55/166 (33%)
		Ferrochelatase_C	195..332	CDD:238240	63/148 (43%)
FC2	NP_001189639.1	PLN02449	30..515	CDD:178068	128/359 (36%)
		Ferrochelatase_N	101..263	CDD:239504	55/165 (33%)
		Ferrochelatase_C	269..417	CDD:238240	63/148 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	216	1.000	Domainoid score	I745
eggNOG	1	0.900	-	-		E1_COG0276
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H113
Inparanoid	1	1.050	217	1.000	Inparanoid score	I1220
OMA	1	1.010	-	-		QHG62486
OrthoDB	1	1.010	-	-		D1003638at2759
OrthoFinder	1	1.000	-	-		FOG0004364
OrthoInspector	1	1.000	-	-		otm3366
orthoMCL	1	0.900	-	-		OOG6_101310
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3086
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.740